Author Wirths, Oliver

• 2007 | Conference Abstract
  ​ ​A beta-induced pathology and neuron loss in the cholinergic system of the APP/PS1ki mouse model of Alzheimer's disease​
  Christensen, D. Z.; Bayer, T. & Wirths, O.​ (2007)
  Biochemical Pharmacology, 74(8) ​Symposium on Nicotinic Acetylcholine Receptors as Therapeutic Targets​, San Diego, CA.
  Oxford​: Pergamon-elsevier Science Ltd.
  ​Details  WoS 

• 2007 | Journal Article
  ​ ​Altered cholesterol metabolism in APP695-transfected neuroblastoma cells​
  Wirths, O.; Thelen, K. M.; Luetjohann, D.; Falkai, P. & Bayer, T. A.​ (2007) 
  Brain Research, 1152 pp. 209​-214​.​ DOI: https://doi.org/10.1016/j.brainres.2007.03.029 
  ​Details  DOI  PMID  PMC  WoS 

• 2008 | Journal Article | 
  ​ ​Effect of copper intake on CSF parameters in patients with mild Alzheimer’s disease: a pilot phase 2 clinical trial​
  Kessler, H.; Pajonk, F.-G.; Bach, D.; Schneider-Axmann, T.; Falkai, P.; Herrmann, W. & Multhaup, G. et al.​ (2008) 
  Journal of Neural Transmission, 115(12) pp. 1651​-1659​.​ DOI: https://doi.org/10.1007/s00702-008-0136-2 
  ​Details  DOI 

• 2008 | Journal Article
  ​ ​Alzheimer's disease Molecular pathology, animal models, and current treatment​
  Bayer, T. A. & Wirths, O.​ (2008) 
  Der Nervenarzt, 79 pp. 117​-125​.​ DOI: https://doi.org/10.1007/s00115-008-2496-0 
  ​Details  DOI  PMID  PMC  WoS 

• 2008 | Conference Paper
  ​ ​Review on the APP/PS1KI mouse model: intraneuronal A beta accumulation triggers axonopathy, neuron loss and working memory impairment​
  Bayer, T. A. & Wirths, O.​ (2008)
  Genes, Brain and Behavior, 7 pp. 6​-11. ​Annual Meeting of the Genes-Brain-and-Behavior-Society​, Doorwerth, NETHERLANDS.
  Oxford​: Blackwell Publishing. DOI: https://doi.org/10.1111/j.1601-183X.2007.00372.x 
  ​Details  DOI  PMID  PMC  WoS 

• 2008 | Journal Article
  ​ ​Age-dependent loss of dentate gyrus granule cells in APP/PS1KI mice​
  Cotel, M.-C.; Bayer, T. A. & Wirths, O.​ (2008) 
  Brain Research, 1222 pp. 207​-213​.​ DOI: https://doi.org/10.1016/j.brainres.2008.05.052 
  ​Details  DOI  PMID  PMC  WoS 

• 2008 | Journal Article
  ​ ​Deficits in working memory and motor performance in the APP/PS1ki mouse model for Alzheimer's disease​
  Wirths, O.; Breyhan, H.; Schaefer, S.; Roth, C. & Bayer, T. A.​ (2008) 
  Neurobiology of Aging, 29(6) pp. 891​-901​.​ DOI: https://doi.org/10.1016/j.neurobiolaging.2006.12.004 
  ​Details  DOI  PMID  PMC  WoS 

• 2008 | Journal Article
  ​ ​Motor impairment in Alzheimer's disease and transgenic Alzheimer's disease mouse models​
  Wirths, O. & Bayer, T. A.​ (2008) 
  Genes, Brain and Behavior, 7 pp. 1​-5​.​ DOI: https://doi.org/10.1111/j.1601-183X.2007.00373.x 
  ​Details  DOI  PMID  PMC  WoS 

• 2008 | Journal Article | 
  ​ ​Transient intraneuronal A beta rather than extracellular plaque pathology correlates with neuron loss in the frontal cortex of APP/PS1KI mice​
  Christensen, D. Z.; Kraus, S. L.; Flohr, A.; Cotel, M.-C.; Wirths, O. & Bayer, T. A.​ (2008) 
  Acta Neuropathologica, 116(6) pp. 647​-655​.​ DOI: https://doi.org/10.1007/s00401-008-0451-6 
  ​Details  DOI  PMID  PMC  WoS 

• 2008 | Conference Paper | 
  ​ ​Intraneuronal beta-amyloid is a major risk factor - Novel evidence from the APP/PS1KI mouse model​
  Bayer, T. A.; Breyhan, H.; Duan, K.; Rettig, J. & Wirths, O.​ (2008)
  Neurodegenerative Diseases, 5(3-4) pp. 140​-142. ​8th International Conference on Alzheimers and Parkinsons Diseases​, Salzburg, AUSTRIA.
  Basel​: Karger. DOI: https://doi.org/10.1159/000113684 
  ​Details  DOI  PMID  PMC  WoS 

• 2009 | Conference Abstract
  ​ ​Increasing Abeta peptide levels aggravate axonal degeneration in an Alzheimer mouse model​
  Wirths, O.; Christensen, D. Z. & Bayer, T. A.​ (2009)
  Journal of Neurochemistry, 110 pp. 38​-39. ​4th European-Society-for-Neurochemistry Conference on Advances in Molecular Mechanisms of Neurological Disorders​, Leipzig, GERMANY.
  Malden​: Wiley-blackwell Publishing, Inc.
  ​Details  WoS 

• 2009 | Conference Abstract
  ​ ​Alzheimer's Disease pathology is not sufficient for CCR2(+) bone marrow engraftment in the CNS​
  Mildner, A.; Schlevogt, B.; Kierdorf, K.; Boettcher, C.; Kummer, M. P.; Wirths, O. & Henneka, M. et al.​ (2009)
  Acta Neuropathologica, 118(3) ​54th Annual Meeting of the German-Society-of-Neuropathology-and-Neuroanatomy​, Dusseldorf, GERMANY.
  New york​: Springer.
  ​Details  WoS 

• 2009 | Journal Article
  ​ ​The modified amyloid hypothesis of Alzheimer dementia - intraneuronal Abeta induces neurodegeneration​
  Wirths, O. & Bayer, T. A.​ (2009) 
  Neuroforum, 15(3) pp. 76​-82​.​
  ​Details  WoS 

• 2009 | Conference Abstract
  ​ ​Paradigm shift in Abeta toxicity​
  Bayer, T. A. & Wirths, O.​ (2009)
  European Neuropsychopharmacology, 19 ​22nd Congress of the European-College-of-Neuropsychopharmacology​, Istanbul, TURKEY.
  Amsterdam​: Elsevier Science Bv.
  ​Details  WoS 

• 2009 | Journal Article | 
  ​ ​Circulating immune complexes of Aβ and IgM in plasma of patients with Alzheimer’s disease​
  Marcello, A.; Wirths, O.; Schneider-Axmann, T.; Degerman-Gunnarsson, M.; Lannfelt, L. & Bayer, T.​ (2009) 
  Journal of Neural Transmission, 116(7) pp. 913​-920​.​ DOI: https://doi.org/10.1007/s00702-009-0224-y 
  ​Details  DOI 

• 2009 | Journal Article | 
  ​ ​APP/PS1KI bigenic mice develop early synaptic deficits and hippocampus atrophy​
  Breyhan, H.; Wirths, O.; Duan, K.; Marcello, A.; Rettig, J. & Bayer, T. A.​ (2009) 
  Acta Neuropathologica, 117(6) pp. 677​-685​.​ DOI: https://doi.org/10.1007/s00401-009-0539-7 
  ​Details  DOI  PMID  PMC  WoS 

• 2009 | Journal Article | 
  ​ ​Intraneuronal pyroglutamate-Abeta 3-42 triggers neurodegeneration and lethal neurological deficits in a transgenic mouse model​
  Wirths, O.; Breyhan, H.; Cynis, H.; Schilling, S.; Demuth, H.-U. & Bayer, T. A.​ (2009) 
  Acta Neuropathologica, 118(4) pp. 487​-496​.​ DOI: https://doi.org/10.1007/s00401-009-0557-5 
  ​Details  DOI  PMID  PMC  WoS 

• 2009 | Journal Article
  ​ ​Formic acid is essential for immunohistochemical detection of aggregated intraneuronal A beta peptides in mouse models of Alzheimer's disease​
  Christensen, D. Z.; Bayer, T. A. & Wirths, O.​ (2009) 
  Brain Research, 1301 pp. 116​-125​.​ DOI: https://doi.org/10.1016/j.brainres.2009.09.014 
  ​Details  DOI  PMID  PMC  WoS 

• 2010 | Journal Article
  ​ ​Gene expression of neuregulin-1 isoforms in different brain regions of elderly schizophrenia patients​
  Parlapani, E.; Schmitt, A.; Wirths, O.; Bauer, M.; Sommer, C.; Rueb, U. & Skowronek, M. H. et al.​ (2010) 
  The World Journal of Biological Psychiatry, 11(2) pp. 243​-250​.​ DOI: https://doi.org/10.3109/15622970802022376 
  ​Details  DOI  PMID  PMC  WoS 

• 2010 | Journal Article
  ​ ​Concomitant detection of beta-amyloid peptides with N-terminal truncation and different C-terminal endings in cortical plaques from cases with Alzheimer's disease, senile monkeys and triple transgenic mice​
  Haertig, W.; Goldhammer, S.; Bauer, U.; Wegner, F.; Wirths, O.; Bayer, T. A. & Grosche, J.​ (2010) 
  Journal of Chemical Neuroanatomy, 40(1) pp. 82​-92​.​ DOI: https://doi.org/10.1016/j.jchemneu.2010.03.006 
  ​Details  DOI  PMID  PMC  WoS 

• 2010 | Review | 
  ​ ​Intracellular accumulation of amyloid-beta - a predictor for synaptic dysfunction and neuron loss in Alzheimer's disease​
  Bayer, T. A.& Wirths, O.​ (2010)
  Frontiers in Aging Neuroscience, 2​.​
  Frontiers Research Foundation. DOI: https://doi.org/10.3389/fnagi.2010.00008 
  ​Details  DOI  PMID  PMC  WoS 

• 2010 | Journal Article
  ​ ​Intracellular A beta triggers neuron loss in the cholinergic system of the APP/PS1KI mouse model of Alzheimer's disease​
  Christensen, D. Z.; Bayer, T. A. & Wirths, O.​ (2010) 
  Neurobiology of Aging, 31(7) pp. 1153​-1163​.​ DOI: https://doi.org/10.1016/j.neurobiolaging.2008.07.022 
  ​Details  DOI  PMID  PMC  WoS 

• 2010 | Journal Article | 
  ​ ​Histone Deacetylase Inhibitor Valproic Acid Inhibits Cancer Cell Proliferation via Down-regulation of the Alzheimer Amyloid Precursor Protein​
  Venkataramani, V. ; Rossner, C.; Iffland, L.; Schweyer, S.; Tamboli, I. Y.; Walter, J. & Wirths, O. et al.​ (2010) 
  Journal of Biological Chemistry, 285(14) pp. 10678​-10689​.​ DOI: https://doi.org/10.1074/jbc.M109.057836 
  ​Details  DOI  PMID  PMC  WoS 

• 2010 | Journal Article | 
  ​ ​Pyroglutamate Abeta pathology in APP/PS1KI mice, sporadic and familial Alzheimer's disease cases​
  Wirths, O.; Bethge, T.; Marcello, A.; Harmeier, A.; Jawhar, S.; Lucassen, P. J. & Multhaup, G. et al.​ (2010) 
  Journal of Neural Transmission, 117(1) pp. 85​-96​.​ DOI: https://doi.org/10.1007/s00702-009-0314-x 
  ​Details  DOI  PMID  PMC  WoS 

• 2010 | Journal Article
  ​ ​Inflammatory changes are tightly associated with neurodegeneration in the brain and spinal cord of the APP/PS1KI mouse model of Alzheimer's disease​
  Wirths, O.; Breyhan, H.; Marcello, A.; Cotel, M.-C.; Brueck, W. & Bayer, T. A.​ (2010) 
  Neurobiology of Aging, 31(5) pp. 747​-757​.​ DOI: https://doi.org/10.1016/j.neurobiolaging.2008.06.011 
  ​Details  DOI  PMID  PMC  WoS 

• 2010 | Journal Article
  ​ ​Identification of Low Molecular Weight Pyroglutamate A beta Oligomers in Alzheimer Disease A NOVEL TOOL FOR THERAPY AND DIAGNOSIS​
  Wirths, O.; Erck, C.; Martens, H.; Harmeier, A.; Geumann, C. ; Jawhar, S. & Kumar, S. et al.​ (2010) 
  Journal of Biological Chemistry, 285(53) pp. 41517​-41524​.​ DOI: https://doi.org/10.1074/jbc.M110.178707 
  ​Details  DOI  PMID  PMC  WoS 

• 2010 | Journal Article | 
  ​ ​Neuron loss in transgenic mouse models of Alzheimer's disease.​
  Wirths, O. & Bayer, T. A.​ (2010) 
  International journal of Alzheimer's disease, 2010 art. 723782​.​ DOI: https://doi.org/10.4061/2010/723782 
  ​Details  DOI  PMID  PMC 

• 2010 | Journal Article | 
  ​ ​Accumulation of intraneuronal A beta correlates with ApoE4 genotype​
  Christensen, D. Z.; Schneider-Axmann, T.; Lucassen, P. J.; Bayer, T. A. & Wirths, O.​ (2010) 
  Acta Neuropathologica, 119(5) pp. 555​-566​.​ DOI: https://doi.org/10.1007/s00401-010-0666-1 
  ​Details  DOI  PMID  PMC  WoS 

• 2011 | Journal Article
  ​ ​Overexpression of Glutaminyl Cyclase, the Enzyme Responsible for Pyroglutamate Aβ Formation, Induces Behavioral Deficits, and Glutaminyl Cyclase Knock-out Rescues the Behavioral Phenotype in 5XFAD Mice​
  Jawhar, S.; Wirths, O.; Schilling, S.; Graubner, S.; Demuth, H.-U. & Bayer, T. A.​ (2011) 
  Journal of Biological Chemistry, 286(6) pp. 4454​-4460​.​ DOI: https://doi.org/10.1074/jbc.M110.185819 
  ​Details  DOI 

• 2011 | Journal Article
  ​ ​Reduced levels of IgM autoantibodies against N-truncated pyroglutamate Aβ in plasma of patients with Alzheimer's disease​
  Marcello, A.; Wirths, O.; Schneider-Axmann, T.; Degerman-Gunnarsson, M.; Lannfelt, L. & Bayer, T. A.​ (2011) 
  Neurobiology of Aging, 32(8) pp. 1379​-1387​.​ DOI: https://doi.org/10.1016/j.neurobiolaging.2009.08.011 
  ​Details  DOI 

• 2011 | Journal Article
  ​ ​Intraneuronal A beta as a trigger for neuron loss: can this be translated into human pathology?​
  Bayer, T. A. & Wirths, O.​ (2011) 
  Biochemical Society Transactions, 39 pp. 857​-861​.​ DOI: https://doi.org/10.1042/BST0390857 
  ​Details  DOI  PMID  PMC  WoS 

• 2011 | Review
  ​ ​Pyroglutamate Amyloid-beta (A beta): A Hatchet Man in Alzheimer Disease​
  Jawhar, S.; Wirths, O.& Bayer, T. A.​ (2011)
  Journal of Biological Chemistry, 286​(45) pp. 38825​-38832​.​
  Amer Soc Biochemistry Molecular Biology Inc. DOI: https://doi.org/10.1074/jbc.R111.288308 
  ​Details  DOI  PMID  PMC  WoS 

• 2012 | Conference Abstract
  ​ ​The Alzheimer Amyloid Precursor Protein (APP) is a biomarker for transformed human pluripotent stem cells - from Alzheimer's disease to cancer biology and beyond​
  Venkataramani, V.; Behnes, C. L.; Thiele, K.; Wulf, G. G.; Thelen, F.; Opitz, L. & Salinas-Riester, G. et al.​ (2012)
  Onkologie, 35 
  Basel​: Karger.
  ​Details  WoS 

• 2012 | Journal Article | 
  ​ ​Amyloid Precursor Protein Is a Biomarker for Transformed Human Pluripotent Stem Cells​
  Venkataramani, V.; Thiele, K.; Behnes, C. L.; Wulf, G. G.; Thelen, P.; Opitz, L. & Salinas-Riester, G. et al.​ (2012) 
  The American Journal of Pathology, 180(4) pp. 1636​-1652​.​ DOI: https://doi.org/10.1016/j.ajpath.2011.12.015 
  ​Details  DOI 

• 2012 | Journal Article
  ​ ​A beta PP Accumulation and/or Intraneuronal Amyloid-beta Accumulation? The 3xTg-AD Mouse Model Revisited​
  Wirths, O.; Dins, A. & Bayer, T. A.​ (2012) 
  Journal of Alzheimer s Disease, 28(4) pp. 897​-904​.​ DOI: https://doi.org/10.3233/JAD-2011-111529 
  ​Details  DOI  PMID  PMC  WoS 

• 2012 | Journal Article
  ​ ​Motor deficits, neuron loss, and reduced anxiety coinciding with axonal degeneration and intraneuronal A beta aggregation in the 5XFAD mouse model of Alzheimer's disease​
  Jawhar, S.; Trawicka, A.; Jenneckens, C.; Bayer, T. A. & Wirths, O.​ (2012) 
  Neurobiology of Aging, 33(1) art. 196.e29​.​ DOI: https://doi.org/10.1016/j.neurobiolaging.2010.05.027 
  ​Details  DOI  PMID  PMC  WoS 

• 2012 | Review
  ​ ​Intraneuronal A beta accumulation and neurodegeneration: Lessons from transgenic models​
  Wirths, O.& Bayer, T. A.​ (2012)
  Life Sciences, 91​(23-24) pp. 1148​-1152​.​
  Pergamon-elsevier Science Ltd. DOI: https://doi.org/10.1016/j.lfs.2012.02.001 
  ​Details  DOI  PMID  PMC  WoS 

• 2012 | Journal Article
  ​ ​Antibody 9D5 Recognizes Oligomeric Pyroglutamate Amyloid-beta in a Fraction of Amyloid-beta Deposits in Alzheimer's Disease without Cross-Reactivity with other Protein Aggregates​
  Venkataramani, V.; Wirths, O.; Budka, H.; Haertig, W.; Kovacs, G. G. & Bayer, T. A.​ (2012) 
  Journal of Alzheimer s Disease, 29(2) pp. 361​-371​.​ DOI: https://doi.org/10.3233/JAD-2011-111379 
  ​Details  DOI  PMID  PMC  WoS 

• 2012 | Journal Article
  ​ ​No improvement after chronic ibuprofen treatment in the 5XFAD mouse model of Alzheimer's disease​
  Hillmann, A.; Hahn, S.; Schilling, S.; Hoffmann, T.; Demuth, H.-U.; Bulic, B. & Schneider-Axmann, T. et al.​ (2012) 
  Neurobiology of Aging, 33(4) art. 833.e39​.​ DOI: https://doi.org/10.1016/j.neurobiolaging.2011.08.006 
  ​Details  DOI  PMID  PMC  WoS 

• 2012 | Journal Article
  ​ ​Environmental enrichment fails to rescue working memory deficits, neuron loss, and neurogenesis in APP/PS1KI mice​
  Cotel, M.-C.; Jawhar, S.; Christensen, D. Z.; Bayer, T. A. & Wirths, O.​ (2012) 
  Neurobiology of Aging, 33(1) pp. 96​-107​.​ DOI: https://doi.org/10.1016/j.neurobiolaging.2010.02.012 
  ​Details  DOI  PMID  PMC  WoS 

• 2012 | Journal Article
  ​ ​Pyroglutamate Amyloid beta (A beta) Aggravates Behavioral Deficits in Transgenic Amyloid Mouse Model for Alzheimer Disease​
  Wittnam, J. L.; Portelius, E.; Zetterberg, H.; Gustavsson, M. K.; Schilling, S.; Koch, B. & Demuth, H.-U. et al.​ (2012) 
  Journal of Biological Chemistry, 287(11) pp. 8154​-8162​.​ DOI: https://doi.org/10.1074/jbc.M111.308601 
  ​Details  DOI  PMID  PMC  WoS 

• 2013 | Journal Article
  ​ ​P2–381: Tg4–42: A new mouse model of Alzheimer's disease—N‐truncated beta‐amyloid 4–42 affects memory decline and synaptic plasticity​
  Dietrich, K.; Bouter, Y.; Wittnam, J.; Pillot, T.; Papot‐Couturier, S.; Lefebvre, T. & Sprenger, F. et al.​ (2013) 
  Alzheimer's & Dementia, 9(4S_Part_12).​ DOI: https://doi.org/10.1016/j.jalz.2013.05.1030 
  ​Details  DOI 

• 2013 | Journal Article
  ​ ​Accelerated tau pathology with synaptic and neuronal loss in a novel triple transgenic mouse model of Alzheimer's disease​
  Saul, A.; Sprenger, F.; Bayer, T. A. & Wirths, O.​ (2013) 
  Neurobiology of Aging, 34(11) pp. 2564​-2573​.​ DOI: https://doi.org/10.1016/j.neurobiolaging.2013.05.003 
  ​Details  DOI 

• 2013 | Journal Article
  ​ ​P2–382: Tg4–42: A new mouse model of Alzheimer's disease—N‐truncated amyloid β (Aβ) 4–42 induces severe neuron loss and behavioral deficits​
  Bouter, Y.; Dietrich, K.; Wittnam, J.; Pillot, T.; Papot‐Couturier, S.; Lefebvre, T. & Sprenger, F. et al.​ (2013) 
  Alzheimer's & Dementia, 9(4S_Part_12).​ DOI: https://doi.org/10.1016/j.jalz.2013.05.1031 
  ​Details  DOI 

• 2013 | Journal Article
  ​ ​Early intraneuronal accumulation and increased aggregation of phosphorylated Abeta in a mouse model of Alzheimer's disease​
  Kumar, S.; Wirths, O.; Theil, S.; Gerth, J.; Bayer, T. A. & Walter, J.​ (2013) 
  Acta Neuropathologica, 125(5) pp. 699​-709​.​ DOI: https://doi.org/10.1007/s00401-013-1107-8 
  ​Details  DOI  PMID  PMC  WoS 

• 2013 | Journal Article | 
  ​ ​The Arctic AβPP mutation leads to Alzheimer's disease pathology with highly variable topographic deposition of differentially truncated Aβ.​
  Kalimo, H.; Lalowski, M.; Bogdanovic, N.; Philipson, O.; Bird, T. D.; Nochlin, D. & Schellenberg, G. D. et al.​ (2013) 
  Acta neuropathologica communications, 1(1).​ DOI: https://doi.org/10.1186/2051-5960-1-60 
  ​Details  DOI  PMID  PMC 

• 2013 | Journal Article
  ​ ​Abundant pyroglutamate-modified ABri and ADan peptides in extracellular and vascular amyloid deposits in familial British and Danish dementias​
  Saul, A. ; Lashley, T.; Revesz, T.; Holton, J.; Ghiso, J. A.; Coomaraswamy, J. & Wirths, O.​ (2013) 
  Neurobiology of Aging, 34(5) pp. 1416​-1425​.​ DOI: https://doi.org/10.1016/j.neurobiolaging.2012.11.014 
  ​Details  DOI  PMID  PMC  WoS 

• 2013 | Journal Article
  ​ ​Oligomeric Pyroglutamate Amyloid-beta is Present in Microglia and a Subfraction of Vessels in Patients with Alzheimer's Disease: Implications for Immunotherapy​
  Wirths, O.; Hillmann, A.; Pradier, L.; Haertig, W. & Bayer, T. A.​ (2013) 
  Journal of Alzheimer s Disease, 35(4) pp. 741​-749​.​ DOI: https://doi.org/10.3233/JAD-121945 
  ​Details  DOI  PMID  PMC  WoS 

• 2013 | Journal Article | 
  ​ ​N-truncated amyloid beta (A beta) 4-42 forms stable aggregates and induces acute and long-lasting behavioral deficits​
  Bouter, Y.; Dietrich, K.; Wittnam, J. L.; Rezaei-Ghaleh, N.; Pillot, T.; Papot-Couturier, S. & Lefebvre, T. et al.​ (2013) 
  Acta Neuropathologica, 126(2) pp. 189​-205​.​ DOI: https://doi.org/10.1007/s00401-013-1129-2 
  ​Details  DOI  PMID  PMC  WoS 

• 2014 | Journal Article | 
  ​ ​Deciphering the molecular profile of plaques, memory decline and neuron loss in two mouse models for Alzheimer's disease by deep sequencing​
  Bouter, Y.; Kacprowski, T.; Weissmann, R.; Dietrich, K.; Borgers, H.; Brauss, A. & Sperling, C. et al.​ (2014) 
  Frontiers in Aging Neuroscience, 6.​ DOI: https://doi.org/10.3389/fnagi.2014.00075 
  ​Details  DOI  WoS 

• 2014 | Review | 
  ​ ​Focusing the amyloid cascade hypothesis on N-truncated Abeta peptides as drug targets against Alzheimer's disease​
  Bayer, T. A.& Wirths, O.​ (2014)
  Acta Neuropathologica, 127​(6) pp. 787​-801​.​
  Springer. DOI: https://doi.org/10.1007/s00401-014-1287-x 
  ​Details  DOI  PMID  PMC  WoS 

• 2014 | Journal Article
  ​ ​A beta(38) in the Brains of Patients with Sporadic and Familial Alzheimer's Disease and Transgenic Mouse Models​
  Reinert, J.; Martens, H.; Huettenrauch, M.; Kolbow, T.; Lannfelt, L.; Ingelsson, M. & Paetau, A. et al.​ (2014) 
  Journal of Alzheimer s Disease, 39(4) pp. 871​-881​.​ DOI: https://doi.org/10.3233/JAD-131373 
  ​Details  DOI  PMID  PMC  WoS 

• 2014 | Journal Article | 
  ​ ​Axonal degeneration in an Alzheimer mouse model is PS1 gene dose dependent and linked to intraneuronal A beta accumulation​
  Christensen, D. Z.; Huettenrauch, M. ; Mitkovski, M.; Pradier, L. & Wirths, O.​ (2014) 
  Frontiers in Aging Neuroscience, 6 art. 139​.​ DOI: https://doi.org/10.3389/fnagi.2014.00139 
  ​Details  DOI  PMID  PMC  WoS 

• 2014 | Journal Article
  ​ ​Immunolesion-induced loss of cholinergic projection neurones promotes beta-amyloidosis and tau hyperphosphorylation in the hippocampus of triple-transgenic mice​
  Haertig, W.; Saul, A.; Kacza, J.; Grosche, J.; Goldhammer, S.; Michalski, D. & Wirths, O.​ (2014) 
  Neuropathology and Applied Neurobiology, 40(2) pp. 106​-120​.​ DOI: https://doi.org/10.1111/nan.12050 
  ​Details  DOI  PMID  PMC  WoS 

• 2014 | Journal Article | 
  ​ ​Abundance of Aß5-x like immunoreactivity in transgenic 5XFAD, APP/PS1KI and 3xTG mice, sporadic and familial Alzheimer´s disease​
  Guzmán, E. A.; Bouter, Y.; Richard, B. C.; Lannfelt, L.; Ingelsson, M.; Paetau, A. & Verkkoniemi-Ahola, A. et al.​ (2014) 
  Molecular Neurodegeneration, 9(1) art. 13​.​ DOI: https://doi.org/10.1186/1750-1326-9-13 
  ​Details  DOI  PMID  PMC 

• 2015 | Journal Article
  ​ ​I716F AβPP Mutation Associates with the Deposition of Oligomeric Pyroglutamate Amyloid-β and α-Synucleinopathy with Lewy Bodies​
  Sieczkowski, E.; Milenkovic, I.; Venkataramani, V.; Giera, R.; Ströbel, T.; Höftberger, R. & Liberski, P. P. et al.​ (2015) 
  Journal of Alzheimer's Disease, 44(1) pp. 103​-114​.​ DOI: https://doi.org/10.3233/JAD-141524 
  ​Details  DOI 

• 2015 | Journal Article
  ​ ​Gene Dosage Dependent Aggravation of the Neurological Phenotype in the 5XFAD Mouse Model of Alzheimer's Disease​
  Richard, B. C. ; Kurdakova, A.; Baches, S.; Bayer, T. A.; Weggen, S. & Wirths, O.​ (2015) 
  Journal of Alzheimer s Disease, 45(4) pp. 1223​-1236​.​ DOI: https://doi.org/10.3233/JAD-143120 
  ​Details  DOI  PMID  PMC  WoS 

• 2016 | Journal Article
  ​ ​Gene Expression Profiling in the APP/PS1KI Mouse Model of Familial Alzheimer's Disease​
  Weissmann, R.; Huettenrauch, M.; Kacprowski, T.; Bouter, Y.; Pradier, L.; Bayer, T. A. & Kuss, A. W. et al.​ (2016) 
  Journal of Alzheimer s Disease, 50(2) pp. 397​-409​.​ DOI: https://doi.org/10.3233/JAD-150745 
  ​Details  DOI  PMID  PMC  WoS 

• 2016 | Journal Article
  ​ ​N-Truncated A beta(2-X) Starting with Position Two in Sporadic Alzheimer's Disease Cases and Two Alzheimer Mouse Models​
  Savastano, A.; Klafki, H.; Haussman, U.; Oberstein, T. J.; Mueller, P.; Wirths, O. & Wiltfang, J. et al.​ (2016) 
  Journal of Alzheimer s Disease, 49(1) pp. 101​-110​.​ DOI: https://doi.org/10.3233/JAD-150394 
  ​Details  DOI  PMID  PMC  WoS 

• 2021 | Journal Article | Research Paper | 
  ​ ​Evaluation of cerebrospinal fluid glycoprotein NMB (GPNMB) as a potential biomarker for Alzheimer’s disease​
  Aichholzer, F.; Klafki, H.-W.; Ogorek, I.; Vogelgsang, J.; Wiltfang, J.; Scherbaum, N. & Weggen, S. et al.​ (2021) 
  Alzheimer's Research & Therapy, 13(1) art. 94​.​ DOI: https://doi.org/10.1186/s13195-021-00828-1 
  ​Details  DOI 

• 2021 | Journal Article | 
  ​ ​Long-term caffeine treatment of Alzheimer mouse models ameliorates behavioural deficits and neuron loss and promotes cellular and molecular markers of neurogenesis​
  Stazi, M.; Lehmann, S.; Sakib, M. S.; Pena-Centeno, T.; Büschgens, L.; Fischer, A. & Weggen, S. et al.​ (2021) 
  Cellular and Molecular Life Sciences, 79(1) art. 55​.​ DOI: https://doi.org/10.1007/s00018-021-04062-8 
  ​Details  DOI 

• 2022 | Journal Article | 
  ​ ​Combined long-term enriched environment and caffeine supplementation improve memory function in C57Bl6 mice​
  Stazi, M.; Zampar, S.; Nadolny, M.; Büschgens, L.; Meyer, T. & Wirths, O.​ (2022) 
  European Archives of Psychiatry and Clinical Neuroscience,.​ DOI: https://doi.org/10.1007/s00406-022-01431-7 
  ​Details  DOI 

• 2022 | Journal Article | Research Paper
  ​ ​An inhibitory effect on the nuclear accumulation of phospho-STAT1 by its unphosphorylated form​
  Menon, P. R.; Staab, J.; Gregus, A.; Wirths, O. & Meyer, T.​ (2022) 
  Cell Communication and Signaling, 20(1) art. 42​.​ DOI: https://doi.org/10.1186/s12964-022-00841-3 
  ​Details  DOI 

• 2022 | Journal Article | 
  ​ ​Is plasma amyloid-β 1–42/1–40 a better biomarker for Alzheimer’s disease than AβX–42/X–40?​
  Klafki, H.-W.; Morgado, B.; Wirths, O.; Jahn, O.; Bauer, C.; Esselmann, H. & Schuchhardt, J. et al.​ (2022) 
  Fluids and Barriers of the CNS, 19(1) art. 96​.​ DOI: https://doi.org/10.1186/s12987-022-00390-4 
  ​Details  DOI 

• 2023 | Journal Article
  ​ ​Matrix Development for the Detection of Phosphorylated Amyloid-β Peptides by MALDI-TOF-MS​
  Liepold, T.; Klafki, H.-W.; Kumar, S.; Walter, J.; Wirths, O.; Wiltfang, J. & Jahn, O.​ (2023) 
  Journal of the American Society for Mass Spectrometry, art. jasms.2c00270​.​ DOI: https://doi.org/10.1021/jasms.2c00270 
  ​Details  DOI 

• 2023 | Journal Article | 
  ​ ​Brain Region-Specific Differences in Amyloid-β Plaque Composition in 5XFAD Mice​
  Bader, A. S.; Gnädig, M.-U.; Fricke, M.; Büschgens, L.; Berger, L. J.; Weggen, S. & Klafki, H.-W. et al.​ (2023) 
  Life, 13(4) pp. 1053​.​ DOI: https://doi.org/10.3390/life13041053 
  ​Details  DOI 

• 2023 | Journal Article
  ​ ​Blood plasma biomarkers for Alzheimer’s disease: Aβ1–42/1–40 vs. AβX–42/X–40​
  Klafki, H.-W.; Wirths, O.; Jahn, O.; Morgado, B.; Esselmann, H. & Wiltfang, J.​ (2023) 
  Clinical Chemistry and Laboratory Medicine,.​ DOI: https://doi.org/10.1515/cclm-2023-0990 
  ​Details  DOI 

• 2023 | Preprint
  ​ ​Oligodendrocytes and neurons contribute to amyloid-β deposition in Alzheimer’s disease​
  Sasmita, A. O.; Depp, C.; Nazarenko, T.; Sun, T.; Siems, S. B.; Yu, X.& Boehler, C. et al.​ (2023). DOI: https://doi.org/10.1101/2023.12.11.570514 
  ​Details  DOI 

• 2023 | Journal Article | 
  ​ ​A Combination of Caffeine Supplementation and Enriched Environment in an Alzheimer’s Disease Mouse Model​
  Stazi, M.; Zampar, S.; Klafki, H.-W.; Meyer, T. & Wirths, O.​ (2023) 
  International Journal of Molecular Sciences, 24(3).​ DOI: https://doi.org/10.3390/ijms24032155 
  ​Details  DOI 

• 2023 | Journal Article | 
  ​ ​A novel interface between the N-terminal and coiled-coil domain of STAT1 functions in an auto-inhibitory manner​
  Remling, L.; Gregus, A.; Wirths, O.; Meyer, T. & Staab, J. F. ​ (2023) 
  Cell Communication and Signaling, 21(1) art. 170​.​ DOI: https://doi.org/10.1186/s12964-023-01124-1 
  ​Details  DOI 

• 2024 | Journal Article
  ​ ​Assessment of immunoprecipitation with subsequent immunoassays for the blood-based diagnosis of Alzheimer’s disease​
  Morgado, B.; Klafki, H.-W.; Bauer, C.; Waniek, K.; Esselmann, H.; Wirths, O. & Hansen, N. et al.​ (2024) 
  European Archives of Psychiatry and Clinical Neuroscience,.​ DOI: https://doi.org/10.1007/s00406-023-01751-2 
  ​Details  DOI 

Researcher

Sort

Items per Page