Author Wiltfang, Jens

• 2003 | Journal Article
  ​ ​Different binding pattern of antibodies to prion protein on lymphocytes from patients with sporadic Creutzfeldt–Jakob disease​
  Ratzka, P.; Döhlinger, S.; Cepek, L.; Steinacker, P.; Arlt, S.; Jacobi, C. & Schröter, A. et al.​ (2003) 
  Neuroscience Letters, 343(1) pp. 29​-32​.​ DOI: https://doi.org/10.1016/S0304-3940(03)00315-X 
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• 2006 | Journal Article
  ​ ​International quality control survey of neurochemical dementia diagnostics​
  Lewczuk, P.; Beck, G.; Ganslandt, O.; Esselmann, H.; Deisenhammer, F.; Regeniter, A. & Petereit, H.-F. et al.​ (2006) 
  Neuroscience Letters, 409(1) pp. 1​-4​.​ DOI: https://doi.org/10.1016/j.neulet.2006.07.009 
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• 2006 | Journal Article
  ​ ​Pharmacokinetic characterization of amantadine in human brain tissue​
  Kornhuber, J.; Riederer, P.; Bleich, S.; Wiltfang, J.; Kraus, T. & Meineke, I.​ (2006) 
  Therapeutic Drug Monitoring, 28(5) pp. 693​-695​.​ DOI: https://doi.org/10.1097/01.ftd.0000245390.48552.04 
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• 2006 | Journal Article
  ​ ​Beta-amlyoid 1-42 and tau-protein in cerebrospinal fluid of patients with Parkinson's disease dementia​
  Mollenhauer, B.; Trenkwalder, C.; von Ahsen, N.; Bibl, M.; Steinacker, P.; Brechlin, P. & Schindehuette, J. et al.​ (2006) 
  Dementia and Geriatric Cognitive Disorders, 22(3) pp. 200​-208​.​ DOI: https://doi.org/10.1159/000094871 
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• 2007 | Journal Article
  ​ ​Blood-based neurochemical diagnosis of vascular dementia: A pilot study​
  Bibl, M.; Esselmann, H.; Mollenhauer, B.; Weniger, G.; Welge, V.; Liess, M. & Lewczuk, P. et al.​ (2007) 
  Journal of Neurochemistry, 103(2) pp. 467​-474​.​ DOI: https://doi.org/10.1111/j.1471-4159.2007.04763.x 
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• 2007 | Journal Article
  ​ ​Serum heart-type fatty acid-binding protein and cerebrospinal fluid tau: Marker candidates for dementia with Lewy bodies​
  Mollenhauer, B.; Steinacker, P.; Bahn, E.; Bibl, M.; Brechlin, P.; Schlossmacher, M. G. & Locascio, J. J. et al.​ (2007) 
  Neurodegenerative Diseases, 4(5) pp. 366​-375​.​ DOI: https://doi.org/10.1159/000105157 
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• 2007 | Journal Article
  ​ ​Proteomic analysis of the cerebrospinal fluid of patients with Creutzfeldt-Jakob disease​
  Cepek, L.; Brechlin, P.; Steinacker, P.; Mollenhauer, B.; Klingebiel, E.; Bibl, M. & Kretzschmar, H. A. et al.​ (2007) 
  Dementia and Geriatric Cognitive Disorders, 23(1) pp. 22​-28​.​ DOI: https://doi.org/10.1159/000096589 
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• 2007 | Journal Article
  ​ ​Amyloid beta peptide ratio 42/40 but not A beta 42 correlates with phospho-Tau in patients with low- and high-CSF A beta 40 load​
  Wiltfang, J.; Esselmann, H.; Bibl, M.; Huell, M.; Hampel, H.; Kessler, H. & Froelich, L. et al.​ (2007) 
  Journal of Neurochemistry, 101(4) pp. 1053​-1059​.​ DOI: https://doi.org/10.1111/j.1471-4159.2006.04404.x 
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• 2008 | Journal Article | 
  ​ ​Effect of copper intake on CSF parameters in patients with mild Alzheimer’s disease: a pilot phase 2 clinical trial​
  Kessler, H.; Pajonk, F.-G.; Bach, D.; Schneider-Axmann, T.; Falkai, P.; Herrmann, W. & Multhaup, G. et al.​ (2008) 
  Journal of Neural Transmission, 115(12) pp. 1651​-1659​.​ DOI: https://doi.org/10.1007/s00702-008-0136-2 
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• 2008 | Journal Article
  ​ ​Influence of SORL1 gene variants: Association with CSF amyloid-beta products in probable Alzheimer's disease​
  Koelsch, H.; Jessen, F.; Wiltfang, J.; Lewczuk, P.; Dichgans, M.; Kornhuber, J. & Froelich, L. et al.​ (2008) 
  Neuroscience Letters, 440(1) pp. 68​-71​.​ DOI: https://doi.org/10.1016/j.neulet.2008.05.049 
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• 2008 | Journal Article
  ​ ​Multiplexed quantification of dementia biomarkers in the CSF of patients with early dementias and MCI: A multicenter study​
  Lewczuk, P.; Kornhuber, J.; Vanderstichele, H.; Vanmechelen, E.; Esselmann, H.; Bibl, M. & Wolf, S. et al.​ (2008) 
  Neurobiology of Aging, 29(6) pp. 812​-818​.​ DOI: https://doi.org/10.1016/j.neurobiolaging.2006.12.010 
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• 2008 | Journal Article
  ​ ​Cerebrospinal fluid-optimized two-dimensional difference gel electrophoresis (2-D DIGE) facilitates the differential diagnosis of Creutzfeldt-Jakob disease​
  Brechlin, P.; Jahn, O. ; Steinacker, P.; Cepek, L.; Kratzin, H.; Lehnert, S. & Jesse, S. et al.​ (2008) 
  Proteomics, 8(20) pp. 4357​-4366​.​ DOI: https://doi.org/10.1002/pmic.200800375 
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• 2008 | Journal Article
  ​ ​CSF amyloid-beta 1-38 and 1-42 in FTD and AD: Biomarker performance critically depends on the detergent accessible fraction​
  Bibl, M.; Lewczuk, P.; Esselmann, H.; Mollenhauer, B.; Klafki, H.-W.; Welge, V. & Wolf, S. et al.​ (2008) 
  PROTEOMICS - CLINICAL APPLICATIONS, 2(10-11) pp. 1548​-1556​.​ DOI: https://doi.org/10.1002/prca.200800006 
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• 2008 | Journal Article | 
  ​ ​Cerebrospinal fluid neurochemical phenotypes in vascular dementias: Original data and mini-review​
  Bibl, M.; Mollenhauer, B.; Esselmann, H.; Schneider, M.; Lewczuk, P.; Welge, V. & Gross, M. et al.​ (2008) 
  Dementia and Geriatric Cognitive Disorders, 25(3) pp. 256​-265​.​ DOI: https://doi.org/10.1159/000115975 
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• 2009 | Journal Article
  ​ ​CSF amyloid-beta 1-38 and 1-42 in FTD and AD: Biomarker performance critically depends on the detergent accessible fraction (vol 2, pg 1548, 2008)​
  Bibl, M.; Lewczuk, P.; Esselmann, H.; Mollenhauer, B.; Klafki, H.-W.; Welge, V. & Wolf, S. et al.​ (2009) 
  PROTEOMICS - CLINICAL APPLICATIONS, 3(6).​
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• 2009 | Journal Article
  ​ ​Association of SORL1 gene variants with Alzheimer's disease​
  Koelsch, H.; Jessen, F.; Wiltfang, J.; Lewczuk, P.; Dichgans, M.; Teipel, S. J. & Kornhuber, J. et al.​ (2009) 
  Brain Research, 1264 pp. 1​-6​.​ DOI: https://doi.org/10.1016/j.brainres.2009.01.044 
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• 2009 | Journal Article
  ​ ​Combined CSF tau, p-tau181 and amyloid-beta 38/40/42 for diagnosing Alzheimer's disease​
  Welge, V.; Fiege, O.; Lewczuk, P.; Mollenhauer, B.; Esselmann, H.; Klafki, H.-W. & Wolf, S. et al.​ (2009) 
  Journal of Neural Transmission, 116(2) pp. 203​-212​.​ DOI: https://doi.org/10.1007/s00702-008-0177-6 
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• 2009 | Journal Article | 
  ​ ​Early and Differential Diagnosis of Dementia and Mild Cognitive Impairment Design and Cohort Baseline Characteristics of the German Dementia Competence Network​
  Kornhuber, J.; Schmidtke, K.; Froelich, L.; Perneczky, R.; Wolf, S.; Hampel, H. & Jessen, F. et al.​ (2009) 
  Dementia and Geriatric Cognitive Disorders, 27(5) pp. 404​-417​.​ DOI: https://doi.org/10.1159/000210388 
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• 2009 | Journal Article
  ​ ​Measurement of ERK 1/2 in CSF from Patients with Neuropsychiatric Disorders and Evidence for the Presence of the Activated Form​
  Klafki, H.-W.; Lewczuk, P.; Kamrowski-Kruck, H.; Maler, J. M.; Mueller, K. ; Peters, O. & Heuser, I. et al.​ (2009) 
  Journal of Alzheimer s Disease, 18(3) pp. 613​-622​.​ DOI: https://doi.org/10.3233/JAD-2009-1167 
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• 2010 | Journal Article | 
  ​ ​Combined Analysis of CSF Tau, Aβ42, Aβ1-42% and Aβ1-40% in Alzheimer's Disease, Dementia with Lewy Bodies and Parkinson's Disease Dementia.​
  Bibl, M.; Esselmann, H.; Lewczuk, P.; Trenkwalder, C.; Otto, M.; Kornhuber, J. & Wiltfang, J. et al.​ (2010) 
  International journal of Alzheimer's disease, 2010.​ DOI: https://doi.org/10.4061/2010/761571 
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• 2010 | Journal Article
  ​ ​Recurrent Systemic Infections With Streptococcus pneumoniae Do Not Aggravate the Course of Experimental Neurodegenerative Diseases​
  Ebert, S.; Goos, M.; Rollwagen, L.; Baake, D.; Zech, W.-D.; Esselmann, H. & Wiltfang, J. et al.​ (2010) 
  Journal of Neuroscience Research, 88(5) pp. 1124​-1136​.​ DOI: https://doi.org/10.1002/jnr.22270 
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• 2010 | Journal Article
  ​ ​Multicentre variability of MRI-based medial temporal lobe volumetry in Alzheimer's disease​
  Teipel, S. J.; Ewers, M.; Wolf, S.; Jessen, F.; Koelsch, H.; Arlt, S. & Luckhaus, C. et al.​ (2010) 
  Psychiatry Research Neuroimaging, 182(3) pp. 244​-250​.​ DOI: https://doi.org/10.1016/j.pscychresns.2010.03.003 
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• 2010 | Journal Article | 
  ​ ​Genetic Evidence Implicates the Immune System and Cholesterol Metabolism in the Aetiology of Alzheimer's Disease​
  Jones, L.; Holmans, P. A.; Hamshere, M. L.; Harold, D.; Moskvina, V.; Ivanov, D. & Pocklington, A. et al.​ (2010) 
  PLoS ONE, 5(11) art. e13950​.​ DOI: https://doi.org/10.1371/journal.pone.0013950 
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• 2011 | Journal Article
  ​ ​P1‐132: CSF Aβ peptides in neuropathologically diagnosed dementias with lewy bodies and Alzheimer's type​
  Bibl, M.; Esselmann, H.; Mollenhauer, B.; Trenkwalder, C.; Schulz‐Schaeffer, W.; Kretzschmar, H. & Otto, M. et al.​ (2011) 
  Alzheimer's & Dementia, 7(4S_Part_4).​ DOI: https://doi.org/10.1016/j.jalz.2011.05.412 
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• 2011 | Journal Article | 
  ​ ​Different CSF beta-amyloid processing in Alzheimer's and Creutzfeldt-Jakob disease (vol 118, pg 691, 2011)​
  Mollenhauer, B.; Esselmann, H.; Roeber, S.; Schulz-Schaeffer, W. J.; Trenkwalder, C.; Bibl, M. & Steinacker, P. et al.​ (2011) 
  Journal of Neural Transmission, 118(8) pp. 1261​-1262​.​ DOI: https://doi.org/10.1007/s00702-011-0669-7 
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• 2011 | Journal Article | 
  ​ ​Different CSF beta-amyloid processing in Alzheimer's and Creutzfeldt-Jakob disease​
  Mollenhauer, B.; Esselmann, H.; Roeber, S.; Schulz-Schaeffer, W. J.; Trenkwalder, C.; Bibl, M. & Steinacker, P. et al.​ (2011) 
  Journal of Neural Transmission, 118(5) pp. 691​-697​.​ DOI: https://doi.org/10.1007/s00702-010-0543-z 
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• 2011 | Journal Article | 
  ​ ​Cerebrospinal Fluid Tau, p-Tau 181 and Amyloid-β38/40/42 in Frontotemporal Dementias and Primary Progressive Aphasias​
  Bibl, M.; Mollenhauer, B.; Lewczuk, P.; Esselmann, H.; Wolf, S.; Otto, M. & Kornhuber, J. et al.​ (2011) 
  Dementia and Geriatric Cognitive Disorders, 31(1) pp. 37​-44​.​ DOI: https://doi.org/10.1159/000322370 
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• 2011 | Journal Article
  ​ ​Long-Term Stability of Alzheimer's Disease Biomarker Proteins in Cerebrospinal Fluid​
  Schipke, C. G.; Jessenb, F.; Teipel, S. J.; Luckhaus, C.; Wiltfang, J.; Esselmann, H. & Frolich, L. et al.​ (2011) 
  Journal of Alzheimer s Disease, 26(2) pp. 255​-262​.​ DOI: https://doi.org/10.3233/JAD-2011-110329 
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• 2011 | Journal Article
  ​ ​Atrophy outcomes in multicentre clinical trials on Alzheimer's disease: Effect of different processing and analysis approaches on sample sizes​
  Teipel, S. J.; Peters, O.; Heuser, I.; Jessen, F.; Maier, W.; Froelich, L. & Arlt, S. et al.​ (2011) 
  The World Journal of Biological Psychiatry, 12 pp. 109​-113​.​ DOI: https://doi.org/10.3109/15622975.2011.603222 
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• 2011 | Journal Article
  ​ ​CSF Amyloid-beta Peptides in Neuropathologically Diagnosed Dementia with Lewy Bodies and Alzheimer's Disease​
  Mollenhauer, B.; Esselmann, H.; Trenkwalder, C.; Schulz-Schaeffer, W. J.; Kretzschmar, H. A.; Otto, M. & Wiltfang, J. et al.​ (2011) 
  Journal of Alzheimer s Disease, 24(2) pp. 383​-391​.​ DOI: https://doi.org/10.3233/JAD-2011-101551 
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• 2011 | Journal Article | Research Paper
  ​ ​Beta-amyloid peptide variants in brains and cerebrospinal fluid from amyloid precursor protein (APP) transgenic mice: comparison with human Alzheimer amyloid​
  Schieb, H.; Kratzin, H.; Jahn, O. ; Möbius, W. ; Rabe, S.; Staufenbiel, M. & Wiltfang, J. et al.​ (2011) 
  The Journal of Biological Chemistry, 286(39) pp. 33747​-33758​.​ DOI: https://doi.org/10.1074/jbc.M111.246561 
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• 2012 | Journal Article
  ​ ​Aminoterminally Truncated and Oxidized Amyloid-beta Peptides in the Cerebrospinal Fluid of Alzheimer's Disease Patients​
  Bibl, M.; Gallus, M.; Welge, V.; Esselmann, H. & Wiltfang, J.​ (2012) 
  Journal of Alzheimer s Disease, 29(4) pp. 809​-816​.​ DOI: https://doi.org/10.3233/JAD-2012-111796 
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• 2012 | Journal Article | 
  ​ ​Cerebrospinal fluid amyloid-beta 2-42 is decreased in Alzheimer's, but not in frontotemporal dementia​
  Bibl, M.; Gallus, M.; Welge, V.; Esselmann, H.; Wolf, S.; Ruether, E. & Wiltfang, J.​ (2012) 
  Journal of Neural Transmission, 119(7) pp. 805​-813​.​ DOI: https://doi.org/10.1007/s00702-012-0801-3 
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• 2012 | Journal Article
  ​ ​Genome-Wide Association Study of Vascular Dementia​
  Schrijvers, E. M. C.; Schuermann, B.; Koudstaal, P. J.; van den Bussche, H.; van Duijn, C. M.; Hentschel, F. & Heun, R. et al.​ (2012) 
  Stroke, 43(2) pp. 315​-319​.​ DOI: https://doi.org/10.1161/STROKEAHA.111.628768 
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• 2012 | Journal Article
  ​ ​Plasma Amyloid-BetaPeptides in Acute Cerebral Ischemia: A Pilot Study​
  Bibl, M.; Welge, V.; Schmidt, H.; Esselmann, H.; Mollenhauer, B.; Lewczuk, P. & Otto, M. et al.​ (2012) 
  Journal of Clinical Laboratory Analysis, 26(4) pp. 238​-245​.​ DOI: https://doi.org/10.1002/jcla.21511 
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• 2012 | Journal Article | 
  ​ ​Differential Sialylation of Serpin A1 in the Early Diagnosis of Parkinson’s Disease Dementia​
  Jesse, S.; Lehnert, S.; Jahn, O.; Parnetti, L.; Soininen, H.; Herukka, S.-K. & Steinacker, P. et al.​ (2012) 
  PLoS ONE, 7(11) art. e48783​.​ DOI: https://doi.org/10.1371/journal.pone.0048783 
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• 2013 | Journal Article
  ​ ​P4–154: Subjective memory concerns, objective memory impairment and risk of Alzheimer's dementia in people with MCI​
  Wolfsgruber, S.; Wagner, M.; Wiltfang, J.; Maier, W.; Frolich, L.; Peters, O. & Rüther, E. et al.​ (2013) 
  Alzheimer's & Dementia, 9(4S_Part_19).​ DOI: https://doi.org/10.1016/j.jalz.2013.05.1545 
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• 2013 | Journal Article
  ​ ​APOE-Dependent Phenotypes in Subjects with Mild Cognitive Impairment Converting to Alzheimer's Disease​
  Morgen, K.; Froelich, L.; Tost, H.; Plichta, M. M.; Koelsch, H.; Rakebrandt, F. & Rienhoff, O. et al.​ (2013) 
  Journal of Alzheimer s Disease, 37(2) pp. 389​-401​.​ DOI: https://doi.org/10.3233/JAD-130326 
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• 2013 | Journal Article | Research Paper
  ​ ​Analysis of amino-terminal variants of amyloid-β peptides by capillary isoelectric focusing immunoassay​
  Haußmann, U.; Jahn, O. ; Linning, P.; Janßen, C.; Liepold, T.; Portelius, E. & Zetterberg, H. et al.​ (2013) 
  Analytical Chemistry, 85(17) pp. 8142​-8149​.​ DOI: https://doi.org/10.1021/ac401055y 
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• 2014 | Journal Article | 
  ​ ​Memory Concerns, Memory Performance and Risk of Dementia in Patients with Mild Cognitive Impairment​
  Wolfsgruber, S.; Wagner, M.; Schmidtke, K.; Froelich, L.; Kurz, A.; Schulz, S. & Hampel, H. et al.​ (2014) 
  PLoS ONE, 9(7) art. e100812​.​ DOI: https://doi.org/10.1371/journal.pone.0100812 
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• 2014 | Journal Article
  ​ ​Investigation of the role of rare TREM2 variants in frontotemporal dementia subtypes​
  Thelen, M.; Razquin, C.; Hernandez, I.; Gorostidi, A.; Sanchez-Valle, R.; Ortega-Cubero, S. & Wolfsgruber, S. et al.​ (2014) 
  Neurobiology of Aging, 35(11) art. 2657.e13​.​ DOI: https://doi.org/10.1016/j.neurobiolaging.2014.06.018 
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• 2014 | Journal Article
  ​ ​Genetic interaction of PICALM and APOE is associated with brain atrophy and cognitive impairment in Alzheimer's disease​
  Morgen, K.; Ramirez, A.; Froelich, L.; Tost, H.; Plichta, M. M.; Koelsch, H. & Rakebrandt, F. et al.​ (2014) 
  Alzheimer s & Dementia, 10(5) pp. S269​-S276​.​ DOI: https://doi.org/10.1016/j.jalz.2013.11.001 
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• 2014 | Journal Article | 
  ​ ​Mismatch Negativity Latency and Cognitive Function in Schizophrenia​
  Kaergel, C.; Sartory, G.; Kariofillis, D.; Wiltfang, J. & Mueller, B. W.​ (2014) 
  PLoS ONE, 9(4) art. e84536​.​ DOI: https://doi.org/10.1371/journal.pone.0084536 
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• 2015 | Conference Abstract
  ​ ​Aerobic but not General Physical Activity in the Healthy Elderly Is Associated with Larger Plasticity in Memory Related Brain Structures and Lower Systemic Inflammation​
  Tendolkar, I.; Thielen, J. W.; Mueller, B.; Kaergel, C.; Norris, D. & Wiltfang, J.​ (2015)
  Biological Psychiatry, 77(9) ​70th Annual Scientific Meeting of the Society-of-Biological-Psychiatry on Stress, Emotion, Neurodevelopment and Psychopathology​, Toronto, CANADA.
  New york​: Elsevier Science Inc.
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• 2016 | Journal Article
  ​ ​P4‐122: Prevalence of Vascular Risk Factors in Different Stages of Prodromal Alzheimer’s Disease and Its Influence on Cognitive Decline​
  Bos, I.; Vos, S. J.; Frölich, L.; Kornhuber, J.; Wiltfang, J.; Maier, W. & Peters, O. et al.​ (2016) 
  Alzheimer's & Dementia, 12(7S_Part_22).​ DOI: https://doi.org/10.1016/j.jalz.2016.06.2213 
  ​Details  DOI 

• 2016 | Journal Article
  ​ ​P4‐174: Evaluation of Cutoff Values For Fully Automated Hippocampus Volumetry With Fsl‐First For Prediction Of Alzheimer's Disease Dementia In Mci Subjects​
  Suppa, P.; Schipke, C. G.; Spies, L.; Wiltfang, J. & Peters, O.​ (2016) 
  Alzheimer's & Dementia, 12(7S_Part_22).​ DOI: https://doi.org/10.1016/j.jalz.2016.06.2266 
  ​Details  DOI 

• 2016 | Journal Article | 
  ​ ​Validation of a Commercial Chemiluminescence Immunoassay for the Simultaneous Measurement of Three Different Amyloid-beta Peptides in Human Cerebrospinal Fluid and Application to a Clinical Cohort​
  Klafki, H.-W.; Hafermann, H.; Bauer, C. R.; Haussmann, U.; Kraus, I.; Schuchhardt, J. & Muck, S. et al.​ (2016) 
  Journal of Alzheimer s Disease, 54(2) pp. 691​-705​.​ DOI: https://doi.org/10.3233/JAD-160398 
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• 2016 | Journal Article
  ​ ​N-Truncated A beta(2-X) Starting with Position Two in Sporadic Alzheimer's Disease Cases and Two Alzheimer Mouse Models​
  Savastano, A.; Klafki, H.; Haussman, U.; Oberstein, T. J.; Mueller, P.; Wirths, O. & Wiltfang, J. et al.​ (2016) 
  Journal of Alzheimer s Disease, 49(1) pp. 101​-110​.​ DOI: https://doi.org/10.3233/JAD-150394 
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• 2016 | Journal Article
  ​ ​The Latent Dementia Phenotype delta is Associated with Cerebrospinal Fluid Biomarkers of Alzheimer's Disease and Predicts Conversion to Dementia in Subjects with Mild Cognitive Impairment​
  Koppara, A.; Wolfsgruber, S.; Kleineidam, L.; Schmidtke, K.; Froelich, L.; Kurz, A. & Schulz, S. et al.​ (2016) 
  Journal of Alzheimer s Disease, 49(2) pp. 547​-560​.​ DOI: https://doi.org/10.3233/JAD-150257 
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• 2017 | Journal Article
  ​ ​[IC‐P‐030]: Connectivity of the Left Frontal Cortex Attenuates Detrimental Effects of Csf‐Tau on Memory in Preclinical and Clinical Alzheimer's Disease​
  Franzmeier, N.; Wolfsgruber, S.; Ramirez, A.; Wagner, M.; Buerger, K.; Dichgans, M. & Heneka, M. et al.​ (2017) 
  Alzheimer's & Dementia, 13(7S_Part_1).​ DOI: https://doi.org/10.1016/j.jalz.2017.06.2302 
  ​Details  DOI 

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