Author Wegwitz, Florian

• 2011 | Journal Article
  ​ ​CEACAM1 creates a pro-angiogenic tumor microenvironment that supports tumor vessel maturation​
  Gerstel, D.; Wegwitz, F.; Jannasch, K.; Ludewig, P.; Scheike, K.; Alves, F.   & Beauchemin, N. et al.​ (2011) 
  Oncogene, 30(41) pp. 4275​-4288​.​ DOI: https://doi.org/10.1038/onc.2011.146 
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• 2012 | Journal Article
  ​ ​Impaired CK1 Delta Activity Attenuates SV40-Induced Cellular Transformation In Vitro and Mouse Mammary Carcinogenesis In Vivo​
  Hirner, H.; Guenes, C.; Bischof, J.; Wolff, S.; Grothey, A.; Kueh, M. & Oswald, F. et al.​ (2012) 
  PLoS ONE, 7(1) art. e29709​.​ DOI: https://doi.org/10.1371/journal.pone.0029709 
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• 2014 | Conference Abstract
  ​ ​WAP-T MICE: A PRECLINICAL MOUSE MODEL TO STUDY MAMMARY CARCINOGENESIS, PROGRESSION, AND METASTASIS​
  Wegwitz, F.; Lenfert, E.; Maenz, C.; Tolstonog, G. V. & Deppert, W. R.​ (2014)
  Anticancer Research, 34(10) pp. 5885​-5886. 
  Athens​: Int Inst Anticancer Research.
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• 2015 | Journal Article | 
  ​ ​Epithelial-mesenchymal plasticity is a decisive feature for the metastatic outgrowth of disseminated WAP-T mouse mammary carcinoma cells​
  Maenz, C.; Lenfert, E.; Pantel, K.; Schumacher, U.; Deppert, W. R. & Wegwitz, F.​ (2015) 
  BMC Cancer, 15 art. 178​.​ DOI: https://doi.org/10.1186/s12885-015-1165-5 
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• 2015 | Journal Article
  ​ ​Chemotherapy of WAP-T mouse mammary carcinomas aggravates tumor phenotype and enhances tumor cell dissemination​
  Jannasch, K.; Wegwitz, F.; Lenfert, E.; Maenz, C.; Deppert, W. R. & Alves, F. ​ (2015) 
  International Journal of Cancer, 137(1) pp. 25​-36​.​ DOI: https://doi.org/10.1002/ijc.29369 
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• 2015 | Journal Article
  ​ ​Mutant p53 promotes epithelial-mesenchymal plasticity and enhances metastasis in mammary carcinomas of WAP-T mice​
  Lenfert, E.; Maenz, C.; Heinlein, C.; Jannasch, K.; Schumacher, U.; Pantel, K. & Tolstonog, G. V. et al.​ (2015) 
  International Journal of Cancer, 136(6) pp. E521​-E533​.​ DOI: https://doi.org/10.1002/ijc.29186 
  ​Details  DOI  PMID  PMC  WoS 

• 2015 | Journal Article | 
  ​ ​Usp22 deficiency impairs intestinal epithelial lineage specification in vivo.​
  Kosinsky, R. L.; Wegwitz, F.; Hellbach, N.; Dobbelstein, M. ; Mansouri, A.; Vogel, T. & Begus-Nahrmann, Y. et al.​ (2015) 
  Oncotarget, 6(35) pp. 37906​-37918​.​ DOI: https://doi.org/10.18632/oncotarget.5412 
  ​Details  DOI  PMID  PMC 

• 2016 | Conference Abstract
  ​ ​Kruppel-like Transcription Factor-10 (KLF10) suppresses the TGF beta-induced epithelial-to-mesenchymal transition​
  Mishra, V. K.; Kari, V.; Subramaniam, M.; Baumgart, S. J.; Nagarajan, S.; Wegwitz, F. & Spelsberg, T. C. et al.​ (2016)
  Cancer Research, 76 ​American-Association-for-Cancer-Research (AACR) Special Conference on Chromatin and Epigenetics in Cancer​, Atlanta, GA.
  Philadelphia​: Amer Assoc Cancer Research. DOI: https://doi.org/10.1158/1538-7445.CHROMEPI15-A03 
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• 2016 | Journal Article
  ​ ​Histone Chaperone SSRP1 is Essential for Wnt Signaling Pathway Activity During Osteoblast Differentiation​
  Hossan, T.; Nagarajan, S.; Baumgart, S. J.; Xie, W. ; Magallanes, R. T.; Hernandez, C. & Chiaroni, P.-M. et al.​ (2016) 
  Stem Cells, 34(5) pp. 1369​-1376​.​ DOI: https://doi.org/10.1002/stem.2287 
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• 2016 | Journal Article
  ​ ​Exosomal cellular prion protein drives fibrillization of amyloid beta and counteracts amyloid beta-mediated neurotoxicity​
  Falker, C.; Hartmann, A. K.; Guett, I.; Dohler, F.; Altmeppen, H.; Betzel, C. & Schubert, R. et al.​ (2016) 
  Journal of Neurochemistry, 137(1) pp. 88​-100​.​ DOI: https://doi.org/10.1111/jnc.13514 
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• 2016 | Journal Article | 
  ​ ​CEACAM1 controls the EMT switch in murine mammary carcinoma in vitro and in vivo​
  Wegwitz, F.; Lenfert, E.; Gerstel, D.; von Ehrenstein, L.; Einhoff, J.; Schmidt, G. & Logsdon, M. et al.​ (2016) 
  Oncotarget, 7(39) pp. 63730​-63746​.​ DOI: https://doi.org/10.18632/oncotarget.11650 
  ​Details  DOI  PMID  PMC  WoS 

• 2017 | Journal Article | 
  ​ ​Histone deacetylase class-I inhibition promotes epithelial gene expression in pancreatic cancer cells in a BRD4-and MYC-dependent manner​
  Mishra, V. K.; Wegwitz, F.; Kosinsky, R. L.; Sen, M. ; Baumgartner, R.; Wulff, T. & Siveke, J. T. et al.​ (2017) 
  Nucleic Acids Research, 45(11) pp. 6334​-6349​.​ DOI: https://doi.org/10.1093/nar/gkx212 
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• 2017 | Journal Article | 
  ​ ​RNF40 regulates gene expression in an epigenetic context-dependent manner​
  Xie, W.; Nagarajan, S.; Baumgart, S. J.; Kosinsky, R. L.; Najafova, Z.; Kari, V. & Hennion, M. et al.​ (2017) 
  Genome Biology, 18 art. 32​.​ DOI: https://doi.org/10.1186/s13059-017-1159-5 
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• 2017 | Journal Article | 
  ​ ​BRD4 promotes p63 and GRHL3 expression downstream of FOXO in mammary epithelial cells​
  Nagarajan, S.; Bedi, U.; Budida, A. ; Hamdan, F. H. ; Mishra, V. K.; Najafova, Z. & Xie, W. et al.​ (2017) 
  Nucleic Acids Research, 45(6) pp. 3130​-3145​.​ DOI: https://doi.org/10.1093/nar/gkw1276 
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• 2019 | Journal Article | 
  ​ ​The histone methyltransferase DOT1L is required for proper DNA damage response, DNA repair, and modulates chemotherapy responsiveness​
  Kari, V.; Raul, S. K; Henck, J. M; Kitz, J.; Kramer, F.; Kosinsky, R. L & Übelmesser, N. et al.​ (2019) 
  Clinical Epigenetics, 11(1) art. 4​.​ DOI: https://doi.org/10.1186/s13148-018-0601-1 
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• 2019 | Journal Article | 
  ​ ​The E3 ubiquitin ligase RNF40 suppresses apoptosis in colorectal cancer cells​
  Schneider, D.; Chua, R. L; Molitor, N.; Hamdan, F. H; Rettenmeier, E. M; Prokakis, E. & Mishra, V. K et al.​ (2019) 
  Clinical Epigenetics, 11(1) art. 98​.​ DOI: https://doi.org/10.1186/s13148-019-0698-x 
  ​Details  DOI 

• 2021 | Journal Article
  ​ ​TNF-α-producing macrophages determine subtype identity and prognosis via AP1 enhancer reprogramming in pancreatic cancer​
  Tu, M.; Klein, L.; Espinet, E.; Georgomanolis, T.; Wegwitz, F.; Li, X. & Urbach, L. et al.​ (2021) 
  Nature Cancer, 2(11) pp. 1185​-1203​.​ DOI: https://doi.org/10.1038/s43018-021-00258-w 
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• 2021 | Journal Article | 
  ​ ​USP22 promotes HER2-driven mammary carcinoma aggressiveness by suppressing the unfolded protein response​
  Prokakis, E.; Dyas, A.; Grün, R.; Fritzsche, S.; Bedi, U.; Kazerouni, Z. B. & Kosinsky, R. L. et al.​ (2021) 
  Oncogene,.​ DOI: https://doi.org/10.1038/s41388-021-01814-5 
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• 2021 | Journal Article | Research Paper | 
  ​ ​Suppression of HSF1 activity by wildtype p53 creates a driving force for p53 loss-of-heterozygosity​
  Isermann, T.; Şener, Ö. Ç.; Stender, A.; Klemke, L.; Winkler, N.; Neesse, A. & Li, J. et al.​ (2021) 
  Nature Communications, 12(1) art. 4019​.​ DOI: https://doi.org/10.1038/s41467-021-24064-1 
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• 2022 | Journal Article | 
  ​ ​Osmotic Stress Interferes with DNA Damage Response and H2AX Phosphorylation in Human Keratinocytes​
  Hoen, L.; Rudisch, C.; Wick, M.; Indenbirken, D.; Grundhoff, A.; Wegwitz, F. & Kalkhof, S. et al.​ (2022) 
  Cells, 11(6) pp. 959​.​ DOI: https://doi.org/10.3390/cells11060959 
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