Author Zweckstetter, Markus
-
2006 | Journal Article | Research Paper
Prion Protein Helix1 Promotes Aggregation but Is Not Converted into β-Sheet
Watzlawik, J.; Skora, L.; Frense, D.; Griesinger, C. ; Zweckstetter, M.; Schulz-Schaeffer, W. J. & Kramer, M. L. (2006)
Journal of Biological Chemistry, 281(40) pp. 30242-30250. DOI: https://doi.org/10.1074/jbc.M605141200
Details DOI PMID PMC WoS
-
2007 | Journal Article
The C2A-C2B linker defines the high affinity Ca2+ binding mode of rabphilin-3A
Montaville, P.; Schlicker, C.; Leonov, A.; Zweckstetter, M.; Sheldrick, G. M. & Becker, S. (2007)
Journal of Biological Chemistry, 282(7) pp. 5015-5025. DOI: https://doi.org/10.1074/jbc.M606746200
Details DOI PMID PMC WoS
-
2008 | Journal Article
Titelbild: Dissociation of Amyloid Fibrils of α-Synuclein in Supercooled Water (Angew. Chem. 27/2008)
Kim, H.-Y.; Cho, M.-K.; Riedel, D.; Fernandez, C. & Zweckstetter, M. (2008)
Angewandte Chemie, 120(27) pp. 5017-5017. DOI: https://doi.org/10.1002/ange.200890181
Details DOI
-
2008 | Journal Article
Dissociation of Amyloid Fibrils of α-Synuclein in Supercooled Water
Kim, H.-Y.; Cho, M.-K.; Riedel, D.; Fernandez, C. & Zweckstetter, M. (2008)
Angewandte Chemie, 120(27) pp. 5124-5126. DOI: https://doi.org/10.1002/ange.200800342
Details DOI
-
2008 | Journal Article
Cover Picture: Dissociation of Amyloid Fibrils of α-Synuclein in Supercooled Water (Angew. Chem. Int. Ed. 27/2008)
Kim, H.-Y.; Cho, M.-K.; Riedel, D.; Fernandez, C. & Zweckstetter, M. (2008)
Angewandte Chemie International Edition, 47(27) pp. 4939-4939. DOI: https://doi.org/10.1002/anie.200890127
Details DOI
-
2008 | Journal Article
NMR: prediction of molecular alignment from structure using the PALES software
Zweckstetter, M. (2008)
Nature Protocols, 3(4) pp. 679-690. DOI: https://doi.org/10.1038/nprot.2008.36
Details DOI
-
2008 | Journal Article
Dissociation of Amyloid Fibrils of α-Synuclein in Supercooled Water
Kim, H.-Y.; Cho, M.-K.; Riedel, D.; Fernandez, C. & Zweckstetter, M. (2008)
Angewandte Chemie International Edition, 47(27) pp. 5046-5048. DOI: https://doi.org/10.1002/anie.200800342
Details DOI
-
2010 | Journal Article
Molten Globule Precursor States Are Conformationally Correlated to Amyloid Fibrils of Human β-2-Microglobulin
Skora, L.; Becker, S. & Zweckstetter, M. (2010)
Journal of the American Chemical Society, 132(27) pp. 9223-9225. DOI: https://doi.org/10.1021/ja100453e
Details DOI
-
2010 | Journal Article
Automatic Assignment of the Intrinsically Disordered Protein Tau with 441-Residues
Narayanan, R. L.; Dürr, U. H. N.; Bibow, S.; Biernat, J.; Mandelkow, E. & Zweckstetter, M. (2010)
Journal of the American Chemical Society, 132(34) pp. 11906-11907. DOI: https://doi.org/10.1021/ja105657f
Details DOI
-
2010 | Journal Article
Entacapone and Tolcapone, Two Catechol O-Methyltransferase Inhibitors, Block Fibril Formation of α-Synuclein and β-Amyloid and Protect against Amyloid-induced Toxicity
Di Giovanni, S.; Eleuteri, S.; Paleologou, K. E.; Yin, G.; Zweckstetter, M.; Carrupt, P.-A. & Lashuel, H. A. (2010)
Journal of Biological Chemistry, 285(20) pp. 14941-14954. DOI: https://doi.org/10.1074/jbc.M109.080390
Details DOI
-
2011 | Journal Article
Conserved core of amyloid fibrils of wild type and A30P mutant α-synuclein
Cho, M.-K.; Kim, H.-Y.; Fernandez, C. O.; Becker, S. & Zweckstetter, M. (2011)
Protein Science, 20(2) pp. 387-395. DOI: https://doi.org/10.1002/pro.570
Details DOI
-
2011 | Journal Article |
Integrated analysis of the conformation of a protein-linked spin label by crystallography, EPR and NMR spectroscopy
Gruene, T.; Cho, M.-K.; Karyagina, I.; Kim, H.-Y.; Grosse, C.; Giller, K. & Zweckstetter, M. et al. (2011)
Journal of Biomolecular NMR, 49(2) pp. 111-119. DOI: https://doi.org/10.1007/s10858-011-9471-y
Details DOI PMID PMC WoS
-
2011 | Journal Article |
Interaction between Amyloid Beta Peptide and an Aggregation Blocker Peptide Mimicking Islet Amyloid Polypeptide
Rezaei-Ghaleh, N.; Andreetto, E.; Yan, L.-M.; Kapurniotu, A. & Zweckstetter, M. (2011)
PLoS ONE, 6(5) art. e20289. DOI: https://doi.org/10.1371/journal.pone.0020289
Details DOI PMID PMC
-
2012 | Journal Article
ChemInform Abstract: Intrinsically Disordered Proteins: From Sequence and Conformational Toward Drug Discovery
Rezaei-Ghaleh, N.; Blackledge, M. & Zweckstetter, M. (2012)
ChemInform, 43(29) pp. no-no. DOI: https://doi.org/10.1002/chin.201229271
Details DOI
-
2012 | Journal Article
Intrinsically Disordered Proteins: From Sequence and Conformational Properties toward Drug Discovery
Rezaei-Ghaleh, N.; Blackledge, M. & Zweckstetter, M. (2012)
ChemBioChem, 13(7) pp. 930-950. DOI: https://doi.org/10.1002/cbic.201200093
Details DOI
-
2013 | Journal Article
Phosphorylation of Human Tau Protein by Microtubule Affinity-Regulating Kinase 2
Schwalbe, M.; Biernat, J.; Bibow, S.; Ozenne, V.; Jensen, M. R.; Kadavath, H. & Blackledge, M. et al. (2013)
Biochemistry, 52(50) pp. 9068-9079. DOI: https://doi.org/10.1021/bi401266n
Details DOI PMID PMC WoS
-
2013 | Journal Article
Burial of the Polymorphic Residue 129 in Amyloid Fibrils of Prion Stop Mutants
Skora, L.; Fonseca-Ornelas, L.; Hofele, R. V.; Riedel, D.; Giller, K.; Watzlawik, J. & Schulz-Schaeffer, W. J. et al. (2013)
Journal of Biological Chemistry, 288(5) pp. 2994-3002. DOI: https://doi.org/10.1074/jbc.M112.423715
Details DOI PMID PMC WoS
-
2013 | Journal Article |
N-truncated amyloid beta (A beta) 4-42 forms stable aggregates and induces acute and long-lasting behavioral deficits
Bouter, Y.; Dietrich, K.; Wittnam, J. L.; Rezaei-Ghaleh, N.; Pillot, T.; Papot-Couturier, S. & Lefebvre, T. et al. (2013)
Acta Neuropathologica, 126(2) pp. 189-205. DOI: https://doi.org/10.1007/s00401-013-1129-2
Details DOI PMID PMC WoS
-
2013 | Journal Article |
Structural Plasticity in Human Heterochromatin Protein 1β
Munari, F.; Rezaei-Ghaleh, N.; Xiang, S.; Fischle, W. & Zweckstetter, M. (2013)
PLoS ONE, 8(4) art. e60887. DOI: https://doi.org/10.1371/journal.pone.0060887
Details DOI PMID PMC
-
2014 | Conference Abstract
Routes of internalization for Melan-A/TAT fusion peptides differ considerably between human dendritic cells and other non-phagocytic cell types
Buhl, T.; Braun, A.; Forkel, S.; Möbius, W. ; van Werven, L.; Jahn, O. & Rezaei-Ghaleh, N. et al. (2014)
Experimental Dermatology, 23(3) , Cologne, GERMANY.
Hoboken: Wiley-blackwell.
Details WoS
-
2014 | Review
Exploring Free-Energy Landscapes of Intrinsically Disordered Proteins at Atomic Resolution Using NMR Spectroscopy
Jensen, M. R.; Zweckstetter, M.; Huang, J.-r.& Backledge, M. (2014)
Chemical Reviews, 114(13) pp. 6632-6660.
Amer Chemical Soc. DOI: https://doi.org/10.1021/cr400688u
Details DOI PMID PMC WoS
-
2014 | Journal Article
Hsp90-Tau Complex Reveals Molecular Basis for Specificity in Chaperone Action
Karagoz, G. E.; Duarte, A. M. S.; Akoury, E.; Ippel, H.; Biernat, J.; Luengo, T. M. & Radli, M. et al. (2014)
Cell, 156(5) pp. 963-974. DOI: https://doi.org/10.1016/j.cell.2014.01.037
Details DOI PMID PMC WoS
-
2014 | Journal Article
Characterization of the effects of phosphorylation by CK2 on the structure and binding properties of human HP1 beta
Munari, F.; Gajda, M. J.; Hiragami-Hamada, K.; Fischle, W. & Zweckstetter, M. (2014)
FEBS Letters, 588(7) pp. 1094-1099. DOI: https://doi.org/10.1016/j.febslet.2014.02.019
Details DOI PMID PMC WoS
-
2014 | Journal Article
Molecular Basis of the Dynamic Structure of the TIM23 Complex in the Mitochondrial Intermembrane Space
Bajaj, R.; Jaremko, L.; Jaremko, M.; Becker, S. & Zweckstetter, M. (2014)
Structure, 22(10) pp. 1501-1511. DOI: https://doi.org/10.1016/j.str.2014.07.015
Details DOI PMID PMC WoS
-
2014 | Journal Article
Interaction of the Intermembrane Space Domain of Tim23 Protein with Mitochondrial Membranes
Bajaj, R.; Munari, F.; Becker, S. & Zweckstetter, M. (2014)
Journal of Biological Chemistry, 289(50) pp. 34620-34626. DOI: https://doi.org/10.1074/jbc.M114.595702
Details DOI PMID PMC WoS
-
2014 | Journal Article
Internalization routes of cell-penetrating melanoma antigen peptides into human dendritic cells
Buhl, T.; Braun, A.; Forkel, S.; Möbius, W. ; van Werven, L.; Jahn, O. & Rezaei-Ghaleh, N. et al. (2014)
Experimental Dermatology, 23(1) pp. 20-26. DOI: https://doi.org/10.1111/exd.12285
Details DOI PMID PMC WoS
-
2014 | Journal Article
Toward the functional oligomerization state of tryptophan-rich sensory proteins
Jaremko, L.; Jaremko, M.; Becker, S. & Zweckstetter, M. (2014)
Protein Science, 23(8) pp. 1154-1160. DOI: https://doi.org/10.1002/pro.2487
Details DOI PMID PMC WoS
-
2014 | Journal Article
Cooperative structure of the heterotrimeric pre-mRNA retention and splicing complex
Wysoczanki, P.; Schneider, C.; Xiang, S.; Munari, F.; Trowitzsch, S.; Wahl, M. C. & Luehrmann, R. et al. (2014)
Nature Structural & Molecular Biology, 21(10) pp. 911-918. DOI: https://doi.org/10.1038/nsmb.2889
Details DOI PMID PMC WoS
-
2014 | Journal Article |
NMR-Based Detection of Hydrogen/Deuterium Exchange in Liposome-Embedded Membrane Proteins
Yao, X.; Duerr, U. H. N.; Gattin, Z.; Laukat, Y.; Narayanan, R. L.; Brueckner, A.-K. & Meisinger, C. et al. (2014)
PLoS ONE, 9(11) art. e112374. DOI: https://doi.org/10.1371/journal.pone.0112374
Details DOI PMID PMC WoS
-
2014 | Journal Article
A six-dimensional alpha proton detection-based APSY experiment for backbone assignment of intrinsically disordered proteins
Yao, X.; Becker, S. & Zweckstetter, M. (2014)
Journal of Biomolecular NMR, 60(4) pp. 231-240. DOI: https://doi.org/10.1007/s10858-014-9872-9
Details DOI PMID PMC WoS
-
2014 | Journal Article
Structure of the Mitochondrial Translocator Protein in Complex with a Diagnostic Ligand
Jaremko, L.; Jaremko, M.; Giller, K.; Becker, S. & Zweckstetter, M. (2014)
Science, 343(6177) pp. 1363-1366. DOI: https://doi.org/10.1126/science.1248725
Details DOI PMID PMC WoS
-
2014 | Journal Article |
Small molecule-mediated stabilization of vesicle-associated helical alpha-synuclein inhibits pathogenic misfolding and aggregation
Fonseca-Ornelas, L.; Eisbach, S. E.; Paulat, M.; Giller, K.; Fernandez, C. O.; Outeiro, T. F. & Becker, S. et al. (2014)
Nature Communications, 5 art. 5857. DOI: https://doi.org/10.1038/ncomms6857
Details DOI PMID PMC WoS
-
2014 | Journal Article
Turn Plasticity Distinguishes Different Modes of Amyloid-beta Aggregation
Rezaei-Ghaleh, N.; Amininasab, M.; Giller, K.; Kumar, S.; Stuendl, A.; Schneider, A. & Becker, S. et al. (2014)
Journal of the American Chemical Society, 136(13) pp. 4913-4919. DOI: https://doi.org/10.1021/ja411707y
Details DOI PMID PMC WoS
-
2015 | Journal Article |
Small Molecules Detected by Second-Harmonic Generation Modulate the Conformation of Monomeric alpha-Synuclein and Reduce Its Aggregation in Cells
Moree, B.; Yin, G.; Lazaro, D. F.; Munari, F.; Strohaeker, T.; Giller, K. & Becker, S. et al. (2015)
Journal of Biological Chemistry, 290(46) pp. 27582-27593. DOI: https://doi.org/10.1074/jbc.M114.636027
Details DOI PMID PMC WoS
-
2015 | Journal Article
Structure of the mammalian TSPO/PBR protein
Jaremko, M.; Jaremko, L.; Jaipuria, G.; Becker, S. & Zweckstetter, M. (2015)
Biochemical Society Transactions, 43 pp. 566-571. DOI: https://doi.org/10.1042/BST20150029
Details DOI PMID PMC WoS
-
2015 | Journal Article
Multiple Paramagnetic Effects through a Tagged Reporter Protein
Camacho-Zarco, A. R.; Munari, F.; Wegstroth, M.; Liu, W.-M.; Ubbink, M.; Becker, S. & Zweckstetter, M. (2015)
Angewandte Chemie International Edition, 54(1) pp. 336-339. DOI: https://doi.org/10.1002/anie.201408615
Details DOI PMID PMC WoS
-
2015 | Journal Article
Structural Integrity of the A147T Polymorph of Mammalian TSPO
Jaremko, M.; Jaremko, L.; Giller, K.; Becker, S. & Zweckstetter, M. (2015)
ChemBioChem, 16(10) pp. 1483-1489. DOI: https://doi.org/10.1002/cbic.201500217
Details DOI PMID PMC WoS
-
2015 | Journal Article
Tau stabilizes microtubules by binding at the interface between tubulin heterodimers
Kadavath, H.; Hofele, R. V.; Biernat, J.; Kumar, S.; Tepper, K.; Urlaub, H. & Mandelkow, E. et al. (2015)
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 112(24) pp. 7501-7506. DOI: https://doi.org/10.1073/pnas.1504081112
Details DOI PMID PMC WoS
-
2015 | Review
Lost in translocation: the functions of the 18-kD translocator protein
Gut, P.; Zweckstetter, M.& Banati, R. B. (2015)
Trends in Endocrinology and Metabolism, 26(7) pp. 349-356.
Elsevier Science London. DOI: https://doi.org/10.1016/j.tem.2015.04.001
Details DOI PMID PMC WoS
-
2015 | Journal Article |
Structures of intermediates during RES complex assembly
Wysoczanski, P.; Becker, S. & Zweckstetter, M. (2015)
Scientific Reports, 5 art. 12545. DOI: https://doi.org/10.1038/srep12545
Details DOI PMID PMC WoS
-
2015 | Journal Article
Conformational Flexibility in the Transmembrane Protein TSPO
Jaremko, L.; Jaremko, M.; Giller, K.; Becker, S. & Zweckstetter, M. (2015)
Chemistry - A European Journal, 21(46) pp. 16555-16563. DOI: https://doi.org/10.1002/chem.201502314
Details DOI PMID PMC WoS
-
2015 | Journal Article
Parkinson Disease Mutant E46K Enhances alpha-Synuclein Phosphorylation in Mammalian Cell Lines, in Yeast, and in Vivo
Mbefo, M. K.; Fares, M.-B.; Paleologou, K.; Oueslati, A.; Yin, G.; Tenreiro, S. & Pinto, M. et al. (2015)
Journal of Biological Chemistry, 290(15) pp. 9412-9427. DOI: https://doi.org/10.1074/jbc.M114.610774
Details DOI PMID PMC WoS
-
2015 | Journal Article
Folding of the Tau Protein on Microtubules
Kadavath, H.; Jaremko, M.; Jaremko, L.; Biernat, J.; Mandelkow, E. & Zweckstetter, M. (2015)
Angewandte Chemie International Edition, 54(35) pp. 10347-10351. DOI: https://doi.org/10.1002/ange.201501714
Details DOI PMID PMC WoS
-
2015 | Journal Article
The active Hsc70/tau complex can be exploited to enhance tau turnover without damaging microtubule dynamics
Fontaine, S. N.; Martin, M. D.; Akoury, E.; Assimon, V. A.; Borysov, S.; Nordhues, B. A. & Sabbagh, J. J. et al. (2015)
Human Molecular Genetics, 24(14) pp. 3971-3981. DOI: https://doi.org/10.1093/hmg/ddv135
Details DOI PMID PMC WoS
-
2015 | Journal Article
Structural Impact of Tau Phosphorylation at Threonine 231
Schwalbe, M.; Kadavath, H.; Biernat, J.; Ozenne, V.; Blackledge, M.; Mandelkow, E. & Zweckstetter, M. (2015)
Structure, 23(8) pp. 1448-1458. DOI: https://doi.org/10.1016/j.str.2015.06.002
Details DOI PMID PMC WoS
-
2016 | Journal Article
Structure of Monomeric Transthyretin Carrying the Clinically Important T119M Mutation
Kim, J. H.; Oroz, J. & Zweckstetter, M. (2016)
Angewandte Chemie International Edition, 55(52) pp. 16168-16171. DOI: https://doi.org/10.1002/anie.201608516
Details DOI PMID PMC WoS
-
2016 | Journal Article
Environmental and genetic factors support the dissociation between alpha-synuclein aggregation and toxicity
Villar-Pique, A.; da Fonseca, T. L.; Sant'Anna, R.; Szegoe, E. M.; Fonseca-Ornelas, L.; Pinho, R. & Carija, A. et al. (2016)
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 113(42) pp. E6506-E6515. DOI: https://doi.org/10.1073/pnas.1606791113
Details DOI PMID PMC WoS
-
2016 | Review
Targeting intrinsically disordered proteins in rational drug discovery
Ambadipudi, S.& Zweckstetter, M. (2016)
Expert Opinion on Drug Discovery, 11(1) pp. 65-77.
Taylor & Francis Ltd. DOI: https://doi.org/10.1517/17460441.2016.1107041
Details DOI PMID PMC WoS
-
2016 | Journal Article
Backbone and side-chain resonance assignment of the A147T polymorph of mouse TSPO in complex with a high-affinity radioligand
Jaremko, M.; Jaremko, L.; Giller, K.; Becker, S. & Zweckstetter, M. (2016)
Biomolecular NMR Assignments, 10(1) pp. 79-83. DOI: https://doi.org/10.1007/s12104-015-9642-y
Details DOI PMID PMC WoS
-
2016 | Journal Article |
Phosphorylation of the amyloid beta-peptide at Ser26 stabilizes oligomeric assembly and increases neurotoxicity
Kumar, S.; Wirths, O. ; Stueber, K.; Wunderlich, P.; Koch, P.; Theil, S. & Rezaei-Ghaleh, N. et al. (2016)
Acta Neuropathologica, 131(4) pp. 525-537. DOI: https://doi.org/10.1007/s00401-016-1546-0
Details DOI PMID PMC WoS