Author Otto, Markus

• 2000 | Journal Article
  ​ ​Decreased beta-amyloid(1-42) in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease​
  Otto, M.; Esselmann, H. ; Schulz-Schaeffer, W. J.; Neumann, M.; Schroter, A.; Ratzka, P. & Cepek, L. et al.​ (2000) 
  Neurology, 54(5) pp. 1099​-1102​.​
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• 2000 | Journal Article
  ​ ​Stochastic relaxational dynamics applied to finance: Towards non-equilibrium option pricing theory​
  Otto, M.​ (2000) 
  The European Physical Journal B, 14(2) pp. 383​-394​.​ DOI: https://doi.org/10.1007/s100510050143 
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• 2001 | Journal Article
  ​ ​The direct link model for polymer rings using topological field theory and the second topological moment in dense systems​
  Otto, M.​ (2001) 
  JOURNAL OF PHYSICS A-MATHEMATICAL AND GENERAL, 34(12) pp. 2539​-2547​.​ DOI: https://doi.org/10.1088/0305-4470/34/12/302 
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• 2001 | Journal Article
  ​ ​Reporting cerebrospinal fluid data: Knowledge base and interpretation software​
  Reiber, H.; Otto, M.; Trendelenburg, C. & Wormek, A.​ (2001) 
  Clinical Chemistry and Laboratory Medicine (CCLM), 39(4) pp. 324​-332​.​ DOI: https://doi.org/10.1515/CCLM.2001.051 
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• 2002 | Conference Abstract
  ​ ​Primary cell culture of chicken telencephalon: A model to study the catabolic processing of endogenous amyloid precursor protein and abeta peptides​
  Esselmann, H.; Kunz, N.; Smirnov, A.; Paul, S.; Dombek, M.; Ruether, E. & Wiltfang, J. et al.​ (2002)
  Neurobiology of Aging, 23(1) 
  New york​: Elsevier Science Inc.
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• 2002 | Conference Abstract
  ​ ​The phospho-tau/total-tau ratio in cerebrospinal fluid discriminates Creutzfeldt-Jakob disease from other dementias​
  Riemenschneider, M.; Forstl, H.; Kurz, A.; Wagenpfeil, S.; Vanderstichele, H.; Otto, M. & Wiltfang, J. et al.​ (2002)
  Neurobiology of Aging, 23(1) pp. S274​-S275. 
  New york​: Elsevier Science Inc.
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• 2002 | Conference Abstract
  ​ ​Highly conserved and disease-specific patterns of carboxyterminally truncated abeta peptides 1-37/38/39 in addition to 1-40/42 in Alzheimer's disease and in patients with chronic neuroinflammation​
  Wiltfang, J.; Esselmann, H.; Bibl, M.; Smirnov, A.; Paul, S.; Ruether, E. & Otto, M. et al.​ (2002)
  Neurobiology of Aging, 23(1) 
  New york​: Elsevier Science Inc.
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• 2002 | Conference Abstract
  ​ ​Efficacy of flupirtine on cognitive function in patients with Creutzfeldt-Jakob-disease​
  Otto, M.; Ratzka, P.; Doehlinger, S.; Boekhoff, I.; Poser, S.; Prange, H. & Wiltfang, J. et al.​ (2002)
  Neurobiology of Aging, 23(1) pp. S131​-S132. 
  New york​: Elsevier Science Inc.
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• 2002 | Journal Article
  ​ ​New aspects in the histological examination of polyethylene wear particles in failed total joint replacements​
  Hansen, T. C.; Otto, M.; Buchhorn, G. H.; Scharnweber, D.; Gaumann, A.; Delank, K. S. & Eckardt, A. et al.​ (2002) 
  Acta Histochemica, 104(3) pp. 263​-269​.​ DOI: https://doi.org/10.1078/0065-1281-00649 
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• 2002 | Journal Article
  ​ ​Serum tau protein level as a marker of axonal damage in acute ischemic stroke​
  Bitsch, A.; Horn, C.; Kemmling, Y. ; Seipelt, M.; Hellenbrand, U.; Stiefel, M. & Ciesielczyk, B. et al.​ (2002) 
  European Neurology, 47(1) pp. 45​-51​.​ DOI: https://doi.org/10.1159/000047946 
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• 2002 | Journal Article
  ​ ​A beta peptide(1-42), Tau protein and S-100B protein level in cerebrospinal fluid of three patients with primary progressive aphasia​
  Otto, M.; Stoppe, G.; Maeck, L. ; Meller, J. ; Stiens, G.   & Wiltfang, J. ​ (2002) 
  Neuroscience Letters, 333(1) art. PII S0304-3940(02)00968-0​.​ DOI: https://doi.org/10.1016/S0304-3940(02)00968-0 
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• 2003 | Review
  ​ ​Sports and mild traumatic brain injury​
  Holzgraefe, M.& Otto, M.​ (2003)
  AKTUELLE NEUROLOGIE, 30​(10) pp. 519​-524​.​
  Georg Thieme Verlag Kg. DOI: https://doi.org/10.1055/s-2003-45014 
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• 2003 | Conference Paper
  ​ ​Differential diagnosis of neurodegenerative diseases with special emphasis on Creutzfeldt-Jakob disease​
  Otto, M. & Wiltfang, J.​ (2003)
  Restorative Neurology and Neuroscience, 21(3-4) pp. 191​-209. ​International Symposium on Molecular Markers of Brain Damage - Current State and Future Perspectives​, BREMEN, GERMANY.
  Amsterdam​: Ios Press.
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• 2003 | Journal Article | Letter Note
  ​ ​Diagnostic problems during late course in Creutzfeldt-Jakob disease​
  Mollenhauer, B.; Serafin, S.; Zerr, I.; Steinhoff, B. J.; Otto, M.; Scherer, M. & Schulz-Schaeffer, W. J. et al.​ (2003) 
  Journal of Neurology, 250(5) pp. 629​-630​.​ DOI: https://doi.org/10.1007/s00415-003-1059-3 
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• 2003 | Journal Article
  ​ ​Anisotropy in granular media: Classical elasticity and directed-force chain network​
  Otto, M.; Bouchaud, J. P.; Claudin, P. & Socolar, J.​ (2003) 
  PHYSICAL REVIEW E, 67(3) art. 031302​.​ DOI: https://doi.org/10.1103/PhysRevE.67.031302 
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• 2003 | Journal Article
  ​ ​Phospho-tau/total tau ratio in cerebrospinal fluid discriminates Creutzfeldt-Jakob disease from other dementias​
  Riemenschneider, M.; Wagenpfeil, S.; Vanderstichele, H.; Otto, M.; Wiltfang, J.; Kretzschmar, H. A. & Vanmechelen, E. et al.​ (2003) 
  Molecular Psychiatry, 8(3) pp. 343​-347​.​ DOI: https://doi.org/10.1038/sj.mp.4001220 
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• 2003 | Journal Article
  ​ ​Different binding pattern of antibodies to prion protein on lymphocytes from patients with sporadic Creutzfeldt–Jakob disease​
  Ratzka, P.; Döhlinger, S.; Cepek, L.; Steinacker, P.; Arlt, S.; Jacobi, C. & Schröter, A. et al.​ (2003) 
  Neuroscience Letters, 343(1) pp. 29​-32​.​ DOI: https://doi.org/10.1016/S0304-3940(03)00315-X 
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• 2003 | Journal Article
  ​ ​beta-Amyloid peptides in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease​
  Wiltfang, J.; Esselmann, H.; Smirnov, A.; Bibl, M.; Cepek, L.; Steinacker, P. & Mollenhauer, B. et al.​ (2003) 
  Annals of Neurology, 54(2) pp. 263​-267​.​ DOI: https://doi.org/10.1002/ana.10661 
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• 2003 | Journal Article
  ​ ​The amyloid-beta (A beta) peptide pattern in cerebrospinal fluid in Alzheimer's disease: evidence of a novel carboxyterminally elongated A beta peptide​
  Lewczuk, P.; Esselmann, H.; Meyer, M.; Wollscheid, V.; Neumann, M.; Otto, M. & Maler, J. M. et al.​ (2003) 
  Rapid Communications in Mass Spectrometry, 17(12) pp. 1291​-1296​.​ DOI: https://doi.org/10.1002/rcm.1048 
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• 2004 | Conference Abstract
  ​ ​Surface enhanced laser desorption/ionization time-of-flight mass spectrometry for the differential diagnosis of Creutzfeldt-Jakob disease​
  Steinacker, P.; Cepek, L.; Esselmann, H.; Kretzschmar, H. A.; Lewczuk, P.; Poser, S. & Wiltfang, J. et al.​ (2004)
  Neurobiology of Aging, 25 pp. S34​-S35. ​9th International Conference on Alzheimers Disease and Related Disorders​, Philadelphia, PA.
  New york​: Elsevier Science Inc. DOI: https://doi.org/10.1016/S0197-4580(04)80115-5 
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• 2004 | Conference Abstract
  ​ ​Cerebrospinal fluid investigations in Creutzfeldt-Jakob disease​
  Zerr, I.; Heinemann, U.; Varges, D. A.; Stoeck, K.; Bartl, M. & Otto, M.​ (2004)
  Neurobiology of Aging, 25 ​9th International Conference on Alzheimers Disease and Related Disorders​, Philadelphia, PA.
  New york​: Elsevier Science Inc. DOI: https://doi.org/10.1016/S0197-4580(04)81526-4 
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• 2004 | Journal Article
  ​ ​Topological interactions in systems of mutually interlinked polymer rings​
  Otto, M.​ (2004) 
  JOURNAL OF PHYSICS A-MATHEMATICAL AND GENERAL, 37(8) pp. 2881​-2893​.​ DOI: https://doi.org/10.1088/0305-4470/37/8/003 
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• 2004 | Journal Article
  ​ ​Local equation of state and velocity distributions of a driven granular gas​
  Herbst, O.; Mueller, P.; Otto, M. & Zippelius, A. ​ (2004) 
  Physical Review. E, 70(5) art. 051313​.​ DOI: https://doi.org/10.1103/PhysRevE.70.051313 
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• 2004 | Journal Article
  ​ ​Heart fatty acid binding protein as a potential diagnostic marker for neurodegenerative diseases​
  Steinacker, P.; Mollenhauer, B.; Bibl, M.; Cepek, L.; Esselmann, H.; Brechlin, P. & Lewczuk, P. et al.​ (2004) 
  Neuroscience Letters, 370(1) pp. 36​-39​.​ DOI: https://doi.org/10.1016/j.neulet.2004.07.061 
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• 2004 | Journal Article
  ​ ​Role of interleukin-1 in prion disease-associated astrocyte activation​
  Schultz, J.; Schwarz, A.; Neidhold, S.; Burwinkel, M.; Riemer, C.; Simon, D. & Kopf, M. et al.​ (2004) 
  American Journal Of Pathology, 165(2) pp. 671​-678​.​ DOI: https://doi.org/10.1016/S0002-9440(10)63331-7 
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• 2004 | Conference Paper
  ​ ​Tau protein phosphorylated at threonine 181 in CSF as a neurochemical biomarker in Alzheimer's disease - Original data and review of the literature​
  Lewczuk, P.; Esselmann, H.; Bibl, M.; Beck, G.; Maler, J. M.; Otto, M. & Kornhuber, J. et al.​ (2004)
  Journal of Molecular Neuroscience, 23(1-2) pp. 115​-122. ​Symposium on Novel Therapeutic Opportunities for Neuodegenerative Disease​, Univ Aveiro, Aveiro, PORTUGAL.
  Totowa​: Humana Press Inc. DOI: https://doi.org/10.1385/JMN:23:1-2:115 
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• 2004 | Journal Article
  ​ ​CSF lactate dehydrogenase activity in patients with Creutzfeldt-Jakob disease exceeds that in other dementias​
  Schmidt, H.; Otto, M.; Niedmann, P. ; Cepek, L.; Schroter, A.; Kretzschmar, H. A. & Poser, S.​ (2004) 
  Dementia and Geriatric Cognitive Disorders, 17(3) pp. 204​-206​.​ DOI: https://doi.org/10.1159/000076357 
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• 2004 | Journal Article
  ​ ​Neurochemical diagnosis of Alzheimer's dementia by CSF A beta 42, A beta 42/A beta 40 ratio and total tau​
  Lewczuk, P.; Otto, M.; Maler, J. M.; Reulbach, U.; Kornhuber, J.; Esselmann, H.   & Henkel, A. W. et al.​ (2004) 
  Neurobiology of Aging, 25(3) pp. 273​-281​.​ DOI: https://doi.org/10.1016/S0197-4580(03)00086-1 
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• 2004 | Journal Article
  ​ ​Value of CSF beta-amyloid(1-42) and tau as predictors of Alzheimer's disease in patients with mild cognitive impairment​
  Hampel, H.; Teipel, S. J.; Fuchsberger, T.; Andreasen, N.; Wiltfang, J.; Otto, M. & Shen, Y. et al.​ (2004) 
  Molecular Psychiatry, 9(7) pp. 705​-710​.​ DOI: https://doi.org/10.1038/sj.mp.4001473 
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• 2005 | Journal Article
  ​ ​Follow-up investigations in cerebrospinal fluid of patients with dementia with Lewy bodies and Alzheimer's disease​
  Mollenhauer, B.; Bibl, M.; Trenkwalder, C.; Stiens, G.; Cepek, L.; Steinacker, P. & Ciesielczyk, B. et al.​ (2005) 
  Journal of Neural Transmission, 112(7) pp. 933​-948​.​ DOI: https://doi.org/10.1007/s00702-004-0235-7 
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• 2005 | Journal Article
  ​ ​Follow-up investigations of tau protein and S-100B levels in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease​
  Cepek, L.; Steinacker, P.; Mollenhauer, B.; Wiese, B.; Ciesielczyk, B.; Bibl, M. & Wiltfang, J. et al.​ (2005) 
  Dementia and Geriatric Cognitive Disorders, 19(5-6) pp. 376​-382​.​ DOI: https://doi.org/10.1159/000084708 
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• 2005 | Journal Article
  ​ ​Normal hypocretin-1 (orexin-A) levels in the cerebrospinal fluid of patients with Huntington's disease​
  Meier, A.; Mollenhauer, B.; Cohrs, S.; Rodenbeck, A.; Jordan, W.; Meller, J. & Otto, M.​ (2005) 
  Brain Research, 1063(2) pp. 201​-203​.​ DOI: https://doi.org/10.1016/j.brainres.2005.09.028 
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• 2005 | Journal Article
  ​ ​Creutzfeldt-Jakob disease and homocysteine levels in plasma and cerebrospinal fluid​
  Bleich, S.; Otto, M.; Zerr, I.; Kropp, S.; Kretzschmar, H. A. & Wiltfang, J.​ (2005) 
  Gerontology, 51(2) pp. 142​-144​.​ DOI: https://doi.org/10.1159/000082200 
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• 2005 | Review
  ​ ​Consensus paper of the WFSBP Task Force on biological markers of dementia: The role of CSF and blood analysis in the early and differential diagnosis of dementia​
  Wiltfang, J.; Lewczuk, P.; Riederer, P.; Grunblatt, E.; Hock, C.; Scheltens, P.& Hampel, H. et al.​ (2005)
  The World Journal of Biological Psychiatry, 6​(2) pp. 69​-84​.​
  Taylor & Francis Ltd. DOI: https://doi.org/10.1080/15622970510029786 
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• 2006 | Journal Article
  ​ ​Total tau protein, phosphorylated tau (181p) protein, beta-amyloid(1-42), and beta-amyloid(1-40) in cerebrospinal fluid of patients with dementia with Lewy bodies​
  Mollenhauer, B.; Bibl, M.; Wiltfang, J.; Steinacker, P.; Ciesielczyk, B.; Neubert, K. & Trenkwalder, C. et al.​ (2006) 
  Clinical Chemistry and Laboratory Medicine (CCLM), 44(2) pp. 192​-195​.​ DOI: https://doi.org/10.1515/CCLM.2006.035 
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• 2006 | Journal Article
  ​ ​International quality control survey of neurochemical dementia diagnostics​
  Lewczuk, P.; Beck, G.; Ganslandt, O.; Esselmann, H.; Deisenhammer, F.; Regeniter, A. & Petereit, H.-F. et al.​ (2006) 
  Neuroscience Letters, 409(1) pp. 1​-4​.​ DOI: https://doi.org/10.1016/j.neulet.2006.07.009 
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• 2006 | Journal Article
  ​ ​Beta-amlyoid 1-42 and tau-protein in cerebrospinal fluid of patients with Parkinson's disease dementia​
  Mollenhauer, B.; Trenkwalder, C.; von Ahsen, N.; Bibl, M.; Steinacker, P.; Brechlin, P. & Schindehuette, J. et al.​ (2006) 
  Dementia and Geriatric Cognitive Disorders, 22(3) pp. 200​-208​.​ DOI: https://doi.org/10.1159/000094871 
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• 2006 | Journal Article | Letter Note
  ​ ​Selective reduction of amyloid beta 42 discriminates Alzheimer's disease from Huntington's disease: indication for distinct pathological events in amyloid beta peptide aggregation​
  Mollenhauer, B.; Bibl, M.; Esselmann, H.; Steinacker, P.; Trenkwalder, C.; Brechlin, P. & Wiltfang, J. et al.​ (2006) 
  Journal of Neurology Neurosurgery & Psychiatry, 77(10) pp. 1201​-1203​.​ DOI: https://doi.org/10.1136/jnnp.2005.084673 
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• 2006 | Journal Article
  ​ ​CSF diagnosis of Alzheimer's disease and dementia with Lewy bodies​
  Bibl, M.; Mollenhauer, B.; Esselmann, H.; Lewczuk, P.; Trenkwalder, C.; Brechlin, P. & Ruether, E. et al.​ (2006) 
  Journal of Neural Transmission, 113(11) pp. 1771​-1778​.​ DOI: https://doi.org/10.1007/s00702-006-0537-z 
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• 2006 | Journal Article
  ​ ​CSF amyloid-beta-peptides in Alzheimer's disease, dementia with Lewy bodies and Parkinson's disease dementia​
  Bibl, M.; Mollenhauer, B.; Esselmann, H.; Lewczuk, P.; Klafki, H. W.; Sparbier, K. & Smirnov, A. et al.​ (2006) 
  Brain, 129 pp. 1177​-1187​.​ DOI: https://doi.org/10.1093/brain/awl063 
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• 2007 | Journal Article
  ​ ​Validation of amyloid-beta peptides in CSF diagnosis of neurodegenerative dementias​
  Bibl, M.; Mollenhauer, B.; Lewczuk, P.; Esselmann, H.; Wolf, S.; Trenkwalder, C. & Otto, M. et al.​ (2007) 
  Molecular Psychiatry, 12(7) pp. 671​-680​.​ DOI: https://doi.org/10.1038/sj.mp.4001967 
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• 2007 | Journal Article
  ​ ​Blood-based neurochemical diagnosis of vascular dementia: A pilot study​
  Bibl, M.; Esselmann, H.; Mollenhauer, B.; Weniger, G.; Welge, V.; Liess, M. & Lewczuk, P. et al.​ (2007) 
  Journal of Neurochemistry, 103(2) pp. 467​-474​.​ DOI: https://doi.org/10.1111/j.1471-4159.2007.04763.x 
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• 2007 | Journal Article
  ​ ​Serum heart-type fatty acid-binding protein and cerebrospinal fluid tau: Marker candidates for dementia with Lewy bodies​
  Mollenhauer, B.; Steinacker, P.; Bahn, E.; Bibl, M.; Brechlin, P.; Schlossmacher, M. G. & Locascio, J. J. et al.​ (2007) 
  Neurodegenerative Diseases, 4(5) pp. 366​-375​.​ DOI: https://doi.org/10.1159/000105157 
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• 2007 | Journal Article
  ​ ​Proteomic analysis of the cerebrospinal fluid of patients with Creutzfeldt-Jakob disease​
  Cepek, L.; Brechlin, P.; Steinacker, P.; Mollenhauer, B.; Klingebiel, E.; Bibl, M. & Kretzschmar, H. A. et al.​ (2007) 
  Dementia and Geriatric Cognitive Disorders, 23(1) pp. 22​-28​.​ DOI: https://doi.org/10.1159/000096589 
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• 2007 | Journal Article
  ​ ​Tauopathies and synucleinopathies: Do cerebrospinal fluid beta-amyloid peptides reflect disease-specific pathogenesis?​
  Mollenhauer, B.; Bibl, M.; Esselmann, H.; Steinacker, P.; Trenkwalder, C.; Wiltfang, J. & Otto, M.​ (2007) 
  Journal of Neural Transmission, 114(7) pp. 919​-927​.​ DOI: https://doi.org/10.1007/s00702-007-0629-4 
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• 2008 | Journal Article
  ​ ​Multiplexed quantification of dementia biomarkers in the CSF of patients with early dementias and MCI: A multicenter study​
  Lewczuk, P.; Kornhuber, J.; Vanderstichele, H.; Vanmechelen, E.; Esselmann, H.; Bibl, M. & Wolf, S. et al.​ (2008) 
  Neurobiology of Aging, 29(6) pp. 812​-818​.​ DOI: https://doi.org/10.1016/j.neurobiolaging.2006.12.010 
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• 2008 | Journal Article | 
  ​ ​Upregulation of CRABP1 in human neuroblastoma cells overproducing the Alzheimer-typical A beta(42) reduces their differentiation potential​
  Uhrig, M.; Brechlin, P.; Jahn, O. ; Knyazev, Y.; Weninger, A.; Busia, L. & Honarnejad, K. et al.​ (2008) 
  BMC Medicine, 6 art. 38​.​ DOI: https://doi.org/10.1186/1741-7015-6-38 
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• 2008 | Journal Article
  ​ ​Cerebrospinal fluid-optimized two-dimensional difference gel electrophoresis (2-D DIGE) facilitates the differential diagnosis of Creutzfeldt-Jakob disease​
  Brechlin, P.; Jahn, O. ; Steinacker, P.; Cepek, L.; Kratzin, H.; Lehnert, S. & Jesse, S. et al.​ (2008) 
  Proteomics, 8(20) pp. 4357​-4366​.​ DOI: https://doi.org/10.1002/pmic.200800375 
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• 2008 | Journal Article
  ​ ​CSF amyloid-beta 1-38 and 1-42 in FTD and AD: Biomarker performance critically depends on the detergent accessible fraction​
  Bibl, M.; Lewczuk, P.; Esselmann, H.; Mollenhauer, B.; Klafki, H.-W.; Welge, V. & Wolf, S. et al.​ (2008) 
  PROTEOMICS - CLINICAL APPLICATIONS, 2(10-11) pp. 1548​-1556​.​ DOI: https://doi.org/10.1002/prca.200800006 
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• 2009 | Review
  ​ ​Consensus Paper of the WFSBP Task Force on Biological Markers of Dementia: The role of CSF and blood analysis in the early and differential diagnosis of dementia​
  Wiltfang, J.; Lewczuk, P.; Riederer, P.; Gruenblatt, E.; Hock, C.; Scheltens, P.& Hampel, H. et al.​ (2009)
  REVISTA DE PSIQUIATRIA CLINICA, 36​ pp. 1​-16​.​
  Univ Sao Paulo, Inst Psiquiatria.
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