Author Frölich, Lutz

1 to 33 of 33 Items
  • 2010 | Journal Article | 
    ​ ​Genetic Evidence Implicates the Immune System and Cholesterol Metabolism in the Aetiology of Alzheimer's Disease​
    Jones, L.; Holmans, P. A.; Hamshere, M. L.; Harold, D.; Moskvina, V.; Ivanov, D. & Pocklington, A. et al.​ (2010) 
    PLoS ONE, 5(11) art. e13950​.​ DOI: https://doi.org/10.1371/journal.pone.0013950 
    ​Details  DOI  PMID  PMC 
  • 2013 | Journal Article
    ​ ​Hypocretin in cerebrospinal fluid is positively correlated with Tau and pTau​
    Deuschle, M.; Schilling, C.; Leweke, F. M.; Enning, F.; Pollmächer, T.; Esselmann, H.   & Wiltfang, J.  et al.​ (2013) 
    Neuroscience Letters, 561 pp. 41​-45​.​ DOI: https://doi.org/10.1016/j.neulet.2013.12.036 
    ​Details  DOI 
  • 2014 | Journal Article
    ​ ​SUCLG2 identified as both a determinator of CSF Aβ1–42 levels and an attenuator of cognitive decline in Alzheimer's disease​
    Ramirez, A.; van der Flier, W. M.; Herold, C.; Ramonet, D.; Heilmann, S.; Lewczuk, P.   & Popp, J. et al.​ (2014) 
    Human Molecular Genetics, 23(24) pp. 6644​-6658​.​ DOI: https://doi.org/10.1093/hmg/ddu372 
    ​Details  DOI 
  • 2015 | Journal Article
    ​ ​Prevalence and prognosis of Alzheimer’s disease at the mild cognitive impairment stage​
    Vos, S. J. B.; Verhey, F. R. J.; Frölich, L.; Kornhuber, J. ; Wiltfang, J. ; Maier, W. & Peters, O. et al.​ (2015) 
    Brain, 138(5) pp. 1327​-1338​.​ DOI: https://doi.org/10.1093/brain/awv029 
    ​Details  DOI 
  • 2015 | Journal Article
    ​ ​Subjective cognitive decline is related to CSF biomarkers of AD in patients with MCI​
    Wolfsgruber, S.; Jessen, F.; Koppara, A.; Kleineidam, L.; Schmidtke, K.; Frölich, L. & Kurz, A. et al.​ (2015) 
    Neurology, 84(12) pp. 1261​-1268​.​ DOI: https://doi.org/10.1212/wnl.0000000000001399 
    ​Details  DOI 
  • 2015 | Journal Article | 
    ​ ​PLD3 in non-familial Alzheimer's disease​
    Heilmann, S.; Drichel, D.; Clarimon, J.; Fernández, V.; Lacour, A.; Wagner, H. & Thelen, M. et al.​ (2015) 
    Nature, 520(7545) pp. E3​-E5​.​ DOI: https://doi.org/10.1038/nature14039 
    ​Details  DOI 
  • 2015 | Journal Article | 
    ​ ​Apolipoprotein E-dependent load of white matter hyperintensities in Alzheimer’s disease: a voxel-based lesion mapping study​
    Morgen, K.; Schneider, M.; Frölich, L.; Tost, H.; Plichta, M. M.; Kölsch, H. & Rakebrandt, F.  et al.​ (2015) 
    Alzheimer's Research & Therapy, 7(1).​ DOI: https://doi.org/10.1186/s13195-015-0111-8 
    ​Details  DOI 
  • 2015 | Journal Article
    ​ ​Cerebrospinal fluid cortisol and clinical disease progression in MCI and dementia of Alzheimer's type​
    Popp, J.; Wolfsgruber, S.; Heuser, I.; Peters, O.; Hüll, M.; Schröder, J. & Möller, H.-J. et al.​ (2015) 
    Neurobiology of Aging, 36(2) pp. 601​-607​.​ DOI: https://doi.org/10.1016/j.neurobiolaging.2014.10.031 
    ​Details  DOI  PMID  PMC 
  • 2016 | Journal Article
    ​ ​No association of the variant rs11887120 in DNMT3A with cognitive decline in individuals with mild cognitive impairment​
    Bey, K.; Wolfsgruber, S.; Karaca, I.; Wagner, H.; Lardenoije, R.; Becker, J. & Milz, E. et al.​ (2016) 
    Epigenomics, 8(5) pp. 593​-598​.​ DOI: https://doi.org/10.2217/epi-2015-0014 
    ​Details  DOI 
  • 2016 | Journal Article
    ​ ​Comparison of Different Matrices as Potential Quality Control Samples for Neurochemical Dementia Diagnostics​
    Lelental, N.; Brandner, S.; Kofanova, O.; Blennow, K.; Zetterberg, H.; Andreasson, U. & Engelborghs, S. et al.​ (2016) 
    Journal of Alzheimer's Disease, 52(1) pp. 51​-64​.​ DOI: https://doi.org/10.3233/jad-150883 
    ​Details  DOI 
  • 2016 | Journal Article
    ​ ​The Latent Dementia Phenotype δ is Associated with Cerebrospinal Fluid Biomarkers of Alzheimer’s Disease and Predicts Conversion to Dementia in Subjects with Mild Cognitive Impairment​
    Koppara, A.; Wolfsgruber, S.; Kleineidam, L.; Schmidtke, K.; Frölich, L.; Kurz, A. & Schulz, S. et al.​ (2016) 
    Journal of Alzheimer's Disease, 49(2) pp. 547​-560​.​ DOI: https://doi.org/10.3233/jad-150257 
    ​Details  DOI 
  • 2016 | Journal Article
    ​ ​P4‐122: Prevalence of Vascular Risk Factors in Different Stages of Prodromal Alzheimer’s Disease and Its Influence on Cognitive Decline​
    Bos, I.; Vos, S. J.; Frölich, L.; Kornhuber, J.; Wiltfang, J.; Maier, W. & Peters, O. et al.​ (2016) 
    Alzheimer's & Dementia, 12(7S_Part_22).​ DOI: https://doi.org/10.1016/j.jalz.2016.06.2213 
    ​Details  DOI 
  • 2016 | Journal Article
    ​ ​Alzheimer's disease risk variants modulate endophenotypes in mild cognitive impairment​
    Louwersheimer, E.; Wolfsgruber, S.; Espinosa, A.; Lacour, A.; Heilmann-Heimbach, S.; Alegret, M. & Hernández, I. et al.​ (2016) 
    Alzheimer's & Dementia, 12(8) pp. 872​-881​.​ DOI: https://doi.org/10.1016/j.jalz.2016.01.006 
    ​Details  DOI 
  • 2016 | Journal Article | 
    ​ ​Das Kompetenznetz Demenzen: ​Erfolge und Ausblicke​
    Peters, O.; Heuser, I.; Frölich, L.; Rüther, E. ; Rienhoff, O. ; Kornhuber, J.   & Wiltfang, J.  et al.​ (2016) 
    Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz, 59(4) pp. 438​-443​.​ DOI: https://doi.org/10.1007/s00103-016-2314-y 
    ​Details  DOI  PMID  PMC 
  • 2017 | Journal Article
    ​ ​The frequency and influence of dementia risk factors in prodromal Alzheimer's disease​
    Bos, I.; Vos, S. J.; Frölich, L.; Kornhuber, J. ; Wiltfang, J. ; Maier, W. & Peters, O. et al.​ (2017) 
    Neurobiology of Aging, 56 pp. 33​-40​.​ DOI: https://doi.org/10.1016/j.neurobiolaging.2017.03.034 
    ​Details  DOI 
  • 2017 | Journal Article | 
    ​ ​Incremental value of biomarker combinations to predict progression of mild cognitive impairment to Alzheimer’s dementia​
    Frölich, L.; Peters, O.; Lewczuk, P. ; Gruber, O. ; Teipel, S. J.; Gertz, H. J. & Jahn, H. et al.​ (2017) 
    Alzheimer's Research & Therapy, 9(1) art. 84​.​ DOI: https://doi.org/10.1186/s13195-017-0301-7 
    ​Details  DOI 
  • 2017 | Journal Article
    ​ ​Cerebrospinal Fluid Biomarkers and Clinical Progression in Patients with Subjective Cognitive Decline and Mild Cognitive Impairment​
    Wolfsgruber, S.; Polcher, A.; Koppara, A.; Kleineidam, L.; Frölich, L.; Peters, O. & Hüll, M. et al.​ (2017) 
    Journal of Alzheimer's Disease, 58(3) pp. 939​-950​.​ DOI: https://doi.org/10.3233/JAD-161252 
    ​Details  DOI  PMID  PMC  WoS 
  • 2018 | Journal Article
    ​ ​Exploring Genetic Associations of Alzheimer’s Disease Loci With Mild Cognitive Impairment Neurocognitive Endophenotypes​
    Espinosa, A.; Hernández-Olasagarre, B.; Moreno-Grau, S.; Kleineidam, L.; Heilmann-Heimbach, S.; Hernández, I. & Wolfsgruber, S. et al.​ (2018) 
    Frontiers in Aging Neuroscience, 10.​ DOI: https://doi.org/10.3389/fnagi.2018.00340 
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​P3-016: Bupropion for the Treatment of Apathy in Alzheimer's Disease: a Multicenter Randomized Controlled Trial​
    Jessen, F.; Maier, F.; Buerger, K.; Dodel, R.; Fellgiebel, A.; Frölich, L. & Horn, R. et al.​ (2019) 
    Alzheimer's & Dementia, 15 pp. P930​-P931​.​ DOI: https://doi.org/10.1016/j.jalz.2019.06.3042 
    ​Details  DOI 
  • 2019 | Journal Article | 
    ​ ​A rare heterozygous TREM2 coding variant identified in familial clustering of dementia affects an intrinsically disordered protein region and function of TREM2​
    Karsak, M.; Glebov, K.; Scheffold, M.; Bajaj, T.; Kawalia, A.; Karaca, I. & Rading, S. et al.​ (2019) 
    Human Mutation, 41(1) pp. 1​-13​.​ DOI: https://doi.org/10.1002/humu.23904 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Identification of a Cascade of Changes in Activities of Daily Living Preceding Short-Term Clinical Deterioration in Mild Alzheimer’s Disease Dementia via Lead-Lag Analysis​
    Fuentes, M.; Klostermann, A.; Kleineidam, L.; Bauer, C.; Schuchhardt, J.; Maier, W. & Jessen, F. et al.​ (2020) 
    Journal of Alzheimer's Disease, 76(3) pp. 1005​-1015​.​ DOI: https://doi.org/10.3233/JAD-200230 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Bupropion for the Treatment of Apathy in Alzheimer Disease​
    Maier, F.; Spottke, A.; Bach, J.-P.; Bartels, C. ; Buerger, K.; Dodel, R. & Fellgiebel, A. et al.​ (2020) 
    JAMA Network Open, 3(5) pp. e206027​.​ DOI: https://doi.org/10.1001/jamanetworkopen.2020.6027 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Association of a CAMK2A genetic variant with logical memory performance and hippocampal volume in the elderly​
    Rhein, C.; Mühle, C.; Lenz, B.; Richter-Schmidinger, T.; Kogias, G.; Boix, F. & Lourdusamy, A. et al.​ (2020) 
    Brain Research Bulletin, 161 pp. 13​-20​.​ DOI: https://doi.org/10.1016/j.brainresbull.2020.05.001 
    ​Details  DOI 
  • 2020 | Journal Article | 
    ​ ​Gedächtnisambulanzen in Deutschland – strukturell-organisatorische Voraussetzungen und Aufgabenfelder​
    Hausner, L.; Frölich, L.; von Arnim, C. A. F. ; Bohlken, J.; Dodel, R.; Otto, M.   & Rapp, M. et al.​ (2020) 
    Der Nervenarzt,.​ DOI: https://doi.org/10.1007/s00115-020-01007-7 
    ​Details  DOI 
  • 2020 | Journal Article | 
    ​ ​PLCG2 protective variant p.P522R modulates tau pathology and disease progression in patients with mild cognitive impairment​
    Kleineidam, L.; Chouraki, V.; Próchnicki, T.; van der Lee, S. J.; Madrid-Márquez, L.; Wagner-Thelen, H. & Karaca, I. et al.​ (2020) 
    Acta Neuropathologica, 139(6) pp. 1025​-1044​.​ DOI: https://doi.org/10.1007/s00401-020-02138-6 
    ​Details  DOI 
  • 2021 | Journal Article
    ​ ​Cognitive profiles of patients with mild cognitive impairment due to Alzheimer's versus Parkinson's disease defined using a base rate approach: Implications for neuropsychological assessments​
    Ophey, A.; Wolfsgruber, S.; Roeske, S.; Polcher, A.; Spottke, A.; Frölich, L. & Hüll, M. et al.​ (2021) 
    Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 13(1).​ DOI: https://doi.org/10.1002/dad2.12223 
    ​Details  DOI 
  • 2022 | Journal Article
    ​ ​Kosten der Diagnostik kognitiver Störungen in deutschen Gedächtnisambulanzen​
    Onur, O. A.; Wolff-Menzler, C. ; Arnim, C. A. F. von ; Jessen, F.; Fink, G. R.; Wiltfang, J.   & Laske, C. et al.​ (2022) 
    Fortschritte der Neurologie · Psychiatrie, 90(07/08) pp. 361​-367​.​ DOI: https://doi.org/10.1055/a-1871-9889 
    ​Details  DOI 
  • 2022 | Journal Article
    ​ ​Leichte kognitive Beeinträchtigung (MCI) in der altersmedizinischen Praxis: Patientenorientierung, Diagnostik, Behandlung und Ethik​
    Frölich, L.; Arnim, C. von ; Bohlken, J.; Pantel, J.; Peters, O. & Förstl, H.​ (2022) 
    Zeitschrift für Gerontologie und Geriatrie,.​ DOI: https://doi.org/10.1007/s00391-022-02098-4 
    ​Details  DOI 
  • 2022 | Journal Article | 
    ​ ​Don’t forget about tau: the effects of ApoE4 genotype on Alzheimer’s disease cerebrospinal fluid biomarkers in subjects with mild cognitive impairment—data from the Dementia Competence Network​
    Benson, G. S.; Bauer, C.; Hausner, L.; Couturier, S.; Lewczuk, P.; Peters, O. & Hüll, M. et al.​ (2022) 
    Journal of Neural Transmission,.​ DOI: https://doi.org/10.1007/s00702-022-02461-0 
    ​Details  DOI 
  • 2022 | Journal Article | 
    ​ ​A Comparison of Operational Definitions for Mild Cognitive Impairment​
    Polcher, A.; Wolfsgruber, S.; Peters, O.; Frölich, L.; Wiltfang, J. ; Kornhuber, J.   & Hüll, M. et al.​ (2022) 
    Journal of Alzheimer's Disease, 88(4) pp. 1663​-1678​.​ DOI: https://doi.org/10.3233/JAD-215548 
    ​Details  DOI 
  • 2022 | Journal Article | Erratum | 
    ​ ​Erratum zu: Leichte kognitive Beeinträchtigung (MCI) in der altersmedizinischen Praxis: Patientenorientierung, Diagnostik, Behandlung und Ethik​
    Frölich, L.; Arnim, C. A. F. von ; Bohlken, J.; Pantel, J.; Peters, O. & Förstl, H.​ (2022) 
    Zeitschrift für Gerontologie und Geriatrie,.​ DOI: https://doi.org/10.1007/s00391-022-02114-7 
    ​Details  DOI 
  • 2023 | Journal Article
    ​ ​Apathy in patients with Alzheimer's disease is a cost‐driving factor​
    Kruse, C.; Maier, F.; Spottke, A.; Bach, J.; Bartels, C.; Buerger, K. & Fellgiebel, A. et al.​ (2023) 
    Alzheimer's & Dementia, art. alz.12915​.​ DOI: https://doi.org/10.1002/alz.12915 
    ​Details  DOI 
  • 2024 | Book Chapter
    ​ ​Blood-Based Biomarkers for Early Alzheimer’s Disease Diagnosis in Real-World Settings​
    Perneczky, R.; Hansen, N.; Hofmann, A.; Laske, C.; Priller, J.; Grimmer, T.& Frölich, L. et al.​ (2024)
    In:​Perneczky, Robert​ (Ed.), Biomarkers for Alzheimer’s Disease Drug Development pp. 3​-14. ​New York, NY: ​Springer US. DOI: https://doi.org/10.1007/978-1-0716-3774-6_1 
    ​Details  DOI 

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