Author Pukrop, Tobias

• 2001 | Journal Article
  ​ ​Identification of two regulatory elements within the high mobility group box transcription factor XTCF-4​
  Pukrop, T.; Gradl, D.; Henningfeld, K. A.; Knochel, W.; Wedlich, D. & Kuhl, M.​ (2001) 
  Journal of Biological Chemistry, 276(12) pp. 8968​-8978​.​ DOI: https://doi.org/10.1074/jbc.M007533200 
  ​Details  DOI  PMID  PMC  WoS 

• 2001 | Journal Article
  ​ ​Antagonistic regulation of convergent extension movements in Xenopus by Wnt/beta-catenin and Wnt/Ca2+ signaling​
  Kuhl, M.; Geis, K.; Sheldahl, L. C.; Pukrop, T.; Moon, R. T. & Wedlich, D.​ (2001) 
  Mechanisms of Development, 106(1-2) pp. 61​-76​.​ DOI: https://doi.org/10.1016/S0925-4773(01)00416-6 
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• 2003 | Conference Abstract
  ​ ​The multipotent ETV6-ARG positive MT-ALL cell line demonstrates a functional ETV6 double knock-out by modification of the ETS-binding domain of the non-rearranged ETV6 gene by a point mutation in the ETV6-FTS domain.​
  Hillmer, F.; Hennig, H.; Becker, A.; Podleschny, M.; Truemper, L. H.; Pukrop, T. & Griesinger, F.​ (2003)
  Blood, 102(11) ​45th Annual Meeting of the American-Society-of-Hematology​, SAN DIEGO, CALIFORNIA.
  Washington​: Amer Soc Hematology.
  ​Details  WoS 

• 2004 | Conference Abstract
  ​ ​R399H mutated ETS domain leads to a functional ETV6 double-knock-out in acute leukemia and completely alters the physiological function of ETV6.​
  Hennig, H.; Hillmer, F.; Becker, A.; Podleschny, M.; Pukrop, T.; Truemper, L. H. & Griesinger, F.​ (2004)
  Blood, 104(11) ​46th Annual Meeting of the American-Society-of-Hematology​, San Diego, CA.
  Washington​: Amer Soc Hematology.
  ​Details  WoS 

• 2004 | Journal Article
  ​ ​B-cell chronic lymphocytic leukemia with aberrant CD8 expression: Genetic and immunophenotypic analysis of prognostic factors​
  Schroers, R.; Pukrop, T.; Durig, J.; Haase, D.; Duhrsen, U.; Truemper, L. H. & Griesinger, F.​ (2004) 
  Leukemia & Lymphoma, 45(8) pp. 1677​-1681​.​ DOI: https://doi.org/10.1080/10428190410001683697 
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• 2004 | Journal Article
  ​ ​Mesengenic progenitor cells derived from human placenta​
  Wulf, G. G.; Viereck, V.; Hemmerlein, B.; Haase, D.; Vehmeyer, K.; Pukrop, T. & Glass, B. et al.​ (2004) 
  TISSUE ENGINEERING, 10(7-8) pp. 1136​-1147​.​ DOI: https://doi.org/10.1089/ten.2004.10.1136 
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• 2005 | Journal Article
  ​ ​Macrophages induce invasiveness of epithelial cancer cells via NF-kappa B and JNK​
  Hagemann, T.; Wilson, J. K.; Kulbe, H.; Li, N.; Leinster, D. A.; Charles, K. & Klemm, F. et al.​ (2005) 
  The Journal of Immunology, 175(2) pp. 1197​-1205​.​
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• 2005 | Journal Article
  ​ ​Expression of endothelins and their receptors promotes an invasive phenotype of breast tumor cells but is insufficient to induce invasion in benign cells​
  Hagemann, T.; Binder, C.; Binder, L.; Pukrop, T.; Truemper, L. H. & Grimshaw, M. J.​ (2005) 
  DNA and Cell Biology, 24(11) pp. 766​-776​.​ DOI: https://doi.org/10.1089/dna.2005.24.766 
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• 2006 | Journal Article
  ​ ​Wnt 5a signaling is critical for macrophage-induced invasion of breast cancer cell lines​
  Pukrop, T.; Klemm, F.; Hagemann, T.; Gradl, D.; Schulz, M.; Siemes, S. & Truemper, L. H. et al.​ (2006) 
  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 103(14) pp. 5454​-5459​.​ DOI: https://doi.org/10.1073/pnas.0509703103 
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• 2008 | Review
  ​ ​The complex pathways of Wnt 5a in cancer progression​
  Pukrop, T.& Binder, C.​ (2008)
  Journal of Molecular Medicine, 86​(3) pp. 259​-266​.​
  Springer. DOI: https://doi.org/10.1007/s00109-007-0266-2 
  ​Details  DOI  PMID  PMC  WoS 

• 2009 | Journal Article
  ​ ​Web-based collaborative training of clinical reasoning: A randomized trial​
  Raupach, T.; Muenscher, C.; Anders, S.; Steinbach, R.; Pukrop, T.; Hege, I. & Tullius, M.​ (2009) 
  Medical Teacher, 31(9) pp. E431​-E437​.​ DOI: https://doi.org/10.1080/01421590903095502 
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• 2009 | Journal Article
  ​ ​A Contribution to the Needs Assessment of Faculty Development Measures in Medical Schools​
  Raupach, T.; Spering, C.; Baeumler, C.; Burckhardt, G.; Truemper, L. H. & Pukrop, T.​ (2009) 
  MEDIZINISCHE KLINIK, 104(11) pp. 841​-845​.​ DOI: https://doi.org/10.1007/s00063-009-1180-x 
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• 2009 | Journal Article | Letter Note
  ​ ​Rapid progression of hormone receptor-negative breast cancer concomitant with ovarian stimulation-a paradoxon?​
  Pukrop, T.; Bleckmann, A.; Einspanier, A. & Binder, C.​ (2009) 
  Annals of Oncology, 20(12) pp. 2020​-2022​.​ DOI: https://doi.org/10.1093/annonc/mdp457 
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• 2010 | Conference Abstract
  ​ ​Silencing of TCF7L2 sensitizes colorectal cancer cells to radiation therapy​
  Grade, M.; Kendziorra, E.; Ahlborn, K.; Spitzner, M.; Gaedcke, J.; Rave-Fraenk, M. & Becker, H. et al.​ (2010)
  EJC SUPPLEMENTS, 8(7) ​22nd EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics​, Berlin, GERMANY.
  Oxford​: Pergamon-elsevier Science Ltd. DOI: https://doi.org/10.1016/S1359-6349(10)72008-5 
  ​Details  DOI  WoS 

• 2010 | Journal Article | 
  ​ ​Significant increase in factual knowledge with web-assisted problem-based learning as part of an undergraduate cardio-respiratory curriculum​
  Raupach, T.; Muenscher, C.; Pukrop, T.; Anders, S. & Harendza, S.​ (2010) 
  Advances in Health Sciences Education, 15(3) pp. 349​-356​.​ DOI: https://doi.org/10.1007/s10459-009-9201-3 
  ​Details  DOI  PMID  PMC  WoS 

• 2010 | Journal Article | 
  ​ ​Microglia Promote Colonization of Brain Tissue by Breast Cancer Cells in a Wnt-Dependent Way​
  Pukrop, T.; Dehghani, F.; Chuang, H.-N.; Lohaus, R.; Bayanga, K.; Heermann, S. & Regen, T. et al.​ (2010) 
  Glia, 58(12) pp. 1477​-1489​.​ DOI: https://doi.org/10.1002/glia.21022 
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• 2010 | Journal Article
  ​ ​Impact of teaching and assessment format on electrocardiogram interpretation skills​
  Raupach, T.; Hanneforth, N.; Anders, S.; Pukrop, T.; ten Cate, O. T. J. & Harendza, S.​ (2010) 
  Medical Education, 44(7) pp. 731​-740​.​ DOI: https://doi.org/10.1111/j.1365-2923.2010.03687.x 
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• 2010 | Journal Article
  ​ ​Tumor Stroma-Derived Wnt5a Induces Differentiation of Basal Cell Carcinoma of Ptch-Mutant Mice via CaMKII​
  Nitzki, F.; Zibat, A.; Koenig, S.; Wijgerde, M.; Rosenberger, A. ; Brembeck, F. H.   & Carstens, P.-O.  et al.​ (2010) 
  Cancer Research, 70(7) pp. 2739​-2748​.​ DOI: https://doi.org/10.1158/0008-5472.CAN-09-3743 
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• 2011 | Conference Abstract
  ​ ​Identification and further characterization of microparticle populations in microparticle-induced breast cancer invasion​
  Menck, K.; Klemm, F.; Schulz, M.; Pukrop, T. & Binder, C.​ (2011)
  Onkologie, 34 
  Basel​: Karger.
  ​Details  WoS 

• 2011 | Conference Abstract
  ​ ​LEF1 identifies a prognostically unfavourable subgroup of lung adenocarcinoma brain metastases​
  Bleckmann, A.; Siam, L.; Klemm, F.; Rietkoetter, E.; Binder, C.; Stadelmann, C.   & Pukrop, T.​ (2011)
  Onkologie, 34 
  Basel​: Karger.
  ​Details  WoS 

• 2012 | Conference Abstract
  ​ ​Breast cancer invasion mediated by plasma membrane-derived microvesicles is EMMPRIN-dependent​
  Menck, K.; Pukrop, T.; Schulz, M.; Dyck, L.; Binder, C. & Klemm, F.​ (2012)
  Onkologie, 35 
  Basel​: Karger.
  ​Details  WoS 

• 2012 | Journal Article | Research Paper | 
  ​ ​Piloting an outcome-based programme evaluation tool in undergraduate medical education​
  Raupach, T.; Schiekirka, S.; Münscher, C.; Beißbarth, T. ; Himmel, W. ; Burckhardt, G. & Pukrop, T.​ (2012) 
  GMS Zeitschrift für medizinische Ausbildung, 29(3) art. Doc44​.​ DOI: https://doi.org/10.3205/zma000814 
  ​Details  DOI  PMID  PMC 

• 2012 | Journal Article
  ​ ​Toll-like receptor activation reveals developmental reorganization and unmasks responder subsets of microglia​
  Scheffel, J.; Regen, T.; van Rossum, D.; Seifert, S.; Ribes, S.; Nau, R. & Parsa, R. et al.​ (2012) 
  Glia, 60(12) pp. 1930​-1943​.​ DOI: https://doi.org/10.1002/glia.22409 
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• 2012 | Journal Article | 
  ​ ​Student perceptions of evaluation in undergraduate medical education: A qualitative study from one medical school​
  Schiekirka, S.; Reinhardt, D.; Heim, S. ; Fabry, G.; Pukrop, T.; Anders, S. & Raupach, T.​ (2012) 
  BMC Medical Education, 12 art. 45​.​ DOI: https://doi.org/10.1186/1472-6920-12-45 
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• 2013 | Journal Article
  ​ ​Coculture System with an Organotypic Brain Slice and 3D Spheroid of Carcinoma Cells​
  Chuang, H.-N.; Lohaus, R.; Hanisch, U.-K.; Binder, C.; Dehghani, F. & Pukrop, T.​ (2013) 
  Journal of Visualized Experiments,(80) art. UNSP e50881​.​ DOI: https://doi.org/10.3791/50881 
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• 2013 | Conference Abstract
  ​ ​Proliferation index Ki67 and beta-Catenin independent WNT signaling are associated with poor prognosis in patients with liver metastases of breast cancer​
  Bleckmann, A.; Conrad, L.-C.; Schmick, A. N.; Bueyuektas, D.; Liersch, T.; Klemm, F. & Binder, C. et al.​ (2013)
  Onkologie, 36 
  Basel​: Karger.
  ​Details  WoS 

• 2013 | Journal Article
  ​ ​Maldevelopment of dermal lymphatics in Wnt5a-knockout-mice​
  Buttler, K.; Becker, J.; Pukrop, T. & Wilting, J.​ (2013) 
  Developmental Biology, 381(2) pp. 365​-376​.​ DOI: https://doi.org/10.1016/j.ydbio.2013.06.028 
  ​Details  DOI 

• 2013 | Conference Abstract
  ​ ​CARCINOMA CELLS MISUSE THE HOST TISSUE DANGER RESPONSE TO INVADE THE BRAIN​
  Chuang, H.-N.; vanRossum, D. V.; Sieger, D.; Siam, L.; Klemm, F.; Bleckmann, A. & Bayerlova, M. et al.​ (2013)
  Glia, 61 , Berlin, GERMANY.
  Hoboken​: Wiley-blackwell.
  ​Details  WoS 

• 2013 | Journal Article
  ​ ​Empty liposomes induce antitumoral effects associated with macrophage responses distinct from those of the TLR1/2 agonist Pam(3)CSK(4) (BLP)​
  Koenig, S.; Regen, T.; Dittmann, K.; Engelke, M.; Wienands, J. ; Schwendener, R. & Hanisch, U.-K. et al.​ (2013) 
  Cancer Immunology Immunotherapy, 62(10) pp. 1587​-1597​.​ DOI: https://doi.org/10.1007/s00262-013-1444-4 
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• 2013 | Journal Article | 
  ​ ​Carcinoma cells misuse the host tissue damage response to invade the brain​
  Chuang, H.-N.; van Rossum, D.; Sieger, D.; Siam, L.; Klemm, F.; Bleckmann, A. & Bayerlova, M.  et al.​ (2013) 
  Glia, 61(8) pp. 1331​-1346​.​ DOI: https://doi.org/10.1002/glia.22518 
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• 2013 | Journal Article | 
  ​ ​Zoledronic acid inhibits macrophage/microglia-assisted breast cancer cell invasion.​
  Rietkötter, E.; Menck, K.; Bleckmann, A.; Farhat, K.; Schaffrinski, M.; Schulz, M. & Hanisch, U.-K. et al.​ (2013) 
  Oncotarget, 4(9) pp. 1449​-1460​.​
  ​Details  PMID  PMC 

• 2013 | Journal Article | 
  ​ ​Induction and transport of Wnt 5a during macrophage-induced malignant invasion is mediated by two types of extracellular vesicles.​
  Menck, K.; Klemm, F.; Gross, J. C.; Pukrop, T.; Wenzel, D. & Binder, C.​ (2013) 
  Oncotarget, 4(11) pp. 2057​-2066​.​
  ​Details  PMID  PMC 

• 2014 | Conference Abstract
  ​ ​Impact of pre-OP frailty on mortality after resection of limited brain metastases​
  Bleckmann, A.; Kirchner, B.; Siam, L. & Pukrop, T.​ (2014)
  Oncology Research and Treatment, 37 pp. 118​-119. 
  Basel​: Karger.
  ​Details  WoS 

• 2014 | Conference Abstract
  ​ ​EMMPRIN/CD147-positive tumor cell microvesicles are pro-invasive and detectable in the blood of cancer patients with metastasis​
  Menck, K.; Bleckmann, A.; Scharf, C.; Pukrop, T.; Dyck, L.; Klemm, F. & Binder, C.​ (2014)
  Oncology Research and Treatment, 37 pp. 285​-286. 
  Basel​: Karger.
  ​Details  WoS 

• 2014 | Journal Article | 
  ​ ​Depletion of Cutaneous Macrophages and Dendritic Cells Promotes Growth of Basal Cell Carcinoma in Mice​
  Koenig, S.; Nitzki, F.; Uhmann, A.; Dittmann, K.; Theiss-Suennemann, J.; Herrmann, M. & Reichardt, H. M. et al.​ (2014) 
  PLoS ONE, 9(4) art. e93555​.​ DOI: https://doi.org/10.1371/journal.pone.0093555 
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• 2014 | Journal Article
  ​ ​Isolation of Human Monocytes by Double Gradient Centrifugation and Their Differentiation to Macrophages in Teflon-coated Cell Culture Bags​
  Menck, K.; Behme, D.; Pantke, M.; Reiling, N.; Binder, C.; Pukrop, T. & Klemm, F.​ (2014) 
  Journal of Visualized Experiments,(91) art. e51554​.​ DOI: https://doi.org/10.3791/51554 
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• 2015 | Conference Abstract
  ​ ​The crucial impact of the unique organ-specific defense system during colonization and outgrowth of brain metastasis​
  Pukrop, T. & Hanisch, U.-K.​ (2015)
  Clinical & Experimental Metastasis, 32(3) 
  Dordrecht​: Springer.
  ​Details  WoS 

• 2015 | Conference Abstract
  ​ ​Wnt5a signaling mediates cell migration and invasion of Hodgkin Lymphoma in vitro and in xenograft models​
  Linke, F.; Zaunig, S.; von Bonin, F.; Wilting, J.; Bryja, V.; Pukrop, T. & Truemper, L. H. et al.​ (2015)
  Oncology Research and Treatment, 38 
  Basel​: Karger.
  ​Details  WoS 

• 2015 | Journal Article
  ​ ​Tyrphostin AG126 Exerts Neuroprotection in CNS Inflammation by a Dual Mechanism​
  Menzfeld, C.; John, M.; van Rossum, D.; Regen, T.; Scheffel, J.; Janova, H.   & Goetz, A. A. et al.​ (2015) 
  Glia, 63(6) pp. 1083​-1099​.​ DOI: https://doi.org/10.1002/glia.22803 
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• 2015 | Journal Article | 
  ​ ​The metastatic infiltration at the metastasis/brain parenchyma-interface is very heterogeneous and has a significant impact on survival in a prospective study​
  Siam, L.; Bleckmann, A.; Chaung, H.-N.; Mohr, A.; Klemm, F.; Barrantes-Freer, A. & Blazquez, R. et al.​ (2015) 
  Oncotarget, 6(30) pp. 29254​-29267​.​ DOI: https://doi.org/10.18632/oncotarget.4201 
  ​Details  DOI  PMID  PMC  WoS 

• 2015 | Journal Article | 
  ​ ​Tumor-derived microvesicles mediate human breast cancer invasion through differentially glycosylated EMMPRIN​
  Menck, K.; Scharf, C.; Bleckmann, A.; Dyck, L.; Rost, U.; Wenzel, D. & Dhople, V. M. et al.​ (2015) 
  Journal of Molecular Cell Biology, 7(2) pp. 143​-153​.​ DOI: https://doi.org/10.1093/jmcb/mju047 
  ​Details  DOI  PMID  PMC  WoS 

• 2015 | Journal Article | 
  ​ ​Anti-CSF-1 treatment is effective to prevent carcinoma invasion induced by monocyte-derived cells but scarcely by microglia.​
  Rietkötter, E.; Bleckmann, A.; Bayerlová, M.; Menck, K.; Chuang, H.-N.; Wenske, B. & Schwartz, H. et al.​ (2015) 
  Oncotarget, 6(17) pp. 15482​-15493​.​ DOI: https://doi.org/10.18632/oncotarget.3855 
  ​Details  DOI  PMID  PMC 

• 2016 | Conference Abstract
  ​ ​DVL3 in breast cancer and tumor progression​
  Schubert, A.; Bleckmann, A.; Pukrop, T. & Binder, C.​ (2016)
  Oncology Research and Treatment, 39 
  Basel​: Karger.
  ​Details  WoS 

• 2016 | Journal Article
  ​ ​The anthelmintic niclosamide inhibits colorectal cancer cell lines via modulation of the canonical and noncanonical Wnt signaling pathway​
  Monin, M. B.; Krause, P.; Stelling, R.; Bocuk, D.; Niebert, S.; Klemm, F. & Pukrop, T. et al.​ (2016) 
  Journal of Surgical Research, 203(1) pp. 193​-205​.​ DOI: https://doi.org/10.1016/j.jss.2016.03.051 
  ​Details  DOI  PMID  PMC  WoS 

• 2017 | Journal Article | 
  ​ ​LEF1 reduces tumor progression and induces myodifferentiation in a subset of rhabdomyosarcoma​
  Draeger, J.; Simon-Keller, K.; Pukrop, T.; Klemm, F.; Wilting, J.; Sticht, C. & Dittmann, K. et al.​ (2017) 
  Oncotarget, 8(2) pp. 3259​-3273​.​ DOI: https://doi.org/10.18632/oncotarget.13887 
  ​Details  DOI  PMID  PMC  WoS 

• 2017 | Journal Article
  ​ ​PTEN mediates the cross talk between breast and glial cells in brain metastases leading to rapid disease progression​
  Hohensee, I.; Chuang, H.-N.; Grottke, A.; Werner, S.; Schulte, A.; Horn, S. & Lamszus, K. et al.​ (2017) 
  Oncotarget, 8(4) pp. 6155​-6168​.​ DOI: https://doi.org/10.18632/oncotarget.14047 
  ​Details  DOI  PMID  PMC  WoS 

• 2018 | Journal Article
  ​ ​PI3K: A master regulator of brain metastasis-promoting macrophages/microglia​
  Blazquez, R.; Wlochowitz, D.; Wolff, A.; Seitz, S.; Wachter, A.; Perera-Bel, J. & Bleckmann, A. et al.​ (2018) 
  Glia, 66(11) pp. 2438​-2455​.​ DOI: https://doi.org/10.1002/glia.23485 
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• 2018 | Journal Article
  ​ ​Isolated metastasis of an EGFR-L858R-mutated NSCLC of the meninges: the potential impact of CXCL12/CXCR4 axis in EGFRmut NSCLC in diagnosis, follow-up and treatment​
  Lüke, F.; Blazquez, R.; Yamaci, R. F.; Lu, X.; Pregler, B.; Hannus, S. & Menhart, K. et al.​ (2018) 
  Oncotarget, 9(27) pp. 18844-18857​.​ DOI: https://doi.org/10.18632/oncotarget.24787 
  ​Details  DOI  PMID  PMC 

• 2020 | Journal Article
  ​ ​5-Aminolevulinic Acid Fluorescence Indicates Perilesional Brain Infiltration in Brain Metastases​
  Schatlo, B.; Stockhammer, F.; Barrantes-Freer, A.; Bleckmann, A.; Siam, L.; Pukrop, T. & Rohde, V.​ (2020) 
  World Neurosurgery: X, 5 pp. 100069​.​ DOI: https://doi.org/10.1016/j.wnsx.2019.100069 
  ​Details  DOI 

• 2020 | Journal Article | 
  ​ ​LEF1 supports metastatic brain colonization by regulating glutathione metabolism and increasing ROS resistance in breast cancer​
  Blazquez, R.; Rietkötter, E.; Wenske, B.; Wlochowitz, D.; Sparrer, D.; Vollmer, E. & Müller, G. et al.​ (2020) 
  International Journal of Cancer, 146(11) pp. 3170​-3183​.​ DOI: https://doi.org/10.1002/ijc.32742 
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