Author Shipkova, Maria
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2000 | Journal Article
Determination of the acyl glucuronide metabolite of mycophenolic acid in human plasma by HPLC and Emit
Shipkova, M.; Schutz, E.; Armstrong, V. W.; Niedmann, P. D.; Oellerich, M. & Wieland, E. (2000)
Clinical Chemistry, 46(3) pp. 365-372.
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2000 | Conference Paper
An ex vivo model to study the intestinal biotransformation of immunosuppressive drugs
Braun, F.; Christians, U.; Laabs, S.; Elias, K.; Shipkova, M.; Schutz, E. & Ringe, B. (2000)
Transplantation Proceedings, 32(7) 6th Congress of the Asian-Society-of-Transplantation, SUNTEC CITY, SINGAPORE.
New york: Elsevier Science Inc. DOI: https://doi.org/10.1016/S0041-1345(00)01529-3
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2000 | Journal Article
Induction of cytokine release by the acyl glucuronide of mycophenolic acid: A link to side effects?
Wieland, E.; Shipkova, M.; Schellhaas, U.; Schütz, E.; Niedmann, P. D.; Armstrong, V. W. & Oellerich, M. (2000)
Clinical Biochemistry, 33(2) pp. 107-113. DOI: https://doi.org/10.1016/S0009-9120(99)00101-0
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2000 | Conference Paper
New strategies in GVHD prophylaxis
Kiehl, M. G.; Shipkova, M.; Basara, N.; Blau, W. I. & Fauser, A. A. (2000)
Bone Marrow Transplantation, 25 pp. S16-S19. 2nd International Symposium on Transplantation and Gene Therapy, IDAR OBERSTEIN, GERMANY.
Basingstoke: Nature Publishing Group. DOI: https://doi.org/10.1038/sj.bmt.1702346
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2000 | Conference Paper
An ex vivo model to study the intestinal biotransformation of immunosuppressives
Braun, F.; Christians, U.; Laabs, S.; Elias, K.; Shipkova, M.; Schutz, E. & Ringe, B. (2000)
Transplantation Proceedings, 32(7) 6th Congress of the Asian-Society-of-Transplantation, SUNTEC CITY, SINGAPORE.
New york: Elsevier Science Inc. DOI: https://doi.org/10.1016/S0041-1345(00)01780-2
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2000 | Journal Article
Pharmacokinetic and metabolic investigations of mycophenolic acid in pediatric patients after renal transplantation: Implications for therapeutic drug monitoring
Oellerich, M.; Shipkova, M.; Schutz, E.; Wieland, E.; Weber, L. T.; Tonshoff, B. & Armstrong, V. W. (2000)
Therapeutic Drug Monitoring, 22(1) pp. 20-26. DOI: https://doi.org/10.1097/00007691-200002000-00004
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2000 | Journal Article
Mycophenolate mofetil decreases endothelial prostaglandin E-2 in response to allogeneic T cells or cytokines
Blaheta, R. A.; Nelson, K.; Oppermann, E.; Leckel, K.; Harder, S.; Cinatl, J. & Weber, S. et al. (2000)
Transplantation Journal, 69(9) pp. 1977-1981. DOI: https://doi.org/10.1097/00007890-200005150-00044
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2000 | Journal Article | Letter Note
Evaluation of an immunoassay for mycophenolic acid
Schutz, E.; Shipkova, M.; Wieland, E.; Niedmann, P. D.; Armstrong, V. W. & Oellerich, M. (2000)
Therapeutic Drug Monitoring, 22(1) pp. 141-142. DOI: https://doi.org/10.1097/00007691-200002000-00030
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2000 | Conference Paper
The monoethylglycinexylidide (MEGX) test as a marker of hepatic dysfunction in septic patients with pneumonia
Igonin, A. A.; Armstrong, V. W.; Shipkova, M.; Kukes, V. G. & Oellerich, M. (2000)
Clinical Chemistry and Laboratory Medicine (CCLM), 38(11) pp. 1125-1128. European Meeting on Biomarkers of Organ Damage and Dysfunction, CAMBRIDGE, ENGLAND.
Berlin: Walter De Gruyter & Co. DOI: https://doi.org/10.1515/CCLM.2000.169
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2000 | Journal Article
Mycophenolate mofetil in stem cell transplant patients in relation to plasma level of active metabolite
Kiehl, M. G.; Shipkova, M.; Basara, N.; Blau, I. W.; Schutz, E.; Armstrong, V. W. & Oellerich, M. et al. (2000)
Clinical Biochemistry, 33(3) pp. 203-208. DOI: https://doi.org/10.1016/S0009-9120(00)00053-9
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2001 | Journal Article | Letter Note
Quantification of mycophenolic acid in plasma samples collected during and immediately after intravenous administration of mycophenolate mofetil
Shipkova, M.; Armstrong, V. W.; Kiehl, M. G.; Niedmann, P. D.; Schutz, E.; Oellerich, M. & Wieland, E. (2001)
Clinical Chemistry, 47(8) pp. 1485-1488.
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2001 | Journal Article | Letter Note
Rapid and sensitive liquid chromatography-tandem mass spectrometry method for determination of monoethylglycinexylidide
Streit, F.; Niedmann, P. D.; Shipkova, M.; Armstrong, V. W. & Oellerich, M. (2001)
Clinical Chemistry, 47(10) pp. 1853-1856.
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2001 | Conference Abstract
Randomized multicenter prospective clinical trial on the efficacy of mycophenolate mofetil in comparison to methotrexate for the prophylaxis of acute GvHD in stem cell transplant recipients.
Kiehl, M. G.; Schaefer-Eckart, K.; Kienast, J.; Jenke, A.; Wandt, H.; Blau, I. W. & Shipkova, M. et al. (2001)
Blood, 98(11) pp. 664A-665A.
Washington: Amer Soc Hematology.
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2001 | Conference Paper
The acyl glucuronide metabolite of mycophenolic acid inhibits the proliferation of human mononuclear leukocytes
Shipkova, M.; Wieland, E.; Schutz, E.; Wiese, C. H.; Niedmann, P. D.; Oellerich, M. & Armstrong, V. W. (2001)
Transplantation Proceedings, 33(1-2) pp. 1080-1081. 18th World Congress of the Transplantation-Society, ROME, ITALY.
New york: Elsevier Science Inc. DOI: https://doi.org/10.1016/S0041-1345(00)02424-6
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2001 | Conference Paper
Monitoring of mycophenolic acid in pediatric renal transplant recipients
Armstrong, V. W.; Shipkova, M.; Schutz, E.; Weber, L. T.; Tonshoff, B. & Oellerich, M. (2001)
Transplantation Proceedings, 33(1-2) pp. 1040-1043. 18th World Congress of the Transplantation-Society, ROME, ITALY.
New york: Elsevier Science Inc. DOI: https://doi.org/10.1016/S0041-1345(00)02322-8
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2001 | Conference Paper
Preliminary report on the effect of xenoperfusion with human blood on cyclosporin A metabolism and cytochrome-P-4503A4-mRNA expression in a pig liver perfusion model
Wieland, E.; Shipkova, M.; Schütz, E.; Braun, F.; Niedmann, P.-D.; Armstrong, V. W. & Ringe, B. et al. (2001)
Clinical Biochemistry, 34(1) pp. 53-57. Analytical Conference 2000, MUNICH, GERMANY.
Oxford: Pergamon-elsevier Science Ltd. DOI: https://doi.org/10.1016/S0009-9120(00)00203-4
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2001 | Journal Article
Effect of cyclosporine withdrawal on mycophenolic acid pharmacokinetics in kidney transplant recipients with deteriorating renal function: Preliminary report
Shipkova, M.; Armstrong, V. W.; Kuypers, D.; Perner, F.; Fabrizi, V.; Holzer, H. & Wieland, E. et al. (2001)
Therapeutic Drug Monitoring, 23(6) pp. 717-721. DOI: https://doi.org/10.1097/00007691-200112000-00020
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2001 | Journal Article
Glucuronide and glucoside conjugation of mycophenolic acid by human liver, kidney and intestinal microsomes
Shipkova, M.; Strassburg, C. P.; Braun, F.; Streit, F.; Grone, H. J.; Armstrong, V. W. & Tukey, R. H. et al. (2001)
British Journal of Pharmacology, 132(5) pp. 1027-1034. DOI: https://doi.org/10.1038/sj.bjp.0703898
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2002 | Conference Abstract
Results of a 12 month multicenter trial investigating the kinetics of MPA and MPA-metabolites and the efficacy and side-effect profile of mycophenolate mofetil in renal transplant patients in view of MPA and MPA-metabolites.
Kuypers, D.; Vanrenterghem, Y.; Squifflet, J. P.; Mourad, M.; Abramowicz, D.; Oellerich, H. & Armstrong, V. W. et al. (2002)
Journal of the American Society of Nephrology, 13 pp. 367A-368A.
Philadelphia: Lippincott Williams & Wilkins.
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2002 | Journal Article
Comparison of the Emit immunoassay with HPLC for therapeutic drug monitoring of mycophenolic acid in pediatric renal-transplant recipients on mycophenolate mofetil therapy
Weber, L. T.; Shipkova, M.; Armstrong, V. W.; Wagner, N.; Schutz, E.; Mehls, O. & Zimmerhackl, L. B. et al. (2002)
Clinical Chemistry, 48(3) pp. 517-525.
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2002 | Journal Article
The pharmacokinetic-pharmacodynamic relationship for total and free mycophenolic acid in pediatric renal transplant recipients: A report of the German Study Group on Mycophenolate Mofetil Therapy
Weber, L. T.; Shipkova, M.; Armstrong, V. W.; Wagner, N.; Schutz, E.; Mehls, O. & Zimmerhackl, L. B. et al. (2002)
Journal of the American Society of Nephrology, 13(3) art. UNSP 1046-6673/1303-0759.
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2002 | Journal Article
Atypical pharmacokinetics and metabolism of mycophenolic acid in a young kidney transplant recipient with impaired renal function
Wigger, M.; Armstrong, V. W.; Shipkova, M.; Wacke, R.; Nizze, H.; Streit, F. & von Ahsen, N. et al. (2002)
Therapeutic Drug Monitoring, 24(3) pp. 438-443. DOI: https://doi.org/10.1097/00007691-200206000-00019
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2002 | Journal Article
Pharmacokinetics and protein adduct formation of the pharmacologically active acyl glucuronide metabolite of mycophenolic acid in pediatric renal transplant recipients
Shipkova, M.; Armstrong, V. W.; Weber, L. T.; Niedmann, P. D.; Wieland, E.; Haley, J. & Tonshoff, B. et al. (2002)
Therapeutic Drug Monitoring, 24(3) pp. 390-399. DOI: https://doi.org/10.1097/00007691-200206000-00011
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2002 | Journal Article
A new acute inflammatory syndrome related to the introduction of mycophenolate mofetil in patients with Wegener's granulomatosis
Maes, B.; Oellerich, M.; Ceuppens, J. L.; Armstrong, V. W.; Evenepoel, P.; Kuypers, D. & Messiaen, T. et al. (2002)
Nephrology Dialysis Transplantation, 17(5) pp. 923-926. DOI: https://doi.org/10.1093/ndt/17.5.923
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2003 | Conference Abstract
Pre-dose plums concentrations of the reactive acyl glucuronide of mycophenolic acid (AcMPAG) in kidney transplant recipients under therapy with mycophenolate mofeto (MMF), tacrolimus and steroids
Shipkova, M.; Maes, B.; Armstrong, V. W.; Wieland, E. & Oellerich, M. (2003)
Therapeutic Drug Monitoring, 25(4) 8th International Congress of Therapeutic Drug Monitoring and Clinical Toxicology, BASEL, SWITZERLAND.
Philadelphia: Lippincott Williams & Wilkins.
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2003 | Conference Abstract
Genotypic and phenotypic evaluations in connection with azathioprine toxicity.
Oellerich, M.; von Ahsen, N.; Shipkova, M. & Armstrong, V. W. (2003)
Toxicological Sciences, 72 42nd Annual Meeting of the Society-of-Toxicology, SALT LAKE CITY, UTAH.
Oxford: Oxford Univ Press.
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2003 | Journal Article | Letter Note
Commentary on: Differences in nucleotide hydrolysis contribute to the differences between erythrocyte 6-thioguanine nucleotide concentrations determined by two widely used methods - Response
Shipkova, M.; Armstrong, V. W.; Wieland, E. & Oellerich, M. (2003)
Clinical Chemistry, 49(9) pp. 1551-1552.
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2003 | Conference Abstract
Quantification of plasma total MPA and free MPA 80 mass interferences in quantification of using liquid chromatography tandem mass cyclosporine using tandem mass spectrometry spectrometry
Streit, F.; Shipkova, M.; Armstrong, V. W. & Oellerich, M. (2003)
Therapeutic Drug Monitoring, 25(4) 8th International Congress of Therapeutic Drug Monitoring and Clinical Toxicology, BASEL, SWITZERLAND.
Philadelphia: Lippincott Williams & Wilkins.
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2003 | Conference Abstract
Relationship between plasma concentrations of mycophenolic acid (MPA) and its acyl glucuronide (AcMPAG) and intestinal damage in Wistar rats treated with mycophenolate mofetil (MMF)
Shipkova, M.; Voland, A.; Grone, H. J.; Armstrong, V. W.; Oellerich, M. & Wieland, E. (2003)
Therapeutic Drug Monitoring, 25(4) 8th International Congress of Therapeutic Drug Monitoring and Clinical Toxicology, BASEL, SWITZERLAND.
Philadelphia: Lippincott Williams & Wilkins.
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2003 | Conference Abstract
Phenotypic and genotypic analysis of thiopurine S-methyltransferase polymorphism in the Bulgarian population
Indiova, D.; Atanasova, S.; Shipkova, M.; Armstrong, V. W.; Oellerich, M. & Svinarov, D. (2003)
Therapeutic Drug Monitoring, 25(4) 8th International Congress of Therapeutic Drug Monitoring and Clinical Toxicology, BASEL, SWITZERLAND.
Philadelphia: Lippincott Williams & Wilkins.
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2003 | Review
Acyl glucuronide drug metabolites: Toxicological and analytical implications
Shipkova, M.; Armstrong, V. W.; Oellerich, M.& Wieland, E. (2003)
Therapeutic Drug Monitoring, 25(1) pp. 1-16.
Lippincott Williams & Wilkins. DOI: https://doi.org/10.1097/00007691-200302000-00001
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2003 | Journal Article
Differences in nucleotide hydrolysis contribute to the differences between erythrocyte 6-thioguanine nucleotide concentrations determined by two widely used methods
Shipkova, M.; Armstrong, V. W.; Wieland, E. & Oellerich, M. (2003)
Clinical Chemistry, 49(2) pp. 260-268. DOI: https://doi.org/10.1373/49.2.260
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2003 | Journal Article
Phenotypic and genotypic analysis of thiopurine S-methyltransferase polymorphism in the Bulgarian population
Indjova, D.; Atanasova, S.; Shipkova, M.; Armstrong, V. W.; Oellerich, M. & Svinarov, D. (2003)
Therapeutic Drug Monitoring, 25(5) pp. 631-636. DOI: https://doi.org/10.1097/00007691-200310000-00013
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2003 | Journal Article
Determination of thiopurine methyltransferase phenotype in isolated human erythrocytes using a new simple nonradioactive HPLC method
Indjova, D.; Shipkova, M.; Atanasova, S.; Niedmann, P. D.; Armstrong, V. W.; Svinarov, D. & Oellerich, M. (2003)
Therapeutic Drug Monitoring, 25(5) pp. 637-644. DOI: https://doi.org/10.1097/00007691-200310000-00014
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2003 | Journal Article
Twelve-month evaluation of the clinical pharmacokinetics of total and free mycophenolic acid and its glucuronide metabolites in renal allograft recipients on low dose tacrolimus in combination with mycophenolate mofetil
Kuypers, D.; Vanrenterghem, Y.; Squifflet, J. P.; Mourad, M.; Abramowicz, D.; Oellerich, M. & Armstrong, V. W. et al. (2003)
Therapeutic Drug Monitoring, 25(5) pp. 609-622. DOI: https://doi.org/10.1097/00007691-200310000-00011
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2003 | Journal Article
Erosive enterocolitis in mycophenolate mofetil-treated renal-transplant recipients with persistent afebrile diarrhea
Maes, B. D.; Dalle, I.; Geboes, K.; Oellerich, M.; Armstrong, V. W.; Evenepoel, P. & Geypens, B. et al. (2003)
Transplantation Journal, 75(5) pp. 665-672. DOI: https://doi.org/10.1097/01.TP.0000053753.43268.F0
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2003 | Journal Article
The immunosuppressive drug mycophenolate mofetil impairs the adhesion capacity of gastrointestinal tumour cells
Leckel, K.; Beecken, W. D.; Jonas, D.; Oppermann, E.; Coman, M. C.; Beck, K. F. & Cinatl, J. et al. (2003)
Clinical & Experimental Immunology, 134(2) pp. 238-245. DOI: https://doi.org/10.1046/j.1365-2249.2003.02290.x
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2004 | Journal Article
cDNA microarray analysis reveals new candidate genes possibly linked to side effects under mycophenolate mofetil therapy
Shipkova, M.; Spielbauer, B.; Voland, A.; Grone, H. J.; Armstrong, V. W.; Oellerich, M. & Wieland, E. (2004)
Transplantation Journal, 78(8) pp. 1145-1152. DOI: https://doi.org/10.1097/01.TP.0000137262.06252.05
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2004 | Journal Article
Validation of a rapid and sensitive liquid chromatography-tandem mass spectrometry method for free and total mycophenolic acid
Streit, F.; Shipkova, M.; Armstrong, V. W. & Oellerich, M. (2004)
Clinical Chemistry, 50(1) pp. 152-159. DOI: https://doi.org/10.1373/clinchem.2003.024323
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2004 | Conference Paper
Analytic aspects of monitoring therapy with thiopurine medications
Armstrong, V. W.; Shipkova, M.; von Ahsen, N. & Oellerich, M. (2004)
Therapeutic Drug Monitoring, 26(2) pp. 220-226. 8th International Congress of Therapeutic Drug Monitoring and Clinical Toxicology, BASEL, SWITZERLAND.
Philadelphia: Lippincott Williams & Wilkins. DOI: https://doi.org/10.1097/00007691-200404000-00024
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2004 | Journal Article
Synergistic effects of sirolimus with cyclosporine and tacrolimus: Analysis of immunosuppression on lymphocyte proliferation and activation in rat whole blood
Barten, M. J.; Streit, F.; Boeger, M.; Dhein, S.; Tarnok, A.; Shipkova, M. & Armstrong, V. W. et al. (2004)
Transplantation Journal, 77(8) pp. 1154-1162. DOI: https://doi.org/10.1097/01.TP.0000120391.42712.E8
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2004 | Journal Article
Cyclosporin A absorption profiles in pediatric renal transplant recipients predict the risk of acute rejection
Weber, L. T.; Armstrong, V. W.; Shipkova, M.; Feneberg, R.; Wiesel, M.; Mehls, O. & Zimmerhackl, L. B. et al. (2004)
Therapeutic Drug Monitoring, 26(4) pp. 415-424. DOI: https://doi.org/10.1097/00007691-200408000-00012
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2004 | Journal Article
Identification of protein targets for mycophenolic acid acyl glucuronide in rat liver and colon tissue
Shipkova, M.; Beck, H.; Voland, A.; Armstrong, V. W.; Grone, H. J.; Oellerich, M. & Wieland, E. (2004)
PROTEOMICS, 4(9) pp. 2728-2738. DOI: https://doi.org/10.1002/pmic.200300836
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2004 | Journal Article
Circulating cytokines as markers of systemic inflammatory response in severe community-acquired pneumonia
Igonin, A. A.; Armstrong, V. W.; Shipkova, M.; Lazareva, N. B.; Kukes, V. G. & Oellerich, M. (2004)
Clinical Biochemistry, 37(3) pp. 204-209. DOI: https://doi.org/10.1016/j.clinbiochem.2003.11.001
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2004 | Journal Article | Letter Note
Determination of thiopurine methyltransferase activity in isolated human erythrocytes does not reflect putative in vivo enzyme inhibition by sulfasalazine
Shipkova, M.; Niedmann, P. D.; Armstrong, V. W.; Oellerich, M. & Wieland, E. (2004)
Clinical Chemistry, 50(2) pp. 438-441. DOI: https://doi.org/10.1373/clinchem.2003.026096
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2005 | Conference Abstract
A prospective evaluation of the association between adverse drug reactions to azathioprine therapy and polymorphisms in the gene encoding inosine triphosphate pyrophosphatase
Armstrong, V. W.; Reinshagen, M.; von Ahsen, N.; Behrens, C.; Shipkova, M.; von Tirpitz, C. & Malchow, H. et al. (2005)
Therapeutic Drug Monitoring, 27(2) 9th International Congress of Therapeutic Drug Monitoring and Clinical Toxicology, Louisville, KY.
Philadelphia: Lippincott Williams & Wilkins. DOI: https://doi.org/10.1097/00007691-200504000-00148
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2005 | Journal Article
Analytic Aspects of Monitoring Therapy with Thiopurine Medications
Armstrong, V. W.; Shipkova, M.; von Ahsen, N. & Oellerich, M. (2005)
ChemInform, 36(2). DOI: https://doi.org/10.1002/chin.200502276
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2005 | Journal Article
Pharmacokinetics and bioavailability of mycophenolic acid after intravenous administration and oral administration of mycophenolate mofetil to heart transplant recipients
Armstrong, V. W.; Tenderich, G.; Shipkova, M.; Parsa, A.; Koerfer, R.; Schroder, H. & Oellerich, M. (2005)
Therapeutic Drug Monitoring, 27(3) pp. 315-321. DOI: https://doi.org/10.1097/01.ftd.0000163949.40686.0f
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2005 | Journal Article
Association of inosine triphosphatase 94C > A and thiopurine S-methyltransferase deficiency with adverse events and study drop-outs under azathioprine therapy in a prospective Crohn disease study
von Ahsen, N.; Armstrong, V. W.; Behrens, C.; von Tirpitz, C.; Stallmach, A.; Herfarth, H. & Stein, J. et al. (2005)
Clinical Chemistry, 51(12) pp. 2282-2288. DOI: https://doi.org/10.1373/clinchem.2005.057158
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2005 | Journal Article
Mycophenolic acid interaction with cyclosporine and tacrolimus in vitro and in vivo - Evaluation of additive effects on rat blood lymphocyte function
Barten, M. J.; Shipkova, M.; Bartsch, P.; Dhein, S.; Streit, F.; Tarnok, A. & Armstrong, V. W. et al. (2005)
Therapeutic Drug Monitoring, 27(2) pp. 123-131. DOI: https://doi.org/10.1097/01.ftd.0000146874.11480.8a
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