Author Wirths, Oliver
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2007 | Conference Abstract
A beta-induced pathology and neuron loss in the cholinergic system of the APP/PS1ki mouse model of Alzheimer's disease
Christensen, D. Z.; Bayer, T. & Wirths, O. (2007)
Biochemical Pharmacology, 74(8) Symposium on Nicotinic Acetylcholine Receptors as Therapeutic Targets, San Diego, CA.
Oxford: Pergamon-elsevier Science Ltd.
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2007 | Journal Article
Altered cholesterol metabolism in APP695-transfected neuroblastoma cells
Wirths, O.; Thelen, K. M.; Luetjohann, D.; Falkai, P. & Bayer, T. A. (2007)
Brain Research, 1152 pp. 209-214. DOI: https://doi.org/10.1016/j.brainres.2007.03.029
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2008 | Journal Article |
Effect of copper intake on CSF parameters in patients with mild Alzheimer’s disease: a pilot phase 2 clinical trial
Kessler, H.; Pajonk, F.-G.; Bach, D.; Schneider-Axmann, T.; Falkai, P.; Herrmann, W. & Multhaup, G. et al. (2008)
Journal of Neural Transmission, 115(12) pp. 1651-1659. DOI: https://doi.org/10.1007/s00702-008-0136-2
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2008 | Journal Article
Alzheimer's disease Molecular pathology, animal models, and current treatment
Bayer, T. A. & Wirths, O. (2008)
Der Nervenarzt, 79 pp. 117-125. DOI: https://doi.org/10.1007/s00115-008-2496-0
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2008 | Conference Paper
Review on the APP/PS1KI mouse model: intraneuronal A beta accumulation triggers axonopathy, neuron loss and working memory impairment
Bayer, T. A. & Wirths, O. (2008)
Genes, Brain and Behavior, 7 pp. 6-11. Annual Meeting of the Genes-Brain-and-Behavior-Society, Doorwerth, NETHERLANDS.
Oxford: Blackwell Publishing. DOI: https://doi.org/10.1111/j.1601-183X.2007.00372.x
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2008 | Journal Article
Age-dependent loss of dentate gyrus granule cells in APP/PS1KI mice
Cotel, M.-C.; Bayer, T. A. & Wirths, O. (2008)
Brain Research, 1222 pp. 207-213. DOI: https://doi.org/10.1016/j.brainres.2008.05.052
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2008 | Journal Article
Deficits in working memory and motor performance in the APP/PS1ki mouse model for Alzheimer's disease
Wirths, O.; Breyhan, H.; Schaefer, S.; Roth, C. & Bayer, T. A. (2008)
Neurobiology of Aging, 29(6) pp. 891-901. DOI: https://doi.org/10.1016/j.neurobiolaging.2006.12.004
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2008 | Journal Article
Motor impairment in Alzheimer's disease and transgenic Alzheimer's disease mouse models
Wirths, O. & Bayer, T. A. (2008)
Genes, Brain and Behavior, 7 pp. 1-5. DOI: https://doi.org/10.1111/j.1601-183X.2007.00373.x
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2008 | Journal Article |
Transient intraneuronal A beta rather than extracellular plaque pathology correlates with neuron loss in the frontal cortex of APP/PS1KI mice
Christensen, D. Z.; Kraus, S. L.; Flohr, A.; Cotel, M.-C.; Wirths, O. & Bayer, T. A. (2008)
Acta Neuropathologica, 116(6) pp. 647-655. DOI: https://doi.org/10.1007/s00401-008-0451-6
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2008 | Conference Paper |
Intraneuronal beta-amyloid is a major risk factor - Novel evidence from the APP/PS1KI mouse model
Bayer, T. A.; Breyhan, H.; Duan, K.; Rettig, J. & Wirths, O. (2008)
Neurodegenerative Diseases, 5(3-4) pp. 140-142. 8th International Conference on Alzheimers and Parkinsons Diseases, Salzburg, AUSTRIA.
Basel: Karger. DOI: https://doi.org/10.1159/000113684
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2009 | Conference Abstract
Increasing Abeta peptide levels aggravate axonal degeneration in an Alzheimer mouse model
Wirths, O.; Christensen, D. Z. & Bayer, T. A. (2009)
Journal of Neurochemistry, 110 pp. 38-39. 4th European-Society-for-Neurochemistry Conference on Advances in Molecular Mechanisms of Neurological Disorders, Leipzig, GERMANY.
Malden: Wiley-blackwell Publishing, Inc.
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2009 | Conference Abstract
Alzheimer's Disease pathology is not sufficient for CCR2(+) bone marrow engraftment in the CNS
Mildner, A.; Schlevogt, B.; Kierdorf, K.; Boettcher, C.; Kummer, M. P.; Wirths, O. & Henneka, M. et al. (2009)
Acta Neuropathologica, 118(3) 54th Annual Meeting of the German-Society-of-Neuropathology-and-Neuroanatomy, Dusseldorf, GERMANY.
New york: Springer.
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2009 | Journal Article
The modified amyloid hypothesis of Alzheimer dementia - intraneuronal Abeta induces neurodegeneration
Wirths, O. & Bayer, T. A. (2009)
Neuroforum, 15(3) pp. 76-82.
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2009 | Conference Abstract
Paradigm shift in Abeta toxicity
Bayer, T. A. & Wirths, O. (2009)
European Neuropsychopharmacology, 19 22nd Congress of the European-College-of-Neuropsychopharmacology, Istanbul, TURKEY.
Amsterdam: Elsevier Science Bv.
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2009 | Journal Article |
Circulating immune complexes of Aβ and IgM in plasma of patients with Alzheimer’s disease
Marcello, A.; Wirths, O.; Schneider-Axmann, T.; Degerman-Gunnarsson, M.; Lannfelt, L. & Bayer, T. (2009)
Journal of Neural Transmission, 116(7) pp. 913-920. DOI: https://doi.org/10.1007/s00702-009-0224-y
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2009 | Journal Article |
APP/PS1KI bigenic mice develop early synaptic deficits and hippocampus atrophy
Breyhan, H.; Wirths, O.; Duan, K.; Marcello, A.; Rettig, J. & Bayer, T. A. (2009)
Acta Neuropathologica, 117(6) pp. 677-685. DOI: https://doi.org/10.1007/s00401-009-0539-7
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2009 | Journal Article |
Intraneuronal pyroglutamate-Abeta 3-42 triggers neurodegeneration and lethal neurological deficits in a transgenic mouse model
Wirths, O.; Breyhan, H.; Cynis, H.; Schilling, S.; Demuth, H.-U. & Bayer, T. A. (2009)
Acta Neuropathologica, 118(4) pp. 487-496. DOI: https://doi.org/10.1007/s00401-009-0557-5
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2009 | Journal Article
Formic acid is essential for immunohistochemical detection of aggregated intraneuronal A beta peptides in mouse models of Alzheimer's disease
Christensen, D. Z.; Bayer, T. A. & Wirths, O. (2009)
Brain Research, 1301 pp. 116-125. DOI: https://doi.org/10.1016/j.brainres.2009.09.014
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2010 | Journal Article
Gene expression of neuregulin-1 isoforms in different brain regions of elderly schizophrenia patients
Parlapani, E.; Schmitt, A.; Wirths, O.; Bauer, M.; Sommer, C.; Rueb, U. & Skowronek, M. H. et al. (2010)
The World Journal of Biological Psychiatry, 11(2) pp. 243-250. DOI: https://doi.org/10.3109/15622970802022376
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2010 | Journal Article
Concomitant detection of beta-amyloid peptides with N-terminal truncation and different C-terminal endings in cortical plaques from cases with Alzheimer's disease, senile monkeys and triple transgenic mice
Haertig, W.; Goldhammer, S.; Bauer, U.; Wegner, F.; Wirths, O.; Bayer, T. A. & Grosche, J. (2010)
Journal of Chemical Neuroanatomy, 40(1) pp. 82-92. DOI: https://doi.org/10.1016/j.jchemneu.2010.03.006
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2010 | Review |
Intracellular accumulation of amyloid-beta - a predictor for synaptic dysfunction and neuron loss in Alzheimer's disease
Bayer, T. A.& Wirths, O. (2010)
Frontiers in Aging Neuroscience, 2.
Frontiers Research Foundation. DOI: https://doi.org/10.3389/fnagi.2010.00008
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2010 | Journal Article
Intracellular A beta triggers neuron loss in the cholinergic system of the APP/PS1KI mouse model of Alzheimer's disease
Christensen, D. Z.; Bayer, T. A. & Wirths, O. (2010)
Neurobiology of Aging, 31(7) pp. 1153-1163. DOI: https://doi.org/10.1016/j.neurobiolaging.2008.07.022
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2010 | Journal Article |
Histone Deacetylase Inhibitor Valproic Acid Inhibits Cancer Cell Proliferation via Down-regulation of the Alzheimer Amyloid Precursor Protein
Venkataramani, V. ; Rossner, C.; Iffland, L.; Schweyer, S.; Tamboli, I. Y.; Walter, J. & Wirths, O. et al. (2010)
Journal of Biological Chemistry, 285(14) pp. 10678-10689. DOI: https://doi.org/10.1074/jbc.M109.057836
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2010 | Journal Article |
Pyroglutamate Abeta pathology in APP/PS1KI mice, sporadic and familial Alzheimer's disease cases
Wirths, O.; Bethge, T.; Marcello, A.; Harmeier, A.; Jawhar, S.; Lucassen, P. J. & Multhaup, G. et al. (2010)
Journal of Neural Transmission, 117(1) pp. 85-96. DOI: https://doi.org/10.1007/s00702-009-0314-x
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2010 | Journal Article
Inflammatory changes are tightly associated with neurodegeneration in the brain and spinal cord of the APP/PS1KI mouse model of Alzheimer's disease
Wirths, O.; Breyhan, H.; Marcello, A.; Cotel, M.-C.; Brueck, W. & Bayer, T. A. (2010)
Neurobiology of Aging, 31(5) pp. 747-757. DOI: https://doi.org/10.1016/j.neurobiolaging.2008.06.011
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2010 | Journal Article
Identification of Low Molecular Weight Pyroglutamate A beta Oligomers in Alzheimer Disease A NOVEL TOOL FOR THERAPY AND DIAGNOSIS
Wirths, O.; Erck, C.; Martens, H.; Harmeier, A.; Geumann, C. ; Jawhar, S. & Kumar, S. et al. (2010)
Journal of Biological Chemistry, 285(53) pp. 41517-41524. DOI: https://doi.org/10.1074/jbc.M110.178707
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2010 | Journal Article |
Neuron loss in transgenic mouse models of Alzheimer's disease.
Wirths, O. & Bayer, T. A. (2010)
International journal of Alzheimer's disease, 2010 art. 723782. DOI: https://doi.org/10.4061/2010/723782
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2010 | Journal Article |
Accumulation of intraneuronal A beta correlates with ApoE4 genotype
Christensen, D. Z.; Schneider-Axmann, T.; Lucassen, P. J.; Bayer, T. A. & Wirths, O. (2010)
Acta Neuropathologica, 119(5) pp. 555-566. DOI: https://doi.org/10.1007/s00401-010-0666-1
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2011 | Journal Article
Overexpression of Glutaminyl Cyclase, the Enzyme Responsible for Pyroglutamate Aβ Formation, Induces Behavioral Deficits, and Glutaminyl Cyclase Knock-out Rescues the Behavioral Phenotype in 5XFAD Mice
Jawhar, S.; Wirths, O.; Schilling, S.; Graubner, S.; Demuth, H.-U. & Bayer, T. A. (2011)
Journal of Biological Chemistry, 286(6) pp. 4454-4460. DOI: https://doi.org/10.1074/jbc.M110.185819
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2011 | Journal Article
Reduced levels of IgM autoantibodies against N-truncated pyroglutamate Aβ in plasma of patients with Alzheimer's disease
Marcello, A.; Wirths, O.; Schneider-Axmann, T.; Degerman-Gunnarsson, M.; Lannfelt, L. & Bayer, T. A. (2011)
Neurobiology of Aging, 32(8) pp. 1379-1387. DOI: https://doi.org/10.1016/j.neurobiolaging.2009.08.011
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2011 | Journal Article
Intraneuronal A beta as a trigger for neuron loss: can this be translated into human pathology?
Bayer, T. A. & Wirths, O. (2011)
Biochemical Society Transactions, 39 pp. 857-861. DOI: https://doi.org/10.1042/BST0390857
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2011 | Review
Pyroglutamate Amyloid-beta (A beta): A Hatchet Man in Alzheimer Disease
Jawhar, S.; Wirths, O.& Bayer, T. A. (2011)
Journal of Biological Chemistry, 286(45) pp. 38825-38832.
Amer Soc Biochemistry Molecular Biology Inc. DOI: https://doi.org/10.1074/jbc.R111.288308
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2012 | Conference Abstract
The Alzheimer Amyloid Precursor Protein (APP) is a biomarker for transformed human pluripotent stem cells - from Alzheimer's disease to cancer biology and beyond
Venkataramani, V.; Behnes, C. L.; Thiele, K.; Wulf, G. G.; Thelen, F.; Opitz, L. & Salinas-Riester, G. et al. (2012)
Onkologie, 35
Basel: Karger.
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2012 | Journal Article |
Amyloid Precursor Protein Is a Biomarker for Transformed Human Pluripotent Stem Cells
Venkataramani, V.; Thiele, K.; Behnes, C. L.; Wulf, G. G.; Thelen, P.; Opitz, L. & Salinas-Riester, G. et al. (2012)
The American Journal of Pathology, 180(4) pp. 1636-1652. DOI: https://doi.org/10.1016/j.ajpath.2011.12.015
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2012 | Journal Article
A beta PP Accumulation and/or Intraneuronal Amyloid-beta Accumulation? The 3xTg-AD Mouse Model Revisited
Wirths, O.; Dins, A. & Bayer, T. A. (2012)
Journal of Alzheimer s Disease, 28(4) pp. 897-904. DOI: https://doi.org/10.3233/JAD-2011-111529
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2012 | Journal Article
Motor deficits, neuron loss, and reduced anxiety coinciding with axonal degeneration and intraneuronal A beta aggregation in the 5XFAD mouse model of Alzheimer's disease
Jawhar, S.; Trawicka, A.; Jenneckens, C.; Bayer, T. A. & Wirths, O. (2012)
Neurobiology of Aging, 33(1) art. 196.e29. DOI: https://doi.org/10.1016/j.neurobiolaging.2010.05.027
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2012 | Review
Intraneuronal A beta accumulation and neurodegeneration: Lessons from transgenic models
Wirths, O.& Bayer, T. A. (2012)
Life Sciences, 91(23-24) pp. 1148-1152.
Pergamon-elsevier Science Ltd. DOI: https://doi.org/10.1016/j.lfs.2012.02.001
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2012 | Journal Article
Antibody 9D5 Recognizes Oligomeric Pyroglutamate Amyloid-beta in a Fraction of Amyloid-beta Deposits in Alzheimer's Disease without Cross-Reactivity with other Protein Aggregates
Venkataramani, V.; Wirths, O.; Budka, H.; Haertig, W.; Kovacs, G. G. & Bayer, T. A. (2012)
Journal of Alzheimer s Disease, 29(2) pp. 361-371. DOI: https://doi.org/10.3233/JAD-2011-111379
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2012 | Journal Article
No improvement after chronic ibuprofen treatment in the 5XFAD mouse model of Alzheimer's disease
Hillmann, A.; Hahn, S.; Schilling, S.; Hoffmann, T.; Demuth, H.-U.; Bulic, B. & Schneider-Axmann, T. et al. (2012)
Neurobiology of Aging, 33(4) art. 833.e39. DOI: https://doi.org/10.1016/j.neurobiolaging.2011.08.006
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2012 | Journal Article
Environmental enrichment fails to rescue working memory deficits, neuron loss, and neurogenesis in APP/PS1KI mice
Cotel, M.-C.; Jawhar, S.; Christensen, D. Z.; Bayer, T. A. & Wirths, O. (2012)
Neurobiology of Aging, 33(1) pp. 96-107. DOI: https://doi.org/10.1016/j.neurobiolaging.2010.02.012
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2012 | Journal Article
Pyroglutamate Amyloid beta (A beta) Aggravates Behavioral Deficits in Transgenic Amyloid Mouse Model for Alzheimer Disease
Wittnam, J. L.; Portelius, E.; Zetterberg, H.; Gustavsson, M. K.; Schilling, S.; Koch, B. & Demuth, H.-U. et al. (2012)
Journal of Biological Chemistry, 287(11) pp. 8154-8162. DOI: https://doi.org/10.1074/jbc.M111.308601
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2013 | Journal Article
P2–381: Tg4–42: A new mouse model of Alzheimer's disease—N‐truncated beta‐amyloid 4–42 affects memory decline and synaptic plasticity
Dietrich, K.; Bouter, Y.; Wittnam, J.; Pillot, T.; Papot‐Couturier, S.; Lefebvre, T. & Sprenger, F. et al. (2013)
Alzheimer's & Dementia, 9(4S_Part_12). DOI: https://doi.org/10.1016/j.jalz.2013.05.1030
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2013 | Journal Article
Accelerated tau pathology with synaptic and neuronal loss in a novel triple transgenic mouse model of Alzheimer's disease
Saul, A.; Sprenger, F.; Bayer, T. A. & Wirths, O. (2013)
Neurobiology of Aging, 34(11) pp. 2564-2573. DOI: https://doi.org/10.1016/j.neurobiolaging.2013.05.003
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2013 | Journal Article
P2–382: Tg4–42: A new mouse model of Alzheimer's disease—N‐truncated amyloid β (Aβ) 4–42 induces severe neuron loss and behavioral deficits
Bouter, Y.; Dietrich, K.; Wittnam, J.; Pillot, T.; Papot‐Couturier, S.; Lefebvre, T. & Sprenger, F. et al. (2013)
Alzheimer's & Dementia, 9(4S_Part_12). DOI: https://doi.org/10.1016/j.jalz.2013.05.1031
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2013 | Journal Article
Early intraneuronal accumulation and increased aggregation of phosphorylated Abeta in a mouse model of Alzheimer's disease
Kumar, S.; Wirths, O.; Theil, S.; Gerth, J.; Bayer, T. A. & Walter, J. (2013)
Acta Neuropathologica, 125(5) pp. 699-709. DOI: https://doi.org/10.1007/s00401-013-1107-8
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2013 | Journal Article |
The Arctic AβPP mutation leads to Alzheimer's disease pathology with highly variable topographic deposition of differentially truncated Aβ.
Kalimo, H.; Lalowski, M.; Bogdanovic, N.; Philipson, O.; Bird, T. D.; Nochlin, D. & Schellenberg, G. D. et al. (2013)
Acta neuropathologica communications, 1(1). DOI: https://doi.org/10.1186/2051-5960-1-60
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2013 | Journal Article
Abundant pyroglutamate-modified ABri and ADan peptides in extracellular and vascular amyloid deposits in familial British and Danish dementias
Saul, A. ; Lashley, T.; Revesz, T.; Holton, J.; Ghiso, J. A.; Coomaraswamy, J. & Wirths, O. (2013)
Neurobiology of Aging, 34(5) pp. 1416-1425. DOI: https://doi.org/10.1016/j.neurobiolaging.2012.11.014
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2013 | Journal Article
Oligomeric Pyroglutamate Amyloid-beta is Present in Microglia and a Subfraction of Vessels in Patients with Alzheimer's Disease: Implications for Immunotherapy
Wirths, O.; Hillmann, A.; Pradier, L.; Haertig, W. & Bayer, T. A. (2013)
Journal of Alzheimer s Disease, 35(4) pp. 741-749. DOI: https://doi.org/10.3233/JAD-121945
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2013 | Journal Article |
N-truncated amyloid beta (A beta) 4-42 forms stable aggregates and induces acute and long-lasting behavioral deficits
Bouter, Y.; Dietrich, K.; Wittnam, J. L.; Rezaei-Ghaleh, N.; Pillot, T.; Papot-Couturier, S. & Lefebvre, T. et al. (2013)
Acta Neuropathologica, 126(2) pp. 189-205. DOI: https://doi.org/10.1007/s00401-013-1129-2
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2014 | Journal Article |
Deciphering the molecular profile of plaques, memory decline and neuron loss in two mouse models for Alzheimer's disease by deep sequencing
Bouter, Y.; Kacprowski, T.; Weissmann, R.; Dietrich, K.; Borgers, H.; Brauss, A. & Sperling, C. et al. (2014)
Frontiers in Aging Neuroscience, 6. DOI: https://doi.org/10.3389/fnagi.2014.00075
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