Author Friede, Tim

1 to 100 of 187 Items

2010 | Journal Article
Aspects of Modernizing Drug Development Using Clinical Scenario Planning and Evaluation
Benda, N.; Branson, M.; Maurer, W. & Friede, T. (2010)
DRUG INFORMATION JOURNAL, 44(3) pp. 299-315.
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2010 | Journal Article
Blinded Sample Size Recalculation in Noninferiority Trials: A Case Study in Dermatology
Friede, T. & Stammer, H. (2010)
DRUG INFORMATION JOURNAL, 44(5) pp. 599-607.
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2010 | Journal Article
Refinement of the Clinical Scenario Evaluation Framework for Assessment of Competing Development Strategies With an Application to Multiple Sclerosis
Friede, T.; Nicholas, R.; Stallard, N.; Todd, S.; Parsons, N.; Valdes-Marquez, E. & Chataway, J. (2010)
DRUG INFORMATION JOURNAL, 44(6) pp. 713-718.
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2010 | Journal Article
Perspectives on the Use of Adaptive Designs in Clinical Trials. Part II. Panel Discussion
Benda, N.; Brannath, W.; Bretz, F.; Burger, H.-U.; Friede, T.; Maurer, W. & Wang, S. (2010)
Journal of Biopharmaceutical Statistics, 20(6) art. PII 929076459. DOI: https://doi.org/10.1080/10543406.2010.514447
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2010 | Conference Paper |
Blinded sample size reestimation with count data: Methods and applications in multiple sclerosis
Friede, T. & Schmidli, H. (2010)
Statistics in Medicine, 29(10) pp. 1145-1156. Annual Conference on Statistical Issues in Clinical Trials-Early, Translational and Proof of Concept Studies - The Go/No Go Decisions, Philadelphia, PA.
Malden: Wiley-blackwell. DOI: https://doi.org/10.1002/sim.3861
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2010 | Review
Bladder symptoms in multiple sclerosis: a review of pathophysiology and management
Nicholas, R.; Young, C. A.& Friede, T. (2010)
Expert Opinion on Drug Safety, 9(6) pp. 905-915.
Informa Healthcare. DOI: https://doi.org/10.1517/14740338.2010.501793
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2011 | Conference Abstract
Interleukin 2 Receptor Antagonists for Liver Transplant Recipients: A Systematic Review and Meta-Analysis of Controlled Trials
Goralczyk, A. D.; Hauke, N.; Bari, N.; Lorf, T.; Friede, T. & Obed, A. (2011)
Liver Transplantation, 17(6) pp. S262-S263. Joint International Congress of ILTS, ELITA, and LICAGE, Valencia, SPAIN.
Malden: Wiley-blackwell.
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2011 | Journal Article | Letter Note
Planning and analysis of three-arm non-inferiority trials with binary endpoints
Kieser, M. & Friede, T. (2011)
Statistics in Medicine, 30(3). DOI: https://doi.org/10.1002/sim.4113
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2011 | Journal Article |
Software tools for implementing simulation studies in adaptive seamless designs: introducing R package ASD
Parsons, N.; Friede, T.; Todd, S. & Stallard, N. (2011)
Trials, 12(Suppl 1) pp. A8. DOI: https://doi.org/10.1186/1745-6215-12-S1-A8
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2011 | Review |
Development of oral immunomodulatory agents in the management of multiple sclerosis
Nicholas, R.; Giannetti, P.; Alsanousi, A.; Friede, T.& Muraro, P. A. (2011)
Drug Design Development and Therapy, 5 pp. 255-274.
Dove Medical Press Ltd. DOI: https://doi.org/10.2147/DDDT.S10498
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2011 | Journal Article
Sample Size Reassessment in Non-inferiority Trials
Friede, T. & Kieser, M. (2011)
METHODS OF INFORMATION IN MEDICINE, 50(3) pp. 237-243. DOI: https://doi.org/10.3414/ME09-01-0063
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2011 | Conference Paper
Designing a seamless phase II/III clinical trial using early outcomes for treatment selection: An application in multiple sclerosis
Friede, T.; Parsons, N.; Stallard, N.; Todd, S.; Marquez, E. V.; Chataway, J. & Nicholas, R. (2011)
Statistics in Medicine, 30(13) pp. 1528-1540. , Biopharm & Hlth Grp French Soc Stat, Paris, FRANCE.
Hoboken: Wiley-blackwell. DOI: https://doi.org/10.1002/sim.4202
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2011 | Journal Article |
Trends in annualized relapse rates in relapsing-remitting multiple sclerosis and consequences for clinical trial design
Nicholas, R.; Straube, S.; Schmidli, H.; Schneider, S. & Friede, T. (2011)
Multiple Sclerosis Journal, 17(10) pp. 1211-1217. DOI: https://doi.org/10.1177/1352458511406309
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2011 | Journal Article |
Warwick-Edinburgh Mental Well-being Scale (WEMWBS): Validated for teenage school students in England and Scotland. A mixed methods assessment
Clarke, A.; Friede, T.; Putz, R.; Ashdown, J.; Martin, S.; Blake, A. & Adi, Y. et al. (2011)
BMC Public Health, 11 art. 487. DOI: https://doi.org/10.1186/1471-2458-11-487
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2011 | Journal Article |
A novel adaptive design strategy increases the efficiency of clinical trials in secondary progressive multiple sclerosis
Chataway, J.; Nicholas, R.; Todd, S.; Miller, D. H.; Parsons, N.; Valdes-Marquez, E. & Stallard, N. et al. (2011)
MULTIPLE SCLEROSIS, 17(1) pp. 81-88. DOI: https://doi.org/10.1177/1352458510382129
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2011 | Review
Systematic review of sonographic chronic cerebrospinal venous insufficiency findings in multiple sclerosis
Thapar, A.; Lane, T.; Nicholas, R.; Friede, T.; Ellis, M.; Assenheim, J.& Franklin, I. J. et al. (2011)
Phlebology The Journal of Venous Disease, 26(8) pp. 319-325.
Royal Soc Medicine Press Ltd. DOI: https://doi.org/10.1258/phleb.2011.011098
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2011 | Journal Article |
Study protocol: Improving patient choice in treating low back pain (IMPACT - LBP): A randomised controlled trial of a decision support package for use in physical therapy
Patel, S.; Brown, S.; Friede, T.; Griffiths, F.; Lord, J.; Ngunjiri, A. & Thistlethwaite, J. et al. (2011)
BMC Musculoskeletal Disorders, 12 art. 52. DOI: https://doi.org/10.1186/1471-2474-12-52
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2012 | Journal Article
Assess, compare and enhance the status of Persons with Multiple Sclerosis (MS) in Europe: a European Register for MS
Pugliatti, M.; Eskic, D.; Mikolcic, T.; Pitschnau-Michel, D.; Myhr, K.-M.; Sastre-Garriga, J. & Otero, S. et al. (2012)
Acta Neurologica Scandinavica, 126 pp. 24-30. DOI: https://doi.org/10.1111/ane.12024
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2012 | Conference Abstract
Calcineurin Inhibitor Sparing with Mycophenolate Mofetil in Liver Transplant Recipients: A Systematic Review and Meta-Analysis
Goralczyk, A. D.; Abu-Ajaj, W.; Bari, N.; Lorf, T.; Ramadori, G.; Friede, T. & Obed, A. (2012)
Transplantation Journal, 94(10)
Philadelphia: Lippincott Williams & Wilkins.
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2012 | Conference Abstract
Time trends in baseline characteristics and eligibility criteria in trials in relapsing mutliple sclerosis - a systematic review and meta-analysis
Steinvorth, S. M.; Nicholas, R.; Roever, C. ; Schneider, S.; Straube, S. & Friede, T. (2012)
Multiple Sclerosis Journal, 18 pp. 474-475. 28th Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis, Lyon, FRANCE.
London: Sage Publications Ltd.
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2012 | Journal Article
An R package for implementing simulations for seamless phase II/III clinical trials using early outcomes for treatment selection
Parsons, N.; Friede, T.; Todd, S.; Marquez, E. V.; Chataway, J.; Nicholas, R. & Stallard, N. (2012)
Computational Statistics & Data Analysis, 56(5) pp. 1150-1160. DOI: https://doi.org/10.1016/j.csda.2010.10.027
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2012 | Journal Article
Blinded continuous monitoring of nuisance parameters in clinical trials
Friede, T. & Miller, F. (2012)
Journal of the Royal Statistical Society Series C (Applied Statistics), 61 pp. 601-618. DOI: https://doi.org/10.1111/j.1467-9876.2011.01029.x
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2012 | Journal Article |
Safety and Efficacy of the ACE-Inhibitor Ramipril in Alport Syndrome: The Double-Blind, Randomized, Placebo-Controlled, Multicenter Phase III EARLY PRO-TECT Alport Trial in Pediatric Patients
Gross, O.; Friede, T.; Hilgers, R.; Görlitz, A.; Gavénis, K.; Ahmed, R. & Dürr, U. (2012)
ISRN Pediatrics, 2012 pp. 1-6. DOI: https://doi.org/10.5402/2012/436046
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2012 | Review |
Time-patterns of annualized relapse rates in randomized placebo-controlled clinical trials in relapsing multiple sclerosis: A systematic review and meta-analysis
Nicholas, R.; Straube, S.; Schmidli, H.; Pfeiffer, S.& Friede, T. (2012)
Multiple Sclerosis Journal, 18(9) pp. 1290-1296.
Sage Publications Ltd. DOI: https://doi.org/10.1177/1352458511435715
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2012 | Conference Paper
A conditional error function approach for subgroup selection in adaptive clinical trials
Friede, T.; Parsons, N. & Stallard, N. (2012)
Statistics in Medicine, 31(30) pp. 4309-4320. 32nd Annual Conference of the International-Society-for-Clinical-Biostatistics, Ontario, CANADA.
Hoboken: Wiley-blackwell. DOI: https://doi.org/10.1002/sim.5541
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2012 | Journal Article
Early angiotensin-converting enzyme inhibition in Alport syndrome delays renal failure and improves life expectancy
Gross, O.; Licht, C.; Anders, H.-J.; Hoppe, B.; Beck, B.; Toenshoff, B. & Hoecker, B. et al. (2012)
Kidney International, 81(5) pp. 494-501. DOI: https://doi.org/10.1038/ki.2011.407
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2012 | Conference Paper
Considerations on what constitutes a 'qualified statistician' in regulatory guidelines
Gerlinger, C.; Edler, L.; Friede, T.; Kieser, M.; Nakas, C. T.; Schumacher, M. & Seldrup, J. et al. (2012)
Statistics in Medicine, 31(11-12) pp. 1303-1305. 31st Annual Conference of the International-Society-for-Clinical-Biostatistics, Montpellier, FRANCE.
Hoboken: Wiley-blackwell. DOI: https://doi.org/10.1002/sim.4345
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2012 | Review
Calcineurin Inhibitor Sparing With Mycophenolate Mofetil in Liver Transplantion: A Systematic Review of Randomized Controlled Trials
Goralczyk, A. D.; Bari, N.; Abu-Ajaj, W.; Lorf, T.; Ramadori, G.; Friede, T.& Obed, A. (2012)
American Journal of Transplantation, 12(10) pp. 2601-2607.
Wiley-blackwell. DOI: https://doi.org/10.1111/j.1600-6143.2012.04157.x
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2013 | Journal Article
A conditional error function approach for subgroup selection in adaptive clinical trials (vol 31, pg 4309, 2012)
Friede, T.; Parsons, N. & Stallard, N. (2013)
Statistics in Medicine, 32(14) pp. 2513-2514. DOI: https://doi.org/10.1002/sim.5759
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2013 | Conference Abstract
Using the internet in the management of multiple sclerosis: an overview of the evidence available
Schilling, J.; Friede, T. & Straube, S. (2013)
Multiple Sclerosis Journal, 19(11) pp. 302-303. 29th Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis / 18th Annual Conference of Rehabilitation in MS, Copenhagen, DENMARK.
London: Sage Publications Ltd.
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2013 | Conference Abstract
Comparison of disability scores and annualised relapse rates as trial outcomes in randomized, placebo controlled trials in relapsing multiple sclerosis: a systematic review
Roever, C. ; Nicholas, R.; Steinvorth, S.; Straube, S. & Friede, T. (2013)
Multiple Sclerosis Journal, 19(11) pp. 498-499. 29th Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis / 18th Annual Conference of Rehabilitation in MS, Copenhagen, DENMARK.
London: Sage Publications Ltd.
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2013 | Journal Article |
Study protocol: improving patient choice in treating Low back pain (IMPACT-LBP): a randomised controlled trial of a decision support package for use in physical therapy (vol 12, 52, 2011)
Patel, S.; Brown, S.; Friede, T.; Griffiths, F.; Lord, J.; Ngunjiri, A. & Thistlethwaite, J. et al. (2013)
BMC Musculoskeletal Disorders, 14 art. 158. DOI: https://doi.org/10.1186/1471-2474-14-158
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2013 | Journal Article
Blinded sample size re-estimation in superiority and noninferiority trials: bias versus variance in variance estimation
Friede, T. & Kieser, M. (2013)
Pharmaceutical Statistics, 12(3) pp. 141-146. DOI: https://doi.org/10.1002/pst.1564
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2013 | Journal Article
Cross cultural evaluation of the Warwick-Edinburgh mental well-being scale (WEMWBS) -a mixed methods study
Taggart, F.; Friede, T.; Weich, S.; Clarke, A.; Johnson, M. A. & Stewart-Brown, S. (2013)
Health and Quality of Life Outcomes, 11 art. 27. DOI: https://doi.org/10.1186/1477-7525-11-27
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2013 | Journal Article
Assessment of statistical significance and clinical relevance
Kieser, M.; Friede, T. & Gondan, M. (2013)
Statistics in Medicine, 32(10) pp. 1707-1719. DOI: https://doi.org/10.1002/sim.5634
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2013 | Review
Systematic Review of Randomized Controlled Trials of Clinical Prediction Rules for Physical Therapy in Low Back Pain
Patel, S.; Psychol, C.; Friede, T.; Froud, R.; Evans, D. W.& Underwood, M. (2013)
Spine, 38(9) pp. 762-769.
Lippincott Williams & Wilkins. DOI: https://doi.org/10.1097/BRS.0b013e31827b158f
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2013 | Journal Article | Research Paper
Adhesion maturation of neutrophils on nanoscopically presented platelet glycoprotein Ibα
Kruss, S.; Erpenbeck, L.; Amschler, K.; Mundinger, T. A. ; Boehm, H.; Helms, H.-J. & Friede, T. et al. (2013)
ACS Nano, 7(11) pp. 9984-9996. DOI: https://doi.org/10.1021/nn403923h
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2013 | Journal Article
Robustness of methods for blinded sample size re-estimation with overdispersed count data
Schneider, S.; Schmidli, H. & Friede, T. (2013)
Statistics in Medicine, 32(21) pp. 3623-3635. DOI: https://doi.org/10.1002/sim.5800
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2013 | Journal Article
Blinded sample size re-estimation for recurrent event data with time trends
Schneider, S.; Schmidli, H. & Friede, T. (2013)
Statistics in Medicine, 32(30) pp. 5448-5457. DOI: https://doi.org/10.1002/sim.5977
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2013 | Journal Article |
Explaining temporal trends in annualised relapse rates in placebo groups of randomised controlled trials in relapsing multiple sclerosis: systematic review and meta-regression
Steinvorth, S. M.; Roever, C. ; Schneider, S.; Nicholas, R.; Straube, S. & Friede, T. (2013)
Multiple Sclerosis Journal, 19(12) pp. 1580-1586. DOI: https://doi.org/10.1177/1352458513481009
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2013 | Journal Article
Blinded and unblinded internal pilot study designs for clinical trials with count data
Schneider, S.; Schmidli, H. & Friede, T. (2013)
Biometrical Journal, 55(4) pp. 617-633. DOI: https://doi.org/10.1002/bimj.201200189
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2014 | Journal Article
Guest Editors' Introduction
Friede, T.; Henderson, R. & Hougaard, P. (2014)
Statistics in Medicine, 33(30) pp. 5221-5222. DOI: https://doi.org/10.1002/sim.6362
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2014 | Journal Article
Plasma prion protein concentration and progression of Alzheimer disease
Schmidt, C. D.; Becker, H.; Peter, C.; Lange, K.; Friede, T. & Zerr, I. (2014)
Prion, 8(2) pp. 210-214. DOI: https://doi.org/10.4161/pri.27964
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2014 | Journal Article |
Work-related outcomes in randomised placebo-controlled pain trials: a systematic review and meta-analysis
Wolf, I.; Friede, T.; Hallier, E. & Straube, S. (2014)
Journal of Occupational Medicine and Toxicology, 9 art. 25. DOI: https://doi.org/10.1186/1745-6673-9-25
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2014 | Journal Article
CR1 is potentially associated with rate of decline in sporadic Alzheimer's disease
Schmidt, C. D.; Wolff, M.; von Ahsen, N.; Lange, K.; Friede, T. & Zerr, I. (2014)
Journal of Clinical Neuroscience, 21(10) pp. 1705-1708. DOI: https://doi.org/10.1016/j.jocn.2014.03.015
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2014 | Journal Article |
Efficacy of Ambroxol lozenges for pharyngitis: a meta-analysis
Chenot, J.-F.; Weber, P. & Friede, T. (2014)
BMC Family Practice, 15 art. 45. DOI: https://doi.org/10.1186/1471-2296-15-45
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2014 | Journal Article |
Data-driven treatment selection for seamless phase II/III trials incorporating early-outcome data
Kunz, C. U.; Friede, T.; Parsons, N.; Todd, S. & Stallard, N. (2014)
Pharmaceutical Statistics, 13(4) pp. 238-246. DOI: https://doi.org/10.1002/pst.1619
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2014 | Journal Article |
Primum non nocere: shared informed decision making in low back pain - a pilot cluster randomised trial
Patel, S.; Ngunjiri, A.; Hee, S. W.; Yang, Y.; Brown, S.; Friede, T. & Griffiths, F. et al. (2014)
BMC Musculoskeletal Disorders, 15 art. 282. DOI: https://doi.org/10.1186/1471-2474-15-282
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2014 | Journal Article |
Design and Development of a Decision Support Package for Low Back Pain
Patel, S.; Ngunjiri, A.; Sandhu, H.; Griffiths, F.; Thistlewaite, J.; Brown, S. & Friede, T. et al. (2014)
Arthritis Care & Research, 66(6) pp. 925-933. DOI: https://doi.org/10.1002/acr.22252
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2014 | Journal Article
ADAPTIVE DESIGNS FOR CONFIRMATORY CLINICAL TRIALS WITH SUBGROUP SELECTION
Stallard, N.; Hamborg, T.; Parsons, N. & Friede, T. (2014)
Journal of Biopharmaceutical Statistics, 24(1) pp. 168-187. DOI: https://doi.org/10.1080/10543406.2013.857238
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2014 | Journal Article |
Multiple sclerosis registries in Europe - results of a systematic survey
Flachenecker, P.; Buckow, K.; Pugliatti, M.; Kes, V. B.; Battaglia, M. A.; Boyko, A. & Confavreux, C. et al. (2014)
Multiple Sclerosis Journal, 20(11) pp. 1523-1532. DOI: https://doi.org/10.1177/1352458514528760
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2014 | Journal Article
Blinded sample size re-estimation in crossover bioequivalence trials
Golkowski, D.; Friede, T. & Kieser, M. (2014)
Pharmaceutical Statistics, 13(3) pp. 157-162. DOI: https://doi.org/10.1002/pst.1617
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2014 | Journal Article |
Interleukin-2 receptor antagonists for pediatric liver transplant recipients: A systematic review and meta-analysis of controlled studies
Crins, N. D.; Roever, C. ; Goralczyk, A. D. & Friede, T. (2014)
Pediatric Transplantation, 18(8) pp. 839-850. DOI: https://doi.org/10.1111/petr.12362
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2015 | Conference Abstract
Validation of the German version of the multiple sclerosis work difficulties questionnaire (MSWDQ)
Ellenberger, D. ; Friede, T.; Sterz, C. & Flachenecker, P. (2015)
Multiple Sclerosis Journal, 21 31st Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis (ECTRIMS), Barcelona, SPAIN.
London: Sage Publications Ltd.
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2015 | Conference Abstract
Development and validation of employment-specific assessment instruments in German MS patients
Flachenecker, P.; Sterz, C.; Ellenberger, D. ; Meissner, H.; Gusowski, K. & Friede, T. (2015)
Multiple Sclerosis Journal, 21 31st Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis (ECTRIMS), Barcelona, SPAIN.
London: Sage Publications Ltd.
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2015 | Journal Article |
Regression to the Mean and Predictors of MRI Disease Activity in RRMS Placebo Cohorts - Is There a Place for Baseline-to-Treatment Studies in MS?
Stellmann, J.-P.; Stuerner, K. H.; Young, K. L.; Siemonsen, S.; Friede, T. & Heesen, C. (2015)
PLoS ONE, 10(2) art. e0116559. DOI: https://doi.org/10.1371/journal.pone.0116559
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2015 | Journal Article |
Flexible selection of a single treatment incorporating short-term endpoint information in a phase II/III clinical trial
Stallard, N.; Kunz, C. U.; Todd, S.; Parsons, N. & Friede, T. (2015)
Statistics in Medicine, 34(23) pp. 3104-3115. DOI: https://doi.org/10.1002/sim.6567
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2015 | Journal Article
Patients characteristics influencing the longitudinal utilization of steroids in multiple sclerosis - an observational study
Rommer, P. S.; Buckow, K.; Ellenberger, D. ; Friede, T.; Pitschnau-Michel, D.; Fuge, J. & Stueve, O. et al. (2015)
European Journal of Clinical Investigation, 45(6) pp. 587-593. DOI: https://doi.org/10.1111/eci.12450
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2015 | Review |
Changing EDSS Progression in Placebo Cohorts in Relapsing MS: A Systematic Review and Meta-Regression
Roever, C. ; Nicholas, R.; Straube, S.& Friede, T. (2015)
PLoS ONE, 10(9).
Public Library Science. DOI: https://doi.org/10.1371/journal.pone.0137052
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2015 | Journal Article
Cerebrospinal Fluid Apolipoprotein E Concentration and Progression of Alzheimer's Disease
Schmidt, C. D.; Gerlach, N.; Peter, C.; Gherib, K.; Lange, K.; Friede, T. & Zerr, I. (2015)
Journal of Alzheimer s Disease, 43(4) pp. 1229-1236. DOI: https://doi.org/10.3233/JAD-141581
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2015 | Journal Article |
Hartung-Knapp-Sidik-Jonkman approach and its modification for random-effects meta-analysis with few studies
Roever, C. ; Knapp, G. & Friede, T. (2015)
BMC Medical Research Methodology, 15 art. 99. DOI: https://doi.org/10.1186/s12874-015-0091-1
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2015 | Journal Article |
POINT AND INTERVAL ESTIMATORS OF THE TARGET DOSE IN CLINICAL DOSE-FINDING STUDIES WITH ACTIVE CONTROL
Helms, H.-J.; Benda, N. & Friede, T. (2015)
Journal of Biopharmaceutical Statistics, 25(5) pp. 939-957. DOI: https://doi.org/10.1080/10543406.2014.920343
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2015 | Journal Article
Memorandum "Open Metadata"
Dugas, M.; Joeckel, K.-H.; Friede, T.; Gefeller, O.; Kieser, M.; Marschollek, M. & Ammenwerth, E. et al. (2015)
METHODS OF INFORMATION IN MEDICINE, 54(4) pp. 376-378. DOI: https://doi.org/10.3414/ME15-05-0007
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2015 | Journal Article
Anticholinergics for urinary symptoms in multiple sclerosis (Withdrawn Paper. 2015, Art. no. CD004193)
Nicholas, R. S.; Friede, T.; Hollis, S. & Young, C. A. (2015)
COCHRANE DATABASE OF SYSTEMATIC REVIEWS,(6) art. CD004193. DOI: https://doi.org/10.1002/14651858.CD004193.pub3
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2015 | Review
A systematic review identifies shortcomings in the reporting of crossover trials in chronic painful conditions
Straube, S.; Werny, B.& Friede, T. (2015)
Journal of Clinical Epidemiology, 68(12) pp. 1496-1503.
Elsevier Science Inc. DOI: https://doi.org/10.1016/j.jclinepi.2015.04.006
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2015 | Journal Article |
A Comparison of Methods for Treatment Selection in Seamless Phase II/III Clinical Trials Incorporating Information on Short-Term Endpoints
Kunz, C. U.; Friede, T.; Parsons, N.; Todd, S. & Stallard, N. (2015)
Journal of Biopharmaceutical Statistics, 25(1) pp. 170-189. DOI: https://doi.org/10.1080/10543406.2013.840646
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2015 | Journal Article
Baseline CSF/Serum-Ratio of Apolipoprotein E and Rate of Differential Decline in Alzheimer's Disease
Schmidt, C. D.; Gerlach, N.; Schmitz, M.; Thom, T.; Kramer, K.; Friede, T. & Zerr, I. (2015)
Journal of Alzheimer s Disease, 48(1) pp. 189-196. DOI: https://doi.org/10.3233/JAD-150286
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2016 | Conference Abstract
Gender differences in the outcome of primary preventive implantable defibrillator therapy-data from the EU-CERT ICD study
Sticherling, C.; Svendsen, J. H.; Arendacka, B.; Wijers, S.; Stockinger, J.; Schmidt, G. & Merkely, B. et al. (2016)
European Heart Journal, 37 pp. 693-694. , Rome, ITALY.
Oxford: Oxford Univ Press.
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2016 | Conference Abstract
Value of microvolt T-wave alternans assessed by ergometer and pacing as predictor for shock and mortality in a large ICD cohort
Bergau, L.; Flevari, P.; Willems, R.; Tuinenburg, A. E.; Vos, M. A.; Munoz-Exposito, P. & Fischer, T. H. et al. (2016)
European Heart Journal, 37 pp. 304-305. , Rome, ITALY.
Oxford: Oxford Univ Press.
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2016 | Conference Abstract
Efficacy of immunotherapies and predictors of therapy response in neuromyelitis optica spectrum disorders: analysis of 397 treatment years from 150 patients
Stellmann, J.-P.; Krumbholz, M.; Friede, T.; Trebst, C. & Kleiter, I. (2016)
Multiple Sclerosis Journal, 22 32nd Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis (ECTRIMS), London, ENGLAND.
London: Sage Publications Ltd.
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2016 | Conference Abstract
Increased multiple sclerosis impact scale-29 score is associated with reduced survival in multiple sclerosis
Wallace, A. C.; Raffel, J.; Reynolds, R.; Friede, T. & Nicholas, R. (2016)
Multiple Sclerosis Journal, 22 pp. 455-456. 32nd Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis (ECTRIMS), London, ENGLAND.
London: Sage Publications Ltd.
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2016 | Journal Article |
EFSPI/PSI working group on data sharing: accessing and working with pharmaceutical clinical trial patient level datasets – a primer for academic researchers
Sudlow, R.; Branson, J.; Friede, T.; Morgan, D. & Whately-Smith, C. (2016)
BMC Medical Research Methodology, 16(S1). DOI: https://doi.org/10.1186/s12874-016-0171-x
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2016 | Research Data |
Data from: T-wave loop area from a pre-implant 12-lead ECG is associated with appropriate ICD shocks
Seegers, J.; Hnatkova, K.; Friede, T.; Malik, M.& Zabel, M. (2016)
DOI: https://doi.org/10.3249/ugoe-data-1
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2016 | Journal Article |
Peripheral Nerve Dysfunction in Middle-Aged Subjects Born with Thalidomide Embryopathy
Nicotra, A.; Newman, C.; Johnson, M.; Eremin, O.; Friede, T.; Malik, O. & Nicholas, R. (2016)
PLoS ONE, 11(4) art. e0152902. DOI: https://doi.org/10.1371/journal.pone.0152902
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2016 | Review |
Gender Differences in Appropriate Shocks and Mortality among Patients with Primary Prophylactic Implantable Cardioverter-Defibrillators: Systematic Review and Meta-Analysis
Conen, D.; Arendacka, B.; Roever, C. ; Bergau, L.; Munoz, P.; Wijers, S.& Sticherling, C. et al. (2016)
PLoS ONE, 11(9).
Public Library Science. DOI: https://doi.org/10.1371/journal.pone.0162756
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2016 | Journal Article |
Evidence synthesis for count distributions based on heterogeneous and incomplete aggregated data
Roever, C. ; Andreas, S. & Friede, T. (2016)
Biometrical Journal, 58(1) pp. 170-185. DOI: https://doi.org/10.1002/bimj.201300288
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2016 | Review
Back schools for the treatment of chronic low back pain: possibility of benefit but no convincing evidence after 47 years of research-systematic review and meta-analysis
Straube, S.; Harden, M.; Schroeder, H.; Arendacka, B.; Fan, X.; Moore, R. A.& Friede, T. (2016)
Pain, 157(10) pp. 2160-2172.
Lippincott Williams & Wilkins. DOI: https://doi.org/10.1097/j.pain.0000000000000640
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2016 | Journal Article | Letter Note
The N-MOmentum trial: Building momentum to advance trial methodology in a rare disease
Chataway, J. & Friede, T. (2016)
Multiple Sclerosis Journal, 22(7) pp. 852-853. DOI: https://doi.org/10.1177/1352458516643399
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2016 | Journal Article |
Methods for identification and confirmation of targeted subgroups in clinical trials: A systematic review
Ondra, T.; Dmitrienko, A.; Friede, T.; Graf, A.; Miller, F.; Stallard, N. & Posch, M. (2016)
Journal of Biopharmaceutical Statistics, 26(1) pp. 99-119. DOI: https://doi.org/10.1080/10543406.2015.1092034
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2016 | Review |
Systematic reviews in paediatric multiple sclerosis and Creutzfeldt-Jakob disease exemplify shortcomings in methods used to evaluate therapies in rare conditions
Unkel, S.; Roever, C. ; Stallard, N.; Benda, N.; Posch, M.; Zohar, S.& Friede, T. (2016)
Orphanet Journal of Rare Diseases, 11.
Biomed Central Ltd. DOI: https://doi.org/10.1186/s13023-016-0402-6
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2016 | Journal Article
Improving clinical trials for cardiovascular diseases: a position paper from the Cardiovascular Round Table of the European Society of Cardiology
Jackson, N.; Atar, D.; Borentain, M.; Breithardt, G.; van Eickels, M.; Endres, M. & Fraass, U. et al. (2016)
European Heart Journal, 37(9) pp. 747-U16. DOI: https://doi.org/10.1093/eurheartj/ehv213
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2017 | Journal Article
Meta-analytic-predictive use of historical variance data for the design and analysis of clinical trials
Schmidli, H.; Neuenschwander, B. & Friede, T. (2017)
Computational Statistics & Data Analysis, 113 pp. 100-110. DOI: https://doi.org/10.1016/j.csda.2016.08.007
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2017 | Journal Article |
Sex differences in outcomes of primary prevention implantable cardioverter-defibrillator therapy: combined registry data from eleven European countries
Sticherling, C.; Arendacka, B.; Svendsen, J. H.; Wijers, S.; Friede, T.; Stockinger, J. & Dommasch, M. et al. (2017)
EP Europace, 20(6) pp. 963-970. DOI: https://doi.org/10.1093/europace/eux176
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2017 | Journal Article |
Discrete Approximation of a Mixture Distribution via Restricted Divergence
Roever, C. & Friede, T. (2017)
Journal of Computational and Graphical Statistics, 26(1) pp. 217-222. DOI: https://doi.org/10.1080/10618600.2016.1276840
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2017 | Journal Article |
Using phase II data for the analysis of phase III studies: An application in rare diseases
Wandel, S.; Neuenschwander, B.; Roever, C. & Friede, T. (2017)
Clinical Trials, 14(3) pp. 277-285. DOI: https://doi.org/10.1177/1740774517699409
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2017 | Review
Independent academic Data Monitoring Committees for clinical trials in cardiovascular and cardiometabolic diseases
Filippatos, G. S.; de Graeff, P.; Bax, J. J.; Borg, J.-J.; Cleland, J. G. F.; Dargie, H. J.& Flather, M. et al. (2017)
European Journal of Heart Failure, 19(4) pp. 449-456.
Wiley. DOI: https://doi.org/10.1002/ejhf.761
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2017 | Journal Article |
Meta-analysis of few small studies in orphan diseases
Friede, T.; Roever, C. ; Wandel, S. & Neuenschwander, B. (2017)
Research Synthesis Methods, 8(1) pp. 79-91. DOI: https://doi.org/10.1002/jrsm.1217
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2017 | Journal Article
Predictors of mortality and ICD shock therapy in primary prophylactic ICD patients-A systematic review and meta-analysis.
Bergau, L.; Tichelbäcker, T.; Kessel, B.; Lüthje, L.; Fischer, T. H.; Friede, T. & Zabel, M. (2017)
PloS one, 12(10) art. e0186387. DOI: https://doi.org/10.1371/journal.pone.0186387
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2017 | Review
Advances and unmet needs in genetic, basic and clinical science in Alport syndrome: report from the 2015 International Workshop on Alport Syndrome
Gross, O.; Kashtan, C. E.; Rheault, M. N.; Flinter, F.; Savige, J.; Miner, J. H.& Torra, R. et al. (2017)
Nephrology Dialysis Transplantation, 32(6) pp. 916-924.
Oxford Univ Press. DOI: https://doi.org/10.1093/ndt/gfw095
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2017 | Journal Article
Toward evidence-based diagnosis of myocarditis in children and adolescents: Rationale, design, and first baseline data of MYKKE, a multicenter registry and study platform
Messroghli, D. R.; Pickardt, T.; Fischer, M.; Opgen-Rhein, B.; Papakostas, K.; Bocker, D. & Jakob, A. et al. (2017)
American Heart Journal, 187 pp. 133-144. DOI: https://doi.org/10.1016/j.ahj.2017.02.027
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2017 | Journal Article
Doxycycline in early CJD: a double-blinded randomised phase II and observational study
Varges, D. A.; Manthey, H.; Heinemann, U.; Ponto, C.; Schmitz, M.; Schulz-Schaeffer, W. J. & Krasnianski, A. et al. (2017)
Journal of Neurology Neurosurgery & Psychiatry, 88(2) pp. 119-125. DOI: https://doi.org/10.1136/jnnp-2016-313541
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2017 | Journal Article
Do we consent to rules of consent and confidentiality?
Wegscheider, K. & Friede, T. (2017)
Biometrical Journal, 59(2) pp. 235-239. DOI: https://doi.org/10.1002/bimj.201600150
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2017 | Journal Article |
Blinded versus unblinded estimation of a correlation coefficient to inform interim design adaptations
Kunz, C. U.; Stallard, N.; Parsons, N.; Todd, S. & Friede, T. (2017)
Biometrical Journal, 59(2) pp. 344-357. DOI: https://doi.org/10.1002/bimj.201500233
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2017 | Journal Article |
T-wave loop area from a pre-implant 12-lead ECG is associated with appropriate ICD shocks
Seegers, J.; Hnatkova, K.; Friede, T.; Malik, M. & Zabel, M. (2017)
PLoS ONE, 12(3) art. e0173868. DOI: https://doi.org/10.1371/journal.pone.0173868
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2017 | Review
Pharmacological Approaches to the Management of Secondary Progressive Multiple Sclerosis
Nandoskar, A.; Raffel, J.; Scalfari, A. S.; Friede, T.& Nicholas, R. S. (2017)
Drugs, 77(8) pp. 885-910.
Adis Int Ltd. DOI: https://doi.org/10.1007/s40265-017-0726-0
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2017 | Journal Article |
Meta-analysis of two studies in the presence of heterogeneity with applications in rare diseases.
Friede, T.; Röver, C. ; Wandel, S. & Neuenschwander, B. (2017)
Biometrical journal. Biometrische Zeitschrift, 59(4) pp. 658-671. DOI: https://doi.org/10.1002/bimj.201500236
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2017 | Journal Article |
Patient-reported outcomes and survival in multiple sclerosis: A 10-year retrospective cohort study using the Multiple Sclerosis Impact Scale-29.
Raffel, J.; Wallace, A.; Gveric, D.; Reynolds, R.; Friede, T. & Nicholas, R. (2017)
PLoS medicine, 14(7) art. e1002346. DOI: https://doi.org/10.1371/journal.pmed.1002346
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2018 | Journal Article |
A dose finding design for seizure reduction in neonates
Ursino, M.; Yuan, Y.; Alberti, C.; Comets, E.; Favrais, G.; Friede, T. & Lentz, F. et al. (2018)
Journal of the Royal Statistical Society: Series C (Applied Statistics), 68(2) pp. 427-444. DOI: https://doi.org/10.1111/rssc.12289
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2018 | Journal Article |
Sample size calculation in multi-centre clinical trials
Harden, M. & Friede, T. (2018)
BMC Medical Research Methodology, 18(1) art. 156. DOI: https://doi.org/10.1186/s12874-018-0602-y
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2018 | Journal Article |
Insights into permanent pacemaker implantation following TAVR in a real-world cohort
Tichelbäcker, T.; Bergau, L.; Puls, M.; Friede, T.; Mütze, T.; Maier, L. S. & Frey, N. et al. (2018)
PLoS One, 13(10) art. e0204503. DOI: https://doi.org/10.1371/journal.pone.0204503
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