Author Giese, Armin

• 1999 | Journal Article | Research Paper
  ​ ​Evidence of presynaptic location and function of the prion protein​
  Herms, J.; Tings, T.; Gall, S.; Madlung, A.; Giese, A.; Siebert, H.   & Schurmann, P. et al.​ (1999) 
  The Journal of neuroscience, 19(20) pp. 8866​-8875​.​ DOI: https://doi.org/10.1523/JNEUROSCI.19-20-08866.1999 
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• 2009 | Journal Article | 
  ​ ​Incidence and spectrum of sporadic Creutzfeldt-Jakob disease variants with mixed phenotype and co-occurrence of PrPSc types: an updated classification​
  Parchi, P.; Strammiello, R.; Notari, S.; Giese, A.; Langeveld, J. P. M.; Ladogana, A. & Zerr, I. et al.​ (2009) 
  Acta Neuropathologica, 118(5) pp. 659​-671​.​ DOI: https://doi.org/10.1007/s00401-009-0585-1 
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• 2010 | Journal Article
  ​ ​Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1​
  Kamp, F.; Exner, N.; Lutz, A. K.; Wender, N.; Hegermann, J.; Brunner, B. & Nuscher, B. et al.​ (2010) 
  The EMBO Journal, 29(20) pp. 3571​-3589​.​ DOI: https://doi.org/10.1038/emboj.2010.223 
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• 2010 | Journal Article
  ​ ​Agent strain variation in human prion disease: insights from a molecular and pathological review of the National Institutes of Health series of experimentally transmitted disease​
  Parchi, P.; Cescatti, M.; Notari, S.; Schulz-Schaeffer, W. J.; Capellari, S.; Giese, A. & Zou, W.-Q. et al.​ (2010) 
  Brain, 133 pp. 3030​-3042​.​ DOI: https://doi.org/10.1093/brain/awq234 
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• 2011 | Journal Article
  ​ ​Comprehensive Neuropathologic Analysis of Genetic Prion Disease Associated With the E196K Mutation in PRNP Reveals Phenotypic Heterogeneity​
  Eigenbrod, S.; Frick, P.; Giese, A.; Schelzke, G.; Zerr, I. & Kretzschmar, H. A.​ (2011) 
  Journal of Neuropathology and Experimental Neurology, 70(3) pp. 192​-200​.​ DOI: https://doi.org/10.1097/NEN.0b013e31820cd8a4 
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• 2014 | Journal Article | Letter Note | 
  ​ ​The oligomer modulator anle138b inhibits disease progression in a Parkinson mouse model even with treatment started after disease onset​
  Levin, J.; Schmidt, F.; Boehm, C.; Prix, C.; Boetzel, K.; Ryazanov, S.   & Leonov, A.  et al.​ (2014) 
  Acta Neuropathologica, 127(5) pp. 779​-780​.​ DOI: https://doi.org/10.1007/s00401-014-1265-3 
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• 2015 | Conference Abstract
  ​ ​Assessing the pathogenicity of rare PRNP variants by comparing case and control allele frequency​
  Minikel, E. V.; Vallabh, S. M.; Lek, M.; Estrada, K. O.; Samocha, K. E.; Sathirapongsasuti, J. F. & McLean, C. Y. et al.​ (2015)
  Prion, 9 pp. S90​-S91. 
  Philadelphia​: Taylor & Francis Inc.
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• 2015 | Journal Article
  ​ ​The Novel Inhibitor “Anle145C” Efficiently Inhibits Fibril Formation of Islet Amyloid Polypeptide (IAPP) and uses Distinctly Different Modes of Action in the Absence and Presence of Membranes​
  Saravanan, M. S.; Ryazanov, S.; Leonov, A.; Seeliger, J.; Winter, R.; Giese, A. & Griesinger, C.  et al.​ (2015) 
  Biophysical Journal, 108(2) pp. 256a​.​ DOI: https://doi.org/10.1016/j.bpj.2014.11.1416 
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• 2015 | Journal Article | Research Paper
  ​ ​Anle138b and related compounds are aggregation specific fluorescence markers and reveal high affinity binding to ot-synuclein aggregates​
  Deeg, A. A.; Reiner, A. M.; Schmidt, F.; Schueder, F.; Ryazanov, S. ; Ruf, V. C. & Giller, K.  et al.​ (2015) 
  Biochimica et Biophysica Acta (BBA) - General Subjects, 1850(9) pp. 1884​-1890​.​ DOI: https://doi.org/10.1016/j.bbagen.2015.05.021 
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• 2015 | Journal Article | Research Paper | 
  ​ ​Extracellular vesicle sorting of alpha-Synuclein is regulated by sumoylation​
  Kunadt, M.; Eckermann, K.; Stuendl, A.; Gong, J.; Russo, B.; Strauss, K. & Rai, S. et al.​ (2015) 
  Acta Neuropathologica, 129(5) pp. 695​-713​.​ DOI: https://doi.org/10.1007/s00401-015-1408-1 
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• 2015 | Journal Article | Research Paper
  ​ ​Quantitative Real-Time Quaking-Induced Conversion Allows Monitoring of Disease-Modifying Therapy in the Urine of Prion-Infected Mice​
  Shi, S.; Wagner, J. ; Mitteregger-Kretzschmar, G.; Ryazanov, S. ; Leonov, A. ; Griesinger, C.   & Giese, A.​ (2015) 
  Journal of Neuropathology and Experimental Neurology, 74(9) pp. 924​-933​.​ DOI: https://doi.org/10.1097/NEN.0000000000000233 
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• 2016 | Journal Article
  ​ ​Effect of the Novel Amyloid Inhibitor “anle145c” on Aggregation of Islet Amyloid Polypeptide and how it is Modulated by Membranes​
  Sadasivam, S. M.; Ryazanov, S. ; Leonov, A. ; Roeters, S.; Wouterson, S.; Giese, A. & Griesinger, C.  et al.​ (2016) 
  Biophysical Journal, 110(3) art. 420a​.​ DOI: https://doi.org/10.1016/j.bpj.2015.11.2271 
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• 2016 | Journal Article | 
  ​ ​The PROMESA-protocol: progression rate of multiple system atrophy under EGCG supplementation as anti-aggregation-approach (vol 123, pg 439, 2016)​
  Levin, J.; Maass, S.; Schuberth, M.; Respondek, G.; Paul, F.; Mansmann, U. & Oertel, W. H. et al.​ (2016) 
  Journal of Neural Transmission, 123(11) pp. 1357​-1358​.​ DOI: https://doi.org/10.1007/s00702-016-1602-x 
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• 2016 | Journal Article
  ​ ​Quantifying prion disease penetrance using large population control cohorts​
  Minikel, E. V.; Vallabh, S. M.; Lek, M.; Estrada, K. O.; Samocha, K. E.; Sathirapongsasuti, J. F. & McLean, C. Y. et al.​ (2016) 
  Science Translational Medicine, 8(322) art. 322ra9​.​ DOI: https://doi.org/10.1126/scitranslmed.aad5169 
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• 2016 | Journal Article | Research Paper | 
  ​ ​Anle138b Partly Ameliorates Motor Deficits Despite Failure of Neuroprotection in a Model of Advanced Multiple System Atrophy​
  Fellner, L.; Kuzdas-Wood, D.; Levin, J.; Ryazanov, S. ; Leonov, A. ; Griesinger, C.   & Giese, A. et al.​ (2016) 
  Frontiers in Neuroscience, 10 art. 99​.​ DOI: https://doi.org/10.3389/fnins.2016.00099 
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• 2017 | Journal Article
  ​ ​Treatment with diphenyl–pyrazole compound anle138b/c reveals that α-synuclein protects melanoma cells from autophagic cell death​
  Turriani, E.; Lázaro, D. F. ; Ryazanov, S. ; Leonov, A. ; Giese, A.; Schön, M.   & Schön, M. P.  et al.​ (2017) 
  Proceedings of the National Academy of Sciences of the United States of America, 114(25) pp. E4971​-E4977​.​ DOI: https://doi.org/10.1073/pnas.1700200114 
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• 2017 | Journal Article
  ​ ​Photophysics of diphenyl-pyrazole compounds in solutions and α-synuclein aggregates​
  Reiner, A. M.; Schmidt, F.; Ryazanov, S. ; Leonov, A. ; Weckbecker, D.; Deeg, A. A. & Griesinger, C.  et al.​ (2017) 
  Biochimica et Biophysica Acta (BBA) - General Subjects, 1862(4) pp. 800​-807​.​ DOI: https://doi.org/10.1016/j.bbagen.2017.12.007 
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• 2017 | Journal Article
  ​ ​Clinical diagnosis of progressive supranuclear palsy: The movement disorder society criteria​
  Höglinger, G.; Respondek, G.; Stamelou, M.; Kurz, C.; Josephs, K.; Lang, A. & Mollenhauer, B.  et al.​ (2017) 
  Movement Disorders, 32(6) pp. 853​-864​.​ DOI: https://doi.org/10.1002/mds.26987 
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• 2017 | Journal Article
  ​ ​Which ante mortem clinical features predict progressive supranuclear palsy pathology?​
  Respondek, G.; Kurz, C.; Arzberger, T.; Compta, Y.; Englund, E.; Ferguson, L. & Gelpi, E. et al.​ (2017) 
  Movement Disorders, 32(7) pp. 995​-1005​.​ DOI: https://doi.org/10.1002/mds.27034 
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• 2017 | Journal Article | 
  ​ ​The diphenylpyrazole compound anle138b blocks Aβ channels and rescues disease phenotypes in a mouse model for amyloid pathology​
  Martinez-Hernandez, A. ; Urbanke, H. ; Gillman, A. L.; Lee, J.; Ryazanov, S. ; Agbemenyah, H. Y.   & Benito, E.  et al.​ (2017) 
  EMBO molecular medicine, 10(1) pp. 32​-47​.​ DOI: https://doi.org/10.15252/emmm.201707825 
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