Author Weber, Martin S.

• 2012 | Journal Article | 
  ​ ​IgG glycan hydrolysis by EndoS inhibits experimental autoimmune encephalomyelitis​
  Benkhoucha, M.; Molnarfi, N.; Santiago-Raber, M.-L.; Weber, M. S.; Merkler, D.; Collin, M. & Lalive, P. H.​ (2012) 
  Journal of Neuroinflammation, 9 art. 209​.​ DOI: https://doi.org/10.1186/1742-2094-9-209 
  ​Details  DOI  PMID  PMC  WoS 

• 2012 | Journal Article | 
  ​ ​Favourable response to plasma exchange in tumefactive CNS demyelination with delayed B-cell response​
  Seifert, C. L.; Wegner, C.; Sprenger, T.; Weber, M. S.; Brueck, W.; Hemmer, B. & Sellner, J.​ (2012) 
  Multiple Sclerosis Journal, 18(7) pp. 1045​-1049​.​ DOI: https://doi.org/10.1177/1352458511429012 
  ​Details  DOI  PMID  PMC  WoS 

• 2013 | Journal Article | 
  ​ ​The neonatal CNS is not conducive for encephalitogenic Th1 T cells and B cells during experimental autoimmune encephalomyelitis​
  Cravens, P. D.; Kieseier, B. C.; Hussain, R. Z.; Herndon, E.; Arellano, B.; Ben, L.-H. & Timmons, B. C. et al.​ (2013) 
  Journal of Neuroinflammation, 10 art. 67​.​ DOI: https://doi.org/10.1186/1742-2094-10-67 
  ​Details  DOI  PMID  PMC  WoS 

• 2013 | Review
  ​ ​Targeting B cells in the treatment of multiple sclerosis: recent advances and remaining challenges​
  Lehmann-Horn, K.; Kronsbein, H. C.& Weber, M. S.​ (2013)
  Therapeutic Advances in Neurological Disorders, 6​(3) pp. 161​-173​.​
  Sage Publications Ltd. DOI: https://doi.org/10.1177/1756285612474333 
  ​Details  DOI  PMID  PMC  WoS 

• 2013 | Journal Article
  ​ ​Developmental maturation of innate immune cell function correlates with susceptibility to central nervous system autoimmunity​
  Hertzenberg, D.; Lehmann-Horn, K.; Kinzel, S.; Husterer, V.; Cravens, P. D.; Kieseier, B. C. & Hemmer, B. et al.​ (2013) 
  European Journal of Immunology, 43(8) pp. 2078​-2088​.​ DOI: https://doi.org/10.1002/eji.201343338 
  ​Details  DOI  PMID  PMC  WoS 

• 2013 | Review
  ​ ​Therapeutic Decisions in Multiple Sclerosis Moving Beyond Efficacy​
  Brueck, W.; Gold, R.; Lund, B. T.; Oreja-Guevara, C.; Prat, A.; Spencer, C. M.& Steinman, L. et al.​ (2013)
  JAMA Neurology, 70​(10) pp. 1315​-1324​.​
  Amer Medical Assoc. DOI: https://doi.org/10.1001/jamaneurol.2013.3510 
  ​Details  DOI  PMID  PMC  WoS 

• 2014 | Conference Abstract
  ​ ​Myelin-specific antibodies trigger spontaneous CNS autoimmune disease in the absence of myelin-specific B cells​
  Kinzel, S.; Lehmann-Horn, K.; Zamvil, S. S.; Winkler, A. ; Bernard, C. C.; Stadelmann-Nessler, C.   & Brueck, W. et al.​ (2014)
  Journal of Neuroimmunology, 275(1-2) pp. 7​-8. , Mainz, GERMANY.
  Amsterdam​: Elsevier Science Bv. DOI: https://doi.org/10.1016/j.jneuroim.2014.08.026 
  ​Details  DOI  WoS 

• 2014 | Conference Abstract
  ​ ​Following anti-CD20 treatment, compartment-specific repletion with immune-competent B cells depends on activation of reappearing B cells​
  Feldmann, L. & Weber, M. S.​ (2014)
  Journal of Neuroimmunology, 275(1-2) ​12th International Congress of Neuroimmunology (ISNI)​, Mainz, GERMANY.
  Amsterdam​: Elsevier Science Bv. DOI: https://doi.org/10.1016/j.jneuroim.2014.08.052 
  ​Details  DOI  WoS 

• 2014 | Journal Article
  ​ ​Immunopathogenesis of Neuromyelitis Optica​
  Levy, M.; Wildemann, B.; Jarius, S.; Orellano, B.; Sasidharan, S.; Weber, M. S. & Stuve, O.​ (2014) 
  Advances in Immunology, 121 pp. 213​-242​.​ DOI: https://doi.org/10.1016/B978-0-12-800100-4.00006-4 
  ​Details  DOI  PMID  PMC  WoS 

• 2014 | Journal Article | 
  ​ ​Intrathecal anti-CD20 efficiently depletes meningeal B cells in CNS autoimmunity​
  Lehmann-Horn, K.; Kinzel, S.; Feldmann, L.; Radelfahr, F.; Hemmer, B.; Traffehn, S. & Bernard, C. C. A. et al.​ (2014) 
  Annals of Clinical and Translational Neurology, 1(7) pp. 490​-496​.​ DOI: https://doi.org/10.1002/acn3.71 
  ​Details  DOI  PMID  PMC  WoS 

• 2014 | Journal Article | 
  ​ ​Neither T-helper type 2 nor Foxp3(+) regulatory T cells are necessary for therapeutic benefit of atorvastatin in treatment of central nervous system autoimmunity​
  Weber, M. S.; Prod'homme, T.; Youssef, S.; Dunn, S. E.; Steinman, L. & Zamvil, S. S.​ (2014) 
  Journal of Neuroinflammation, 11 art. 29​.​ DOI: https://doi.org/10.1186/1742-2094-11-29 
  ​Details  DOI  PMID  PMC  WoS 

• 2014 | Journal Article | 
  ​ ​MOG transmembrane and cytoplasmic domains contain highly stimulatory T-cell epitopes in MS.​
  Varrin-Doyer, M.; Shetty, A.; Spencer, C. M.; Schulze-Topphoff, U.; Weber, M. S.; Bernard, C. C. A. & Forsthuber, T. et al.​ (2014) 
  Neurology® neuroimmunology & neuroinflammation, 1(2) art. e20​.​ DOI: https://doi.org/10.1212/NXI.0000000000000020 
  ​Details  DOI  PMID  PMC 

• 2014 | Journal Article | 
  ​ ​Immunodominant T-cell epitopes of MOG reside in its transmembrane and cytoplasmic domains in EAE.​
  Shetty, A.; Gupta, S. G.; Varrin-Doyer, M.; Weber, M. S.; Prod'homme, T.; Molnarfi, N. & Ji, N. et al.​ (2014) 
  Neurology® neuroimmunology & neuroinflammation, 1(2) art. e22​.​ DOI: https://doi.org/10.1212/NXI.0000000000000022 
  ​Details  DOI  PMID  PMC 

• 2015 | Journal Article | Letter Note
  ​ ​Targeting Central Nervous System B Cells in Progression of Multiple Sclerosis Is Intrathecal Anti-CD20 a Therapeutic Option?​
  Fereidan-Esfahani, M. ; Brueck, W. & Weber, M. S.​ (2015) 
  JAMA Neurology, 72(12) pp. 1407​-1408​.​ DOI: https://doi.org/10.1001/jamaneurol.2015.2869 
  ​Details  DOI  PMID  PMC  WoS 

• 2015 | Journal Article
  ​ ​Tyrphostin AG126 Exerts Neuroprotection in CNS Inflammation by a Dual Mechanism​
  Menzfeld, C.; John, M.; van Rossum, D.; Regen, T.; Scheffel, J.; Janova, H.   & Goetz, A. A. et al.​ (2015) 
  Glia, 63(6) pp. 1083​-1099​.​ DOI: https://doi.org/10.1002/glia.22803 
  ​Details  DOI  PMID  PMC  WoS 

• 2015 | Journal Article | 
  ​ ​Is intrathecal anti-CD20 an option to target compartmentalized CNS inflammation in progressive MS?​
  Weber, M. S.​ (2015) 
  Neurology® neuroimmunology & neuroinflammation, 2(2) art. e84​.​ DOI: https://doi.org/10.1212/NXI.0000000000000084 
  ​Details  DOI  PMID  PMC 

• 2015 | Journal Article | 
  ​ ​Glial cells express nuclear nrf2 after fumarate treatment for multiple sclerosis and psoriasis.​
  Metz, I.; Traffehn, S.; Straßburger-Krogias, K.; Keyvani, K.; Bergmann, M.; Nolte, K. & Weber, M. S. et al.​ (2015) 
  Neurology® neuroimmunology & neuroinflammation, 2(3) art. e99​.​ DOI: https://doi.org/10.1212/NXI.0000000000000099 
  ​Details  DOI  PMID  PMC 

• 2015 | Journal Article | 
  ​ ​Glatiramer acetate treatment negatively regulates type I interferon signaling.​
  Molnarfi, N.; Prod'homme, T.; Schulze-Topphoff, U.; Spencer, C. M.; Weber, M. S.; Patarroyo, J. C. & Lalive, P. H. et al.​ (2015) 
  Neurology® neuroimmunology & neuroinflammation, 2(6) art. e179​.​ DOI: https://doi.org/10.1212/NXI.0000000000000179 
  ​Details  DOI  PMID  PMC 

• 2016 | Journal Article | 
  ​ ​B cell-derived transforming growth factor-beta 1 expression limits the induction phase of autoimmune neuroinflammation​
  Bjarnadottir, K.; Benkhoucha, M.; Merkler, D.; Weber, M. S.; Payne, N. L.; Bernard, C. C. A. & Molnarfi, N. et al.​ (2016) 
  Scientific Reports, 6 art. 34594​.​ DOI: https://doi.org/10.1038/srep34594 
  ​Details  DOI  PMID  PMC  WoS 

• 2016 | Review
  ​ ​The Use of Oral Disease-Modifying Therapies in Multiple Sclerosis​
  Kretzschmar, B.; Pellkofer, H. L.& Weber, M. S.​ (2016)
  Current Neurology and Neuroscience Reports, 16​(4).​
  Springer. DOI: https://doi.org/10.1007/s11910-016-0639-4 
  ​Details  DOI  PMID  PMC  WoS 

• 2016 | Review
  ​ ​B Cell-Directed Therapeutics in Multiple Sclerosis: Rationale and Clinical Evidence​
  Kinzel, S.& Weber, M. S.​ (2016)
  CNS Drugs, 30​(12) pp. 1137​-1148​.​
  Adis Int Ltd. DOI: https://doi.org/10.1007/s40263-016-0396-6 
  ​Details  DOI  PMID  PMC  WoS 

• 2016 | Journal Article | 
  ​ ​Myelinosome formation represents an early stage of oligodendrocyte damage in multiple sclerosis and its animal model​
  Romanelli, E.; Merkler, D.; Mezydlo, A.; Weil, M.-T.; Weber, M. S.; Nikic, I. & Potz, S. et al.​ (2016) 
  Nature Communications, 7 art. 13275​.​ DOI: https://doi.org/10.1038/ncomms13275 
  ​Details  DOI  PMID  PMC  WoS 

• 2016 | Journal Article | 
  ​ ​Myelin-reactive antibodies initiate T cell-mediated CNS autoimmune disease by opsonization of endogenous antigen​
  Kinzel, S.; Lehmann-Horn, K.; Torke, S.; Haeusler, D.; Winkler, A.; Stadelmann, C.   & Payne, N. L. et al.​ (2016) 
  Acta Neuropathologica, 132(1) pp. 43​-58​.​ DOI: https://doi.org/10.1007/s00401-016-1559-8 
  ​Details  DOI  PMID  PMC  WoS 

• 2017 | Journal Article | Letter Note
  ​ ​Biomarkers in radiologically isolated syndrome: The missing piece in the puzzle of treatment indication?​
  Fereidan-Esfahani, M.; Mahmudi, F.; Jahansouz, M.; Weber, M. S. & Rodriguez, M.​ (2017) 
  Journal of the Neurological Sciences, 375.​ DOI: https://doi.org/10.1016/j.jns.2017.01.055 
  ​Details  DOI  PMID  PMC  WoS 

• 2017 | Review | 
  ​ ​Primary Progressive Multiple Sclerosis: Putting Together the Puzzle​
  Abdelhak, A.; Weber, M. S.& Tumani, H.​ (2017)
  Frontiers in Neurology, 8​.​
  Frontiers Media S.A.. DOI: https://doi.org/10.3389/fneur.2017.00234 
  ​Details  DOI  PMID  PMC  WoS 

• 2017 | Journal Article | Research Paper | 
  ​ ​Deciphering the Role of B Cells in Multiple Sclerosis-Towards Specific Targeting of Pathogenic Function.​
  Lehmann-Horn, K.; Kinzel, S. & Weber, M. S.​ (2017) 
  International journal of molecular sciences, 18(10) art. 2048​.​ DOI: https://doi.org/10.3390/ijms18102048 
  ​Details  DOI  PMID  PMC 

• 2018 | Journal Article
  ​ ​Functional characterization of reappearing B cells after anti-CD20 treatment of CNS autoimmune disease​
  Häusler, D.; Häusser-Kinzel, S.; Feldmann, L.; Torke, S.; Lepennetier, G.; Bernard, C. C. A. & Zamvil, S. S. et al.​ (2018) 
  Proceedings of the National Academy of Sciences, 115(39) pp. 9773​-9778​.​ DOI: https://doi.org/10.1073/pnas.1810470115 
  ​Details  DOI 

• 2018 | Journal Article
  ​ ​Anti–Myelin Oligodendrocyte Glycoprotein Antibody–Associated Central Nervous System Demyelination—A Novel Disease Entity?​
  Weber, M. S.; Derfuss, T. & Brück, W.​ (2018) 
  JAMA Neurology, 75(8) pp. 909​.​ DOI: https://doi.org/10.1001/jamaneurol.2018.1055 
  ​Details  DOI 

• 2019 | Journal Article | 
  ​ ​Natalizumab promotes activation and pro-inflammatory differentiation of peripheral B cells in multiple sclerosis patients​
  Traub, J. W.; Pellkofer, H. L.; Grondey, K.; Seeger, I.; Rowold, C.; Brück, W. & Husseini, L. et al.​ (2019) 
  Journal of Neuroinflammation, 16(1).​ DOI: https://doi.org/10.1186/s12974-019-1593-2 
  ​Details  DOI 

• 2019 | Journal Article
  ​ ​Modification of CSF findings in multiple sclerosis in the era of rapidly expanding treatment options​
  Giotaki, I.; Lange, P. & Weber, M. S.​ (2019) 
  Expert Review of Neurotherapeutics, 19(3) pp. 277​-283​.​ DOI: https://doi.org/10.1080/14737175.2019.1583557 
  ​Details  DOI 

• 2019 | Journal Article
  ​ ​Immunological Aspects of Approved MS Therapeutics​
  Rommer, P. S.; Milo, R.; Han, M. H.; Satyanarayan, S.; Sellner, J.; Hauer, L. & Illes, Z. et al.​ (2019) 
  Frontiers in Immunology, 10 art. 1564​.​ DOI: https://doi.org/10.3389/fimmu.2019.01564 
  ​Details  DOI 

• 2019 | Journal Article
  ​ ​Placebo-Controlled Trial of an Oral BTK Inhibitor in Multiple Sclerosis​
  Montalban, X.; Arnold, D. L.; Weber, M. S.; Staikov, I.; Piasecka-Stryczynska, K.; Willmer, J. & Martin, E. C. et al.​ (2019) 
  New England Journal of Medicine, 380(25) pp. 2406​-2417​.​ DOI: https://doi.org/10.1056/NEJMoa1901981 
  ​Details  DOI 

• 2019 | Journal Article | 
  ​ ​The Role of B Cells and Antibodies in Multiple Sclerosis, Neuromyelitis Optica, and Related Disorders.​
  Häusser-Kinzel, S. & Weber, M. S.​ (2019) 
  Frontiers in Immunology, 10 art. 201​.​ DOI: https://doi.org/10.3389/fimmu.2019.00201 
  ​Details  DOI  PMID  PMC 

• 2019 | Journal Article | 
  ​ ​Dimethyl fumarate impairs differentiated B cells and fosters central nervous system integrity in treatment of multiple sclerosis​
  Traub, J.; Traffehn, S.; Ochs, J.; Häusser‐Kinzel, S.; Stephan, S.; Scannevin, R. & Brück, W. et al.​ (2019) 
  Brain Pathology, 29(5) pp. 640​-657​.​ DOI: https://doi.org/10.1111/bpa.12711 
  ​Details  DOI  PMID  PMC 

• 2019 | Journal Article | Research Paper | 
  ​ ​Vitamin D Supplementation in Central Nervous System Demyelinating Disease-Enough Is Enough​
  Häusler, D. & Weber, M. S.​ (2019) 
  International Journal of Molecular Sciences, 20(1) art. 218​.​ DOI: https://doi.org/10.3390/ijms20010218 
  ​Details  DOI  PMID  PMC 

• 2021 | Journal Article | Research Paper | 
  ​ ​Proinflammatory CD20 + T Cells are Differentially Affected by Multiple Sclerosis Therapeutics​
  Quendt, C.; Ochs, J.; Häusser‐Kinzel, S.; Häusler, D. & Weber, M. S.​ (2021) 
  Annals of Neurology, 90(5) pp. 834​-839​.​ DOI: https://doi.org/10.1002/ana.26216 
  ​Details  DOI 

• 2021 | Journal Article | Research Paper | 
  ​ ​Microglia: The Missing Link to Decipher and Therapeutically Control MS Progression?​
  Geladaris, A.; Häusler, D. & Weber, M. S.​ (2021) 
  International Journal of Molecular Sciences, 22(7) pp. 3461​.​ DOI: https://doi.org/10.3390/ijms22073461 
  ​Details  DOI 

• 2021 | Journal Article | 
  ​ ​A Milestone in Multiple Sclerosis Therapy: Monoclonal Antibodies Against CD20—Yet Progress Continues​
  Frisch, E. S.; Pretzsch, R. & Weber, M. S.​ (2021) 
  Neurotherapeutics, 18(3) pp. 1602​-1622​.​ DOI: https://doi.org/10.1007/s13311-021-01048-z 
  ​Details  DOI 

• 2022 | Journal Article
  ​ ​Safety, Adherence and Persistence in a Real-World Cohort of German MS Patients Newly Treated With Ocrelizumab: First Insights From the CONFIDENCE Study​
  Weber, M. S.; Buttmann, M.; Meuth, S. G.; Dirks, P.; Muros-Le Rouzic, E.; Eggebrecht, J. C. & Hieke-Schulz, S. et al.​ (2022) 
  Frontiers in Neurology, 13 art. 863105​.​ DOI: https://doi.org/10.3389/fneur.2022.863105 
  ​Details  DOI 

• 2022 | Journal Article
  ​ ​Proinflammatory CD20 + T cells contribute to CNS-directed autoimmunity​
  Ochs, J.; Nissimov, N.; Torke, S.; Freier, M.; Grondey, K.; Koch, J. & Klein, M. et al.​ (2022) 
  Science Translational Medicine, 14(638).​ DOI: https://doi.org/10.1126/scitranslmed.abi4632 
  ​Details  DOI 

• 2023 | Journal Article
  ​ ​Association of Higher Ocrelizumab Exposure With Reduced Disability Progression in Multiple Sclerosis​
  Hauser, S. L.; Bar-Or, A.; Weber, M. S.; Kletzl, H.; Günther, A.; Manfrini, M. & Model, F. et al.​ (2023) 
  Neurology - Neuroimmunology Neuroinflammation, 10(2) art. e200094​.​ DOI: https://doi.org/10.1212/NXI.0000000000200094 
  ​Details  DOI 

• 2023 | Journal Article
  ​ ​Bruton’s tyrosine kinase as a promising therapeutic target for multiple sclerosis​
  Saberi, D.; Geladaris, A.; Dybowski, S. & Weber, M. S.​ (2023) 
  Expert Opinion on Therapeutic Targets, 27(4-5) pp. 347​-359​.​ DOI: https://doi.org/10.1080/14728222.2023.2218615 
  ​Details  DOI 

• 2023 | Journal Article | 
  ​ ​IL-10-providing B cells govern pro-inflammatory activity of macrophages and microglia in CNS autoimmunity​
  Geladaris, A.; Häusser-Kinzel, S.; Pretzsch, R.; Nissimov, N.; Lehmann-Horn, K.; Häusler, D. & Weber, M. S.​ (2023) 
  Acta Neuropathologica, 145(4) pp. 461​-477​.​ DOI: https://doi.org/10.1007/s00401-023-02552-6 
  ​Details  DOI 

• 2023 | Journal Article
  ​ ​Trogocytosis challenges the cellular specificity of lineage markers and monoclonal antibodies​
  Ochs, J.; Häusser-Kinzel, S. & Weber, M. S.​ (2023) 
  Nature Reviews. Immunology, 23(9) pp. 539​-540​.​ DOI: https://doi.org/10.1038/s41577-023-00920-7 
  ​Details  DOI 

• 2023 | Conference Paper
  ​ ​Efficacy and Safety of the Bruton’s Tyrosine Kinase Inhibitor Evobrutinib for Relapsing Multiple Sclerosis Over 3.5 Years of Treatment: An Ongoing Phase II Open-Label Extension (S16.008)​
  Montalban, X.; Wolinsky, J. S.; Arnold, D. L.; Weber, M. S.; Piasecka-Stryczynska, K.; Tomic, D. & Seitzinger, A. et al.​ (2023)
  p. 3752. ​2023 Annual Meeting Abstracts​
  Lippincott Williams & Wilkins. DOI: https://doi.org/10.1212/WNL.0000000000203500 
  ​Details  DOI 

• 2023 | Journal Article
  ​ ​Toward identifying key mechanisms of progression in multiple sclerosis​
  Husseini, L.; Geladaris, A. & Weber, M. S.​ (2023) 
  Trends in Neurosciences,.​ DOI: https://doi.org/10.1016/j.tins.2023.11.005 
  ​Details  DOI 

• 2023 | Journal Article | 
  ​ ​T Cell Energy Metabolism Is a Target of Glucocorticoids in Mice, Healthy Humans, and MS Patients​
  Meyer-Heemsoth, L.; Mitschke, K.; Bier, J.; Schütz, K.; Villunger, A.; Legler, T. J. & Weber, M. S. et al.​ (2023) 
  Cells, 12(3).​ DOI: https://doi.org/10.3390/cells12030450 
  ​Details  DOI 

• 2024 | Journal Article | Overview
  ​ ​Differential Role of Factor XIII in Acute Myocardial Infarction and Ischemic Stroke​
  Traub, J.; Weber, M. S. & Frey, A.​ (2024) 
  Biomedicines, 12(3) pp. 497​.​ DOI: https://doi.org/10.3390/biomedicines12030497 
  ​Details  DOI 

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