Author Wirths, Oliver

• 2010 | Review | 
  ​ ​Intracellular accumulation of amyloid-beta - a predictor for synaptic dysfunction and neuron loss in Alzheimer's disease​
  Bayer, T. A.& Wirths, O.​ (2010)
  Frontiers in Aging Neuroscience, 2​.​
  Frontiers Research Foundation. DOI: https://doi.org/10.3389/fnagi.2010.00008 
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• 2010 | Journal Article
  ​ ​Intracellular A beta triggers neuron loss in the cholinergic system of the APP/PS1KI mouse model of Alzheimer's disease​
  Christensen, D. Z.; Bayer, T. A. & Wirths, O.​ (2010) 
  Neurobiology of Aging, 31(7) pp. 1153​-1163​.​ DOI: https://doi.org/10.1016/j.neurobiolaging.2008.07.022 
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• 2010 | Journal Article | 
  ​ ​Histone Deacetylase Inhibitor Valproic Acid Inhibits Cancer Cell Proliferation via Down-regulation of the Alzheimer Amyloid Precursor Protein​
  Venkataramani, V. ; Rossner, C.; Iffland, L.; Schweyer, S.; Tamboli, I. Y.; Walter, J. & Wirths, O. et al.​ (2010) 
  Journal of Biological Chemistry, 285(14) pp. 10678​-10689​.​ DOI: https://doi.org/10.1074/jbc.M109.057836 
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• 2010 | Journal Article | 
  ​ ​Pyroglutamate Abeta pathology in APP/PS1KI mice, sporadic and familial Alzheimer's disease cases​
  Wirths, O.; Bethge, T.; Marcello, A.; Harmeier, A.; Jawhar, S.; Lucassen, P. J. & Multhaup, G. et al.​ (2010) 
  Journal of Neural Transmission, 117(1) pp. 85​-96​.​ DOI: https://doi.org/10.1007/s00702-009-0314-x 
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• 2010 | Journal Article
  ​ ​Inflammatory changes are tightly associated with neurodegeneration in the brain and spinal cord of the APP/PS1KI mouse model of Alzheimer's disease​
  Wirths, O.; Breyhan, H.; Marcello, A.; Cotel, M.-C.; Brueck, W. & Bayer, T. A.​ (2010) 
  Neurobiology of Aging, 31(5) pp. 747​-757​.​ DOI: https://doi.org/10.1016/j.neurobiolaging.2008.06.011 
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• 2010 | Journal Article
  ​ ​Identification of Low Molecular Weight Pyroglutamate A beta Oligomers in Alzheimer Disease A NOVEL TOOL FOR THERAPY AND DIAGNOSIS​
  Wirths, O.; Erck, C.; Martens, H.; Harmeier, A.; Geumann, C. ; Jawhar, S. & Kumar, S. et al.​ (2010) 
  Journal of Biological Chemistry, 285(53) pp. 41517​-41524​.​ DOI: https://doi.org/10.1074/jbc.M110.178707 
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• 2010 | Journal Article | 
  ​ ​Neuron loss in transgenic mouse models of Alzheimer's disease.​
  Wirths, O. & Bayer, T. A.​ (2010) 
  International journal of Alzheimer's disease, 2010 art. 723782​.​ DOI: https://doi.org/10.4061/2010/723782 
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• 2010 | Journal Article | 
  ​ ​Accumulation of intraneuronal A beta correlates with ApoE4 genotype​
  Christensen, D. Z.; Schneider-Axmann, T.; Lucassen, P. J.; Bayer, T. A. & Wirths, O.​ (2010) 
  Acta Neuropathologica, 119(5) pp. 555​-566​.​ DOI: https://doi.org/10.1007/s00401-010-0666-1 
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• 2011 | Journal Article
  ​ ​Overexpression of Glutaminyl Cyclase, the Enzyme Responsible for Pyroglutamate Aβ Formation, Induces Behavioral Deficits, and Glutaminyl Cyclase Knock-out Rescues the Behavioral Phenotype in 5XFAD Mice​
  Jawhar, S.; Wirths, O.; Schilling, S.; Graubner, S.; Demuth, H.-U. & Bayer, T. A.​ (2011) 
  Journal of Biological Chemistry, 286(6) pp. 4454​-4460​.​ DOI: https://doi.org/10.1074/jbc.M110.185819 
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• 2011 | Journal Article
  ​ ​Reduced levels of IgM autoantibodies against N-truncated pyroglutamate Aβ in plasma of patients with Alzheimer's disease​
  Marcello, A.; Wirths, O.; Schneider-Axmann, T.; Degerman-Gunnarsson, M.; Lannfelt, L. & Bayer, T. A.​ (2011) 
  Neurobiology of Aging, 32(8) pp. 1379​-1387​.​ DOI: https://doi.org/10.1016/j.neurobiolaging.2009.08.011 
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• 2011 | Journal Article
  ​ ​Intraneuronal A beta as a trigger for neuron loss: can this be translated into human pathology?​
  Bayer, T. A. & Wirths, O.​ (2011) 
  Biochemical Society Transactions, 39 pp. 857​-861​.​ DOI: https://doi.org/10.1042/BST0390857 
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• 2011 | Review
  ​ ​Pyroglutamate Amyloid-beta (A beta): A Hatchet Man in Alzheimer Disease​
  Jawhar, S.; Wirths, O.& Bayer, T. A.​ (2011)
  Journal of Biological Chemistry, 286​(45) pp. 38825​-38832​.​
  Amer Soc Biochemistry Molecular Biology Inc. DOI: https://doi.org/10.1074/jbc.R111.288308 
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• 2012 | Conference Abstract
  ​ ​The Alzheimer Amyloid Precursor Protein (APP) is a biomarker for transformed human pluripotent stem cells - from Alzheimer's disease to cancer biology and beyond​
  Venkataramani, V.; Behnes, C. L.; Thiele, K.; Wulf, G. G.; Thelen, F.; Opitz, L. & Salinas-Riester, G. et al.​ (2012)
  Onkologie, 35 
  Basel​: Karger.
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• 2012 | Journal Article | 
  ​ ​Amyloid Precursor Protein Is a Biomarker for Transformed Human Pluripotent Stem Cells​
  Venkataramani, V.; Thiele, K.; Behnes, C. L.; Wulf, G. G.; Thelen, P.; Opitz, L. & Salinas-Riester, G. et al.​ (2012) 
  The American Journal of Pathology, 180(4) pp. 1636​-1652​.​ DOI: https://doi.org/10.1016/j.ajpath.2011.12.015 
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• 2012 | Journal Article
  ​ ​A beta PP Accumulation and/or Intraneuronal Amyloid-beta Accumulation? The 3xTg-AD Mouse Model Revisited​
  Wirths, O.; Dins, A. & Bayer, T. A.​ (2012) 
  Journal of Alzheimer s Disease, 28(4) pp. 897​-904​.​ DOI: https://doi.org/10.3233/JAD-2011-111529 
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• 2012 | Journal Article
  ​ ​Motor deficits, neuron loss, and reduced anxiety coinciding with axonal degeneration and intraneuronal A beta aggregation in the 5XFAD mouse model of Alzheimer's disease​
  Jawhar, S.; Trawicka, A.; Jenneckens, C.; Bayer, T. A. & Wirths, O.​ (2012) 
  Neurobiology of Aging, 33(1) art. 196.e29​.​ DOI: https://doi.org/10.1016/j.neurobiolaging.2010.05.027 
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• 2012 | Review
  ​ ​Intraneuronal A beta accumulation and neurodegeneration: Lessons from transgenic models​
  Wirths, O.& Bayer, T. A.​ (2012)
  Life Sciences, 91​(23-24) pp. 1148​-1152​.​
  Pergamon-elsevier Science Ltd. DOI: https://doi.org/10.1016/j.lfs.2012.02.001 
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• 2012 | Journal Article
  ​ ​Antibody 9D5 Recognizes Oligomeric Pyroglutamate Amyloid-beta in a Fraction of Amyloid-beta Deposits in Alzheimer's Disease without Cross-Reactivity with other Protein Aggregates​
  Venkataramani, V.; Wirths, O.; Budka, H.; Haertig, W.; Kovacs, G. G. & Bayer, T. A.​ (2012) 
  Journal of Alzheimer s Disease, 29(2) pp. 361​-371​.​ DOI: https://doi.org/10.3233/JAD-2011-111379 
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• 2012 | Journal Article
  ​ ​No improvement after chronic ibuprofen treatment in the 5XFAD mouse model of Alzheimer's disease​
  Hillmann, A.; Hahn, S.; Schilling, S.; Hoffmann, T.; Demuth, H.-U.; Bulic, B. & Schneider-Axmann, T. et al.​ (2012) 
  Neurobiology of Aging, 33(4) art. 833.e39​.​ DOI: https://doi.org/10.1016/j.neurobiolaging.2011.08.006 
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• 2012 | Journal Article
  ​ ​Environmental enrichment fails to rescue working memory deficits, neuron loss, and neurogenesis in APP/PS1KI mice​
  Cotel, M.-C.; Jawhar, S.; Christensen, D. Z.; Bayer, T. A. & Wirths, O.​ (2012) 
  Neurobiology of Aging, 33(1) pp. 96​-107​.​ DOI: https://doi.org/10.1016/j.neurobiolaging.2010.02.012 
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