Author Hoffmann, Markus
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2011 | Journal Article
Comparative Analysis of Ebola Virus Glycoprotein Interactions With Human and Bat Cells
Kühl, A.; Hoffmann, M.; Müller, M. A.; Munster, V. J.; Gnirß, K.; Kiene, M. & Tsegaye, T. S. et al. (2011)
The Journal of Infectious Diseases, 204(suppl_3) pp. S840-S849. DOI: https://doi.org/10.1093/infdis/jir306
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2015 | Journal Article
Interferon-Induced Transmembrane Protein–Mediated Inhibition of Host Cell Entry of Ebolaviruses
Wrensch, F.; Karsten, C. B.; Gnirß, K.; Hoffmann, M.; Lu, K.; Takada, A. & Winkler, M. et al. (2015)
Journal of Infectious Diseases, 212(suppl 2) pp. S210-S218. DOI: https://doi.org/10.1093/infdis/jiv255
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2016 | Journal Article
Recombinant mumps viruses expressing the batMuV fusion glycoprotein are highly fusion active and neurovirulent
Krüger, N.; Sauder, C.; Hoffmann, M.; Örvell, C.; Drexler, J. F.; Rubin, S. & Herrler, G. (2016)
Journal of General Virology, 97(11) pp. 2837-2848. DOI: https://doi.org/10.1099/jgv.0.000596
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2016 | Journal Article
The Tetherin Antagonism of the Ebola Virus Glycoprotein Requires an Intact Receptor-Binding Domain and Can Be Blocked by GP1-Specific Antibodies
Brinkmann, C.; Nehlmeier, I.; Walendy-Gnirß, K.; Nehls, J.; González Hernández, M.; Hoffmann, M. & Qiu, X. et al. (2016)
Journal of Virology, 90(24) pp. 11075-11086. DOI: https://doi.org/10.1128/JVI.01563-16
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2016 | Journal Article |
The Glycoproteins of All Filovirus Species Use the Same Host Factors for Entry into Bat and Human Cells but Entry Efficiency Is Species Dependent.
Hoffmann, M.; González Hernández, M.; Berger, E.; Marzi, A. & Pöhlmann, S. (2016)
PloS one, 11(2) art. e0149651. DOI: https://doi.org/10.1371/journal.pone.0149651
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2016 | Journal Article |
The Hemagglutinin of Bat-Associated Influenza Viruses Is Activated by TMPRSS2 for pH-Dependent Entry into Bat but Not Human Cells.
Hoffmann, M.; Krüger, N.; Zmora, P.; Wrensch, F.; Herrler, G. & Pöhlmann, S. (2016)
PloS one, 11(3) art. e0152134. DOI: https://doi.org/10.1371/journal.pone.0152134
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2017 | Journal Article
A Polymorphism within the Internal Fusion Loop of the Ebola Virus Glycoprotein Modulates Host Cell Entry
Hoffmann, M.; Crone, L.; Dietzel, E.; Paijo, J.; González-Hernández, M.; Nehlmeier, I. & Kalinke, U. et al. (2017)
Journal of Virology, 91(9) art. e00177-17. DOI: https://doi.org/10.1128/JVI.00177-17
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2017 | Journal Article
Virion Background and Efficiency of Virion Incorporation Determine Susceptibility of Simian Immunodeficiency Virus Env-Driven Viral Entry to Inhibition by IFITM Proteins
Wrensch, F.; Hoffmann, M.; Gärtner, S.; Nehlmeier, I.; Winkler, M. & Pöhlmann, S. (2017)
Journal of Virology, 91(2) art. e01488-16. DOI: https://doi.org/10.1128/JVI.01488-16
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2017 | Journal Article | Research Paper |
The glycoprotein of vesicular stomatitis virus promotes release of virus-like particles from tetherin-positive cells
Brinkmann, C.; Hoffmann, M.; Lübke, A.; Nehlmeier, I.; Krämer-Kühl, A.; Winkler, M. & Pöhlmann, S. (2017)
PLoS One, 12(12) art. e0189073. DOI: https://doi.org/10.1371/journal.pone.0189073
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2017 | Journal Article |
Different residues in the SARS-CoV spike protein determine cleavage and activation by the host cell protease TMPRSS2.
Reinke, L. M.; Spiegel, M.; Plegge, T.; Hartleib, A.; Nehlmeier, I.; Gierer, S. & Hoffmann, M. et al. (2017)
PloS one, 12(6) art. e0179177. DOI: https://doi.org/10.1371/journal.pone.0179177
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2018 | Journal Article
TMPRSS11A activates the influenza A virus hemagglutinin and the MERS coronavirus spike protein and is insensitive against blockade by HAI-1
Zmora, P.; Hoffmann, M.; Kollmus, H.; Moldenhauer, A.-S.; Danov, O.; Braun, A. & Winkler, M. et al. (2018)
Journal of Biological Chemistry, 293(36) pp. 13863-13873. DOI: https://doi.org/10.1074/jbc.RA118.001273
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2018 | Journal Article
A GXXXA Motif in the Transmembrane Domain of the Ebola Virus Glycoprotein Is Required for Tetherin Antagonism
González-Hernández, M.; Hoffmann, M.; Brinkmann, C.; Nehls, J.; Winkler, M.; Schindler, M. & Pöhlmann, S. (2018)
Journal of Virology, 92(13) art. e00403-18. DOI: https://doi.org/10.1128/JVI.00403-18
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2018 | Journal Article
Cell Entry of Influenza A Viruses: Sweet Talk between HA and CaV1.2
Hoffmann, M. & Pöhlmann, S. (2018)
Cell Host & Microbe, 23(6) pp. 697-699. DOI: https://doi.org/10.1016/j.chom.2018.05.019
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2018 | Journal Article
Entry, Replication, Immune Evasion, and Neurotoxicity of Synthetically Engineered Bat-Borne Mumps Virus
Krüger, N.; Sauder, C.; Hüttl, S.; Papies, J.; Voigt, K.; Herrler, G. & Hardes, K. et al. (2018)
Cell Reports, 25(2) pp. 312-320.e7. DOI: https://doi.org/10.1016/j.celrep.2018.09.018
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2018 | Journal Article |
Functional analysis of potential cleavage sites in the MERS-coronavirus spike protein
Kleine-Weber, H.; Elzayat, M. T.; Hoffmann, M. & Pöhlmann, S. (2018)
Scientific Reports, 8(1) art. 16597. DOI: https://doi.org/10.1038/s41598-018-34859-w
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2019 | Journal Article
Calu-3 cells are largely resistant to entry driven by filovirus glycoproteins and the entry defect can be rescued by directed expression of DC-SIGN or cathepsin L
González-Hernández, M.; Müller, A.; Hoenen, T.; Hoffmann, M. & Pöhlmann, S. (2019)
Virology, 532 pp. 22-29. DOI: https://doi.org/10.1016/j.virol.2019.03.020
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2019 | Journal Article
Mutations in the Spike Protein of Middle East Respiratory Syndrome Coronavirus Transmitted in Korea Increase Resistance to Antibody-Mediated Neutralization
Kleine-Weber, H.; Elzayat, M. T.; Wang, L.; Graham, B. S.; Müller, M. A.; Drosten, C. & Pöhlmann, S. et al. (2019)
Journal of Virology, 93(2). DOI: https://doi.org/10.1128/JVI.01381-18
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2019 | Journal Article
Tetherin Inhibits Nipah Virus but Not Ebola Virus Replication in Fruit Bat Cells
Hoffmann, M.; Nehlmeier, I.; Brinkmann, C.; Krähling, V.; Behner, L.; Moldenhauer, A.-S. & Krüger, N. et al. (2019)
Journal of Virology, 93(3). DOI: https://doi.org/10.1128/JVI.01821-18
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2019 | Journal Article
Release of Immunomodulatory Ebola Virus Glycoprotein-Containing Microvesicles Is Suppressed by Tetherin in a Species-Specific Manner
Nehls, J.; Businger, R.; Hoffmann, M.; Brinkmann, C.; Fehrenbacher, B.; Schaller, M. & Maurer, B. et al. (2019)
Cell Reports, 26(7) pp. 1841-1853.e6. DOI: https://doi.org/10.1016/j.celrep.2019.01.065
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2019 | Journal Article
Spike proteins of novel MERS-coronavirus isolates from North- and West-African dromedary camels mediate robust viral entry into human target cells
Kleine-Weber, H.; Pöhlmann, S. & Hoffmann, M. (2019)
Virology, 535 pp. 261-265. DOI: https://doi.org/10.1016/j.virol.2019.07.016
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2019 | Journal Article |
Disease Manifestation and Viral Sequences in a Bonobo More Than 30 Years after Papillomavirus Infection
Hoffmann, M.; Schütze, E.; Bernhard, A. ; Schlaphoff, L.; Kaul, A.; Schöniger, S. & Pöhlmann, S. (2019)
Pathogens, 8(1) pp. 13. DOI: https://doi.org/10.3390/pathogens8010013
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2019 | Journal Article |
Analysis of Resistance of Ebola Virus Glycoprotein-Driven Entry Against MDL28170, An Inhibitor of Cysteine Cathepsins
Hoffmann, M.; Kaufmann, S. V.; Fischer, C.; Maurer, W.; Moldenhauer, A.-S. & Pöhlmann, S. (2019)
Pathogens, 8(4) pp. 192. DOI: https://doi.org/10.3390/pathogens8040192
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2019 | Journal Article |
Fusogenicity of the Ghana Virus (Henipavirus: Ghanaian bat henipavirus) Fusion Protein is Controlled by the Cytoplasmic Domain of the Attachment Glycoprotein
Voigt, K.; Hoffmann, M.; Drexler, J. F.; Müller, M. A.; Drosten, C.; Herrler, G. & Krüger, N. (2019)
Viruses, 11(9) art. 800. DOI: https://doi.org/10.3390/v11090800
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2019 | Journal Article |
Modulation of HIV-1 Gag/Gag-Pol frameshifting by tRNA abundance
Korniy, N.; Goyal, A. ; Hoffmann, M.; Samatova, E. ; Peske, F. ; Pöhlmann, S. & Rodnina, M. V (2019)
Nucleic Acids Research, 47(10) pp. 5210-5222. DOI: https://doi.org/10.1093/nar/gkz202
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2019 | Journal Article |
Role of rhesus macaque IFITM3(2) in simian immunodeficiency virus infection of macaques
Winkler, M. ; Gärtner, S.; Markus, L.; Hoffmann, M.; Nehlmeier, I.; Krawczak, M. & Sauermann, U. et al. (2019)
PLoS One, 14(11) art. e0224082. DOI: https://doi.org/10.1371/journal.pone.0224082
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2019 | Journal Article |
A system for production of defective interfering particles in the absence of infectious influenza A virus
Bdeir, N.; Arora, P.; Gärtner, S.; Hoffmann, M.; Reichl, U.; Pöhlmann, S. & Winkler, M. (2019)
PlOS ONE, 14(3) art. e0212757. DOI: https://doi.org/10.1371/journal.pone.0212757
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2020 | Journal Article
Polymorphisms in dipeptidyl peptidase 4 reduce host cell entry of Middle East respiratory syndrome coronavirus
Kleine-Weber, H.; Schroeder, S.; Krüger, N.; Prokscha, A.; Naim, H. Y.; Müller, M. A. & Drosten, C. et al. (2020)
Emerging Microbes & Infections, 9(1) pp. 155-168. DOI: https://doi.org/10.1080/22221751.2020.1713705
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2020 | Journal Article
Nafamostat Mesylate Blocks Activation of SARS-CoV-2: New Treatment Option for COVID-19
Hoffmann, M.; Schroeder, S.; Kleine-Weber, H.; Müller, M. A.; Drosten, C. & Pöhlmann, S. (2020)
Antimicrobial Agents and Chemotherapy, 64(6). DOI: https://doi.org/10.1128/AAC.00754-20
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2020 | Journal Article
A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells
Hoffmann, M.; Kleine-Weber, H. & Pöhlmann, S. (2020)
Molecular Cell, 78(4) pp. 779-784.e5. DOI: https://doi.org/10.1016/j.molcel.2020.04.022
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2020 | Journal Article
Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies
Wrapp, D.; De Vlieger, D.; Corbett, K. S.; Torres, G. M.; Wang, N.; Van Breedam, W. & Roose, K. et al. (2020)
Cell, 181(5) pp. 1004-1015.e15. DOI: https://doi.org/10.1016/j.cell.2020.04.031
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2020 | Journal Article
The Amino Acid at Position 8 of the Proteolytic Cleavage Site of the Mumps Virus Fusion Protein Affects Viral Proteolysis and Fusogenicity
Hüttl, S.; Hoffmann, M.; Steinmetzer, T.; Sauder, C. & Krüger, N. (2020)
Journal of Virology, 94(22). DOI: https://doi.org/10.1128/JVI.01732-20
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2020 | Journal Article
Sphingosine prevents binding of SARS–CoV-2 spike to its cellular receptor ACE2
Edwards, M. J.; Becker, K. A.; Gripp, B.; Hoffmann, M.; Keitsch, S.; Wilker, B. & Soddemann, M. et al. (2020)
Journal of Biological Chemistry, 295(45) pp. 15174-15182. DOI: https://doi.org/10.1074/jbc.RA120.015249
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2020 | Journal Article
Myeloperoxidase Modulates Inflammation in Generalized Pustular Psoriasis and Additional Rare Pustular Skin Diseases
Haskamp, S.; Bruns, H.; Hahn, M.; Hoffmann, M.; Gregor, A.; Löhr, S. & Hahn, J. et al. (2020)
The American Journal of Human Genetics, 107(3) pp. 527-538. DOI: https://doi.org/10.1016/j.ajhg.2020.07.001
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2020 | Journal Article
SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
Hoffmann, M.; Kleine-Weber, H.; Schroeder, S.; Krüger, N.; Herrler, T.; Erichsen, S. & Schiergens, T. S. et al. (2020)
Cell, 181(2) pp. 271-280.e8. DOI: https://doi.org/10.1016/j.cell.2020.02.052
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2020 | Journal Article | Research Paper |
Pharmacological Inhibition of Acid Sphingomyelinase Prevents Uptake of SARS-CoV-2 by Epithelial Cells
Carpinteiro, A.; Edwards, M. J.; Hoffmann, M.; Kochs, G.; Gripp, B.; Weigang, S. & Adams, C. et al. (2020)
Cell Reports. Medicine, 1(8) pp. 100142. DOI: https://doi.org/10.1016/j.xcrm.2020.100142
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2020 | Journal Article |
Rapid response flow cytometric assay for the detection of antibody responses to SARS-CoV-2
Lapuente, D.; Maier, C.; Irrgang, P.; Hübner, J.; Peter, A. S.; Hoffmann, M. & Ensser, A. et al. (2020)
European Journal of Clinical Microbiology & Infectious Diseases, 40(4) pp. 751-759. DOI: https://doi.org/10.1007/s10096-020-04072-7
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2020 | Journal Article |
LY6E impairs coronavirus fusion and confers immune control of viral disease
Pfaender, S.; Mar, K. B.; Michailidis, E.; Kratzel, A.; Boys, I. N.; V’kovski, P. & Fan, W. et al. (2020)
Nature Microbiology, 5(11) pp. 1330-1339. DOI: https://doi.org/10.1038/s41564-020-0769-y
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2020 | Journal Article |
Chloroquine does not inhibit infection of human lung cells with SARS-CoV-2
Hoffmann, M.; Mösbauer, K.; Hofmann-Winkler, H.; Kaul, A.; Kleine-Weber, H.; Krüger, N. & Gassen, N. C. et al. (2020)
Nature, 585(7826) pp. 588-590. DOI: https://doi.org/10.1038/s41586-020-2575-3
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2020 | Journal Article |
Low serum neutralizing anti-SARS-CoV-2 S antibody levels in mildly affected COVID-19 convalescent patients revealed by two different detection methods
Bošnjak, B.; Stein, S. C.; Willenzon, S.; Cordes, A. K.; Puppe, W.; Bernhardt, G. & Ravens, I. et al. (2020)
Cellular & Molecular Immunology, 18(4) pp. 936-944. DOI: https://doi.org/10.1038/s41423-020-00573-9
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2021 | Journal Article
Molecular mechanism of inhibiting the SARS-CoV-2 cell entry facilitator TMPRSS2 with camostat and nafamostat
Hempel, T.; Raich, L.; Olsson, S.; Azouz, N. P.; Klingler, A. M.; Hoffmann, M. & Pöhlmann, S. et al. (2021)
Chemical Science, 12(3) pp. 983-992. DOI: https://doi.org/10.1039/d0sc05064d
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2021 | Journal Article
Therapeutic Application of alpha-1-antitrypsin in COVID-19
Ritzmann, F.; Chitirala, P.; Krüger, N.; Hoffmann, M.; Zuo, W.; Lammert, F. & Smola, S. et al. (2021)
American Journal of Respiratory and Critical Care Medicine, art. rccm.202104-0833LE. DOI: https://doi.org/10.1164/rccm.202104-0833LE
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2021 | Journal Article
SARS-CoV-2 variant B.1.617 is resistant to bamlanivimab and evades antibodies induced by infection and vaccination
Hoffmann, M.; Hofmann-Winkler, H.; Krüger, N.; Kempf, A.; Nehlmeier, I.; Graichen, L. & Arora, P. et al. (2021)
Cell Reports, 36(3) art. S2211124721008287. DOI: https://doi.org/10.1016/j.celrep.2021.109415
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2021 | Journal Article
A novel class of TMPRSS2 inhibitors potently block SARS-CoV-2 and MERS-CoV viral entry and protect human epithelial lung cells
Mahoney, M.; Damalanka, V. C.; Tartell, M. A.; Chung, D. hee; Lourenço, A. L.; Pwee, D. & Mayer Bridwell, A. E. et al. (2021)
Proceedings of the National Academy of Sciences, 118(43) pp. e2108728118. DOI: https://doi.org/10.1073/pnas.2108728118
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2021 | Journal Article
SARS-CoV-2 delta variant neutralisation after heterologous ChAdOx1-S/BNT162b2 vaccination
Behrens, G. M.; Cossmann, A.; Stankov, M. V; Nehlmeier, I.; Kempf, A.; Hoffmann, M. & Pöhlmann, S. (2021)
The Lancet, 398(10305) pp. 1041-1042. DOI: https://doi.org/10.1016/S0140-6736(21)01891-2
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2021 | Journal Article
B.1.617.2 enters and fuses lung cells with increased efficiency and evades antibodies induced by infection and vaccination
Arora, P.; Sidarovich, A.; Krüger, N.; Kempf, A.; Nehlmeier, I.; Graichen, L. & Moldenhauer, A.-S. et al. (2021)
Cell Reports, 37(2) art. S2211124721012894. DOI: https://doi.org/10.1016/j.celrep.2021.109825
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2021 | Journal Article
Inhibition of acid sphingomyelinase by ambroxol prevents SARS-CoV-2 entry into epithelial cells
Carpinteiro, A.; Gripp, B.; Hoffmann, M.; Pöhlmann, S. ; Hoertel, N.; Edwards, M. J. & Kamler, M. et al. (2021)
Journal of Biological Chemistry, 296 art. S0021925821004907. DOI: https://doi.org/10.1016/j.jbc.2021.100701
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2021 | Journal Article
SARS-CoV-2 mutations acquired in mink reduce antibody-mediated neutralization
Hoffmann, M.; Zhang, L.; Krüger, N.; Graichen, L.; Kleine-Weber, H.; Hofmann-Winkler, H. & Kempf, A. et al. (2021)
Cell Reports, 35(3) pp. 109017. DOI: https://doi.org/10.1016/j.celrep.2021.109017
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2021 | Journal Article
SARS-CoV-2 variants B.1.351 and P.1 escape from neutralizing antibodies
Hoffmann, M.; Arora, P.; Groß, R.; Seidel, A.; Hörnich, B. F.; Hahn, A. S. & Krüger, N. et al. (2021)
Cell, 184(9) pp. 2384-2393.e12. DOI: https://doi.org/10.1016/j.cell.2021.03.036
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2021 | Journal Article
The SARS-CoV-2 and other human coronavirus spike proteins are fine-tuned towards temperature and proteases of the human airways
Laporte, M.; Raeymaekers, V.; Van Berwaer, R.; Vandeput, J.; Marchand-Casas, I.; Thibaut, H.-J. & Van Looveren, D. et al. (2021)
PLoS Pathogens, 17(4) pp. e1009500. DOI: https://doi.org/10.1371/journal.ppat.1009500
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2021 | Journal Article
Camostat mesylate inhibits SARS-CoV-2 activation by TMPRSS2-related proteases and its metabolite GBPA exerts antiviral activity
Hoffmann, M.; Hofmann-Winkler, H.; Smith, J. C.; Krüger, N.; Arora, P.; Sørensen, L. K. & Søgaard, O. S. et al. (2021)
EBioMedicine, 65 art. 103255. DOI: https://doi.org/10.1016/j.ebiom.2021.103255
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