Author Mandelkow, Eckhard
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2005 | Journal Article | Research Paper
Sites of tau important for aggregation populate beta-structure and bind to microtubules and polyanions
Mukrasch, M. D.; Biernat, J.; von Bergen, M.; Griesinger, C. ; Mandelkow, E. & Zweckstetter, M. (2005)
Journal of biological chemistry, 280(26) pp. 24978-24986. DOI: https://doi.org/10.1074/jbc.M501565200
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2007 | Journal Article | Research Paper
Structural and microtubule binding properties of tau mutants of frontotemporal dementias
Fischer, D.; Mukrasch, M. D.; von Bergen, M.; Klos-Witkowska, A.; Biernat, J.; Griesinger, C. & Mandelkow, E. et al. (2007)
Biochemistry, 46(10) pp. 2574-2582. DOI: https://doi.org/10.1021/bi061318s
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2007 | Journal Article | Research Paper
Highly populated turn conformations in natively unfolded Tau protein identified from residual dipolar couplings and molecular simulation
Mukrasch, M. D.; Markwick, P.; Biernat, J.; von Bergen, M.; Bernado, P.; Griesinger, C. & Mandelkow, E. et al. (2007)
Journal of the American Chemical Society, 129(16) pp. 5235-5243. DOI: https://doi.org/10.1021/ja0690159
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2007 | Journal Article | Research Paper
The "jaws" of the Tau-microtubule interaction
Mukrasch, M. D.; von Bergen, M.; Biernat, J.; Fischer, D.; Griesinger, C. ; Mandelkow, E. & Zweckstetter, M. (2007)
Journal of biological chemistry, 282(16) pp. 12230-12239. DOI: https://doi.org/10.1074/jbc.M607159200
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2008 | Journal Article | Research Paper
Structural characterization of binding of Cu(II) to Tau protein
Soragni, A.; Zambelli, B.; Mukrasch, M. D.; Biemat, J.; Jeganathan, S.; Griesinger, C. & Ciurli, S. et al. (2008)
Biochemistry, 47(41) pp. 10841-10851. DOI: https://doi.org/10.1021/bi8008856
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2008 | Review
Tau-based treatment strategies in neurodegenerative diseases
Schneider, A.& Mandelkow, E. (2008)
Neurotherapeutics, 5(3) pp. 443-457.
Springer. DOI: https://doi.org/10.1016/j.nurt.2008.05.006
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2008 | Journal Article | Research Paper
Characterization of Alzheimer's-like paired helical filaments from the core domain of tau protein using solid-state NMR spectroscopy
Andronesi, O. C.; von Bergen, M.; Biernat, J.; Seidel, K. ; Griesinger, C. ; Mandelkow, E. & Baldus, M. (2008)
Journal of the American Chemical Society, 130(18) pp. 5922-5928. DOI: https://doi.org/10.1021/ja7100517
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2009 | Journal Article | Research Paper |
Structural Polymorphism of 441-Residue Tau at Single Residue Resolution
Mukrasch, M. D.; Bibow, S.; Korukottu, J.; Jeganathan, S.; Biernat, J.; Griesinger, C. & Mandelkow, E. et al. (2009)
PLoS Biology, 7(2) art. e1000034. DOI: https://doi.org/10.1371/journal.pbio.1000034
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2009 | Journal Article | Research Paper
Conformational Changes Specific for Pseudophosphorylation at Serine 262 Selectively Impair Binding of Tau to Microtubules
Fischer, D.; Mukrasch, M. D.; Biernat, J.; Bibow, S.; Blackledge, M.; Griesinger, C. & Mandelkow, E. et al. (2009)
Biochemistry, 48(42) pp. 10047-10055. DOI: https://doi.org/10.1021/bi901090m
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2010 | Journal Article
Automatic Assignment of the Intrinsically Disordered Protein Tau with 441-Residues
Narayanan, R. L.; Dürr, U. H. N.; Bibow, S.; Biernat, J.; Mandelkow, E. & Zweckstetter, M. (2010)
Journal of the American Chemical Society, 132(34) pp. 11906-11907. DOI: https://doi.org/10.1021/ja105657f
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2011 | Journal Article | Research Paper
The Dynamic Structure of Filamentous Tau
Bibow, S.; Mukrasch, M. D.; Chinnathambi, S.; Biernat, J.; Griesinger, C. ; Mandelkow, E. & Zweckstetter, M. (2011)
Angewandte Chemie International Edition, 50(48) pp. 11520-11524. DOI: https://doi.org/10.1002/anie.201105493
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2012 | Journal Article | Research Paper
beta-Sheet Core of Tau Paired Helical Filaments Revealed by Solid-State NMR
Daebel, V.; Chinnathambi, S.; Biernat, J.; Schwalbe, M.; Habenstein, B. ; Loquet, A. & Akoury, E. et al. (2012)
Journal of the American Chemical Society, 134(34) pp. 13982-13989. DOI: https://doi.org/10.1021/ja305470p
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2013 | Journal Article
Phosphorylation of Human Tau Protein by Microtubule Affinity-Regulating Kinase 2
Schwalbe, M.; Biernat, J.; Bibow, S.; Ozenne, V.; Jensen, M. R.; Kadavath, H. & Blackledge, M. et al. (2013)
Biochemistry, 52(50) pp. 9068-9079. DOI: https://doi.org/10.1021/bi401266n
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2013 | Journal Article | Research Paper
Inhibition of Tau Filament Formation by Conformational Modulation
Akoury, E.; Gajda, M. J.; Pickhard, M.; Biernat, J.; Soraya, P.; Griesinger, C. & Mandelkow, E. et al. (2013)
Journal of the American Chemical Society, 135(7) pp. 2853-2862. DOI: https://doi.org/10.1021/ja312471h
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2014 | Journal Article
Hsp90-Tau Complex Reveals Molecular Basis for Specificity in Chaperone Action
Karagoz, G. E.; Duarte, A. M. S.; Akoury, E.; Ippel, H.; Biernat, J.; Luengo, T. M. & Radli, M. et al. (2014)
Cell, 156(5) pp. 963-974. DOI: https://doi.org/10.1016/j.cell.2014.01.037
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2014 | Journal Article
Predictive Atomic Resolution Descriptions of Intrinsically Disordered hTau40 and alpha-Synuclein in Solution from NMR and Small Angle Scattering
Schwalbe, M.; Ozenne, V.; Bibow, S.; Jaremko, M.; Jaremko, L.; Gajda, M. & Ringkjobing Jensen, M. et al. (2014)
Structure, 22(2) pp. 238-249. DOI: https://doi.org/10.1016/j.str.2013.10.020
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2015 | Journal Article
Tau stabilizes microtubules by binding at the interface between tubulin heterodimers
Kadavath, H.; Hofele, R. V.; Biernat, J.; Kumar, S.; Tepper, K.; Urlaub, H. & Mandelkow, E. et al. (2015)
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 112(24) pp. 7501-7506. DOI: https://doi.org/10.1073/pnas.1504081112
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2015 | Journal Article
Folding of the Tau Protein on Microtubules
Kadavath, H.; Jaremko, M.; Jaremko, L.; Biernat, J.; Mandelkow, E. & Zweckstetter, M. (2015)
Angewandte Chemie International Edition, 54(35) pp. 10347-10351. DOI: https://doi.org/10.1002/ange.201501714
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2015 | Journal Article
Structural Impact of Tau Phosphorylation at Threonine 231
Schwalbe, M.; Kadavath, H.; Biernat, J.; Ozenne, V.; Blackledge, M.; Mandelkow, E. & Zweckstetter, M. (2015)
Structure, 23(8) pp. 1448-1458. DOI: https://doi.org/10.1016/j.str.2015.06.002
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2016 | Journal Article
Remodeling of the conformational ensemble of the repeat domain of tau by an aggregation enhancer
Akoury, E.; Mukrasch, M. D.; Biernat, J.; Tepper, K.; Ozenne, V.; Mandelkow, E. & Blackledge, M. et al. (2016)
Protein Science, 25(5) pp. 1010-1020. DOI: https://doi.org/10.1002/pro.2911
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2017 | Journal Article |
Human cyclophilin 40 unravels neurotoxic amyloids
Baker, J. D.; Shelton, L. B.; Zheng, D.; Favretto, F.; Nordhues, B. A.; Darling, A. & Sullivan, L. E. et al. (2017)
PLoS Biology, 15(6) art. e2001336. DOI: https://doi.org/10.1371/journal.pbio.2001336
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2017 | Journal Article |
Multivalent cross-linking of actin filaments and microtubules through the microtubule-associated protein Tau
Cabrales Fontela, Y.; Kadavath, H.; Biernat, J.; Riedel, D. ; Mandelkow, E. & Zweckstetter, M. (2017)
Nature Communications, 8(1). DOI: https://doi.org/10.1038/s41467-017-02230-8
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2017 | Journal Article |
Liquid–liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau
Ambadipudi, S.; Biernat, J.; Riedel, D.; Mandelkow, E. & Zweckstetter, M. (2017)
Nature Communications, 8(1). DOI: https://doi.org/10.1038/s41467-017-00480-0
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2017 | Journal Article
A Two-Component Adhesive: Tau Fibrils Arise from a Combination of a Well-Defined Motif and Conformationally Flexible Interactions
Xiang, S.; Kulminskaya, N. ; Habenstein, B. ; Biernat, J.; Tepper, K.; Paulat, M. & Griesinger, C. et al. (2017)
Journal of the American Chemical Society, 139(7) pp. 2639-2646. DOI: https://doi.org/10.1021/jacs.6b09619
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2017 | Journal Article |
The release and trans-synaptic transmission of Tau via exosomes
Wang, Y.; Balaji, V.; Kaniyappan, S.; Krueger, L.; Irsen, S.; Tepper, K. & Chandupatla, R. et al. (2017)
Molecular Neurodegeneration, 12 art. 5. DOI: https://doi.org/10.1186/s13024-016-0143-y
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2018 | Journal Article
The Binding Mode of a Tau Peptide with Tubulin
Kadavath, H.; Cabrales Fontela, Y.; Jaremko, M.; Jaremko, Ł.; Overkamp, K.; Biernat, J. & Mandelkow, E. et al. (2018)
Angewandte Chemie International Edition, 57(12) pp. 3246-3250. DOI: https://doi.org/10.1002/anie.201712089
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2018 | Journal Article |
Structure and pro-toxic mechanism of the human Hsp90/PPIase/Tau complex
Oroz, J.; Chang, B. J.; Wysoczanski, P.; Lee, C.-T.; Pérez-Lara, Á.; Chakraborty, P. & Hofele, R. V. et al. (2018)
Nature Communications, 9(1) art. 4532. DOI: https://doi.org/10.1038/s41467-018-06880-0
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2019 | Journal Article |
Residue-specific identification of phase separation hot spots of Alzheimer's-related protein tau
Ambadipudi, S.; Reddy, J. G.; Biernat, J.; Mandelkow, E. & Zweckstetter, M. (2019)
Chemical Science, 10(26) pp. 6503-6507. DOI: https://doi.org/10.1039/C9SC00531E
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2019 | Journal Article |
Lysine/RNA-interactions drive and regulate biomolecular condensation
Ukmar-Godec, T.; Hutten, S.; Grieshop, M. P.; Rezaei-Ghaleh, N. ; Cima-Omori, M.-S.; Biernat, J. & Mandelkow, E. et al. (2019)
Nature Communications, 10(1) art. 2909. DOI: https://doi.org/10.1038/s41467-019-10792-y
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