Author Friede, Tim
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2010 | Journal Article
Aspects of Modernizing Drug Development Using Clinical Scenario Planning and Evaluation
Benda, N.; Branson, M.; Maurer, W. & Friede, T. (2010)
DRUG INFORMATION JOURNAL, 44(3) pp. 299-315.
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2010 | Journal Article
Blinded Sample Size Recalculation in Noninferiority Trials: A Case Study in Dermatology
Friede, T. & Stammer, H. (2010)
DRUG INFORMATION JOURNAL, 44(5) pp. 599-607.
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2010 | Journal Article
Refinement of the Clinical Scenario Evaluation Framework for Assessment of Competing Development Strategies With an Application to Multiple Sclerosis
Friede, T.; Nicholas, R.; Stallard, N.; Todd, S.; Parsons, N.; Valdes-Marquez, E. & Chataway, J. (2010)
DRUG INFORMATION JOURNAL, 44(6) pp. 713-718.
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2010 | Journal Article
Perspectives on the Use of Adaptive Designs in Clinical Trials. Part II. Panel Discussion
Benda, N.; Brannath, W.; Bretz, F.; Burger, H.-U.; Friede, T.; Maurer, W. & Wang, S. (2010)
Journal of Biopharmaceutical Statistics, 20(6) art. PII 929076459. DOI: https://doi.org/10.1080/10543406.2010.514447
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2010 | Conference Paper |
Blinded sample size reestimation with count data: Methods and applications in multiple sclerosis
Friede, T. & Schmidli, H. (2010)
Statistics in Medicine, 29(10) pp. 1145-1156. Annual Conference on Statistical Issues in Clinical Trials-Early, Translational and Proof of Concept Studies - The Go/No Go Decisions, Philadelphia, PA.
Malden: Wiley-blackwell. DOI: https://doi.org/10.1002/sim.3861
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2010 | Review
Bladder symptoms in multiple sclerosis: a review of pathophysiology and management
Nicholas, R.; Young, C. A.& Friede, T. (2010)
Expert Opinion on Drug Safety, 9(6) pp. 905-915.
Informa Healthcare. DOI: https://doi.org/10.1517/14740338.2010.501793
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2011 | Conference Abstract
Interleukin 2 Receptor Antagonists for Liver Transplant Recipients: A Systematic Review and Meta-Analysis of Controlled Trials
Goralczyk, A. D.; Hauke, N.; Bari, N.; Lorf, T.; Friede, T. & Obed, A. (2011)
Liver Transplantation, 17(6) pp. S262-S263. Joint International Congress of ILTS, ELITA, and LICAGE, Valencia, SPAIN.
Malden: Wiley-blackwell.
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2011 | Journal Article | Letter Note
Planning and analysis of three-arm non-inferiority trials with binary endpoints
Kieser, M. & Friede, T. (2011)
Statistics in Medicine, 30(3). DOI: https://doi.org/10.1002/sim.4113
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2011 | Journal Article |
Software tools for implementing simulation studies in adaptive seamless designs: introducing R package ASD
Parsons, N.; Friede, T.; Todd, S. & Stallard, N. (2011)
Trials, 12(Suppl 1) pp. A8. DOI: https://doi.org/10.1186/1745-6215-12-S1-A8
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2011 | Review |
Development of oral immunomodulatory agents in the management of multiple sclerosis
Nicholas, R.; Giannetti, P.; Alsanousi, A.; Friede, T.& Muraro, P. A. (2011)
Drug Design Development and Therapy, 5 pp. 255-274.
Dove Medical Press Ltd. DOI: https://doi.org/10.2147/DDDT.S10498
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2011 | Journal Article
Sample Size Reassessment in Non-inferiority Trials
Friede, T. & Kieser, M. (2011)
METHODS OF INFORMATION IN MEDICINE, 50(3) pp. 237-243. DOI: https://doi.org/10.3414/ME09-01-0063
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2011 | Conference Paper
Designing a seamless phase II/III clinical trial using early outcomes for treatment selection: An application in multiple sclerosis
Friede, T.; Parsons, N.; Stallard, N.; Todd, S.; Marquez, E. V.; Chataway, J. & Nicholas, R. (2011)
Statistics in Medicine, 30(13) pp. 1528-1540. , Biopharm & Hlth Grp French Soc Stat, Paris, FRANCE.
Hoboken: Wiley-blackwell. DOI: https://doi.org/10.1002/sim.4202
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2011 | Journal Article |
Trends in annualized relapse rates in relapsing-remitting multiple sclerosis and consequences for clinical trial design
Nicholas, R.; Straube, S.; Schmidli, H.; Schneider, S. & Friede, T. (2011)
Multiple Sclerosis Journal, 17(10) pp. 1211-1217. DOI: https://doi.org/10.1177/1352458511406309
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2011 | Journal Article |
Warwick-Edinburgh Mental Well-being Scale (WEMWBS): Validated for teenage school students in England and Scotland. A mixed methods assessment
Clarke, A.; Friede, T.; Putz, R.; Ashdown, J.; Martin, S.; Blake, A. & Adi, Y. et al. (2011)
BMC Public Health, 11 art. 487. DOI: https://doi.org/10.1186/1471-2458-11-487
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2011 | Journal Article |
A novel adaptive design strategy increases the efficiency of clinical trials in secondary progressive multiple sclerosis
Chataway, J.; Nicholas, R.; Todd, S.; Miller, D. H.; Parsons, N.; Valdes-Marquez, E. & Stallard, N. et al. (2011)
MULTIPLE SCLEROSIS, 17(1) pp. 81-88. DOI: https://doi.org/10.1177/1352458510382129
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2011 | Review
Systematic review of sonographic chronic cerebrospinal venous insufficiency findings in multiple sclerosis
Thapar, A.; Lane, T.; Nicholas, R.; Friede, T.; Ellis, M.; Assenheim, J.& Franklin, I. J. et al. (2011)
Phlebology The Journal of Venous Disease, 26(8) pp. 319-325.
Royal Soc Medicine Press Ltd. DOI: https://doi.org/10.1258/phleb.2011.011098
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2011 | Journal Article |
Study protocol: Improving patient choice in treating low back pain (IMPACT - LBP): A randomised controlled trial of a decision support package for use in physical therapy
Patel, S.; Brown, S.; Friede, T.; Griffiths, F.; Lord, J.; Ngunjiri, A. & Thistlethwaite, J. et al. (2011)
BMC Musculoskeletal Disorders, 12 art. 52. DOI: https://doi.org/10.1186/1471-2474-12-52
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2012 | Journal Article
Assess, compare and enhance the status of Persons with Multiple Sclerosis (MS) in Europe: a European Register for MS
Pugliatti, M.; Eskic, D.; Mikolcic, T.; Pitschnau-Michel, D.; Myhr, K.-M.; Sastre-Garriga, J. & Otero, S. et al. (2012)
Acta Neurologica Scandinavica, 126 pp. 24-30. DOI: https://doi.org/10.1111/ane.12024
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2012 | Conference Abstract
Calcineurin Inhibitor Sparing with Mycophenolate Mofetil in Liver Transplant Recipients: A Systematic Review and Meta-Analysis
Goralczyk, A. D.; Abu-Ajaj, W.; Bari, N.; Lorf, T.; Ramadori, G.; Friede, T. & Obed, A. (2012)
Transplantation Journal, 94(10)
Philadelphia: Lippincott Williams & Wilkins.
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2012 | Conference Abstract
Time trends in baseline characteristics and eligibility criteria in trials in relapsing mutliple sclerosis - a systematic review and meta-analysis
Steinvorth, S. M.; Nicholas, R.; Roever, C. ; Schneider, S.; Straube, S. & Friede, T. (2012)
Multiple Sclerosis Journal, 18 pp. 474-475. 28th Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis, Lyon, FRANCE.
London: Sage Publications Ltd.
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2012 | Journal Article
An R package for implementing simulations for seamless phase II/III clinical trials using early outcomes for treatment selection
Parsons, N.; Friede, T.; Todd, S.; Marquez, E. V.; Chataway, J.; Nicholas, R. & Stallard, N. (2012)
Computational Statistics & Data Analysis, 56(5) pp. 1150-1160. DOI: https://doi.org/10.1016/j.csda.2010.10.027
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2012 | Journal Article
Blinded continuous monitoring of nuisance parameters in clinical trials
Friede, T. & Miller, F. (2012)
Journal of the Royal Statistical Society Series C (Applied Statistics), 61 pp. 601-618. DOI: https://doi.org/10.1111/j.1467-9876.2011.01029.x
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2012 | Journal Article |
Safety and Efficacy of the ACE-Inhibitor Ramipril in Alport Syndrome: The Double-Blind, Randomized, Placebo-Controlled, Multicenter Phase III EARLY PRO-TECT Alport Trial in Pediatric Patients
Gross, O.; Friede, T.; Hilgers, R.; Görlitz, A.; Gavénis, K.; Ahmed, R. & Dürr, U. (2012)
ISRN Pediatrics, 2012 pp. 1-6. DOI: https://doi.org/10.5402/2012/436046
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2012 | Review |
Time-patterns of annualized relapse rates in randomized placebo-controlled clinical trials in relapsing multiple sclerosis: A systematic review and meta-analysis
Nicholas, R.; Straube, S.; Schmidli, H.; Pfeiffer, S.& Friede, T. (2012)
Multiple Sclerosis Journal, 18(9) pp. 1290-1296.
Sage Publications Ltd. DOI: https://doi.org/10.1177/1352458511435715
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2012 | Conference Paper
A conditional error function approach for subgroup selection in adaptive clinical trials
Friede, T.; Parsons, N. & Stallard, N. (2012)
Statistics in Medicine, 31(30) pp. 4309-4320. 32nd Annual Conference of the International-Society-for-Clinical-Biostatistics, Ontario, CANADA.
Hoboken: Wiley-blackwell. DOI: https://doi.org/10.1002/sim.5541
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2012 | Journal Article
Early angiotensin-converting enzyme inhibition in Alport syndrome delays renal failure and improves life expectancy
Gross, O.; Licht, C.; Anders, H.-J.; Hoppe, B.; Beck, B.; Toenshoff, B. & Hoecker, B. et al. (2012)
Kidney International, 81(5) pp. 494-501. DOI: https://doi.org/10.1038/ki.2011.407
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2012 | Conference Paper
Considerations on what constitutes a 'qualified statistician' in regulatory guidelines
Gerlinger, C.; Edler, L.; Friede, T.; Kieser, M.; Nakas, C. T.; Schumacher, M. & Seldrup, J. et al. (2012)
Statistics in Medicine, 31(11-12) pp. 1303-1305. 31st Annual Conference of the International-Society-for-Clinical-Biostatistics, Montpellier, FRANCE.
Hoboken: Wiley-blackwell. DOI: https://doi.org/10.1002/sim.4345
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2012 | Review
Calcineurin Inhibitor Sparing With Mycophenolate Mofetil in Liver Transplantion: A Systematic Review of Randomized Controlled Trials
Goralczyk, A. D.; Bari, N.; Abu-Ajaj, W.; Lorf, T.; Ramadori, G.; Friede, T.& Obed, A. (2012)
American Journal of Transplantation, 12(10) pp. 2601-2607.
Wiley-blackwell. DOI: https://doi.org/10.1111/j.1600-6143.2012.04157.x
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2013 | Journal Article
A conditional error function approach for subgroup selection in adaptive clinical trials (vol 31, pg 4309, 2012)
Friede, T.; Parsons, N. & Stallard, N. (2013)
Statistics in Medicine, 32(14) pp. 2513-2514. DOI: https://doi.org/10.1002/sim.5759
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2013 | Conference Abstract
Using the internet in the management of multiple sclerosis: an overview of the evidence available
Schilling, J.; Friede, T. & Straube, S. (2013)
Multiple Sclerosis Journal, 19(11) pp. 302-303. 29th Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis / 18th Annual Conference of Rehabilitation in MS, Copenhagen, DENMARK.
London: Sage Publications Ltd.
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2013 | Conference Abstract
Comparison of disability scores and annualised relapse rates as trial outcomes in randomized, placebo controlled trials in relapsing multiple sclerosis: a systematic review
Roever, C. ; Nicholas, R.; Steinvorth, S.; Straube, S. & Friede, T. (2013)
Multiple Sclerosis Journal, 19(11) pp. 498-499. 29th Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis / 18th Annual Conference of Rehabilitation in MS, Copenhagen, DENMARK.
London: Sage Publications Ltd.
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2013 | Journal Article |
Study protocol: improving patient choice in treating Low back pain (IMPACT-LBP): a randomised controlled trial of a decision support package for use in physical therapy (vol 12, 52, 2011)
Patel, S.; Brown, S.; Friede, T.; Griffiths, F.; Lord, J.; Ngunjiri, A. & Thistlethwaite, J. et al. (2013)
BMC Musculoskeletal Disorders, 14 art. 158. DOI: https://doi.org/10.1186/1471-2474-14-158
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2013 | Journal Article
Blinded sample size re-estimation in superiority and noninferiority trials: bias versus variance in variance estimation
Friede, T. & Kieser, M. (2013)
Pharmaceutical Statistics, 12(3) pp. 141-146. DOI: https://doi.org/10.1002/pst.1564
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2013 | Journal Article
Cross cultural evaluation of the Warwick-Edinburgh mental well-being scale (WEMWBS) -a mixed methods study
Taggart, F.; Friede, T.; Weich, S.; Clarke, A.; Johnson, M. A. & Stewart-Brown, S. (2013)
Health and Quality of Life Outcomes, 11 art. 27. DOI: https://doi.org/10.1186/1477-7525-11-27
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2013 | Journal Article
Assessment of statistical significance and clinical relevance
Kieser, M.; Friede, T. & Gondan, M. (2013)
Statistics in Medicine, 32(10) pp. 1707-1719. DOI: https://doi.org/10.1002/sim.5634
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2013 | Review
Systematic Review of Randomized Controlled Trials of Clinical Prediction Rules for Physical Therapy in Low Back Pain
Patel, S.; Psychol, C.; Friede, T.; Froud, R.; Evans, D. W.& Underwood, M. (2013)
Spine, 38(9) pp. 762-769.
Lippincott Williams & Wilkins. DOI: https://doi.org/10.1097/BRS.0b013e31827b158f
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2013 | Journal Article | Research Paper
Adhesion maturation of neutrophils on nanoscopically presented platelet glycoprotein Ibα
Kruss, S.; Erpenbeck, L.; Amschler, K.; Mundinger, T. A. ; Boehm, H.; Helms, H.-J. & Friede, T. et al. (2013)
ACS Nano, 7(11) pp. 9984-9996. DOI: https://doi.org/10.1021/nn403923h
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2013 | Journal Article
Robustness of methods for blinded sample size re-estimation with overdispersed count data
Schneider, S.; Schmidli, H. & Friede, T. (2013)
Statistics in Medicine, 32(21) pp. 3623-3635. DOI: https://doi.org/10.1002/sim.5800
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2013 | Journal Article
Blinded sample size re-estimation for recurrent event data with time trends
Schneider, S.; Schmidli, H. & Friede, T. (2013)
Statistics in Medicine, 32(30) pp. 5448-5457. DOI: https://doi.org/10.1002/sim.5977
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2013 | Journal Article |
Explaining temporal trends in annualised relapse rates in placebo groups of randomised controlled trials in relapsing multiple sclerosis: systematic review and meta-regression
Steinvorth, S. M.; Roever, C. ; Schneider, S.; Nicholas, R.; Straube, S. & Friede, T. (2013)
Multiple Sclerosis Journal, 19(12) pp. 1580-1586. DOI: https://doi.org/10.1177/1352458513481009
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2013 | Journal Article
Blinded and unblinded internal pilot study designs for clinical trials with count data
Schneider, S.; Schmidli, H. & Friede, T. (2013)
Biometrical Journal, 55(4) pp. 617-633. DOI: https://doi.org/10.1002/bimj.201200189
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2014 | Journal Article
Guest Editors' Introduction
Friede, T.; Henderson, R. & Hougaard, P. (2014)
Statistics in Medicine, 33(30) pp. 5221-5222. DOI: https://doi.org/10.1002/sim.6362
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2014 | Journal Article
Plasma prion protein concentration and progression of Alzheimer disease
Schmidt, C. D.; Becker, H.; Peter, C.; Lange, K.; Friede, T. & Zerr, I. (2014)
Prion, 8(2) pp. 210-214. DOI: https://doi.org/10.4161/pri.27964
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2014 | Journal Article |
Work-related outcomes in randomised placebo-controlled pain trials: a systematic review and meta-analysis
Wolf, I.; Friede, T.; Hallier, E. & Straube, S. (2014)
Journal of Occupational Medicine and Toxicology, 9 art. 25. DOI: https://doi.org/10.1186/1745-6673-9-25
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2014 | Journal Article
CR1 is potentially associated with rate of decline in sporadic Alzheimer's disease
Schmidt, C. D.; Wolff, M.; von Ahsen, N.; Lange, K.; Friede, T. & Zerr, I. (2014)
Journal of Clinical Neuroscience, 21(10) pp. 1705-1708. DOI: https://doi.org/10.1016/j.jocn.2014.03.015
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2014 | Journal Article |
Efficacy of Ambroxol lozenges for pharyngitis: a meta-analysis
Chenot, J.-F.; Weber, P. & Friede, T. (2014)
BMC Family Practice, 15 art. 45. DOI: https://doi.org/10.1186/1471-2296-15-45
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2014 | Journal Article |
Data-driven treatment selection for seamless phase II/III trials incorporating early-outcome data
Kunz, C. U.; Friede, T.; Parsons, N.; Todd, S. & Stallard, N. (2014)
Pharmaceutical Statistics, 13(4) pp. 238-246. DOI: https://doi.org/10.1002/pst.1619
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2014 | Journal Article |
Primum non nocere: shared informed decision making in low back pain - a pilot cluster randomised trial
Patel, S.; Ngunjiri, A.; Hee, S. W.; Yang, Y.; Brown, S.; Friede, T. & Griffiths, F. et al. (2014)
BMC Musculoskeletal Disorders, 15 art. 282. DOI: https://doi.org/10.1186/1471-2474-15-282
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2014 | Journal Article |
Design and Development of a Decision Support Package for Low Back Pain
Patel, S.; Ngunjiri, A.; Sandhu, H.; Griffiths, F.; Thistlewaite, J.; Brown, S. & Friede, T. et al. (2014)
Arthritis Care & Research, 66(6) pp. 925-933. DOI: https://doi.org/10.1002/acr.22252
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