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Transmural Ultrasound-based Visualization of Patterns of Action Potential Wave Propagation in Cardiac Tissue
The pattern of action potential propagation during various tachyarrhythmias is strongly suspected to be composed of multiple re-entrant waves, but has never been imaged in detail deep within myocardial tissue. An understanding ...
EndophilinAs regulate endosomal sorting of BDNF-TrkB to mediate survival signaling in hippocampal neurons
The sorting of activated receptors into distinct endosomal compartments is essential to activate specific signaling cascades and cellular events including growth and survival. However, the proteins involved in this sorting ...
Motor modules of human locomotion: influence of EMG averaging, concatenation, and number of step cycles.
Locomotion can be investigated by factorization of electromyographic (EMG) signals, e.g., with non-negative matrix factorization (NMF). This approach is a convenient concise representation of muscle activities as distributed ...
A musculoskeletal model of human locomotion driven by a low dimensional set of impulsive excitation primitives
Human locomotion has been described as being generated by an impulsive (burst-like) excitation of groups of musculotendon units, with timing dependent on the biomechanical goal of the task. Despite this view being supported ...
Synaptic scaling in combination with many generic plasticity mechanisms stabilizes circuit connectivity
Synaptic scaling is a slow process that modifies synapses, keeping the firing rate of neural circuits in specific regimes. Together with other processes, such as conventional synaptic plasticity in the form of long term ...
Spike-Triggered Covariance Analysis Reveals Phenomenological Diversity of Contrast Adaptation in the Retina.
When visual contrast changes, retinal ganglion cells adapt by adjusting their sensitivity as well as their temporal filtering characteristics. The latter has classically been described by contrast-induced gain changes that ...
A myelin gene causative of a catatonia-depression syndrome upon aging
Severe mental illnesses have been linked to white matter abnormalities, documented by postmortem studies. However, cause and effect have remained difficult to distinguish. CNP (20,30-cyclic nucleotide 30-phosphodiesterase) ...
Characterization of In-Body to On-Body Wireless Radio Frequency Link for Upper Limb Prostheses.
Wireless implanted devices can be used to interface patients with disabilities with the aim of restoring impaired motor functions. Implanted devices that record and transmit electromyographic (EMG) signals have been applied ...
Power spectrum of the rectified EMG: when and why is rectification beneficial for identifying neural connectivity?
OBJECTIVE: The identification of common oscillatory inputs to motor neurons in the electromyographic (EMG) signal power spectrum is often preceded by EMG rectification for enhancing the low-frequency oscillatory components. ...
Musculoskeletal representation of a large repertoire of hand grasping actions in primates.
Reach-to-grasp tasks have become popular paradigms for exploring the neural origin of hand and arm movements. This is typically investigated by correlating limb kinematic with electrophysiological signals from intracortical ...