Author Moll, Ute M.

1 to 29 of 29 Items
  • 2007 Journal Article
    ​ ​The role of ubiquitination in the direct mitochondrial death program of p53​
    Marchenko, N. D. & Moll, U. M.​ (2007) 
    Cell Cycle6(14) pp. 1718​-1723​.​
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  • 2007 Journal Article
    ​ ​p73 suppresses polyploidy and aneuploidy in the absence of functional p53​
    Talos, F.; Nemajerova, A.; Flores, E. R.; Petrenko, O. & Moll, U. M.​ (2007) 
    Molecular Cell27(4) pp. 647​-659​.​ DOI: https://doi.org/10.1016/j.molcel.2007.06.036 
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  • 2008 Journal Article
    ​ ​Mitochondrially targeted wild-type p53 induces apoptosis in a solid human tumor xenograft model​
    Palacios, G.; Crawford, H. C.; Vaseva, A. V. & Moll, U. M.​ (2008) 
    Cell Cycle7(16) pp. 2584​-2590​.​
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  • 2008 Journal Article
    ​ ​E2F1 plays a direct role in Rb stabilization and p53-independent tumor suppression​
    Palacios, G.; Talos, F.; Nemajerova, A.; Moll, U. M. & Petrenko, O.​ (2008) 
    Cell Cycle7(12) pp. 1776​-1781​.​ DOI: https://doi.org/10.4161/cc.7.12.6030 
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  • 2008 Journal Article | 
    ​ ​p53-Responsive MicroRNAs 192 and 215 Are Capable of Inducing Cell Cycle Arrest​
    Braun, C. J.; Zhang, X.; Savelyeva, I.; Wolff, S.; Moll, U. M.; Schepeler, T. & Orntoft, T. F. et al.​ (2008) 
    Cancer Research68(24) pp. 10094​-10104​.​ DOI: https://doi.org/10.1158/0008-5472.CAN-08-1569 
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  • 2008 Journal Article | 
    ​ ​p53's mitochondrial translocation and MOMP action is independent of Puma and Bax and severely disrupts mitochondrial membrane integrity​
    Wolff, S.; Erster, S.; Palacios, G. & Moll, U. M.​ (2008) 
    Cell Research18(7) pp. 733​-744​.​ DOI: https://doi.org/10.1038/cr.2008.62 
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  • 2009 Journal Article | 
    ​ ​The alpha/beta carboxy-terminal domains of p63 are required for skin and limb development. New insights from the Brdm2 mouse which is not a complete p63 knockout but expresses p63 gamma-like proteins​
    Wolff, S.; Talos, F.; Palacios, G.; Beyer, U.; Dobbelstein, M.   & Moll, U. M.​ (2009) 
    Cell Death and Differentiation16(8) pp. 1108​-1117​.​ DOI: https://doi.org/10.1038/cdd.2009.25 
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  • 2010 Journal Article | 
    ​ ​Loss of p73 promotes dissemination of Myc-induced B cell lymphomas in mice​
    Nemajerova, A.; Petrenko, O.; Truemper, L. H.; Palacios, G. & Moll, U. M.​ (2010) 
    Journal of Clinical Investigation120(6) pp. 2070​-2080​.​ DOI: https://doi.org/10.1172/JCI40331 
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  • 2010 Journal Article | Letter Note | 
    ​ ​Brdm2-an aberrant hypomorphic p63 allele​
    Talos, F.; Wolff, S.; Beyer, U.; Dobbelstein, M.   & Moll, U. M.​ (2010) 
    Cell Death and Differentiation17(1) pp. 184​-186​.​ DOI: https://doi.org/10.1038/cdd.2009.158 
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  • 2010 Journal Article | 
    ​ ​Stress-mediated nuclear stabilization of p53 is regulated by ubiquitination and importin-alpha 3 binding​
    Marchenko, N. D.; Hanel, W.; Li, D.; Becker, K.; Reich, N. & Moll, U. M.​ (2010) 
    Cell Death and Differentiation17(2) pp. 255​-267​.​ DOI: https://doi.org/10.1038/cdd.2009.173 
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  • 2011 Journal Article
    ​ ​Endogenous retrovirus drives hitherto unknown proapoptotic p63 isoforms in the male germ line of humans and great apes​
    Beyer, U.; Moll-Rocek, J.; Moll, U. M. & Dobbelstein, M. ​ (2011) 
    Proceedings of the National Academy of Sciences of the United States of America108(9) pp. 3624​-3629​.​ DOI: https://doi.org/10.1073/pnas.1016201108 
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  • 2011 Journal Article
    ​ ​Functional Inactivation of Endogenous MDM2 and CHIP by HSP90 Causes Aberrant Stabilization of Mutant p53 in Human Cancer Cells​
    Li, D.; Marchenko, N. D.; Schulz, R.; Fischer, V.; Velasco-Hernandez, T.; Talos, F. & Moll, U. M.​ (2011) 
    Molecular Cancer Research9(5) pp. 577​-588​.​ DOI: https://doi.org/10.1158/1541-7786.MCR-10-0534 
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  • 2011 Journal Article
    ​ ​While p73 is essential, p63 is completely dispensable for the development of the central nervous system​
    Holembowski, L.; Schulz, R.; Talos, F.; Scheel, A.; Holzman, S.; Dobbelstein, M.   & Moll, U. M.​ (2011) 
    Cell Cycle10(4) pp. 680​-689​.​ DOI: https://doi.org/10.4161/cc.10.4.14859 
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  • 2012 Journal Article
    ​ ​HSP90 inhibitor antagonizing MIF The specifics of pleiotropic cancer drug candidates​
    Schulz, R.; Dobbelstein, M.   & Moll, U. M.​ (2012) 
    OncoImmunology1(8) pp. 1425​-1426​.​ DOI: https://doi.org/10.4161/onci.21173 
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  • 2012 Journal Article | 
    ​ ​Inhibiting the HSP90 chaperone destabilizes macrophage migration inhibitory factor and thereby inhibits breast tumor progression​
    Schulz, R.; Marchenko, N. D.; Holembowski, L.; Fingerle-Rowson, G.; Pesic, M.; Zender, L. & Dobbelstein, M.  et al.​ (2012) 
    Journal of Experimental Medicine209(2) pp. 275​-289​.​ DOI: https://doi.org/10.1084/jem.20111117 
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  • 2012 Journal Article
    ​ ​p53 Opens the Mitochondrial Permeability Transition Pore to Trigger Necrosis​
    Vaseva, A. V.; Marchenko, N. D.; Ji, K.; Tsirka, S. E.; Holzmann, S. & Moll, U. M.​ (2012) 
    Cell149(7) pp. 1536​-1548​.​ DOI: https://doi.org/10.1016/j.cell.2012.05.014 
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  • 2012 Review
    ​ ​Role of p53 family members p73 and p63 in human hematological malignancies​
    Alexandrova, E. M.& Moll, U. M.​ (2012)
    Leukemia & Lymphoma, 53​(11) pp. 2116​-2129​.​
    Taylor & Francis Ltd. DOI: https://doi.org/10.3109/10428194.2012.684348 
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  • 2014 Journal Article
    ​ ​TAp73 is essential for germ cell adhesion and maturation in testis​
    Holembowski, L.; Kramer, D. ; Riedel, D.; Sordella, R.; Nemajerova, A.; Dobbelstein, M.   & Moll, U. M.​ (2014) 
    The Journal of Cell Biology204(7) pp. 1173​-1190​.​ DOI: https://doi.org/10.1083/jcb.201306066 
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  • 2014 Journal Article | 
    ​ ​HER2/ErbB2 activates HSF1 and thereby controls HSP90 clients including MIF in HER2-overexpressing breast cancer​
    Schulz, R.; Streller, F.; Scheel, A. H.; Rueschoff, J.; Reinert, M. C.; Dobbelstein, M.   & Marchenko, N. D. et al.​ (2014) 
    Cell Death and Disease5 art. e980​.​ DOI: https://doi.org/10.1038/cddis.2013.508 
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  • 2014 Review
    ​ ​Targeting the heat shock protein 90: a rational way to inhibit macrophage migration inhibitory factor function in cancer​
    Schulz, R.& Moll, U. M.​ (2014)
    Current Opinion in Oncology, 26​(1) pp. 108​-113​.​
    Lippincott Williams & Wilkins. DOI: https://doi.org/10.1097/CCO.0000000000000036 
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  • 2014 Journal Article
    ​ ​Targeting tumour-supportive cellular machineries in anticancer drug development​
    Dobbelstein, M.   & Moll, U. M.​ (2014) 
    Nature Reviews Drug Discovery13(3) pp. 179​-196​.​ DOI: https://doi.org/10.1038/nrd4201 
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  • 2015 Journal Article | 
    ​ ​Improving survival by exploiting tumour dependence on stabilized mutant p53 for treatment​
    Alexandrova, E. M.; Yallowitz, A. R.; Li, D.; Xu, S.; Schulz, R.; Proia, D. A. & Lozano, G. et al.​ (2015) 
    Nature523(7560) pp. 352​-+​.​ DOI: https://doi.org/10.1038/nature14430 
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  • 2016 Journal Article
    ​ ​TAp73 is a central transcriptional regulator of airway multiciliogenesis​
    Nemajerova, A.; Kramer, D.; Siller, S. S.; Herr, C.; Shomroni, O.; Pena, T. & Suazo, C. G. et al.​ (2016) 
    Genes & Development30(11) pp. 1300​-1312​.​ DOI: https://doi.org/10.1101/gad.279836.116 
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  • 2016 Journal Article
    ​ ​MDM2 Associates with Polycomb Repressor Complex 2 and Enhances Stemness-Promoting Chromatin Modifications Independent of p53​
    Wienken, M.; Dickmanns, A.; Nemajerova, A.; Kramer, D.; Najafova, Z.; Weiss, M. & Karpiuk, O. et al.​ (2016) 
    Molecular Cell61(1) pp. 68​-83​.​ DOI: https://doi.org/10.1016/j.molcel.2015.12.008 
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  • 2017 Journal Article | 
    ​ ​Strong antitumor synergy between DNA crosslinking and HSP90 inhibition causes massive premitotic DNA fragmentation in ovarian cancer cells​
    Kramer, D.; Stark, N. ; Schulz-Heddergott, R.; Erytch, N.; Edmunds, S.; Rossmann, L.   & Bastians, H. et al.​ (2017) 
    Cell Death and Differentiation24(2) pp. 300​-316​.​ DOI: https://doi.org/10.1038/cdd.2016.124 
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  • 2017 Journal Article | 
    ​ ​p53 loss-of-heterozygosity is a necessary prerequisite for mutant p53 stabilization and gain-of-function in vivo​
    Alexandrova, E. M.; Mirza, S. A.; Xu, S.; Schulz-Heddergott, R.; Marchenko, N. D. & Moll, U. M.​ (2017) 
    Cell Death and Disease8 art. e2661​.​ DOI: https://doi.org/10.1038/cddis.2017.80 
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  • 2017 Review
    ​ ​Mdm2 as a chromatin modifier​
    Wienken, M.; Moll, U. M.& Dobbelstein, M. ​ (2017)
    Journal of Molecular Cell Biology, 9​(1) pp. 74​-80​.​
    Oxford Univ Press. DOI: https://doi.org/10.1093/jmcb/mjw046 
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  • 2018 Journal Article | 
    ​ ​Gain-of-Function (GOF) Mutant p53 as Actionable Therapeutic Target​
    Schulz-Heddergott, R. & Moll, U. M.​ (2018) 
    Cancers10(6).​ DOI: https://doi.org/10.3390/cancers10060188 
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  • 2021 Journal Article | Research Paper | 
    ​ ​Suppression of HSF1 activity by wildtype p53 creates a driving force for p53 loss-of-heterozygosity​
    Isermann, T.; Şener, Ö. Ç.; Stender, A.; Klemke, L.; Winkler, N.; Neesse, A. & Li, J. et al.​ (2021) 
    Nature Communications12(1) art. 4019​.​ DOI: https://doi.org/10.1038/s41467-021-24064-1 
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