A facile oxygen-17 NMR method to determine effective viscosity in dilute, molecularly crowded and confined aqueous media
Rezaei-Ghaleh, Nasrollah ; Munari, Francesca ; Becker, Stefan ; Assfalg, Michael ; Griesinger, Christian
Citable Link (URL):http://resolver.sub.uni-goettingen.de/purl?gs-1/16666
We present an NMR method based on natural abundance 17O relaxation of water to determine effective viscosity in biological aqueous samples. The method accurately captures viscosity of dilute and crowded protein solutions and offers a fairly simple way to quantify the internal fluidity of biological condensates formed through phase separation.