Author Will, Cindy L.
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2003 | Journal Article | Research Paper
Molecular Architecture of the Multiprotein Splicing Factor SF3b
Golas, M. M.; Sander, B.; Will, C. L.; Lührmann, R. & Stark, H. (2003)
Science, 300(5621) pp. 980-984. DOI: https://doi.org/10.1126/science.1084155
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2005 | Journal Article
Major Conformational Change in the Complex SF3b upon Integration into the Spliceosomal U11/U12 di-snRNP as Revealed by Electron Cryomicroscopy
Golas, M. M.; Sander, B.; Will, C. L.; Lührmann, R. & Stark, H. (2005)
Molecular Cell, 17(6) pp. 869-883. DOI: https://doi.org/10.1016/j.molcel.2005.02.016
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2006 | Journal Article
Protein Composition and Electron Microscopy Structure of Affinity-Purified Human Spliceosomal B Complexes Isolated under Physiological Conditions
Deckert, J.; Hartmuth, K.; Boehringer, D.; Behzadnia, N.; Will, C. L.; Kastner, B. & Stark, H. et al. (2006)
Molecular and Cellular Biology, 26(14) pp. 5528-5543. DOI: https://doi.org/10.1128/MCB.00582-06
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2007 | Journal Article
Composition and three-dimensional EM structure of double affinity-purified, human prespliceosomal A complexes
Behzadnia, N.; Golas, M. M.; Hartmuth, K.; Sander, B.; Kastner, B.; Deckert, J. & Dube, P. et al. (2007)
The EMBO Journal, 26(6) pp. 1737-1748. DOI: https://doi.org/10.1038/sj.emboj.7601631
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2012 | Journal Article
The Prp8 RNase H-like domain inhibits Brr2-mediated U4/U6 snRNA unwinding by blocking Brr2 loading onto the U4 snRNA
Mozaffari-Jovin, S.; Santos, K. F.; Hsiao, H.-H.; Will, C. L.; Urlaub, H.; Wahl, M. C. & Luehrmann, R. (2012)
Genes & Development, 26(21) pp. 2422-2434. DOI: https://doi.org/10.1101/gad.200949.112
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2015 | Journal Article
The RNA helicase Aquarius exhibits structural adaptations mediating its recruitment to spliceosomes
De, I.; Sessonov, S.; Hofele, R. V.; dos Santos, K.; Will, C. L.; Urlaub, H. & Luehrmann, R. et al. (2015)
Nature Structural & Molecular Biology, 22(2) pp. 138-144. DOI: https://doi.org/10.1038/nsmb.2951
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2016 | Journal Article
ATP gamma S stalls splicing after B complex formation but prior to spliceosome activation
Agafonov, D. E.; van Santen, M.; Kastner, B.; Dube, P.; Will, C. L.; Urlaub, H. & Luehrmann, R. (2016)
RNA, 22(9) pp. 1329-1337. DOI: https://doi.org/10.1261/rna.057810.116
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2016 | Journal Article
Molecular Architecture of SF3b and Structural Consequences of Its Cancer-Related Mutations
Cretu, C. ; Schmitzova, J.; Ponce-Salvatierra, A.; Dybkov, O.; De laurentiis, E. I.; Sharma, K. & Will, C. L. et al. (2016)
Molecular Cell, 64(2) pp. 307-319. DOI: https://doi.org/10.1016/j.molcel.2016.08.036
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2016 | Journal Article |
U6atac snRNA stem-loop interacts with U12 p65 RNA binding protein and is functionally interchangeable with the U12 apical stem-loop III.
Singh, J.; Sikand, K.; Conrad, H.; Will, C. L.; Komar, A. A. & Shukla, G. C. (2016)
Scientific reports, 6 art. 31393. DOI: https://doi.org/10.1038/srep31393
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2016 | Journal Article | Research Paper |
A spliceosome intermediate with loosely associated tri-snRNP accumulates in the absence of Prp28 ATPase activity
Boesler, C.; Rigo, N.; Anokhina, M. M.; Tauchert, M. J. ; Agafonov, D. E.; Kastner, B. & Urlaub, H. et al. (2016)
Nature Communications, 7 art. 11997. DOI: https://doi.org/10.1038/ncomms11997
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2017 | Journal Article
Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation
Bertram, K.; Agafonov, D. E.; Dybkov, O.; Haselbach, D.; Leelaram, M. N.; Will, C. L. & Urlaub, H. et al. (2017)
Cell, 170(4) pp. 701-713.e11. DOI: https://doi.org/10.1016/j.cell.2017.07.011
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2017 | Journal Article |
Identification of a small molecule inhibitor that stalls splicing at an early step of spliceosome activation
Sidarovich, A.; Will, C. L.; Anokhina, M. M.; Ceballos, J.; Sievers, S.; Agafonov, D. E. & Samatov, T. et al. (2017)
eLife, 6 art. e23533. DOI: https://doi.org/10.7554/eLife.23533
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2017 | Journal Article |
SUMO conjugation to spliceosomal proteins is required for efficient pre-mRNA splicing
Pozzi, B.; Bragado, L.; Will, C. L.; Mammi, P.; Risso, G.; Urlaub, H. & Luehrmann, R. et al. (2017)
Nucleic Acids Research, 45(11) pp. 6729-6745. DOI: https://doi.org/10.1093/nar/gkx213
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2017 | Journal Article |
Cryo-EM structure of a human spliceosome activated for step 2 of splicing
Bertram, K.; Agafonov, D. E.; Liu, W.-T.; Dybkov, O.; Will, C. L.; Hartmuth, K. & Urlaub, H. et al. (2017)
Nature, 542(7641) pp. 318. DOI: https://doi.org/10.1038/nature21079
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2018 | Journal Article
The RES complex is required for efficient transformation of the precatalytic B spliceosome into an activated B act complex
Bao, P.; Will, C. L.; Urlaub, H. ; Boon, K.-L. & Lührmann, R. (2018)
Genes & Development, 31(23-24) pp. 2416-2429. DOI: https://doi.org/10.1101/gad.308163.117
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2018 | Journal Article
Structural Basis of Splicing Modulation by Antitumor Macrolide Compounds
Cretu, C. ; Agrawal, A. A.; Cook, A.; Will, C. L.; Fekkes, P.; Smith, P. G. & Lührmann, R. et al. (2018)
Molecular Cell, 70(2) pp. 265-273.e8. DOI: https://doi.org/10.1016/j.molcel.2018.03.011
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2019 | Journal Article
Structural Insights into Nuclear pre-mRNA Splicing in Higher Eukaryotes
Kastner, B.; Will, C. L.; Stark, H. & Lührmann, R. (2019)
Cold Spring Harbor Perspectives in Biology, 11(11) pp. a032417. DOI: https://doi.org/10.1101/cshperspect.a032417
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2020 | Journal Article
Structural Insights into the Roles of Metazoan-Specific Splicing Factors in the Human Step 1 Spliceosome
Bertram, K.; El Ayoubi, L.; Dybkov, O.; Agafonov, D. E.; Will, C. L.; Hartmuth, K. & Urlaub, H. et al. (2020)
Molecular Cell, 80(1) pp. 127-139.e6. DOI: https://doi.org/10.1016/j.molcel.2020.09.012
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2020 | Journal Article
Molecular architecture of the human 17S U2 snRNP
Zhang, Z.; Will, C. L.; Bertram, K.; Dybkov, O.; Hartmuth, K.; Agafonov, D. E. & Hofele, R. et al. (2020)
Nature, 583(7815) pp. 310-313. DOI: https://doi.org/10.1038/s41586-020-2344-3
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2020 | Journal Article
Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation
Townsend, C.; Leelaram, M. N.; Agafonov, D. E.; Dybkov, O.; Will, C. L.; Bertram, K. & Urlaub, H. et al. (2020)
Science, 370(6523) art. eabc3753. DOI: https://doi.org/10.1126/science.abc3753
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