Author Johnsen, Steven A.

• 2015 | Journal Article
  ​ ​SUPT6H controls estrogen receptor activity and cellular differentiation by multiple epigenomic mechanisms​
  Bedi, U.; Scheel, A. H.; Hennion, M.; Begus-Nahrmann, Y.; Rueschoff, J. & Johnsen, S. A.​ (2015) 
  Oncogene, 34(4) pp. 465​-473​.​ DOI: https://doi.org/10.1038/onc.2013.558 
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• 2015 | Journal Article
  ​ ​NFATc1 Links EGFR Signaling to Induction of Sox9 Transcription and Acinar-Ductal Transdifferentiation in the Pancreas​
  Chen, N.-M.; Singh, G.; Koenig, A. O.; Liou, G.-Y.; Storz, P.; Zhang, J. & Regul, L. et al.​ (2015) 
  Gastroenterology, 148(5) pp. 1024​-U502​.​ DOI: https://doi.org/10.1053/j.gastro.2015.01.033 
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• 2015 | Journal Article | 
  ​ ​Overexpression of mutant Ptch in rhabdomyosarcomas is associated with promoter hypomethylation and increased Gli1 and H3K4me3 occupancy.​
  Nitzki, F.; Tolosa, E. J.; Cuvelier, N.; Frommhold, A.; Salinas-Riester, G.; Johnsen, S. A. & Fernandez-Zapico, M. E. et al.​ (2015) 
  Oncotarget, 6(11) pp. 9113​-9124​.​ DOI: https://doi.org/10.18632/oncotarget.3272 
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• 2015 | Journal Article | 
  ​ ​Usp22 deficiency impairs intestinal epithelial lineage specification in vivo.​
  Kosinsky, R. L.; Wegwitz, F.; Hellbach, N.; Dobbelstein, M. ; Mansouri, A.; Vogel, T. & Begus-Nahrmann, Y. et al.​ (2015) 
  Oncotarget, 6(35) pp. 37906​-37918​.​ DOI: https://doi.org/10.18632/oncotarget.5412 
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• 2016 | Conference Abstract
  ​ ​Kruppel-like Transcription Factor-10 (KLF10) suppresses the TGF beta-induced epithelial-to-mesenchymal transition​
  Mishra, V. K.; Kari, V.; Subramaniam, M.; Baumgart, S. J.; Nagarajan, S.; Wegwitz, F. & Spelsberg, T. C. et al.​ (2016)
  Cancer Research, 76 ​American-Association-for-Cancer-Research (AACR) Special Conference on Chromatin and Epigenetics in Cancer​, Atlanta, GA.
  Philadelphia​: Amer Assoc Cancer Research. DOI: https://doi.org/10.1158/1538-7445.CHROMEPI15-A03 
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• 2016 | Journal Article
  ​ ​Epigenetic strategies in cancer therapy​
  Hessmann, E. ; Johnsen, S. A. & Ellenrieder, V.​ (2016) 
  Der Onkologe, 22(1) pp. 19​-+​.​ DOI: https://doi.org/10.1007/s00761-015-2998-x 
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• 2016 | Journal Article | 
  ​ ​Relevance of Sp Binding Site Polymorphism in WWOX for Treatment Outcome in Pancreatic Cancer​
  Schirmer, M. A.; Lueske, C. M.; Roppel, S. F.; Schaudinn, A.; Zimmer, C.; Pflueger, R. & Haubrock, M.  et al.​ (2016) 
  JNCI Journal of the National Cancer Institute, 108(5) art. djv387​.​ DOI: https://doi.org/10.1093/jnci/djv387 
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• 2016 | Journal Article
  ​ ​Histone Chaperone SSRP1 is Essential for Wnt Signaling Pathway Activity During Osteoblast Differentiation​
  Hossan, T.; Nagarajan, S.; Baumgart, S. J.; Xie, W. ; Magallanes, R. T.; Hernandez, C. & Chiaroni, P.-M. et al.​ (2016) 
  Stem Cells, 34(5) pp. 1369​-1376​.​ DOI: https://doi.org/10.1002/stem.2287 
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• 2016 | Journal Article
  ​ ​Loss of CHD1 causes DNA repair defects and enhances prostate cancer therapeutic responsiveness​
  Kari, V.; Mansour, W. Y.; Raul, S. K.; Baumgart, S. J. ; Mund, A.; Grade, M. & Sirma, H. et al.​ (2016) 
  EMBO Reports, 17(11) pp. 1609​-1623​.​ DOI: https://doi.org/10.15252/embr.201642352 
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• 2016 | Journal Article
  ​ ​No Significant Cytotoxic Effect of the EZH2 Inhibitor Tazemetostat (EPZ-6438) on Pediatric Glioma Cells with Wildtype Histone 3 or Mutated Histone 3.3​
  Wiese, M.; Schill, F.; Sturm, D.; Pfister, S. M.; Hulleman, E.; Johnsen, S. A. & Kramm, C. M.​ (2016) 
  Klinische Pädiatrie, 228(3) pp. 113​-117​.​ DOI: https://doi.org/10.1055/s-0042-105292 
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• 2016 | Journal Article | 
  ​ ​Twist1 induces distinct cell states depending on TGFBR1-activation​
  Dragoi, D.; Krattenmacher, A.; Mishra, V. K.; Schmidt, J. M.; Kloos, U. J.; Meixner, L. K. & Hauck, S. M. et al.​ (2016) 
  Oncotarget, 7(21) pp. 30396​-30407​.​ DOI: https://doi.org/10.18632/oncotarget.8878 
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• 2016 | Journal Article
  ​ ​MDM2 Associates with Polycomb Repressor Complex 2 and Enhances Stemness-Promoting Chromatin Modifications Independent of p53​
  Wienken, M.; Dickmanns, A.; Nemajerova, A.; Kramer, D.; Najafova, Z.; Weiss, M. & Karpiuk, O. et al.​ (2016) 
  Molecular Cell, 61(1) pp. 68​-83​.​ DOI: https://doi.org/10.1016/j.molcel.2015.12.008 
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• 2017 | Journal Article | 
  ​ ​Histone deacetylase class-I inhibition promotes epithelial gene expression in pancreatic cancer cells in a BRD4-and MYC-dependent manner​
  Mishra, V. K.; Wegwitz, F.; Kosinsky, R. L.; Sen, M. ; Baumgartner, R.; Wulff, T. & Siveke, J. T. et al.​ (2017) 
  Nucleic Acids Research, 45(11) pp. 6334​-6349​.​ DOI: https://doi.org/10.1093/nar/gkx212 
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• 2017 | Journal Article
  ​ ​Epigenetic treatment of pancreatic cancer: is there a therapeutic perspective on the horizon?​
  Hessmann, E. ; Johnsen, S. A.; Siveke, J. T. & Ellenrieder, V.​ (2017) 
  Gut, 66(1) pp. 168​-179​.​ DOI: https://doi.org/10.1136/gutjnl-2016-312539 
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• 2017 | Journal Article | 
  ​ ​BRD4 localization to lineage-specific enhancers is associated with a distinct transcription factor repertoire​
  Najafova, Z.; Tirado-Magallanes, R.; Subramaniam, M.; Hossan, T.; Schmidt, G.; Nagarajan, S. & Baumgart, S. J. et al.​ (2017) 
  Nucleic Acids Research, 45(1) pp. 127​-141​.​ DOI: https://doi.org/10.1093/nar/gkw826 
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• 2017 | Journal Article | 
  ​ ​BRD4 promotes p63 and GRHL3 expression downstream of FOXO in mammary epithelial cells​
  Nagarajan, S.; Bedi, U.; Budida, A. ; Hamdan, F. H. ; Mishra, V. K.; Najafova, Z. & Xie, W. et al.​ (2017) 
  Nucleic Acids Research, 45(6) pp. 3130​-3145​.​ DOI: https://doi.org/10.1093/nar/gkw1276 
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• 2017 | Journal Article | 
  ​ ​RNF40 regulates gene expression in an epigenetic context-dependent manner​
  Xie, W.; Nagarajan, S.; Baumgart, S. J.; Kosinsky, R. L.; Najafova, Z.; Kari, V. & Hennion, M. et al.​ (2017) 
  Genome Biology, 18 art. 32​.​ DOI: https://doi.org/10.1186/s13059-017-1159-5 
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• 2018 | Journal Article | 
  ​ ​Epigenetic Targeting of Aberrant Transcriptional Modulation in Pancreatic Cancer​
  Hamdan, F. H. & Johnsen, S. A.​ (2018) 
  Epigenomes, 2(2) pp. 8​.​ DOI: https://doi.org/10.3390/epigenomes2020008 
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• 2018 | Journal Article
  ​ ​Abstract 1472: The role of the BAF complex in Wnt signaling-mediated transcriptional regulation in colorectal cancer​
  Sen, M.; Hamdan, F. H.; Wang, X.; Rapp, J. & Johnsen, S. A.​ (2018) 
  Cancer Research, 78(13_Supplement) pp. 1472​-1472​.​ DOI: https://doi.org/10.1158/1538-7445.AM2018-1472 
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• 2018 | Journal Article
  ​ ​Abstract 1917: CHD1 depletion leads to androgen-independent growth of prostate cancer cells lines and regulates the TGFβ system in an EZH2-dependent manner​
  Böcker, S. J.; Baumgart, S. J.; Roth, A.; Kari, V.; Johnsen, S. A. & Hahn, O.​ (2018) 
  Cancer Research, 78(13_Supplement) pp. 1917​-1917​.​ DOI: https://doi.org/10.1158/1538-7445.AM2018-1917 
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