Author Saher, Gesine

1 to 20 of 22 Items
  • 2005 Journal Article
    ​ ​High cholesterol level is essential for myelin membrane growth​
    Saher, G.; Brügger, B.; Lappe-Siefke, C.; Möbius, W. ; Tozawa, R.-i.; Wehr, M. C & Wieland, F. et al.​ (2005) 
    Nature Neuroscience8(4) pp. 468​-475​.​ DOI: https://doi.org/10.1038/nn1426 
    Details  DOI 
  • 2007 Journal Article | 
    ​ ​Survival of adult neurons lacking cholesterol synthesis in vivo​
    Fünfschilling, U.; Saher, G.; Xiao, L.; Möbius, W.   & Nave, K.-A.​ (2007) 
    BMC Neuroscience8(1) pp. 1​-9​.​ DOI: https://doi.org/10.1186/1471-2202-8-1 
    Details  DOI 
  • 2009 Conference Abstract
    ​ ​High-Level Expression of the Proteolipids Plp and M6b is Sufficient to Induce Oligodendroglial Process Outgrowth in Vitro and Required for Normal Myelination in Vivo​
    de Monasterio-Schrader, P. ; Werner, H. B. ; Kraemer-Albers, E.-M.; Strenzke, N. ; Saher, G.; Möbius, W.   & Tenzer, S. et al.​ (2009)
    Glia57(13) pp. S115​-S116. ​9th European Meeting on Glial Cells in Health and Disease​, Paris, FRANCE.
    Hoboken​: Wiley-liss.
    Details  WoS 
  • 2011 Journal Article
    ​ ​A role for myelin-associated peroxisomes in maintaining paranodal loops and axonal integrity​
    Kassmann, C. M.; Quintes, S.; Rietdorf, J.; Möbius, W. ; Sereda, M. W.; Nientiedt, T. & Saher, G. et al.​ (2011) 
    FEBS Letters585(14) pp. 2205​-2211​.​ DOI: https://doi.org/10.1016/j.febslet.2011.05.032 
    Details  DOI 
  • 2012 Journal Article
    ​ ​Therapy of Pelizaeus-Merzbacher disease in mice by feeding a cholesterol-enriched diet​
    Saher, G.; Rudolphi, F.; Corthals, K.; Ruhwedel, T.; Schmidt, K.-F.; Loewel, S. & Dibaj, P. et al.​ (2012) 
    Nature Medicine18(7) pp. 1130​-+​.​ DOI: https://doi.org/10.1038/nm.2833 
    Details  DOI  PMID  PMC  WoS 
  • 2012 Journal Article | 
    ​ ​Critical Time Window of Neuronal Cholesterol Synthesis during Neurite Outgrowth​
    Fuenfschilling, U.; Jockusch, W. J.; Sivakumar, N.; Möbius, W. ; Corthals, K.; Li, S. & Quintes, S. et al.​ (2012) 
    Journal of Neuroscience32(22) pp. 7632​-7645​.​ DOI: https://doi.org/10.1523/JNEUROSCI.1352-11.2012 
    Details  DOI  PMID  PMC  WoS 
  • 2013 Journal Article | Research Paper
    ​ ​A critical role for the cholesterol-associated proteolipids PLP and M6B in myelination of the central nervous system​
    Werner, H. B. ; Kraemer-Albers, E.-M.; Strenzke, N. ; Saher, G.; Tenzer, S.; Ohno-Iwashita, Y. & Monasterio-Schrader, P. de  et al.​ (2013) 
    Glia61(4) pp. 567​-586​.​ DOI: https://doi.org/10.1002/glia.22456 
    Details  DOI  PMID  PMC  WoS 
  • 2014 Journal Article
    ​ ​Neuropsychiatric disease relevance of circulating anti-NMDA receptor autoantibodies depends on blood-brain barrier integrity​
    Hammer, C. ; Stepniak, B. ; Schneider, A. ; Papiol, S. ; Tantra, M. ; Begemann, M.   & Sirén, A.-L.  et al.​ (2014) 
    Molecular Psychiatry19(10) pp. 1143​-1149​.​ DOI: https://doi.org/10.1038/mp.2013.110 
    Details  DOI  PMID  PMC 
  • 2016 Journal Article
    ​ ​Inducible targeting of CNS astrocytes in Aldh1l1-CreERT2 BAC transgenic mice​
    Winchenbach, J.; Düking, T.; Berghoff, S. A.; Stumpf, S. K.; Hülsmann, S. ; Nave, K.-A.   & Saher, G.​ (2016) 
    F1000Research5 pp. 2934​.​ DOI: https://doi.org/10.12688/f1000research.10509.1 
    Details  DOI  PMID  PMC 
  • 2017 Journal Article | 
    ​ ​Blood-brain barrier hyperpermeability precedes demyelination in the cuprizone model​
    Berghoff, S. A.; Düking, T.; Spieth, L.; Winchenbach, J.; Stumpf, S. K.; Gerndt, N. & Kusch, K. et al.​ (2017) 
    Acta Neuropathologica Communications5(1).​ DOI: https://doi.org/10.1186/s40478-017-0497-6 
    Details  DOI 
  • 2017 Journal Article | 
    ​ ​Dietary cholesterol promotes repair of demyelinated lesions in the adult brain​
    Berghoff, S. A.; Gerndt, N.; Winchenbach, J.; Stumpf, S. K.; Hosang, L.; Odoardi, F.   & Ruhwedel, T. et al.​ (2017) 
    Nature Communications8 art. 14241​.​ DOI: https://doi.org/10.1038/ncomms14241 
    Details  DOI  PMID  PMC  WoS 
  • 2018 Journal Article | 
    ​ ​Uncoupling the widespread occurrence of anti-NMDAR1 autoantibodies from neuropsychiatric disease in a novel autoimmune model​
    Pan, H.; Oliveira, B. ; Saher, G.; Dere, E. ; Tapken, D.; Mitjans, M. & Seidel, J. et al.​ (2018) 
    Molecular Psychiatry24(10) pp. 1489​-1501​.​ DOI: https://doi.org/10.1038/s41380-017-0011-3 
    Details  DOI 
  • 2019 Journal Article | Erratum | 
    ​ ​Correction to: Ketogenic diet ameliorates axonal defects and promotes myelination in Pelizaeus–Merzbacher disease​
    Stumpf, S. K.; Berghoff, S. A.; Trevisiol, A.; Spieth, L.; Düking, T.; Schneider, L. V. & Schlaphoff, L. et al.​ (2019) 
    Acta Neuropathologica138(4) pp. 673​-674​.​ DOI: https://doi.org/10.1007/s00401-019-02064-2 
    Details  DOI  PMID  PMC 
  • 2019 Journal Article | 
    ​ ​Ketogenic diet ameliorates axonal defects and promotes myelination in Pelizaeus-Merzbacher disease​
    Stumpf, S. K.; Berghoff, S. A.; Trevisiol, A. ; Spieth, L.; Düking, T.; Schneider, L. V. & Schlaphoff, L. et al.​ (2019) 
    Acta Neuropathologica138(1) pp. 147​-161​.​ DOI: https://doi.org/10.1007/s00401-019-01985-2 
    Details  DOI  PMID  PMC 
  • 2020 Journal Article | Research Paper
    ​ ​Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis​
    Berghoff, S. A.; Spieth, L.; Sun, T.; Hosang, L. ; Schlaphoff, L.; Depp, C. & Düking, T. et al.​ (2020) 
    Nature Neuroscience24(1) pp. 47​-60​.​ DOI: https://doi.org/10.1038/s41593-020-00757-6 
    Details  DOI  PMID  PMC 
  • 2021 Journal Article
    ​ ​Neuronal cholesterol synthesis is essential for repair of chronically demyelinated lesions in mice​
    Berghoff, S. A.; Spieth, L.; Sun, T.; Hosang, L.; Depp, C.; Sasmita, A. O. & Vasileva, M. H. et al.​ (2021) 
    Cell Reports37(4) art. S2211124721013590​.​ DOI: https://doi.org/10.1016/j.celrep.2021.109889 
    Details  DOI 
  • 2021 Journal Article
    ​ ​Anesthesia triggers drug delivery to experimental glioma in mice by hijacking caveolar transport​
    Spieth, L.; Berghoff, S. A; Stumpf, S. K; Winchenbach, J.; Michaelis, T.; Watanabe, T. & Gerndt, N. et al.​ (2021) 
    Neuro-Oncology Advances3(1) art. vdab140​.​ DOI: https://doi.org/10.1093/noajnl/vdab140 
    Details  DOI 
  • 2022 Journal Article
    ​ ​Local cholesterol metabolism orchestrates remyelination​
    Berghoff, S. A.; Spieth, L. & Saher, G.​ (2022) 
    Trends in Neurosciences45(4) pp. 272​-283​.​ DOI: https://doi.org/10.1016/j.tins.2022.01.001 
    Details  DOI 
  • 2022 Journal Article | 
    ​ ​Diet triggers specific responses of hypothalamic astrocytes in time and region dependent manner​
    Lutomska, L. M.; Miok, V.; Krahmer, N.; González García, I.; Gruber, T.; Le Thuc, O. & Murat, C. D. et al.​ (2022) 
    Glia, art. glia.24237​.​ DOI: https://doi.org/10.1002/glia.24237 
    Details  DOI 
  • 2022 Journal Article | 
    ​ ​Ketogenic diet uncovers differential metabolic plasticity of brain cells​
    Düking, T.; Spieth, L.; Berghoff, S. A.; Piepkorn, L.; Schmidke, A. M.; Mitkovski, M. & Kannaiyan, N. et al.​ (2022) 
    Science Advances8(37) art. eabo7639​.​ DOI: https://doi.org/10.1126/sciadv.abo7639 
    Details  DOI  PMID  PMC 

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