Author Wirths, Oliver
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2007 | Conference Abstract
A beta-induced pathology and neuron loss in the cholinergic system of the APP/PS1ki mouse model of Alzheimer's disease
Christensen, D. Z.; Bayer, T. & Wirths, O. (2007)
Biochemical Pharmacology, 74(8) Symposium on Nicotinic Acetylcholine Receptors as Therapeutic Targets, San Diego, CA.
Oxford: Pergamon-elsevier Science Ltd.
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2007 | Journal Article
Altered cholesterol metabolism in APP695-transfected neuroblastoma cells
Wirths, O.; Thelen, K. M.; Luetjohann, D.; Falkai, P. & Bayer, T. A. (2007)
Brain Research, 1152 pp. 209-214. DOI: https://doi.org/10.1016/j.brainres.2007.03.029
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2008 | Journal Article |
Effect of copper intake on CSF parameters in patients with mild Alzheimer’s disease: a pilot phase 2 clinical trial
Kessler, H.; Pajonk, F.-G.; Bach, D.; Schneider-Axmann, T.; Falkai, P.; Herrmann, W. & Multhaup, G. et al. (2008)
Journal of Neural Transmission, 115(12) pp. 1651-1659. DOI: https://doi.org/10.1007/s00702-008-0136-2
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2008 | Conference Paper |
Intraneuronal beta-amyloid is a major risk factor - Novel evidence from the APP/PS1KI mouse model
Bayer, T. A.; Breyhan, H.; Duan, K.; Rettig, J. & Wirths, O. (2008)
Neurodegenerative Diseases, 5(3-4) pp. 140-142. 8th International Conference on Alzheimers and Parkinsons Diseases, Salzburg, AUSTRIA.
Basel: Karger. DOI: https://doi.org/10.1159/000113684
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2008 | Journal Article
Alzheimer's disease Molecular pathology, animal models, and current treatment
Bayer, T. A. & Wirths, O. (2008)
Der Nervenarzt, 79 pp. 117-125. DOI: https://doi.org/10.1007/s00115-008-2496-0
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2008 | Conference Paper
Review on the APP/PS1KI mouse model: intraneuronal A beta accumulation triggers axonopathy, neuron loss and working memory impairment
Bayer, T. A. & Wirths, O. (2008)
Genes, Brain and Behavior, 7 pp. 6-11. Annual Meeting of the Genes-Brain-and-Behavior-Society, Doorwerth, NETHERLANDS.
Oxford: Blackwell Publishing. DOI: https://doi.org/10.1111/j.1601-183X.2007.00372.x
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2008 | Journal Article
Age-dependent loss of dentate gyrus granule cells in APP/PS1KI mice
Cotel, M.-C.; Bayer, T. A. & Wirths, O. (2008)
Brain Research, 1222 pp. 207-213. DOI: https://doi.org/10.1016/j.brainres.2008.05.052
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2008 | Journal Article
Deficits in working memory and motor performance in the APP/PS1ki mouse model for Alzheimer's disease
Wirths, O.; Breyhan, H.; Schaefer, S.; Roth, C. & Bayer, T. A. (2008)
Neurobiology of Aging, 29(6) pp. 891-901. DOI: https://doi.org/10.1016/j.neurobiolaging.2006.12.004
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2008 | Journal Article
Motor impairment in Alzheimer's disease and transgenic Alzheimer's disease mouse models
Wirths, O. & Bayer, T. A. (2008)
Genes, Brain and Behavior, 7 pp. 1-5. DOI: https://doi.org/10.1111/j.1601-183X.2007.00373.x
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2008 | Journal Article |
Transient intraneuronal A beta rather than extracellular plaque pathology correlates with neuron loss in the frontal cortex of APP/PS1KI mice
Christensen, D. Z.; Kraus, S. L.; Flohr, A.; Cotel, M.-C.; Wirths, O. & Bayer, T. A. (2008)
Acta Neuropathologica, 116(6) pp. 647-655. DOI: https://doi.org/10.1007/s00401-008-0451-6
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2009 | Conference Abstract
Increasing Abeta peptide levels aggravate axonal degeneration in an Alzheimer mouse model
Wirths, O.; Christensen, D. Z. & Bayer, T. A. (2009)
Journal of Neurochemistry, 110 pp. 38-39. 4th European-Society-for-Neurochemistry Conference on Advances in Molecular Mechanisms of Neurological Disorders, Leipzig, GERMANY.
Malden: Wiley-blackwell Publishing, Inc.
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2009 | Conference Abstract
Alzheimer's Disease pathology is not sufficient for CCR2(+) bone marrow engraftment in the CNS
Mildner, A.; Schlevogt, B.; Kierdorf, K.; Boettcher, C.; Kummer, M. P.; Wirths, O. & Henneka, M. et al. (2009)
Acta Neuropathologica, 118(3) 54th Annual Meeting of the German-Society-of-Neuropathology-and-Neuroanatomy, Dusseldorf, GERMANY.
New york: Springer.
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2009 | Journal Article
The modified amyloid hypothesis of Alzheimer dementia - intraneuronal Abeta induces neurodegeneration
Wirths, O. & Bayer, T. A. (2009)
Neuroforum, 15(3) pp. 76-82.
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2009 | Conference Abstract
Paradigm shift in Abeta toxicity
Bayer, T. A. & Wirths, O. (2009)
European Neuropsychopharmacology, 19 22nd Congress of the European-College-of-Neuropsychopharmacology, Istanbul, TURKEY.
Amsterdam: Elsevier Science Bv.
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2009 | Journal Article |
Circulating immune complexes of Aβ and IgM in plasma of patients with Alzheimer’s disease
Marcello, A.; Wirths, O.; Schneider-Axmann, T.; Degerman-Gunnarsson, M.; Lannfelt, L. & Bayer, T. (2009)
Journal of Neural Transmission, 116(7) pp. 913-920. DOI: https://doi.org/10.1007/s00702-009-0224-y
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2009 | Journal Article |
APP/PS1KI bigenic mice develop early synaptic deficits and hippocampus atrophy
Breyhan, H.; Wirths, O.; Duan, K.; Marcello, A.; Rettig, J. & Bayer, T. A. (2009)
Acta Neuropathologica, 117(6) pp. 677-685. DOI: https://doi.org/10.1007/s00401-009-0539-7
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2009 | Journal Article
Formic acid is essential for immunohistochemical detection of aggregated intraneuronal A beta peptides in mouse models of Alzheimer's disease
Christensen, D. Z.; Bayer, T. A. & Wirths, O. (2009)
Brain Research, 1301 pp. 116-125. DOI: https://doi.org/10.1016/j.brainres.2009.09.014
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2009 | Journal Article |
Intraneuronal pyroglutamate-Abeta 3-42 triggers neurodegeneration and lethal neurological deficits in a transgenic mouse model
Wirths, O.; Breyhan, H.; Cynis, H.; Schilling, S.; Demuth, H.-U. & Bayer, T. A. (2009)
Acta Neuropathologica, 118(4) pp. 487-496. DOI: https://doi.org/10.1007/s00401-009-0557-5
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2010 | Journal Article
Gene expression of neuregulin-1 isoforms in different brain regions of elderly schizophrenia patients
Parlapani, E.; Schmitt, A.; Wirths, O.; Bauer, M.; Sommer, C.; Rueb, U. & Skowronek, M. H. et al. (2010)
The World Journal of Biological Psychiatry, 11(2) pp. 243-250. DOI: https://doi.org/10.3109/15622970802022376
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2010 | Journal Article |
Accumulation of intraneuronal A beta correlates with ApoE4 genotype
Christensen, D. Z.; Schneider-Axmann, T.; Lucassen, P. J.; Bayer, T. A. & Wirths, O. (2010)
Acta Neuropathologica, 119(5) pp. 555-566. DOI: https://doi.org/10.1007/s00401-010-0666-1
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