Prof. Dr. Tiago Fleming Outeiro

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unigoe
 

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  • 2023 | Preprint
    ​ ​Towards a Biological Definition of Parkinson’s Disease​
    Höglinger, G. U.; Adler, C. H.; Berg, D.; Klein, C.; Outeiro, T. F. ; Poewe, W.& Postuma, R. et al.​ (2023). DOI: https://doi.org/10.20944/preprints202304.0108.v1 
    ​Details  DOI 
  • 2023 | Preprint
    ​ ​Alpha-synuclein oligomers activate NFAT proteins modulating synaptic homeostasis and apoptosis​
    Sant’Anna, R.; Robbs, B. K; de Freitas, J. A.; dos Santos, P. P.; König, A.; Outeiro, T. F.  & Foguel, D.​ (2023). DOI: https://doi.org/10.1101/2023.02.21.529374 
    ​Details  DOI 
  • 2023 | Journal Article
    ​ ​Uncovering the molecular link between lead toxicity and Parkinson’s disease​
    Shvachiy, L.; Geraldes, V. & Outeiro, T. ​ (2023) 
    Antioxidants & Redox Signaling, art. ars.2022.0076​.​ DOI: https://doi.org/10.1089/ars.2022.0076 
    ​Details  DOI  PMID  PMC 
  • 2023 | Preprint
    ​ ​Impact of Phosphorylation on alpha-Synuclein Structural Determinants​
    Dorn, A. E.; de Bruyn, E.; Rossetti, G.; Fernandez, C.; Outeiro, T. F. ; Schulz, J. B.& Carloni, P.​ (2023). DOI: https://doi.org/10.1101/2023.03.10.531864 
    ​Details  DOI 
  • 2023 | Journal Article | 
    ​ ​Intermittent Lead Exposure Induces Behavioral and Cardiovascular Alterations Associated with Neuroinflammation​
    Shvachiy, L.; Amaro-Leal, Â.; Outeiro, T. F. ; Rocha, I. & Geraldes, V.​ (2023) 
    Cells, 12(5) pp. 818​.​ DOI: https://doi.org/10.3390/cells12050818 
    ​Details  DOI 
  • 2022 | Journal Article | Research Paper | 
    ​ ​Editorial for the Special Issue “Adaptation, Aging, and Cell Death in Yeast Stress Response: Models, Mechanisms and Applications”​
    Guaragnella, N.; Krisko, A. & Outeiro, T. F. ​ (2022) 
    Microorganisms, 10(6).​ DOI: https://doi.org/10.3390/microorganisms10061126 
    ​Details  DOI 
  • 2022 | Journal Article | Research Paper | 
    ​ ​The small aromatic compound SynuClean-D inhibits the aggregation and seeded polymerization of multiple α-synuclein strains​
    Peña-Díaz, S.; Pujols, J.; Vasili, E.; Pinheiro, F.; Santos, J.; Manglano-Artuñedo, Z. & Outeiro, T. F.  et al.​ (2022) 
    The Journal of Biological Chemistry, art. 101902​.​ DOI: https://doi.org/10.1016/j.jbc.2022.101902 
    ​Details  DOI  PMID  PMC 
  • 2022 | Journal Article | Overview | 
    ​ ​Production of Recombinant Alpha-Synuclein: Still No Standardized Protocol in Sight​
    Al-Azzani, M.; König, A. & Outeiro, T. F. ​ (2022) 
    Biomolecules, 12(2).​ DOI: https://doi.org/10.3390/biom12020324 
    ​Details  DOI  PMID  PMC 
  • 2022 | Journal Article | Research Paper | 
    ​ ​Prion-like α-synuclein pathology in the brain of infants with Krabbe disease​
    Hatton, C.; Ghanem, S. S.; Koss, D. J.; Abdi, I. Y.; Gibbons, E.; Guerreiro, R. & Bras, J. et al.​ (2022) 
    Brain: A Journal of Neurology,.​ DOI: https://doi.org/10.1093/brain/awac002 
    ​Details  DOI  PMID  PMC 
  • 2022 | Journal Article
    ​ ​Stellenwert der COMT-Hemmer in der Therapie motorischer Fluktuationen​
    Jost, W. H.; Buhmann, C.; Classen, J.; Eggert, K.; Kohl, Z.; Outeiro, T.   & Tönges, L. et al.​ (2022) 
    Der Nervenarzt,.​ DOI: https://doi.org/10.1007/s00115-021-01237-3 
    ​Details  DOI 
  • 2022 | Preprint
    ​ ​Expansion microscopy at one nanometer resolution​
    Shaib, A. H.; Chouaib, A. A.; Imani, V.; Chowdhury, R.; Georgiev, S. V.; Mougios, N.& Monga, M. et al.​ (2022). DOI: https://doi.org/10.1101/2022.08.03.502284 
    ​Details  DOI 
  • 2022 | Journal Article
    ​ ​Hexokinase 2: The preferential target of trehalose‐6‐phosphate over hexokinase 1​
    Magalhães, R. S. S.; Boechat, F. C.; Brasil, A. A.; Neto, J. R. M.; Ribeiro, G. D.; Paranhos, L. H. & Neves de Souza, N. et al.​ (2022) 
    Journal of Cellular Biochemistry, art. jcb.30317​.​ DOI: https://doi.org/10.1002/jcb.30317 
    ​Details  DOI 
  • 2022 | Journal Article | Research Paper | 
    ​ ​Glycation modulates alpha-synuclein fibrillization kinetics: a sweet spot for inhibition​
    Farzadfard, A.; König, A.; Petersen, S. V.; Nielsen, J.; Vasili, E.; Dominguez-Meijide, A. & Buell, A. K. et al.​ (2022) 
    Journal of Biological Chemistry, art. S0021925822002885​.​ DOI: https://doi.org/10.1016/j.jbc.2022.101848 
    ​Details  DOI 
  • 2022 | Journal Article | Research Paper | 
    ​ ​Rapidly Signal‐enhanced Metabolites for Atomic Scale Monitoring of Living Cells with Magnetic Resonance​
    Ding, Y.; Korchak, S.; Mamone, S.; Jagtap, A. P.; Stevanato, G.; Sternkopf, S. & Moll, D. et al.​ (2022) 
    Chemistry Methods, 2(7).​ DOI: https://doi.org/10.1002/cmtd.202200023 
    ​Details  DOI 
  • 2022 | Journal Article
    ​ ​Molecular Mechanisms Mediating the Transfer of Disease-Associated Proteins and Effects on Neuronal Activity​
    Brás, I. C.; Khani, M. H. ; Vasili, E.; Möbius, W. ; Riedel, D. ; Parfentev, I. & Gerhardt, E.  et al.​ (2022) 
    Journal of Parkinson's Disease, pp. 1​-26​.​ DOI: https://doi.org/10.3233/JPD-223516 
    ​Details  DOI  PMID  PMC 
  • 2022 | Journal Article | 
    ​ ​From Molecular to Functional Effects of Different Environmental Lead Exposure Paradigms​
    Shvachiy, L.; Amaro-Leal, Â.; Outeiro, T. F. ; Rocha, I. & Geraldes, V.​ (2022) 
    Biology, 11(8) pp. 1164​.​ DOI: https://doi.org/10.3390/biology11081164 
    ​Details  DOI  PMID  PMC 
  • 2022 | Journal Article | Research Paper | 
    ​ ​Endogenous Levels of Alpha-Synuclein Modulate Seeding and Aggregation in Cultured Cells​
    Vasili, E.; Dominguez-Meijide, A.; Flores-León, M.; Al-Azzani, M.; Kanellidi, A.; Melki, R. & Stefanis, L. et al.​ (2022) 
    Molecular Neurobiology,.​ DOI: https://doi.org/10.1007/s12035-021-02713-2 
    ​Details  DOI  PMID  PMC 
  • 2022 | Journal Article | Research Paper
    ​ ​Ectosomes and exosomes modulate neuronal spontaneous activity​
    Brás, I. C.; Khani, M. H. ; Riedel, D. ; Parfentev, I.; Gerhardt, E. ; van Riesen, C. & Urlaub, H.  et al.​ (2022) 
    Journal of Proteomics, 269 art. 104721​.​ DOI: https://doi.org/10.1016/j.jprot.2022.104721 
    ​Details  DOI  PMID  PMC 
  • 2022 | Journal Article | Research Paper | 
    ​ ​Monitoring the interactions between alpha-synuclein and Tau in vitro and in vivo using bimolecular fluorescence complementation​
    Torres-Garcia, L.; P. Domingues, J. M.; Brandi, E.; Haikal, C.; Mudannayake, J. M.; Brás, I. C. & Gerhardt, E.  et al.​ (2022) 
    Scientific Reports, 12(1) art. 2987​.​ DOI: https://doi.org/10.1038/s41598-022-06846-9 
    ​Details  DOI  PMID  PMC 
  • 2022 | Journal Article | 
    ​ ​Nuclear alpha-synuclein is present in the human brain and is modified in dementia with Lewy bodies​
    Koss, D. J.; Erskine, D.; Porter, A.; Palmoski, P.; Menon, H.; Todd, O. G. J. & Leite, M. et al.​ (2022) 
    Acta Neuropathologica Communications, 10(1).​ DOI: https://doi.org/10.1186/s40478-022-01403-x 
    ​Details  DOI  PMID  PMC 
  • 2022 | Journal Article | 
    ​ ​Kynurenine 3-Monooxygenase Interacts with Huntingtin at the Outer Mitochondrial Membrane​
    Swaih, A. M.; Breda, C.; Sathyasaikumar, K. V.; Allcock, N.; Collier, M. E. W.; Mason, R. P. & Feasby, A. et al.​ (2022) 
    Biomedicines, 10(9) pp. 2294​.​ DOI: https://doi.org/10.3390/biomedicines10092294 
    ​Details  DOI  PMID  PMC 
  • 2022 | Journal Article | Overview | 
    ​ ​Extracellular alpha-synuclein: Sensors, receptors, and responses​
    Domingues, R.; Sant’Anna, R.; da Fonseca, A. C. C.; Robbs, B. K.; Foguel, D. & Outeiro, T. F. ​ (2022) 
    Neurobiology of Disease, 168 art. S0969996122000882​.​ DOI: https://doi.org/10.1016/j.nbd.2022.105696 
    ​Details  DOI  PMID  PMC 
  • 2021 | Journal Article
    ​ ​Reply to: “Parkinson's Disease and COVID‐19: Do We Need to Be More Patient?”​
    Outeiro, T. F.   & Krisko, A.​ (2021) 
    Movement Disorders, 36(2) pp. 278​-279​.​ DOI: https://doi.org/10.1002/mds.28482 
    ​Details  DOI 
  • 2021 | Journal Article
    ​ ​In silico analysis of the aggregation propensity of the SARS-CoV-2 proteome: Insight into possible cellular pathologies​
    Flores-León, M.; Lázaro, D. F. ; Shvachiy, L.; Krisko, A. & Outeiro, T. F. ​ (2021) 
    Biochimica et Biophysica Acta. Proteins and Proteomics, 1869(10) art. S1570963921000996​.​ DOI: https://doi.org/10.1016/j.bbapap.2021.140693 
    ​Details  DOI 
  • 2021 | Preprint
    ​ ​Alpha-synuclein induces epigenomic dysregulation of glutamate signaling and locomotor pathways​
    Schaffner, S. L.; Wassouf, Z.; Lazaro, D. F.; Xylaki, M.; Gladish, N.; Lin, D. T. S.& MacIsaac, J. et al.​ (2021). DOI: https://doi.org/10.1101/2021.06.12.448150 
    ​Details  DOI 
  • 2021 | Preprint
    ​ ​Cofilin pathology is a new player on α-synuclein-induced spine impairment in models of hippocampal synucleinopathy​
    Oliveira da Silva, M. I.; Santejo, M.; Babcock, I. W.; Magalhães, A.; Minamide, L. S.; Castillo, E.& Gerhardt, E. et al.​ (2021). DOI: https://doi.org/10.1101/2021.02.02.425931 
    ​Details  DOI 
  • 2021 | Preprint
    ​ ​Endogenous Levels of Alpha-synuclein Modulate Seeding and Aggregation in Cultured Cells​
    Vasili, E.; Dominguez-Meijide, A.; Flores-Léon, M.; Al-Azzani, M.; Kanellidi, A.; Melki, R.& Stefanis, L. et al.​ (2021). DOI: https://doi.org/10.21203/rs.3.rs-1152192/v1 
    ​Details  DOI 
  • 2021 | Preprint
    ​ ​Super-resolution microscopy informs on the molecular architecture of alpha-synuclein inclusions in model systems and in the human brain​
    Weish, P.; Lázaro, D. F.; Palmares, L.; Santos, P. I.; Stadelmann, C. ; Höglinger, G. U.& Rizzoli, S. O.  et al.​ (2021). DOI: https://doi.org/10.1101/2021.04.25.441304 
    ​Details  DOI 
  • 2021 | Preprint
    ​ ​Monitoring Alpha-Synuclein – Tau Interactions In Vitro and In Vivo Using Bimolecular Fluorescence Complementation​
    Torres-Garcia, L.; Domingues, J. M.; Brandi, E.; Haikal, C.; Brás, I. C.; Gerhardt, E.& Li, W. et al.​ (2021). DOI: https://doi.org/10.21203/rs.3.rs-960446/v1 
    ​Details  DOI 
  • 2021 | Preprint
    ​ ​Ectosomes and exosomes are distinct proteomic entities that modulate spontaneous activity in neuronal cells​
    Brás, I. C.; Khani, M. H.; Riedel, D.; Parfentev, I.; Gerhardt, E.; van Riesen, C.& Urlaub, H. et al.​ (2021). DOI: https://doi.org/10.1101/2021.06.24.449731 
    ​Details  DOI 
  • 2021 | Preprint
    ​ ​Common molecular mechanisms underlie the transfer of alpha-synuclein, Tau and huntingtin and modulate spontaneous activity in neuronal cells​
    Brás, I. C.; Khani, M. H.; Vasili, E.; Möbius, W. ; Riedel, D.; Parfentev, I.& Gerhardt, E. et al.​ (2021). DOI: https://doi.org/10.1101/2021.07.18.452825 
    ​Details  DOI 
  • 2021 | Preprint
    ​ ​Nuclear alpha-synuclein is present in the human brain and is modified in dementia with Lewy bodies​
    Koss, D. J.; Erskine, D.; Porter, A.; Palmoski, P.; Leite, M.; Attems, J.& Outeiro, T. F. ​ (2021). DOI: https://doi.org/10.1101/2021.10.20.465125 
    ​Details  DOI 
  • 2021 | Journal Article | Erratum
    ​ ​Erratum to: Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies​
    Miranda, H. V.; Szegő, É. M.; Oliveira, L. M. A.; Breda, C.; Darendelioglu, E.; de Oliveira, R. M. & Ferreira, D. G. et al.​ (2021) 
    Brain, 144(6) pp. e58​-e58​.​ DOI: https://doi.org/10.1093/brain/awab175 
    ​Details  DOI 
  • 2021 | Journal Article | Overview | 
    ​ ​Lipids, lysosomes and mitochondria: insights into Lewy body formation from rare monogenic disorders​
    Erskine, D.; Koss, D.; Korolchuk, V. I.; Outeiro, T. F. ; Attems, J. & McKeith, I.​ (2021) 
    Acta Neuropathologica, 141(4) pp. 511​-526​.​ DOI: https://doi.org/10.1007/s00401-021-02266-7 
    ​Details  DOI  PMID  PMC 
  • 2021 | Journal Article | Research Paper | 
    ​ ​DEAD-box RNA helicase Dbp4/DDX10 is an enhancer of α-synuclein toxicity and oligomerization​
    Popova, B. ; Wang, D.; Pätz, C.; Akkermann, D.; Lázaro, D. F. ; Galka, D. & Kolog Gulko, M. et al.​ (2021) 
    PLoS Genetics, 17(3) pp. e1009407​.​ DOI: https://doi.org/10.1371/journal.pgen.1009407 
    ​Details  DOI  PMID  PMC 
  • 2021 | Journal Article | Research Paper | 
    ​ ​Alpha-Synuclein Antibody Characterization: Why Semantics Matters​
    Outeiro, T. F. ​ (2021) 
    Molecular Neurobiology, 58(5) pp. 2202​-2203​.​ DOI: https://doi.org/10.1007/s12035-020-02269-7 
    ​Details  DOI  PMID  PMC 
  • 2021 | Journal Article | Research Paper | 
    ​ ​Cellular Prion Protein Mediates α‐Synuclein Uptake, Localization, and Toxicity In Vitro and In Vivo​
    Thom, T.; Schmitz, M.; Fischer, A.; Correia, A.; Correia, S.; Llorens, F. & Pique, A. et al.​ (2021) 
    Movement Disorders, 37(1) art. mds.28774​.​ DOI: https://doi.org/10.1002/mds.28774 
    ​Details  DOI  PMID  PMC 
  • 2021 | Journal Article | Research Paper | 
    ​ ​Doxycycline inhibits α-synuclein-associated pathologies in vitro and in vivo​
    Dominguez-Meijide, A.; Parrales, V.; Vasili, E.; González-Lizárraga, F.; König, A.; Lázaro, D. F.   & Lannuzel, A. et al.​ (2021) 
    Neurobiology of Disease, 151 pp. 105256​.​ DOI: https://doi.org/10.1016/j.nbd.2021.105256 
    ​Details  DOI  PMID  PMC 
  • 2021 | Journal Article | Research Paper | 
    ​ ​Identification of Two Novel Peptides That Inhibit α-Synuclein Toxicity and Aggregation​
    Popova, B.; Wang, D.; Rajavel, A.; Dhamotharan, K.; Lázaro, D. F.; Gerke, J. & Uhrig, J. F. et al.​ (2021) 
    Frontiers in Molecular Neuroscience, 14.​ DOI: https://doi.org/10.3389/fnmol.2021.659926 
    ​Details  DOI  PMID  PMC 
  • 2021 | Journal Article | Overview | 
    ​ ​Dysfunction of RAB39B‐ Mediated Vesicular Trafficking in Lewy Body Diseases​
    Koss, D. J.; Campesan, S.; Giorgini, F. & Outeiro, T. F. ​ (2021) 
    Movement Disorders,.​ DOI: https://doi.org/10.1002/mds.28605 
    ​Details  DOI  PMID  PMC 
  • 2021 | Journal Article | Editorial Contribution (Editorial, Introduction, Epilogue) | 
    ​ ​Emerging concepts in synucleinopathies​
    Outeiro, T. F. ​ (2021) 
    Acta Neuropathologica, 141(4) pp. 469​-470​.​ DOI: https://doi.org/10.1007/s00401-021-02290-7 
    ​Details  DOI  PMID  PMC 
  • 2021 | Journal Article | Research Paper
    ​ ​JM-20 protects against 6-hydroxydopamine-induced neurotoxicity in models of Parkinson’s disease: Mitochondrial protection and antioxidant properties​
    Fonseca-Fonseca, L. A.; da Silva, V. D. A.; Wong-Guerra, M.; Ramírez-Sánchez, J.; Yaquis, A. S. P.; Ochoa-Rodríguez, E. & Verdecia-Reyes, Y. et al.​ (2021) 
    NeuroToxicology, 82 pp. 89​-98​.​ DOI: https://doi.org/10.1016/j.neuro.2020.11.005 
    ​Details  DOI  PMID  PMC 
  • 2021 | Journal Article | Overview | 
    ​ ​Alpha-synuclein research: defining strategic moves in the battle against Parkinson’s disease​
    Oliveira, L. M. A.; Gasser, T.; Edwards, R.; Zweckstetter, M. ; Melki, R.; Stefanis, L. & Lashuel, H. A. et al.​ (2021) 
    npj Parkinson's Disease, 7(1) art. 65​.​ DOI: https://doi.org/10.1038/s41531-021-00203-9 
    ​Details  DOI  PMID  PMC 
  • 2021 | Journal Article | Research Paper | 
    ​ ​MPV17 Mutations Are Associated With a Quiescent Energetic Metabolic Profile​
    Jacinto, S.; Guerreiro, P. ; de Oliveira, R. M.; Cunha-Oliveira, T.; Santos, M. J.; Grazina, M. & Rego, A. C. et al.​ (2021) 
    Frontiers in Cellular Neuroscience, 15.​ DOI: https://doi.org/10.3389/fncel.2021.641264 
    ​Details  DOI  PMID  PMC 
  • 2021 | Journal Article | Overview | 
    ​ ​Alpha-Synuclein: Mechanisms of Release and Pathology Progression in Synucleinopathies​
    Brás, I. C. & Outeiro, T. F. ​ (2021) 
    Cells, 10(2) pp. 375​.​ DOI: https://doi.org/10.3390/cells10020375 
    ​Details  DOI  PMID  PMC 
  • 2021 | Journal Article | Research Paper | 
    ​ ​Small Molecule Fisetin Modulates Alpha–Synuclein Aggregation​
    Rosado-Ramos, R.; Godinho-Pereira, J.; Marques, D.; Figueira, I.; Outeiro, T. F. ; Menezes, R. & Nunes dos Santos, C.​ (2021) 
    Molecules, 26(11) pp. 3353​.​ DOI: https://doi.org/10.3390/molecules26113353 
    ​Details  DOI  PMID  PMC 
  • 2021 | Journal Article | Research Paper | 
    ​ ​Alpha‐synuclein oligomerization and aggregation: A model will always be a model​
    Outeiro, T. F. ​ (2021) 
    Journal of Neurochemistry, 157(4) pp. 889​-890​.​ DOI: https://doi.org/10.1111/jnc.15264 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | Research Paper | 
    ​ ​Bioprospection of Natural Sources of Polyphenols with Therapeutic Potential for Redox-Related Diseases​
    Menezes, R.; Foito, A.; Jardim, C.; Costa, I.; Garcia, G.; Rosado-Ramos, R. & Freitag, S. et al.​ (2020) 
    Antioxidants, 9(9) pp. 789​.​ DOI: https://doi.org/10.3390/antiox9090789 
    ​Details  DOI  PMID  PMC 
  • 2020 | Preprint
    ​ ​Doxycycline inhibits α-synuclein-associated pathologies in vitro and in vivo​
    Dominguez-Meijide, A.; Parrales, V.; Vasili, E.; González-Lizárraga, F.; König, A.; Lázaro, D. F.& Lannuzel, A. et al.​ (2020). DOI: https://doi.org/10.1101/2020.11.06.371229 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​A new MAP-Rasagiline conjugate reduces α-synuclein inclusion formation in a cell model​
    Vale, N.; Alves, C.; Sharma, V.; Lázaro, D. F. ; Silva, S.; Gomes, P. & Outeiro, T. F. ​ (2020) 
    Pharmacological Reports, 72(2) pp. 456​-464​.​ DOI: https://doi.org/10.1007/s43440-019-00032-x 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Molecular characterization of an aggregation-prone variant of alpha-synuclein used to model synucleinopathies​
    Masaracchia, C.; König, A.; Valiente-Gabioud, A. A.; Peralta, P.; Favretto, F. ; Strohäker, T. & Lázaro, D. F.  et al.​ (2020) 
    Biochimica et Biophysica Acta. Proteins and Proteomics, 1868(1) pp. 140298​.​ DOI: https://doi.org/10.1016/j.bbapap.2019.140298 
    ​Details  DOI 
  • 2020 | Preprint
    ​ ​Doxycycline interferes with tau amyloid aggregation abolishing its associated neuronal toxicity​
    Medina, L.; González-Lizárraga, F.; Dominguez-Meijide, A.; Ploper, D.; Parrales, V.; Sequeira, S.& Cima-Omori, M. S. et al.​ (2020). DOI: https://doi.org/10.1101/2020.11.18.388561 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Identification of antiparkinsonian drugs in the 6-hydroxydopamine zebrafish model​
    Vaz, R. L.; Sousa, S.; Chapela, D.; van der Linde, H. C.; Willemsen, R.; Correia, A. D. & Outeiro, T. F.  et al.​ (2020) 
    Pharmacology Biochemistry and Behavior, 189 pp. 172828​.​ DOI: https://doi.org/10.1016/j.pbb.2019.172828 
    ​Details  DOI 
  • 2020 | Preprint
    ​ ​The Role of Alpha-Synuclein And Other Parkinson’s Genes in Neurodevelopmental and Neurodegenerative Disorders​
    Morato Torres, C. A.; Wassouf, Z.; Zafar, F.; Sastre, D.; Outeiro, T. F.  & Schüle, B.​ (2020). DOI: https://doi.org/10.20944/preprints202007.0334.v1 
    ​Details  DOI 
  • 2020 | Book Chapter
    ​ ​The Interplay Between Proteostasis Systems and Parkinson’s Disease​
    Lázaro, D. F.& Outeiro, T. F. ​ (2020)
    In:​Barrio, Rosa; Sutherland, James D.; Rodriguez, Manuel S.​ (Eds.), Proteostasis and Disease: From Basic Mechanisms to Clinics pp. 223​-236.  DOI: https://doi.org/10.1007/978-3-030-38266-7_9 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Reply to: SARS‐CoV‐2 as a Potential Trigger of Neurodegenerative Diseases​
    Outeiro, T. F.   & Krisko, A.​ (2020) 
    Movement Disorders, 35(7) pp. 1106​-1107​.​ DOI: https://doi.org/10.1002/mds.28178 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​The courage to change science​
    Outeiro, T. F. ​ (2020) 
    EMBO reports, 21(3).​ DOI: https://doi.org/10.15252/embr.202050124 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Tapentadol Prevents Motor Impairments in a Mouse Model of Dyskinesia​
    Vaz, R. L.; Chapela, D.; Coelho, J. E.; Lopes, L. V.; Ferreira, J. J.; Afonso, N. D. & Sousa, S. et al.​ (2020) 
    Neuroscience, 424 pp. 58​-71​.​ DOI: https://doi.org/10.1016/j.neuroscience.2019.08.046 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​The Neuroprotective Action of Amidated-Kyotorphin on Amyloid β Peptide-Induced Alzheimer’s Disease Pathophysiology​
    Belo, R. F.; Martins, M. L. F.; Shvachiy, L.; Costa-Coelho, T.; de Almeida-Borlido, C.; Fonseca-Gomes, J. & Neves, V. et al.​ (2020) 
    Frontiers in Pharmacology, 11.​ DOI: https://doi.org/10.3389/fphar.2020.00985 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Hsp27 reduces glycation‐induced toxicity and aggregation of alpha‐synuclein​
    Vicente Miranda, H.; Chegão, A.; Oliveira, M. S.; Fernandes Gomes, B.; Enguita, F. J. & Outeiro, T. F. ​ (2020) 
    The FASEB Journal, 34(5) pp. 6718​-6728​.​ DOI: https://doi.org/10.1096/fj.201902936R 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​SARS‐CoV ‐2: At the Crossroad Between Aging and Neurodegeneration​
    Lippi, A.; Domingues, R.; Setz, C. ; Outeiro, T. F.   & Krisko, A.​ (2020) 
    Movement Disorders, 35(5) pp. 716​-720​.​ DOI: https://doi.org/10.1002/mds.28084 
    ​Details  DOI 
  • 2020 | Journal Article | 
    ​ ​Inhibition of HDAC6 activity protects dopaminergic neurons from alpha-synuclein toxicity​
    Francelle, L. ; Outeiro, T. F.   & Rappold, G. A.​ (2020) 
    Scientific Reports, 10(1).​ DOI: https://doi.org/10.1038/s41598-020-62678-5 
    ​Details  DOI 
  • 2020 | Journal Article | 
    ​ ​SARS-CoV-2, immunosenescence and inflammaging: partners in the COVID-19 crime​
    Domingues, R.; Lippi, A.; Setz, C. ; Outeiro, T. F.   & Krisko, A.​ (2020) 
    Aging, 12(18) pp. 18778​-18789​.​ DOI: https://doi.org/10.18632/aging.103989 
    ​Details  DOI 
  • 2020 | Journal Article | Research Paper
    ​ ​Cancer and Parkinson's Disease: Common Targets, Emerging Hopes​
    Filippou, P. S. & Outeiro, T. F. ​ (2020) 
    Movement Disorders, 36(2) pp. 340​-346​.​ DOI: https://doi.org/10.1002/mds.28425 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | Overview | 
    ​ ​Synucleinopathies: Where we are and where we need to go​
    Brás, I. C.; Dominguez‐Meijide, A.; Gerhardt, E. ; Koss, D.; Lázaro, D. F. ; Santos, P. I. & Vasili, E. et al.​ (2020) 
    Journal of Neurochemistry, 153(4) pp. 433​-454​.​ DOI: https://doi.org/10.1111/jnc.14965 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | Research Paper | 
    ​ ​Protein trapping leads to altered synaptic proteostasis in synucleinopathies​
    Santos, P. I. & Outeiro, T. F. ​ (2020) 
    The FEBS Journal,.​ DOI: https://doi.org/10.1111/febs.15364 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | Research Paper
    ​ ​Increased expression of myelin-associated genes in frontal cortex of SNCA overexpressing rats and Parkinson’s disease patients​
    Hentrich, T.; Wassouf, Z.; Ehrhardt, C.; Haas, E.; Mills, J. D.; Aronica, E. & Outeiro, T. F.  et al.​ (2020) 
    Aging, 12(19) pp. 18889​-18906​.​ DOI: https://doi.org/10.18632/aging.103935 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | Overview | 
    ​ ​Pharmacological Modulators of Tau Aggregation and Spreading​
    Dominguez-Meijide, A.; Vasili, E. & Outeiro, T. F. ​ (2020) 
    Brain Sciences, 10(11) pp. 858​.​ DOI: https://doi.org/10.3390/brainsci10110858 
    ​Details  DOI  PMID  PMC 
  • 2020 | Book Chapter
    ​ ​Mechanisms of alpha-synuclein toxicity: An update and outlook​
    Brás, I. C.; Xylaki, M.& Outeiro, T. F. ​ (2020)
    In: Recent Advances in Parkinson's Disease pp. 91​-129.  DOI: https://doi.org/10.1016/bs.pbr.2019.10.005 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | Overview | 
    ​ ​The Role of Alpha-Synuclein and Other Parkinson’s Genes in Neurodevelopmental and Neurodegenerative Disorders​
    Morato Torres, C. A.; Wassouf, Z.; Zafar, F.; Sastre, D.; Outeiro, T. F.   & Schüle, B.​ (2020) 
    International Journal of Molecular Sciences, 21(16) pp. 5724​.​ DOI: https://doi.org/10.3390/ijms21165724 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | Overview | 
    ​ ​From iPS Cells to Rodents and Nonhuman Primates: Filling Gaps in Modeling Parkinson's Disease​
    Outeiro, T. F. ; Heutink, P.; Bezard, E. & Cenci, A. M.​ (2020) 
    Movement Disorders,.​ DOI: https://doi.org/10.1002/mds.28387 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | Research Paper
    ​ ​X1INH, an improved next-generation affinity-optimized hydrazonic ligand, attenuates abnormal copper( i )/copper( ii )-α-Syn interactions and affects protein aggregation in a cellular model of synucleinopathy​
    Cukierman, D. S.; Lázaro, D. F. ; Sacco, P.; Ferreira, P. R.; Diniz, R.; Fernández, C. O. & Outeiro, T. F.  et al.​ (2020) 
    Dalton Transactions, 49(45) pp. 16252​-16267​.​ DOI: https://doi.org/10.1039/d0dt01138j 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | Editorial Contribution (Editorial, Introduction, Epilogue) | 
    ​ ​Editorial: Protein Misfolding and Spreading Pathology in Neurodegenerative Diseases​
    Lázaro, D. F. ; Bellucci, A.; Brundin, P. & Outeiro, T. F. ​ (2020) 
    Frontiers in Molecular Neuroscience, 12.​ DOI: https://doi.org/10.3389/fnmol.2019.00312 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | Research Paper | 
    ​ ​RAB39B is redistributed in dementia with Lewy bodies and is sequestered within aβ plaques and Lewy bodies​
    Koss, D. J.; Bondarevaite, O.; Adams, S.; Leite, M.; Giorgini, F.; Attems, J. & Outeiro, T. F. ​ (2020) 
    Brain Pathology, 31(1) pp. 120​-132​.​ DOI: https://doi.org/10.1111/bpa.12890 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | Research Paper | 
    ​ ​Effects of pharmacological modulators of α-synuclein and tau aggregation and internalization​
    Dominguez-Meijide, A.; Vasili, E.; König, A.; Cima-Omori, M.-S.; Ibáñez de Opakua, A.; Leonov, A.   & Ryazanov, S.  et al.​ (2020) 
    Scientific Reports, 10(1).​ DOI: https://doi.org/10.1038/s41598-020-69744-y 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article
    ​ ​Cellular models of alpha‐synuclein toxicity and aggregation​
    Delenclos, M.; Burgess, J. D.; Lamprokostopoulou, A.; Outeiro, T. F. ; Vekrellis, K. & McLean, P. J.​ (2019) 
    Journal of Neurochemistry, 150(5) pp. 566​-576​.​ DOI: https://doi.org/10.1111/jnc.14806 
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​Glycation in Huntington’s Disease: A Possible Modifier and Target for Intervention​
    Brás, I. C.; König, A. & Outeiro, T. F. ​ (2019) 
    Journal of Huntington's Disease, 8(3) pp. 245​-256​.​ DOI: https://doi.org/10.3233/JHD-190366 
    ​Details  DOI 
  • 2019 | Book Chapter
    ​ ​Yeast-Based Screens to Target Alpha-Synuclein Toxicity​
    Brás, I. C.; Popova, B.; Braus, G. H.& Outeiro, T. F. ​ (2019)
    In:​Bartels, Tim​ (Ed.), Methods in Molecular Biology Alpha-Synuclein : Methods and Protocols pp. 145​-156. ​New York, NY: ​Springer New York. DOI: https://doi.org/10.1007/978-1-4939-9124-2_12 
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​Synthesis and evaluation of esterified Hsp70 agonists in cellular models of protein aggregation and folding​
    Chiang, A. N.; Liang, M.; Dominguez-Meijide, A.; Masaracchia, C.; Goeckeler-Fried, J. L.; Mazzone, C. S. & Newhouse, D. W. et al.​ (2019) 
    Bioorganic & Medicinal Chemistry, 27(1) pp. 79​-91​.​ DOI: https://doi.org/10.1016/j.bmc.2018.11.011 
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​The synthetic cannabinoid JWH-018 modulates Saccharomyces cerevisiae energetic metabolism​
    Ferreira, C.; Couceiro, J.; Família, C.; Jardim, C.; Antas, P.; Santos, C. N & Outeiro, T. F  et al.​ (2019) 
    FEMS Yeast Research, 19(5).​ DOI: https://doi.org/10.1093/femsyr/foz042 
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​Effects of alpha‐synuclein post‐translational modifications on metal binding​
    González, N.; Arcos‐López, T.; König, A.; Quintanar, L.; Menacho Márquez, M.; Outeiro, T. F.   & Fernández, C. O.​ (2019) 
    Journal of Neurochemistry, 150(5) pp. 507​-521​.​ DOI: https://doi.org/10.1111/jnc.14721 
    ​Details  DOI 
  • 2019 | Journal Article | 
    ​ ​α‐Synuclein toxicity in yeast and human cells is caused by cell cycle re‐entry and autophagy degradation of ribonucleotide reductase 1​
    Sampaio‐Marques, B.; Guedes, A.; Vasilevskiy, I.; Gonçalves, S.; Outeiro, T. F. ; Winderickx, J. & Burhans, W. C. et al.​ (2019) 
    Aging Cell, 18(4).​ DOI: https://doi.org/10.1111/acel.12922 
    ​Details  DOI 
  • 2019 | Journal Article | 
    ​ ​Dihydromyricetin and Salvianolic acid B inhibit alpha-synuclein aggregation and enhance chaperone-mediated autophagy​
    Wu, J.-Z.; Ardah, M.; Haikal, C.; Svanbergsson, A.; Diepenbroek, M.; Vaikath, N. N. & Li, W. et al.​ (2019) 
    Translational Neurodegeneration, 8(1) art. 18​.​ DOI: https://doi.org/10.1186/s40035-019-0159-7 
    ​Details  DOI 
  • 2019 | Journal Article | 
    ​ ​Spreading of α-Synuclein and Tau: A Systematic Comparison of the Mechanisms Involved​
    Vasili, E.; Dominguez-Meijide, A. & Outeiro, T. F. ​ (2019) 
    Frontiers in Molecular Neuroscience, 12 art. 107​.​ DOI: https://doi.org/10.3389/fnmol.2019.00107 
    ​Details  DOI 
  • 2019 | Journal Article | Research Paper | 
    ​ ​Biasing the native α-synuclein conformational ensemble towards compact states abolishes aggregation and neurotoxicity​
    Carija, A.; Pinheiro, F.; Pujols, J.; Brás, I. C.; Lázaro, D. F.; Santambrogio, C. & Grandori, R. et al.​ (2019) 
    Redox Biology, 22 pp. 101135​.​ DOI: https://doi.org/10.1016/j.redox.2019.101135 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | Overview | 
    ​ ​Epigenetics of the Synapse in Neurodegeneration​
    Xylaki, M.; Atzler, B. & Outeiro, T. F. ​ (2019) 
    Current Neurology and Neuroscience Reports, 19(10).​ DOI: https://doi.org/10.1007/s11910-019-0995-y 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | Research Paper
    ​ ​Nuclear localization and phosphorylation modulate pathological effects of alpha-synuclein​
    Pinho, R.; Paiva, I.; Jercic, K. G.; Fonseca-Ornelas, L.; Gerhardt, E.; Fahlbusch, C. & Garcia-Esparcia, P. et al.​ (2019) 
    Human Molecular Genetics, 28(1) pp. 31​-50​.​ DOI: https://doi.org/10.1093/hmg/ddy326 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | Research Paper
    ​ ​A 2A R‐induced transcriptional deregulation in astrocytes: An in vitro study​
    Paiva, I. ; Carvalho, K.; Santos, P.; Cellai, L.; Pavlou, M. A. S. ; Jain, G. & Gnad, T. et al.​ (2019) 
    Glia, 67(12) pp. 2329​-2342​.​ DOI: https://doi.org/10.1002/glia.23688 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | 
    ​ ​Dementia with Lewy bodies: an update and outlook​
    Outeiro, T. F. ; Koss, D. J.; Erskine, D.; Walker, L.; Kurzawa-Akanbi, M.; Burn, D. & Donaghy, P. et al.​ (2019) 
    Molecular Neurodegeneration, 14(1) art. 5​.​ DOI: https://doi.org/10.1186/s13024-019-0306-8 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | Overview
    ​ ​In vitro models of synucleinopathies: informing on molecular mechanisms and protective strategies​
    Marvian, A. T.; Koss, D. J.; Aliakbari, F.; Morshedi, D. & Outeiro, T. F. ​ (2019) 
    Journal of Neurochemistry, 150(5) pp. 535​-565​.​ DOI: https://doi.org/10.1111/jnc.14707 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | Overview
    ​ ​LRRK2, alpha-synuclein, and tau: partners in crime or unfortunate bystanders?​
    Outeiro, T. F. ; Harvey, K.; Dominguez-Meijide, A. & Gerhardt, E. ​ (2019) 
    Biochemical Society Transactions, 47(3) pp. 827​-838​.​ DOI: https://doi.org/10.1042/BST20180466 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | Research Paper
    ​ ​Synuclein Meeting 2019: where we are and where we need to go​
    Outeiro, T. F.   & Mestre, T. A.​ (2019) 
    Journal of Neurochemistry, 150(5) pp. 462​-466​.​ DOI: https://doi.org/10.1111/jnc.14825 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | Research Paper | 
    ​ ​Cytosolic Trapping of a Mitochondrial Heat Shock Protein Is an Early Pathological Event in Synucleinopathies​
    Szegő, É. M.; Dominguez-Meijide, A.; Gerhardt, E.; König, A.; Koss, D. J.; Li, W. & Pinho, R. et al.​ (2019) 
    Cell Reports, 28(1) pp. 65.e6​-77.e6​.​ DOI: https://doi.org/10.1016/j.celrep.2019.06.009 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | Overview
    ​ ​Are genetic and idiopathic forms of Parkinson's disease the same disease?​
    Correia Guedes, L.; Mestre, T.; Outeiro, T. F.   & Ferreira, J. J.​ (2019) 
    Journal of Neurochemistry, 152(5) pp. 515​-522​.​ DOI: https://doi.org/10.1111/jnc.14902 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | Overview
    ​ ​The role of LRRK2 in cell signalling​
    Harvey, K. & Outeiro, T. F. ​ (2019) 
    Biochemical Society Transactions, 47(1) pp. 197​-207​.​ DOI: https://doi.org/10.1042/BST20180464 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article
    ​ ​Characterization of the activity, aggregation, and toxicity of heterodimers of WT and ALS-associated mutant Sod1​
    Brasil, A. de A.; de Carvalho, M. D. C.; Gerhardt, E. ; Queiroz, D. D.; Pereira, M. D.; Outeiro, T. F.   & Eleutherio, E. C. A.​ (2019) 
    Proceedings of the National Academy of Sciences of the United States of America, 116(51) pp. 25991​-26000​.​ DOI: https://doi.org/10.1073/pnas.1902483116 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | Overview
    ​ ​Investigating targets for neuropharmacological intervention by molecular dynamics simulations​
    Rossetti, G.; Kless, A.; Lai, L.; Outeiro, T. F.   & Carloni, P.​ (2019) 
    Biochemical Society Transactions, 47(3) pp. 909​-918​.​ DOI: https://doi.org/10.1042/BST20190048 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | Research Paper
    ​ ​Translocator Protein Ligand Protects against Neurodegeneration in the MPTP Mouse Model of Parkinsonism​
    Gong, J.; Szego, É. M. ; Leonov, A. ; Benito, E. ; Becker, S. ; Fischer, A.   & Zweckstetter, M.  et al.​ (2019) 
    The Journal of Neuroscience, 39(19) pp. 3752​-3769​.​ DOI: https://doi.org/10.1523/JNEUROSCI.2070-18.2019 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article
    ​ ​Alpha-Synuclein Glycation and the Action of Anti-Diabetic Agents in Parkinson’s Disease​
    König, A.; Vicente Miranda, H. & Outeiro, T. F. ​ (2018) 
    Journal of Parkinson's Disease, 8(1) pp. 33​-43​.​ DOI: https://doi.org/10.3233/JPD-171285 
    ​Details  DOI 
  • 2018 | Journal Article
    ​ ​Attention-deficit/hyperactivity disorder is associated with reduced levels of serum low-density lipoprotein cholesterol in adolescents. Data from the population-based German KiGGS study​
    Pinho, R. ; Wang, B. ; Becker, A. ; Rothenberger, A. ; Outeiro, T. F. ; Herrmann-Lingen, C.   & Meyer, T. ​ (2018) 
    The World Journal of Biological Psychiatry, 20(6) pp. 496​-504​.​ DOI: https://doi.org/10.1080/15622975.2017.1417636 
    ​Details  DOI 
  • 2018 | Journal Article
    ​ ​Diabetes Mellitus as a Risk Factor for Parkinson’s Disease: a Molecular Point of View​
    Biosa, A.; Outeiro, T. F. ; Bubacco, L. & Bisaglia, M.​ (2018) 
    Molecular Neurobiology, 55(11) pp. 8754​-8763​.​ DOI: https://doi.org/10.1007/s12035-018-1025-9 
    ​Details  DOI 
  • 2018 | Journal Article
    ​ ​The trehalose protective mechanism during thermal stress in Saccharomyces cerevisiae: the roles of Ath1 and Agt1​
    Magalhães, R. S S; Popova, B. ; Braus, G. H ; Outeiro, T. F   & Eleutherio, E. C A​ (2018) 
    FEMS Yeast Research, 18(6).​ DOI: https://doi.org/10.1093/femsyr/foy066 
    ​Details  DOI 
  • 2018 | Journal Article
    ​ ​Identification of novel protein phosphatases as modifiers of alpha-synuclein aggregation in yeast​
    Brás, I. C.; Tenreiro, S.; Silva, A. M & Outeiro, T. F ​ (2018) 
    FEMS Yeast Research, 18(8).​ DOI: https://doi.org/10.1093/femsyr/foy108 
    ​Details  DOI 
  • 2018 | Journal Article
    ​ ​Binding Modes of Phthalocyanines to Amyloid β Peptide and Their Effects on Amyloid Fibril Formation​
    Valiente-Gabioud, A. A.; Riedel, D. ; Outeiro, T. F. ; Menacho-Márquez, M. A.; Griesinger, C.   & Fernández, C. O.​ (2018) 
    Biophysical Journal, 114(5) pp. 1036​-1045​.​ DOI: https://doi.org/10.1016/j.bpj.2018.01.003 
    ​Details  DOI 
  • 2018 | Journal Article
    ​ ​Zebrafish as an Animal Model for Drug Discovery in Parkinson’s Disease and Other Movement Disorders: A Systematic Review​
    Vaz, R. L.; Outeiro, T. F.   & Ferreira, J. J.​ (2018) 
    Frontiers in Neurology, 9.​ DOI: https://doi.org/10.3389/fneur.2018.00347 
    ​Details  DOI 
  • 2018 | Journal Article
    ​ ​Monitoring α‐synuclein multimerization in vivo​
    Prasad, V.; Wasser, Y.; Hans, F.; Goswami, A.; Katona, I.; Outeiro, T. F.   & Kahle, P. J. et al.​ (2018) 
    The FASEB Journal, 33(2) pp. 2116​-2131​.​ DOI: https://doi.org/10.1096/fj.201800148RRR 
    ​Details  DOI 
  • 2018 | Journal Article
    ​ ​SIRT2 in age-related neurodegenerative disorders​
    Fourcade, S.; Outeiro, T. F.   & Pujol, A.​ (2018) 
    Aging, 10(3) pp. 295​-296​.​ DOI: https://doi.org/10.18632/aging.101397 
    ​Details  DOI 
  • 2018 | Journal Article | 
    ​ ​Guidelines and recommendations on yeast cell death nomenclature​
    Carmona-Gutierrez, D.; Bauer, M. A.; Zimmermann, A.; Aguilera, A.; Austriaco, N.; Ayscough, K. & Balzan, R. et al.​ (2018) 
    Microbial Cell, 5(1) pp. 4​-31​.​ DOI: https://doi.org/10.15698/mic2018.01.607 
    ​Details  DOI 
  • 2018 | Journal Article | 
    ​ ​Secretion and Uptake of α-Synuclein Via Extracellular Vesicles in Cultured Cells​
    Gustafsson, G.; Lööv, C.; Persson, E.; Lázaro, D. F. ; Takeda, S.; Bergström, J. & Erlandsson, A. et al.​ (2018) 
    Cellular and Molecular Neurobiology, 38(8) pp. 1539​-1550​.​ DOI: https://doi.org/10.1007/s10571-018-0622-5 
    ​Details  DOI 
  • 2018 | Journal Article | 
    ​ ​(Poly)phenol-digested metabolites modulate alpha-synuclein toxicity by regulating proteostasis​
    Macedo, D.; Jardim, C.; Figueira, I.; Almeida, A. F.; McDougall, G. J.; Stewart, D. & Yuste, J. E. et al.​ (2018) 
    Scientific Reports, 8(1).​ DOI: https://doi.org/10.1038/s41598-018-25118-z 
    ​Details  DOI 
  • 2018 | Journal Article | 
    ​ ​The Parkinson’s Disease-Linked Protein DJ-1 Associates with Cytoplasmic mRNP Granules During Stress and Neurodegeneration​
    Repici, M.; Hassanjani, M.; Maddison, D. C.; Garção, P.; Cimini, S.; Patel, B. & Szegö, É. M.  et al.​ (2018) 
    Molecular Neurobiology, 56(1) pp. 61​-77​.​ DOI: https://doi.org/10.1007/s12035-018-1084-y 
    ​Details  DOI 
  • 2018 | Journal Article | 
    ​ ​Age-related shift in LTD is dependent on neuronal adenosine A2A receptors interplay with mGluR5 and NMDA receptors​
    Temido-Ferreira, M.; Ferreira, D. G. ; Batalha, V. L.; Marques-Morgado, I.; Coelho, J. E.; Pereira, P. & Gomes, R. et al.​ (2018) 
    Molecular Psychiatry, 25(8) pp. 1876​-1900​.​ DOI: https://doi.org/10.1038/s41380-018-0110-9 
    ​Details  DOI 
  • 2018 | Journal Article | Research Paper | 
    ​ ​Membrane binding, internalization, and sorting of alpha-synuclein in the cell​
    Masaracchia, C.; Hnida, M.; Gerhardt, E.; Lopes da Fonseca, T.; Villar-Pique, A.; Branco, T. & Stahlberg, M. A. et al.​ (2018) 
    Acta Neuropathologica Communications, 6(1) art. 79​.​ DOI: https://doi.org/10.1186/s40478-018-0578-1 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | Research Paper | 
    ​ ​Glyoxal as an alternative fixative to formaldehyde in immunostaining and super-resolution microscopy​
    Richter, K. N. ; Revelo, N. H. ; Seitz, K. J.; Helm, M. S.; Sarkar, D.; Saleeb, R. S. & d'Este, E.  et al.​ (2018) 
    The EMBO journal, 37(1) pp. 139​-159​.​ DOI: https://doi.org/10.15252/embj.201695709 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | Research Paper
    ​ ​Sensing α-Synuclein From the Outside via the Prion Protein: Implications for Neurodegeneration​
    Brás, I. C.; Lopes, L. V. & Outeiro, T. F. ​ (2018) 
    Movement Disorders, 33(11) pp. 1675​-1684​.​ DOI: https://doi.org/10.1002/mds.27478 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | Research Paper
    ​ ​Small molecule inhibits α-synuclein aggregation, disrupts amyloid fibrils, and prevents degeneration of dopaminergic neurons​
    Pujols, J.; Peña-Díaz, S.; Lázaro, D. F. ; Peccati, F.; Pinheiro, F.; González, D. & Carija, A. et al.​ (2018) 
    Proceedings of the National Academy of Sciences, 115(41) pp. 10481​-10486​.​ DOI: https://doi.org/10.1073/pnas.1804198115 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | Research Paper
    ​ ​Alpha-synuclein deregulates the expression of COL4A2 and impairs ER-Golgi function​
    Paiva, I. ; Jain, G.; Lázaro, D. F. ; Jerčić, K. G.; Hentrich, T.; Kerimoglu, C.   & Pinho, R.  et al.​ (2018) 
    Neurobiology of Disease, 119 pp. 121​-135​.​ DOI: https://doi.org/10.1016/j.nbd.2018.08.001 
    ​Details  DOI  PMID  PMC 
  • 2017 | Journal Article | 
    ​ ​The influence of dopamine-beta-hydroxylase and catechol O-methyltransferase gene polymorphism on the efficacy of insulin detemir therapy in patients with type 2 diabetes mellitus​
    Bozek, T.; Blazekovic, A.; Sustar, A.; Smircic-Duvnjak, L.; Outeiro, T. F. ; Pivac, N. & Borovecki, F. et al.​ (2017) 
    Diabetology & Metabolic Syndrome, 9(1) art. 97​.​ DOI: https://doi.org/10.1186/s13098-017-0295-0 
    ​Details  DOI 
  • 2017 | Journal Article | 
    ​ ​Posttranslational modifications of blood-derived alpha-synuclein as biochemical markers for Parkinson's disease.​
    Vicente Miranda, H.; Cássio, R.; Correia-Guedes, L.; Gomes, M. A.; Chegão, A.; Miranda, E. & Soares, T. et al.​ (2017) 
    Scientific reports, 7(1) art. 13713​.​ DOI: https://doi.org/10.1038/s41598-017-14175-5 
    ​Details  DOI  PMID  PMC 
  • 2017 | Journal Article
    ​ ​The NAD+-dependent deacetylase SIRT2 attenuates oxidative stress and mitochondrial dysfunction and improves insulin sensitivity in hepatocytes​
    Lemos, V.; de Oliveira, R. M; Naia, L.; Szegö, É. ; Ramos, E.; Pinho, S. & Magro, F. et al.​ (2017) 
    Human Molecular Genetics, 26(21) pp. 4105​-4117​.​ DOI: https://doi.org/10.1093/hmg/ddx298 
    ​Details  DOI 
  • 2017 | Journal Article
    ​ ​Serum lipid alterations in GBA-associated Parkinson's disease​
    Guedes, L. C.; Chan, R. B.; Gomes, M. A.; Conceição, V. A.; Machado, R. B.; Soares, T. & Xu, Y. et al.​ (2017) 
    Parkinsonism & Related Disorders, 44 pp. 58​-65​.​ DOI: https://doi.org/10.1016/j.parkreldis.2017.08.026 
    ​Details  DOI 
  • 2017 | Journal Article
    ​ ​Nrf2 activation by tauroursodeoxycholic acid in experimental models of Parkinson's disease​
    Moreira, S.; Fonseca, I.; Nunes, M. J.; Rosa, A.; Lemos, L.; Rodrigues, E. & Carvalho, A. N. et al.​ (2017) 
    Experimental Neurology, 295 pp. 77​-87​.​ DOI: https://doi.org/10.1016/j.expneurol.2017.05.009 
    ​Details  DOI 
  • 2017 | Journal Article
    ​ ​Cell reprogramming: Therapeutic potential and the promise of rejuvenation for the aging brain​
    López-León, M.; Outeiro, T. F.   & Goya, R. G.​ (2017) 
    Ageing Research Reviews, 40 pp. 168​-181​.​ DOI: https://doi.org/10.1016/j.arr.2017.09.002 
    ​Details  DOI 
  • 2017 | Journal Article
    ​ ​Tau deletion promotes brain insulin resistance​
    Marciniak, E.; Leboucher, A.; Caron, E.; Ahmed, T.; Tailleux, A.; Dumont, J. & Issad, T. et al.​ (2017) 
    Journal of Experimental Medicine, 214(8) pp. 2257​-2269​.​ DOI: https://doi.org/10.1084/jem.20161731 
    ​Details  DOI 
  • 2017 | Journal Article
    ​ ​Sirtuin 2 enhances dopaminergic differentiation via the AKT/GSK-3β/β-catenin pathway​
    Szegő, É. M.; Gerhardt, E. & Outeiro, T. F. ​ (2017) 
    Neurobiology of Aging, 56 pp. 7​-16​.​ DOI: https://doi.org/10.1016/j.neurobiolaging.2017.04.001 
    ​Details  DOI 
  • 2017 | Journal Article | Erratum
    ​ ​Correction: The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease​
    de Oliveira, R. M.; Vicente Miranda, H.; Francelle, L.; Pinho, R.; Szegö, É. M.; Martinho, R. & Munari, F. et al.​ (2017) 
    PLOS Biology, 15(4) pp. e1002601​.​ DOI: https://doi.org/10.1371/journal.pbio.1002601 
    ​Details  DOI 
  • 2017 | Journal Article
    ​ ​Phycocyanin protects against Alpha-Synuclein toxicity in yeast​
    Macedo, D.; Bertolin, T. E.; Oro, T.; Backes, L. T. H.; Brás, I. C.; Santos, C. N. & Tenreiro, S. et al.​ (2017) 
    Journal of Functional Foods, 38 pp. 553​-560​.​ DOI: https://doi.org/10.1016/j.jff.2017.09.044 
    ​Details  DOI 
  • 2017 | Journal Article
    ​ ​Synthesis and Biological Evaluation of Novel 2-Aryl Benzimidazoles as Chemotherapeutic Agents​
    Morais, G. R.; Palma, E.; Marques, F.; Gano, L.; Oliveira, M. C.; Abrunhosa, A. & Vicente Miranda, H. et al.​ (2017) 
    Journal of Heterocyclic Chemistry, 54(1) pp. 255​-267​.​ DOI: https://doi.org/10.1002/jhet.2575 
    ​Details  DOI  WoS 
  • 2017 | Journal Article
    ​ ​Treatment with diphenyl–pyrazole compound anle138b/c reveals that α-synuclein protects melanoma cells from autophagic cell death​
    Turriani, E.; Lázaro, D. F. ; Ryazanov, S. ; Leonov, A. ; Giese, A.; Schön, M.   & Schön, M. P.  et al.​ (2017) 
    Proceedings of the National Academy of Sciences of the United States of America, 114(25) pp. E4971​-E4977​.​ DOI: https://doi.org/10.1073/pnas.1700200114 
    ​Details  DOI 
  • 2017 | Journal Article
    ​ ​IGF-I Gene Therapy in Aging Rats Modulates Hippocampal Genes Relevant to Memory Function​
    Pardo, J.; Abba, M. C; Lacunza, E.; Ogundele, O. M; Paiva, I. ; Morel, G. R & Outeiro, T. F  et al.​ (2017) 
    The Journals of Gerontology. Series A, Biological Sciences, Medical Sciences, 73(4) pp. 459​-467​.​ DOI: https://doi.org/10.1093/gerona/glx125 
    ​Details  DOI 
  • 2017 | Book Chapter
    ​ ​Epigenetics in Parkinson’s Disease​
    Pavlou, M. A. S.& Outeiro, T. F. ​ (2017)
    In:​Delgado-Morales, Raul​ (Ed.), Advances in Experimental Medicine and Biology Neuroepigenomics in Aging and Disease pp. 363​-390. ​Cham: ​Springer International Publishing. DOI: https://doi.org/10.1007/978-3-319-53889-1_19 
    ​Details  DOI 
  • 2017 | Journal Article
    ​ ​Glycation potentiates alpha-synuclein-associated neurodegeneration in synucleinopathies​
    Miranda, H. V.; Szego, E. M.; Oliveira, L. M. A.; Breda, C.; Darendelioglu, E.; de Oliveira, R. M. & Ferreira, D. G. et al.​ (2017) 
    Brain, 140 pp. 1399​-1419​.​ DOI: https://doi.org/10.1093/brain/awx056 
    ​Details  DOI  WoS 
  • 2017 | Journal Article
    ​ ​Neuromelanin magnetic resonance imaging of the substantia nigra in LRRK2 -related Parkinson's disease​
    Correia Guedes, L.; Reimão, S.; Paulino, P.; Nunes, R. G.; Bouça-Machado, R.; Abreu, D. & Gonçalves, N. et al.​ (2017) 
    Movement Disorders, 32(9) pp. 1331​-1333​.​ DOI: https://doi.org/10.1002/mds.27083 
    ​Details  DOI 
  • 2017 | Journal Article
    ​ ​Sodium butyrate rescues dopaminergic cells from alpha-synuclein-induced transcriptional deregulation and DNA damage​
    Paiva, I. ; Pinho, R. ; Pavlou, M. A. ; Hennion, M. ; Wales, P. ; Schütz, A.-L.   & Rajput, A.  et al.​ (2017) 
    Human Molecular Genetics, 26(12) pp. 2231​-2246​.​ DOI: https://doi.org/10.1093/hmg/ddx114 
    ​Details  DOI 
  • 2017 | Journal Article
    ​ ​Protein phosphatase 1 regulates huntingtin exon 1 aggregation and toxicity​
    Branco-Santos, J.; Herrera, F.; Poças, G. M.; Pires-Afonso, Y.; Giorgini, F.; Domingos, P. M. & Outeiro, T. F. ​ (2017) 
    Human Molecular Genetics, 26(19) pp. 3763​-3775​.​ DOI: https://doi.org/10.1093/hmg/ddx260 
    ​Details  DOI 
  • 2017 | Journal Article
    ​ ​Cellular models as tools for the study of the role of alpha-synuclein in Parkinson's disease​
    Lázaro, D. F. ; Pavlou, M. A. S.   & Outeiro, T. F. ​ (2017) 
    Experimental Neurology, 298 pp. 162​-171​.​ DOI: https://doi.org/10.1016/j.expneurol.2017.05.007 
    ​Details  DOI 
  • 2017 | Journal Article
    ​ ​α-synuclein interacts with PrPC to induce cognitive impairment through mGluR5 and NMDAR2B​
    Ferreira, D. G ; Temido-Ferreira, M.; Vicente Miranda, H.; Batalha, V. L; Coelho, J. E; Szegö, É. M   & Marques-Morgado, I. et al.​ (2017) 
    Nature Neuroscience, 20(11) pp. 1569​-1579​.​ DOI: https://doi.org/10.1038/nn.4648 
    ​Details  DOI 
  • 2017 | Journal Article | Erratum
    ​ ​Correction: Gene Expression Differences in Peripheral Blood of Parkinson's Disease Patients with Distinct Progression Profiles​
    Pinho, R.; Guedes, L. C.; Soreq, L.; Lobo, P. P.; Mestre, T.; Coelho, M. & Rosa, M. M. et al.​ (2017) 
    PLOS ONE, 12(12) pp. e0190552​.​ DOI: https://doi.org/10.1371/journal.pone.0190552 
    ​Details  DOI 
  • 2017 | Journal Article | 
    ​ ​Implications of fALS Mutations on Sod1 Function and Oligomerization in Cell Models​
    Brasil, A. A.; Magalhães, R. S. S.; De Carvalho, M. D. C.; Paiva, I. ; Gerhardt, E. ; Pereira, M. D. & Outeiro, T. F.  et al.​ (2017) 
    Molecular Neurobiology, 55(6) pp. 5269​-5281​.​ DOI: https://doi.org/10.1007/s12035-017-0755-4 
    ​Details  DOI 
  • 2017 | Journal Article | Editorial Contribution (Editorial, Introduction, Epilogue) | 
    ​ ​Editorial: Molecular Chaperones and Neurodegeneration​
    Roodveldt, C.; Outeiro, T. F.   & Braun, J. E. A.​ (2017) 
    Frontiers in Neuroscience, 11.​ DOI: https://doi.org/10.3389/fnins.2017.00565 
    ​Details  DOI 
  • 2017 | Journal Article | 
    ​ ​The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease​
    de Oliveira, R. M.; Miranda, H. V.; Francelle, L.; Pinho, R.; Szegoe, E. M.; Martinho, R. & Munari, F. et al.​ (2017) 
    PLoS Biology, 15(3) art. e2000374​.​ DOI: https://doi.org/10.1371/journal.pbio.2000374 
    ​Details  DOI  PMID  PMC  WoS 
  • 2017 | Review | 
    ​ ​Contribution of Neuroepigenetics to Huntington's Disease​
    Francelle, L.; Lotz, C.; Outeiro, T. ; Brouillet, E.& Merienne, K.​ (2017)
    Frontiers in Human Neuroscience, 11​.​
    Frontiers Media Sa. DOI: https://doi.org/10.3389/fnhum.2017.00017 
    ​Details  DOI  PMID  PMC  WoS 
  • 2017 | Journal Article
    ​ ​Adenosine A(2A) Receptors Modulate alpha-Synuclein Aggregation and Toxicity​
    Ferreira, D. G.; Batalha, V. L.; Vicente Miranda, H.; Coelho, J. E.; Gomes, R.; Goncalves, F. Q. & Real, J. I. et al.​ (2017) 
    Cerebral Cortex, 27(1) pp. 718​-730​.​ DOI: https://doi.org/10.1093/cercor/bhv268 
    ​Details  DOI  PMID  PMC  WoS 
  • 2017 | Journal Article
    ​ ​Cellular Uptake of alpha-Synuclein Oligomer-Selective Antibodies is Enhanced by the Extracellular Presence of alpha-Synuclein and Mediated via Fc gamma Receptors​
    Gustafsson, G.; Eriksson, F.; Moller, C.; da Fonseca, T. L.; Outeiro, T. F. ; Lannfelt, L. & Bergstrom, J. et al.​ (2017) 
    Cellular and Molecular Neurobiology, 37(1) pp. 121​-131​.​ DOI: https://doi.org/10.1007/s10571-016-0352-5 
    ​Details  DOI  PMID  PMC  WoS 
  • 2017 | Journal Article | 
    ​ ​Alpha-synuclein prevents the formation of spherical mitochondria and apoptosis under oxidative stress​
    Menges, S.; Minakaki, G.; Schaefer, P. M.; Meixner, H.; Prots, I.; Schloetzer-Schrehardt, U. & Friedland, K. et al.​ (2017) 
    Scientific Reports, 7 art. 42942​.​ DOI: https://doi.org/10.1038/srep42942 
    ​Details  DOI  PMID  PMC  WoS 
  • 2017 | Journal Article
    ​ ​A moderate metal-binding hydrazone meets the criteria for a bioinorganic approach towards Parkinson's disease: Therapeutic potential, blood-brain barrier crossing evaluation and preliminary toxicological studies​
    Cukierman, D. S.; Pinheiro, A. B.; Castineiras-Filho, S. L. P.; da Silva, A. S. P.; Miotto, M. C.; De Falco, A. & Ribeiro, T. de P. et al.​ (2017) 
    Journal of Inorganic Biochemistry, 170 pp. 160​-168​.​ DOI: https://doi.org/10.1016/j.jinorgbio.2017.02.020 
    ​Details  DOI  PMID  PMC  WoS 
  • 2017 | Journal Article
    ​ ​Mutant A53T alpha-Synuclein Improves Rotarod Performance Before Motor Deficits and Affects Metabolic Pathways​
    Guerreiro, P. S.; Coelho, J. E.; Sousa-Lima, I.; Macedo, P.; Lopes, L. V.; Outeiro, T. F.   & Pais, T. F.​ (2017) 
    NeuroMolecular Medicine, 19(1) pp. 113​-121​.​ DOI: https://doi.org/10.1007/s12017-016-8435-5 
    ​Details  DOI  PMID  PMC  WoS 
  • 2017 | Journal Article
    ​ ​Identification of a conserved gene signature associated with an exacerbated inflammatory environment in the hippocampus of aging rats​
    Pardo, J.; Abba, M. C.; Lacunza, E.; Francelle, L.; Morel, G. R.; Outeiro, T. F.   & Goya, R. G.​ (2017) 
    Hippocampus, 27(4) pp. 435​-449​.​ DOI: https://doi.org/10.1002/hipo.22703 
    ​Details  DOI  PMID  PMC  WoS 
  • 2017 | Review
    ​ ​Yeast models of Parkinson's disease-associated molecular pathologies​
    Tenreiro, S.; Franssens, V.; Winderickx, J.& Outeiro, T. F. ​ (2017)
    Current Opinion in Genetics & Development, 44​ pp. 74​-83​.​
    Current Biology Ltd. DOI: https://doi.org/10.1016/j.gde.2017.01.013 
    ​Details  DOI  PMID  PMC  WoS 
  • 2017 | Journal Article
    ​ ​The yin and yang of alpha-synuclein-associated epigenetics in Parkinson's disease​
    Pavlou, M. A. S.; Pinho, R.; Paiva, I. & Outeiro, T. F. ​ (2017) 
    Brain, 140 pp. 878​-886​.​ DOI: https://doi.org/10.1093/brain/aww227 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article
    ​ ​A familial ATP13A2 mutation enhances alpha-synuclein aggregation and promotes cell death​
    da Fonseca, T. L.; Pinho, R. & Outeiro, T. F. ​ (2016) 
    Human Molecular Genetics, 25(14) pp. 2959​-2971​.​ DOI: https://doi.org/10.1093/hmg/ddw147 
    ​Details  DOI  WoS 
  • 2016 | Journal Article
    ​ ​B7 Glycation potentiates neurodegeneration in models of huntington’s disease​
    Outeiro, T. F.   & Miranda, H. V​ (2016) 
    Journal of Neurology, Neurosurgery & Psychiatry, 87(Suppl 1) pp. A11.2​-A11​.​ DOI: https://doi.org/10.1136/jnnp-2016-314597.38 
    ​Details  DOI 
  • 2016 | Journal Article | 
    ​ ​The effects of the novel A53E alpha-synuclein mutation on its oligomerization and aggregation​
    Lázaro, D. F.; Dias, M. C.; Carija, A.; Navarro, S.; Madaleno, C. S.; Tenreiro, S. & Ventura, S. et al.​ (2016) 
    Acta Neuropathologica Communications, 4(1) art. 128​.​ DOI: https://doi.org/10.1186/s40478-016-0402-8 
    ​Details  DOI  PMID  PMC 
  • 2016 | Journal Article | 
    ​ ​Glycation potentiates neurodegeneration in models of Huntington's disease​
    Vicente Miranda, H.; Gomes, M. A.; Branco-Santos, J.; Breda, C.; Lazaro, D. F.; Lopes, L. V. & Herrera, F. et al.​ (2016) 
    Scientific Reports, 6 art. 36798​.​ DOI: https://doi.org/10.1038/srep36798 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article | 
    ​ ​Fasudil attenuates aggregation of α-synuclein in models of Parkinson's disease​
    Tatenhorst, L. ; Eckermann, K.; Dambeck, V. ; Fonseca-Ornelas, L.; Walle, H.; Lopes Da Fonseca, T. & Koch, J. C.  et al.​ (2016) 
    Acta Neuropathologica Communication, 4(1) art. 39​.​ DOI: https://doi.org/10.1186/s40478-016-0310-y 
    ​Details  DOI  PMID  PMC 
  • 2016 | Journal Article
    ​ ​alpha B-Crystallin overexpression in astrocytes modulates the phenotype of the BACHD mouse model of Huntington's disease​
    Oliveira, A. O.; Osmand, A.; Outeiro, T. F. ; Muchowski, P. J. & Finkbeiner, S.​ (2016) 
    Human Molecular Genetics, 25(9) pp. 1677​-1689​.​ DOI: https://doi.org/10.1093/hmg/ddw028 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article
    ​ ​LRRK2 Promotes Tau Accumulation, Aggregation and Release​
    Guerreiro, P. S. ; Gerhardt, E. ; Da Fonseca, T. L.; Bähr, M. ; Outeiro, T. F.   & Eckermann, K.​ (2016) 
    Molecular Neurobiology, 53(5) pp. 3124​-3135​.​ DOI: https://doi.org/10.1007/s12035-015-9209-z 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article | 
    ​ ​Gene Expression Differences in Peripheral Blood of Parkinson's Disease Patients with Distinct Progression Profiles​
    Pinho, R.; Guedes, L. C.; Soreq, L.; Lobo, P. P.; Mestre, T.; Coelho, M. & Rosa, M. M. et al.​ (2016) 
    PLoS ONE, 11(6) art. e0157852​.​ DOI: https://doi.org/10.1371/journal.pone.0157852 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Conference Paper
    ​ ​Glycation in Parkinson's Disease and Alzheimer's Disease​
    Vicente Miranda, H.; El-Agnaf, O. M. A. & Outeiro, T. F. ​ (2016)
    Movement Disorders, 31(6) pp. 782​-790. , Assisi, ITALY.
    Hoboken​: Wiley. DOI: https://doi.org/10.1002/mds.26566 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article
    ​ ​Environmental and genetic factors support the dissociation between alpha-synuclein aggregation and toxicity​
    Villar-Pique, A.; da Fonseca, T. L.; Sant'Anna, R.; Szegoe, E. M.; Fonseca-Ornelas, L.; Pinho, R. & Carija, A. et al.​ (2016) 
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 113(42) pp. E6506​-E6515​.​ DOI: https://doi.org/10.1073/pnas.1606791113 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article
    ​ ​Yeast reveals similar molecular mechanisms underlying alpha- and beta-synuclein toxicity​
    Tenreiro, S.; Rosado-Ramos, R.; Gerhardt, E. ; Favretto, F. ; Magalhães, F.; Popova, B.   & Becker, S.  et al.​ (2016) 
    Human Molecular Genetics, 25(2) pp. 275​-290​.​ DOI: https://doi.org/10.1093/hmg/ddv470 
    ​Details  DOI  PMID  PMC 
  • 2016 | Journal Article | 
    ​ ​The caffeine-binding adenosine A(2A) receptor induces age-like HPA-axis dysfunction by targeting glucocorticoid receptor function​
    Batalha, V. L.; Ferreira, D. G. ; Coelho, J. E.; Valadas, J. S.; Gomes, R.; Temido-Ferreira, M. & Shmidt, T. et al.​ (2016) 
    Scientific Reports, 6 art. 31493​.​ DOI: https://doi.org/10.1038/srep31493 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article | 
    ​ ​shRNA-Based Screen Identifies Endocytic Recycling Pathway Components That Act as Genetic Modifiers of Alpha-Synuclein Aggregation, Secretion and Toxicity​
    Goncalves, S. A.; Macedo, D.; Raquel, H.; Simoes, P. D.; Giorgini, F.; Ramalho, J. S. & Barral, D. C. et al.​ (2016) 
    PLoS Genetics, 12(4) art. e1005995​.​ DOI: https://doi.org/10.1371/journal.pgen.1005995 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article
    ​ ​Distinct roles of N-acetyl and 5-methoxy groups in the antiproliferative and neuroprotective effects of melatonin​
    Letra-Vilela, R.; Maria Sanchez-Sanchez, A.; Rocha, A. M.; Martin, V.; Branco-Santos, J.; Puente-Moncada, N. & Santa-Marta, M. et al.​ (2016) 
    Molecular and Cellular Endocrinology, 434(C) pp. 238​-249​.​ DOI: https://doi.org/10.1016/j.mce.2016.07.012 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Review
    ​ ​Structure, function and toxicity of alpha-synuclein: the Bermuda triangle in synucleinopathies​
    Villar-Pique, A.; da Fonseca, T. L.& Outeiro, T. F. ​ (2016)
    Journal of Neurochemistry, 139​ pp. 240​-255​.​
    Wiley-blackwell. DOI: https://doi.org/10.1111/jnc.13249 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article | 
    ​ ​C-Terminal Tyrosine Residue Modifications Modulate the Protective Phosphorylation of Serine 129 of α-Synuclein in a Yeast Model of Parkinson's Disease​
    Kleinknecht, A. ; Popova, B. ; Lázaro, D. F. ; Pinho, R. ; Valerius, O. ; Outeiro, T. F.   & Braus, G. H. ​ (2016) 
    PLOS Genetics, 12(6) pp. e1006098​.​ DOI: https://doi.org/10.1371/journal.pgen.1006098 
    ​Details  DOI  PMID  PMC 
  • 2016 | Journal Article
    ​ ​Insulin-like growth factor-I gene therapy increases hippocampal neurogenesis, astrocyte branching and improves spatial memory in female aging rats​
    Pardo, J.; Uriarte, M.; Console, G. M.; Reggiani, P. C.; Outeiro, T. F. ; Morel, G. R. & Goya, R. G.​ (2016) 
    European Journal of Neuroscience, 44(4) pp. 2120​-2128​.​ DOI: https://doi.org/10.1111/ejn.13278 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article | 
    ​ ​A Novel Microfluidic Cell Co-culture Platform for the Study of the Molecular Mechanisms of Parkinson's Disease and Other Synucleinopathies​
    Fernandes, J. T. S.; Chutna, O.; Chu, V.; Conde, J. P. & Outeiro, T. F. ​ (2016) 
    Frontiers in Neuroscience, 10 art. 511​.​ DOI: https://doi.org/10.3389/fnins.2016.00511 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Conference Abstract
    ​ ​The baker, sugar, and the molecular basis of Parkinson's disease​
    Outeiro, T. F. ​ (2015)
    Yeast, 32 pp. S42​-S43. , Fondazione Edmund Mach, Levico Terme, ITALY.
    Hoboken​: Wiley-blackwell.
    ​Details  WoS 
  • 2015 | Review
    ​ ​Modeling Neuronal Pathology in Yeast: Insights into the Molecular Basis of Parkinson's Disease​
    Amen, T.; Lazaro, D. F.; Outeiro, T. F.  & Kaganovich, D.​ (2015)
    Israel Journal of Chemistry, 55​(11-12) pp. 1252​-1259​.​
    Wiley-v C H Verlag Gmbh. DOI: https://doi.org/10.1002/ijch.201500071 
    ​Details  DOI  WoS 
  • 2015 | Journal Article | 
    ​ ​From the baker to the bedside: yeast models of Parkinson's disease​
    Menezes, R.; Tenreiro, S.; Macedo, D.; Santos, C. & Outeiro, T. ​ (2015) 
    Microbial Cell, 2(8) pp. 262​-279​.​ DOI: https://doi.org/10.15698/mic2015.08.219 
    ​Details  DOI 
  • 2015 | Journal Article | 
    ​ ​The Sirtuin-2 Inhibitor AK7 Is Neuroprotective in Models of Parkinson's Disease but Not Amyotrophic Lateral Sclerosis and Cerebral Ischemia​
    Chen, X.; Wales, P.; Quinti, L.; Zuo, F.; Moniot, S.; Herisson, F. & Rauf, N. A. et al.​ (2015) 
    PLoS ONE, 10(1) art. UNSP e0116919​.​ DOI: https://doi.org/10.1371/journal.pone.0116919 
    ​Details  DOI  WoS 
  • 2015 | Journal Article
    ​ ​Mutant huntingtin alters Tau phosphorylation and subcellular distribution​
    Blum, D.; Herrera, F.; Francelle, L. ; Mendes, T.; Basquin, M.; Obriot, H. & Demeyer, D. et al.​ (2015) 
    Human Molecular Genetics, 24(1) pp. 76​-85​.​ DOI: https://doi.org/10.1093/hmg/ddu421 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Journal Article | 
    ​ ​Small Molecules Detected by Second-Harmonic Generation Modulate the Conformation of Monomeric alpha-Synuclein and Reduce Its Aggregation in Cells​
    Moree, B.; Yin, G.; Lazaro, D. F.; Munari, F.; Strohaeker, T.; Giller, K. & Becker, S. et al.​ (2015) 
    Journal of Biological Chemistry, 290(46) pp. 27582​-27593​.​ DOI: https://doi.org/10.1074/jbc.M114.636027 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Journal Article | 
    ​ ​Rab11 modulates alpha-synuclein-mediated defects in synaptic transmission and behaviour​
    Breda, C.; Nugent, M. L.; Estranero, J. G.; Kyriacou, C. P.; Outeiro, T. F. ; Steinert, J. R. & Giorgini, F.​ (2015) 
    Human Molecular Genetics, 24(4) pp. 1077​-1091​.​ DOI: https://doi.org/10.1093/hmg/ddu521 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Journal Article | 
    ​ ​Elevated alpha-synuclein caused by SNCA gene triplication impairs neuronal differentiation and maturation in Parkinson's patient-derived induced pluripotent stem cells​
    Oliveira, L. M. A.; Falomir-Lockhart, L. J.; Botelho, M. G.; Lin, K.-H.; Wales, P.; Koch, J. C. & Gerhardt, E. et al.​ (2015) 
    Cell Death and Disease, 6 art. e1994​.​ DOI: https://doi.org/10.1038/cddis.2015.318 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Journal Article
    ​ ​(Poly)phenols protect from alpha-synuclein toxicity by reducing oxidative stress and promoting autophagy​
    Macedo, D.; Tavares, L.; McDougall, G. J.; Vicente Miranda, H.; Stewart, D.; Ferreira, R. B. & Tenreiro, S. et al.​ (2015) 
    Human Molecular Genetics, 24(6) pp. 1717​-1732​.​ DOI: https://doi.org/10.1093/hmg/ddu585 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Journal Article
    ​ ​alpha-Synuclein modifies mutant huntingtin aggregation and neurotoxicity in Drosophila​
    Pocas, G. M.; Branco-Santos, J.; Herrera, F.; Outeiro, T. F.   & Domingos, P. M.​ (2015) 
    Human Molecular Genetics, 24(7) pp. 1898​-1907​.​ DOI: https://doi.org/10.1093/hmg/ddu606 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Journal Article
    ​ ​Knockout of silent information regulator 2 (SIRT2) preserves neurological function after experimental stroke in mice​
    Krey, L.; Luehder, F.; Kusch, K.; Czech-Zechmeister, B.; Koennecke, B.; Outeiro, T. F.   & Trendelenburg, G.​ (2015) 
    Journal of Cerebral Blood Flow & Metabolism, 35(12) pp. 2080​-2088​.​ DOI: https://doi.org/10.1038/jcbfm.2015.178 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Review
    ​ ​Emerging Role of Sirtuin 2 in the Regulation of Mammalian Metabolism​
    Gomes, P.; Outeiro, T. F.  & Cavadas, C.​ (2015)
    Trends in Pharmacological Sciences, 36​(11) pp. 756​-768​.​
    Elsevier Science London. DOI: https://doi.org/10.1016/j.tips.2015.08.001 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Journal Article | Research Paper
    ​ ​Alpha-Synuclein Regulates Neuronal Levels of Manganese and Calcium​
    Dučić, T.; Carboni, E. ; Lai, B.; Chen, S.; Michalke, B.; Lazaro, D. F.   & Outeiro, T. F.  et al.​ (2015) 
    ACS Chemical Neuroscience, 6(10) pp. 1769​-1779​.​ DOI: https://doi.org/10.1021/acschemneuro.5b00093 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Journal Article
    ​ ​Parkinson Disease Mutant E46K Enhances alpha-Synuclein Phosphorylation in Mammalian Cell Lines, in Yeast, and in Vivo​
    Mbefo, M. K.; Fares, M.-B.; Paleologou, K.; Oueslati, A.; Yin, G.; Tenreiro, S. & Pinto, M. et al.​ (2015) 
    Journal of Biological Chemistry, 290(15) pp. 9412​-9427​.​ DOI: https://doi.org/10.1074/jbc.M114.610774 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Journal Article | Research Paper
    ​ ​Super-resolution Microscopy of Clickable Amino Acids Reveals the Effects of Fluorescent Protein Tagging on Protein Assemblies​
    Vreja, I. C.; Nikić, I.; Göttfert, F. ; Bates, M.; Kröhnert, K.; Outeiro, T. F.   & Hell, S.  et al.​ (2015) 
    ACS Nano, 9(11) pp. 11034​-11041​.​ DOI: https://doi.org/10.1021/acsnano.5b04434 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Journal Article
    ​ ​Isostructural Re(I)/Tc-99m(I) tricarbonyl complexes for cancer theranostics​
    Nunes, P.; Morais, G. R.; Palma, E.; Silva, F.; Oliveira, M. C.; Ferreira, V. F. C. & Mendes, F. et al.​ (2015) 
    Organic & Biomolecular Chemistry, 13(18) pp. 5182​-5194​.​ DOI: https://doi.org/10.1039/c5ob00124b 
    ​Details  DOI  PMID  PMC  WoS 
  • 2014 | Journal Article | 
    ​ ​ATP13A2 and Alpha-synuclein: a Metal Taste in Autophagy.​
    Lopes da Fonseca, T. & Outeiro, T. F. ​ (2014) 
    Experimental neurobiology, 23(4) pp. 314​-323​.​ DOI: https://doi.org/10.5607/en.2014.23.4.314 
    ​Details  DOI  PMID  PMC 
  • 2014 | Conference Abstract
    ​ ​AGGREGATION-PRONE PROTEINS EXACERBATE HUNTINGTIN TOXICITY IN YEAST AND DROSOPHILA​
    Branco dos Santos, J.; Staniforth, G.; Breda, C.; Herrera, F.; Outeiro, T. F. ; Tuite, M. & Giorgini, F.​ (2014)
    Journal of Neurology Neurosurgery & Psychiatry, 85 ​8th European-Huntington's-Disease-Network Plenary Meeting​, Barcelona, SPAIN.
    London​: Bmj Publishing Group. DOI: https://doi.org/10.1136/jnnp-2014-309032.35 
    ​Details  DOI  WoS 
  • 2014 | Conference Abstract
    ​ ​EXPLORING THE ROLE OF PHOSPHORYLATION IN HUNTINGTIN AGGREGATION DYNAMICS​
    Branco dos Santos, J.; Herrera, F.; Giorgini, F. & Outeiro, T. F. ​ (2014)
    Journal of Neurology Neurosurgery & Psychiatry, 85 , Barcelona, SPAIN.
    London​: Bmj Publishing Group. DOI: https://doi.org/10.1136/jnnp-2014-309032.34 
    ​Details  DOI  WoS 
  • 2014 | Conference Abstract
    ​ ​GLYCATION MODULATES HUNTINGTIN AGGREGATION AND TOXICITY​
    Vicente Miranda, H.; Gomes, M. A.; Branco dos Santos, J.; Giorgini, F. & Outeiro, T. F. ​ (2014)
    Journal of Neurology Neurosurgery & Psychiatry, 85 , Barcelona, SPAIN.
    London​: Bmj Publishing Group. DOI: https://doi.org/10.1136/jnnp-2014-309032.36 
    ​Details  DOI  WoS 
  • 2014 | Journal Article
    ​ ​SNCA (α-synuclein)-induced toxicity in yeast cells is dependent on Sir2-mediated mitophagy​
    Sampaio-Marques, B.; Felgueiras, C.; Silva, A.; Rodrigues, M.; Tenreiro, S.; Franssens, V. & Reichert, A. S. et al.​ (2014) 
    Autophagy, 8(10) pp. 1494​-1509​.​ DOI: https://doi.org/10.4161/auto.21275 
    ​Details  DOI 
  • 2014 | Journal Article | Research Paper
    ​ ​alpha-Synuclein interacts with the switch region of Rab8a in a Ser129 phosphorylation-dependent manner​
    Yin, G.; Da Fonseca, T. L.; Eisbach, S. E.; Anduaga, A. M.; Breda, C.; Orcellet, M. L. & Szego, E. M.  et al.​ (2014) 
    Neurobiology of Disease, 70 pp. 149​-161​.​ DOI: https://doi.org/10.1016/j.nbd.2014.06.018 
    ​Details  DOI  PMID  PMC  WoS 
  • 2014 | Journal Article | 
    ​ ​Small molecule-mediated stabilization of vesicle-associated helical alpha-synuclein inhibits pathogenic misfolding and aggregation​
    Fonseca-Ornelas, L.; Eisbach, S. E.; Paulat, M.; Giller, K.; Fernandez, C. O.; Outeiro, T. F.   & Becker, S. et al.​ (2014) 
    Nature Communications, 5 art. 5857​.​ DOI: https://doi.org/10.1038/ncomms6857 
    ​Details  DOI  PMID  PMC  WoS 
  • 2014 | Journal Article | Research Paper | 
    ​ ​Systematic Comparison of the Effects of Alpha-synuclein Mutations on Its Oligomerization and Aggregation​
    Lazaro, D. F. ; Rodrigues, E. F. ; Langohr, R.; Shahpasandzadeh, H.; Ribeiro, T.; Guerreiro, P.   & Gerhardt, E.  et al.​ (2014) 
    PLoS Genetics, 10 art. e1004741​.​ DOI: https://doi.org/10.1371/journal.pgen.1004741 
    ​Details  DOI  PMID  PMC  WoS 
  • 2014 | Review
    ​ ​Challenges and Promises in the Development of Neurotrophic Factor-Based Therapies for Parkinson's Disease​
    Rodrigues, T. M.; Jeronimo-Santos, A.; Outeiro, T. F. ; Sebastiao, A. M.& Diogenes, M. J.​ (2014)
    Drugs & Aging, 31​(4) pp. 239​-261​.​
    Adis Int Ltd. DOI: https://doi.org/10.1007/s40266-014-0160-x 
    ​Details  DOI  PMID  PMC  WoS 
  • 2014 | Journal Article
    ​ ​Autophagy modulates SNCA/alpha-synuclein release, thereby generating a hostile microenvironment​
    Poehler, A.-M.; Xiang, W.; Spitzer, P.; May, V. E. L.; Meixner, H.; Rockenstein, E. & Chutna, O. et al.​ (2014) 
    Autophagy, 10(12) pp. 2171​-2192​.​ DOI: https://doi.org/10.4161/auto.36436 
    ​Details  DOI  PMID  PMC  WoS 
  • 2014 | Journal Article | 
    ​ ​Phosphorylation Modulates Clearance of Alpha-Synuclein Inclusions in a Yeast Model of Parkinson's Disease​
    Tenreiro, S.; Reimao-Pinto, M. M.; Antas, P.; Rino, J.; Wawrzycka, D.; Macedo, D. & Rosado-Ramos, R. et al.​ (2014) 
    PLoS Genetics, 10(5) art. e1004302​.​ DOI: https://doi.org/10.1371/journal.pgen.1004302 
    ​Details  DOI  PMID  PMC  WoS 
  • 2014 | Journal Article | 
    ​ ​DJ-1 interactions with alpha-synuclein attenuate aggregation and cellular toxicity in models of Parkinson's disease​
    Zondler, L.; Miller-Fleming, L.; Repici, M.; Goncalves, S. A.; Tenreiro, S.; Rosado-Ramos, R. & Betzer, C. et al.​ (2014) 
    Cell Death and Disease, 5 art. e1350​.​ DOI: https://doi.org/10.1038/cddis.2014.307 
    ​Details  DOI  PMID  PMC  WoS 
  • 2014 | Journal Article
    ​ ​Yeast DJ-1 superfamily members are required for diauxic-shift reprogramming and cell survival in stationary phase​
    Miller-Fleming, L.; Antas, P.; Pais, T. F.; Smalley, J. L.; Giorgini, F. & Outeiro, T. F. ​ (2014) 
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 111(19) pp. 7012​-7017​.​ DOI: https://doi.org/10.1073/pnas.1319221111 
    ​Details  DOI  PMID  PMC  WoS 
  • 2014 | Journal Article | 
    ​ ​Modulation of alpha-synuclein toxicity in yeast using a novel microfluidic-based gradient generator​
    Fernandes, J. T. S.; Tenreiro, S.; Gameiro, A.; Chu, V.; Outeiro, T. F.   & Conde, J. P.​ (2014) 
    Lab on a Chip, 14(20) pp. 3949​-3957​.​ DOI: https://doi.org/10.1039/c4lc00756e 
    ​Details  DOI  PMID  PMC  WoS 
  • 2014 | Review | 
    ​ ​Protein phosphorylation in neurodegeneration: friend or foe?​
    Tenreiro, S.; Eckermann, K.& Outeiro, T. F. ​ (2014)
    Frontiers in Molecular Neuroscience, 7​.​ DOI: https://doi.org/10.3389/fnmol.2014.00042 
    ​Details  DOI  PMID  PMC  WoS 
  • 2014 | Journal Article
    ​ ​DJ-1 modulates aggregation and pathogenesis in models of Huntington's disease​
    Sajjad, M. U.; Green, E. W.; Miller-Fleming, L.; Hands, S.; Herrera, F.; Campesan, S. & Khoshnan, A. et al.​ (2014) 
    Human Molecular Genetics, 23(3) pp. 755​-766​.​ DOI: https://doi.org/10.1093/hmg/ddt466 
    ​Details  DOI  PMID  PMC  WoS 
  • 2014 | Journal Article
    ​ ​Copy-number variation of the neuronal glucose transporter gene SLC2A3 and age of onset in Huntington's disease​
    Vittori, A.; Breda, C.; Repici, M.; Orth, M.; Roos, R. A. C.; Outeiro, T. F.   & Giorgini, F. et al.​ (2014) 
    Human Molecular Genetics, 23(12) pp. 3129​-3137​.​ DOI: https://doi.org/10.1093/hmg/ddu022 
    ​Details  DOI  PMID  PMC  WoS 
  • 2014 | Journal Article
    ​ ​Linking alpha-synuclein phosphorylation to reactive oxygen species formation and mitochondrial dysfunction in SH-SY5Y cells​
    Perfeito, R.; Lazar, D. F.; Outeiro, T. F.   & Rego, A. C.​ (2014) 
    Molecular and Cellular Neuroscience, 62 pp. 51​-59​.​ DOI: https://doi.org/10.1016/j.mcn.2014.08.002 
    ​Details  DOI  PMID  PMC  WoS 
  • 2014 | Journal Article
    ​ ​Interplay between sumoylation and phosphorylation for protection against α-synuclein inclusions​
    Shahpasandzadeh, H.; Popova, B. ; Kleinknecht, A. ; Fraser, P. E.; Outeiro, T. F.   & Braus, G. H. ​ (2014) 
    The Journal of Biological Chemistry, 289(45) pp. 31224​-31240​.​ DOI: https://doi.org/10.1074/jbc.M114.559237 
    ​Details  DOI  PMID  PMC 
  • 2014 | Journal Article
    ​ ​The small GTPase Rab11 co-localizes with alpha-synuclein in intracellular inclusions and modulates its aggregation, secretion and toxicity​
    Chutna, O.; Goncalves, S. A.; Villar-Pique, A. ; Guerreiro, P. S.; Marijanovic, Z.; Mendes, T. & Ramalho, J. S. et al.​ (2014) 
    Human Molecular Genetics, 23(25) pp. 6732​-6745​.​ DOI: https://doi.org/10.1093/hmg/ddu391 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article
    ​ ​The zebrafish homologue of Parkinson's disease ATP13A2 is essential for embryonic survival​
    da Fonseca, T. L.; Correia, A.; Hasselaar, W.; van der Linde, H. C.; Willemsen, R. & Outeiro, T. F. ​ (2013) 
    Brain Research Bulletin, 90 pp. 118​-126​.​ DOI: https://doi.org/10.1016/j.brainresbull.2012.09.017 
    ​Details  DOI  WoS 
  • 2013 | Conference Abstract
    ​ ​Harnessing the power of yeast to decipher the role of alpha-synuclein phosphorylation in Parkinson's disease​
    Tenreiro, S.; Reimao-Pinto, M. M.; Antas, P.; Rino, J.; Waiss, M.; Magalhaes, F. & Wawrzycka, D. et al.​ (2013)
    Yeast, 30 , Frankfurt Main, GERMANY.
    Hoboken​: Wiley-blackwell.
    ​Details  WoS 
  • 2013 | Journal Article
    ​ ​MeCP2: a novel Huntingtin interactor​
    McFarland, K. N.; Huizenga, M. N.; Darnell, S. B.; Sangrey, G. R.; Berezovska, O.; Cha, J. Cha, J.-H. J. & Outeiro, T. F.  et al.​ (2013) 
    Human Molecular Genetics, 23(4) pp. 1036​-1044​.​ DOI: https://doi.org/10.1093/hmg/ddt499 
    ​Details  DOI 
  • 2013 | Journal Article
    ​ ​Live-cell imaging of p53 interactions using a novel Venus-based bimolecular fluorescence complementation system​
    Amaral, J. D.; Herrera, F.; Rodrigues, P. M.; Dionísio, P. A.; Outeiro, T. F.   & Rodrigues, C. M. P.​ (2013) 
    Biochemical Pharmacology, 85(6) pp. 745​-752​.​ DOI: https://doi.org/10.1016/j.bcp.2012.12.009 
    ​Details  DOI 
  • 2013 | Conference Abstract
    ​ ​Polyphenols protect from alpha-synuclein toxicity by increasing autophagy and reducing reactive oxygen species in a yeast model of Parkinson's disease​
    Macedo, D.; Tavares, L.; McDougall, G. J.; Stewart, D.; Ferreira, R. B.; Outeiro, T. F.   & Santos, C. N. et al.​ (2013)
    Yeast, 30 , Frankfurt Main, GERMANY.
    Hoboken​: Wiley-blackwell.
    ​Details  WoS 
  • 2013 | Journal Article
    ​ ​Inhibition of formation of alpha-synuclein inclusions by mannosylglycerate in a yeast model of Parkinson's disease​
    Faria, C.; Jorge, C. D.; Borges, N.; Tenreiro, S.; Outeiro, T. F.   & Santos, H.​ (2013) 
    Biochimica et Biophysica Acta (BBA) - General Subjects, 1830(8) pp. 4065​-4072​.​ DOI: https://doi.org/10.1016/j.bbagen.2013.04.015 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Review
    ​ ​Limelight on Alpha-Synuclein: Pathological and Mechanistic Implications in Neurodegeneration​
    Wales, P.; Pinho, R.; Lazaro, D. F.& Outeiro, T. F. ​ (2013)
    Journal of Parkinson s Disease, 3​(4) pp. 415​-459​.​
    Ios Press. DOI: https://doi.org/10.3233/JPD-130216 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Review
    ​ ​Harnessing the power of yeast to unravel the molecular basis of neurodegeneration​
    Tenreiro, S.; Munder, M. C.; Alberti, S.& Outeiro, T. F. ​ (2013)
    Journal of Neurochemistry, 127​(4) pp. 438​-452​.​
    Wiley-blackwell. DOI: https://doi.org/10.1111/jnc.12271 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article
    ​ ​The NAD-dependent deacetylase sirtuin 2 is a suppressor of microglial activation and brain inflammation​
    Pais, T. F.; Szego, E. M.; Marques, O.; Miller-Fleming, L.; Antas, P.; Guerreiro, P. S. & de Oliveira, R. M. et al.​ (2013) 
    The EMBO Journal, 32(19) pp. 2603​-2616​.​ DOI: https://doi.org/10.1038/emboj.2013.200 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Review | 
    ​ ​Assessing the Subcellular Dynamics of Alpha-synuclein Using Photoactivation Microscopy​
    Goncalves, S. A.& Outeiro, T. F. ​ (2013)
    Molecular Neurobiology, 47​(3) pp. 1081​-1092​.​
    Humana Press Inc. DOI: https://doi.org/10.1007/s12035-013-8406-x 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Review
    ​ ​PLK2 Modulates alpha-Synuclein Aggregation in Yeast and Mammalian Cells​
    Basso, E.; Antas, P.; Marijanovic, Z.; Goncalves, S. A.; Tenreiro, S.& Outeiro, T. F. ​ (2013)
    Molecular Neurobiology, 48​(3) pp. 854​-862​.​
    Humana Press Inc. DOI: https://doi.org/10.1007/s12035-013-8473-z 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Review
    ​ ​Oxidative and nitrative alpha-synuclein modifications and proteostatic stress: implications for disease mechanisms and interventions in synucleinopathies​
    Schildknecht, S.; Gerding, H. R.; Karreman, C.; Drescher, M.; Lashuel, H. A.; Outeiro, T. F.  & Di Monte, D. A. et al.​ (2013)
    Journal of Neurochemistry, 125​(4) pp. 491​-511​.​
    Wiley. DOI: https://doi.org/10.1111/jnc.12226 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article | 
    ​ ​Parkinson's disease-associated mutations in DJ-1 modulate its dimerization in living cells​
    Repici, M.; Straatman, K. R.; Balduccio, N.; Enguita, F. J.; Outeiro, T. F.   & Giorgini, F.​ (2013) 
    Journal of Molecular Medicine, 91(5) pp. 599​-611​.​ DOI: https://doi.org/10.1007/s00109-012-0976-y 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article
    ​ ​Off-pathway alpha-synuclein oligomers seem to alter alpha-synuclein turnover in a cell model but lack seeding capability in vivo​
    Fagerqvist, T.; Nasstrom, T.; Ihse, E.; Lindstrom, V.; Sahlin, C.; Tucker, S. M. F. & Kasaryan, A. et al.​ (2013) 
    Amyloid, 20(4) pp. 233​-244​.​ DOI: https://doi.org/10.3109/13506129.2013.835726 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Review | 
    ​ ​SIRT1 and SIRT2: emerging targets in neurodegeneration​
    Donmez, G.& Outeiro, T. F. ​ (2013)
    EMBO Molecular Medicine, 5​(3) pp. 344​-352​.​
    Wiley-blackwell. DOI: https://doi.org/10.1002/emmm.201302451 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article
    ​ ​Impairment of the septal cholinergic neurons in MPTP-treated A30P alpha-synuclein mice​
    Szego, E. M.; Outeiro, T. F. ; Kermer, P. & Schulz, J. B.​ (2013) 
    Neurobiology of Aging, 34(2) pp. 589​-601​.​ DOI: https://doi.org/10.1016/j.neurobiolaging.2012.04.012 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article | Research Paper
    ​ ​β-Synuclein Aggregates and Induces Neurodegeneration in Dopaminergic Neurons​
    Taschenberger, G. ; Toloe, J. ; Tereshchenko, J. ; Akerboom, J.; Wales, P. ; Benz, R. & Becker, S.  et al.​ (2013) 
    Annals of Neurology, 74(1) pp. 109​-118​.​ DOI: https://doi.org/10.1002/ana.23905 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article
    ​ ​Structural basis of kynurenine 3-monooxygenase inhibition​
    Amaral, M.; Levy, C.; Heyes, D. J.; Lafite, P.; Outeiro, T. F. ; Giorgini, F. & Leys, D. et al.​ (2013) 
    Nature, 496(7445) pp. 382​-+​.​ DOI: https://doi.org/10.1038/nature12039 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Review
    ​ ​The causative role and therapeutic potential of the kynurenine pathway in neurodegenerative disease​
    Amaral, M.; Outeiro, T. F. ; Scrutton, N. S.& Giorgini, F.​ (2013)
    Journal of Molecular Medicine, 91​(6) pp. 705​-713​.​
    Springer. DOI: https://doi.org/10.1007/s00109-013-1046-9 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Review
    ​ ​alpha-Synuclein and intracellular trafficking: impact on the spreading of Parkinson's disease pathology​
    Eisbach, S. E.& Outeiro, T. F. ​ (2013)
    Journal of Molecular Medicine, 91​(6) pp. 693​-703​.​
    Springer. DOI: https://doi.org/10.1007/s00109-013-1038-9 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article
    ​ ​Heat-mediated enrichment of alpha-synuclein from cells and tissue for assessing post-translational modifications​
    Vicente Miranda, H.; Xiang, W.; de Oliveira, R. M.; Simoes, T.; Pimentel, J.; Klucken, J. & Penque, D. et al.​ (2013) 
    Journal of Neurochemistry, 126(5) pp. 673​-684​.​ DOI: https://doi.org/10.1111/jnc.12251 
    ​Details  DOI  PMID  PMC  WoS 
  • 2012 | Journal Article | Editorial Contribution (Editorial, Introduction, Epilogue) | 
    ​ ​Editorial on Special Topic: Sirtuins in Metabolism, Aging, and Disease​
    Kazantsev, A. G. & Outeiro, T. F. ​ (2012) 
    Frontiers in Pharmacology, 3 art. 71​.​ DOI: https://doi.org/10.3389/fphar.2012.00071 
    ​Details  DOI  PMID  PMC 
  • 2012 | Journal Article
    ​ ​Suppression of α-synuclein toxicity and vesicle trafficking defects by phosphorylation at S129 in yeast depends on genetic context​
    Sancenon, V.; Lee, S.-A.; Patrick, C.; Griffith, J.; Paulino, A.; Outeiro, T. F.   & Reggiori, F. et al.​ (2012) 
    Human Molecular Genetics, 21(11) pp. 2432​-2449​.​ DOI: https://doi.org/10.1093/hmg/dds058 
    ​Details  DOI 
  • 2012 | Journal Article
    ​ ​High-throughput study of alpha-synuclein expression in yeast using microfluidics for control of local cellular microenvironment​
    Rosa, P.; Tenreiro, S.; Chu, V.; Outeiro, T. F.   & Conde, J. P.​ (2012) 
    Biomicrofluidics, 6(1) pp. 014109​.​ DOI: https://doi.org/10.1063/1.3683161 
    ​Details  DOI 
  • 2012 | Conference Abstract
    ​ ​Insulin resistance is associated with reduced levels of the age-related protein SIRT2​
    Lemos, V.; Oliveira, R. M.; Outeiro, T. F.   & Gomes, P.​ (2012)
    The FASEB Journal, 26 , San Diego, CA.
    Bethesda​: Federation Amer Soc Exp Biol.
    ​Details  WoS 
  • 2012 | Review | 
    ​ ​Alpha-synuclein: from secretion to dysfunction and death​
    Marques, O.& Outeiro, T. F. ​ (2012)
    Cell Death and Disease, 3​.​
    Nature Publishing Group. DOI: https://doi.org/10.1038/cddis.2012.94 
    ​Details  DOI  PMID  PMC  WoS 
  • 2012 | Journal Article | 
    ​ ​Extracellular Alpha-Synuclein Oligomers Modulate Synaptic Transmission and Impair LTP Via NMDA-Receptor Activation​
    Diogenes, M. J.; Dias, R. B.; Rombo, D. M.; Vicente Miranda, H.; Maiolino, F.; Guerreiro, P. S. & Nasstrom, T. et al.​ (2012) 
    Journal of Neuroscience, 32(34) pp. 11750​-11762​.​ DOI: https://doi.org/10.1523/JNEUROSCI.0234-12.2012 
    ​Details  DOI  PMID  PMC  WoS 
  • 2012 | Journal Article
    ​ ​EPIGENETIC REGULATION OF BACE1 IN ALZHEIMER'S DISEASE PATIENTS AND IN TRANSGENIC MICE​
    Marques, S. C. F.; Lemos, R.; Ferreiro, E.; Martins, M.; de Mendonca, A.; Santana, I. & Outeiro, T. F.  et al.​ (2012) 
    Neuroscience, 220 pp. 256​-266​.​ DOI: https://doi.org/10.1016/j.neuroscience.2012.06.029 
    ​Details  DOI  PMID  PMC  WoS 
  • 2012 | Journal Article
    ​ ​Impaired TrkB receptor signaling contributes to memory impairment in APP/PS1 mice​
    Kemppainen, S.; Rantamaki, T.; Jeronimo-Santos, A.; Lavasseur, G.; Autio, H.; Karpova, N. & Karkkainen, E. et al.​ (2012) 
    Neurobiology of Aging, 33(6) art. 1122.e23​.​ DOI: https://doi.org/10.1016/j.neurobiolaging.2011.11.006 
    ​Details  DOI  PMID  PMC  WoS 
  • 2012 | Review | 
    ​ ​SIRT2 as a therapeutic target for age-related disorders​
    de Oliveira, R. M.; Sarkander, J.; Kazantsev, A. G.& Outeiro, T. F. ​ (2012)
    Frontiers in Pharmacology, 3​.​
    Frontiers Research Foundation. DOI: https://doi.org/10.3389/fphar.2012.00082 
    ​Details  DOI  PMID  PMC  WoS 
  • 2012 | Journal Article
    ​ ​Aggregate clearance of α-synuclein in Saccharomyces cerevisiae depends more on autophagosome and vacuole function than on the proteasome​
    Petroi, D.; Popova, B. ; Taheri-Talesh, N.; Irniger, S. ; Shahpasandzadeh, H.; Zweckstetter, M.   & Outeiro, T. F.  et al.​ (2012) 
    The Journal of Biological Chemistry, 287(33) pp. 27567​-27579​.​ DOI: https://doi.org/10.1074/jbc.M112.361865 
    ​Details  DOI  PMID  PMC 
  • 2012 | Journal Article
    ​ ​alpha-Synuclein modifies huntingtin aggregation in living cells​
    Herrera, F. & Outeiro, T. F. ​ (2012) 
    FEBS Letters, 586(1) pp. 7​-12​.​ DOI: https://doi.org/10.1016/j.febslet.2011.11.019 
    ​Details  DOI  PMID  PMC  WoS 
  • 2012 | Journal Article | 
    ​ ​Highlights of the Keystone Symposium: sirtuins in metabolism, aging and disease​
    Maxwell, M. M.; Zaldivar-Jolissaint, J. F.; Mai, A.; Outeiro, T. F.   & Kazanstev, A. G.​ (2012) 
    EMBO Molecular Medicine, 4(7) pp. 557​-560​.​ DOI: https://doi.org/10.1002/emmm.201201452 
    ​Details  DOI  PMID  PMC 
  • 2012 | Journal Article | 
    ​ ​LRRK2 interactions with α-synuclein in Parkinson’s disease brains and in cell models​
    Guerreiro, P.; Huang, Y.; Gysbers, A.; Cheng, D.; Gai, W.; Outeiro, T.   & Halliday, G.​ (2012) 
    Journal of Molecular Medicine, 91(4) pp. 513​-522​.​ DOI: https://doi.org/10.1007/s00109-012-0984-y 
    ​Details  DOI  PMID  PMC 
  • 2012 | Review
    ​ ​IMAGING PROTEIN OLIGOMERIZATION IN NEURODEGENERATION USING BIMOLECULAR FLUORESCENCE COMPLEMENTATION​
    Herrera, F.; Goncalves, S. A.& Outeiro, T. F. ​ (2012)
    IMAGING AND SPECTROSCOPIC ANALYSIS OF LIVING CELLS: IMAGING LIVE CELLS IN HEALTH AND DISEASE pp. 157​-174​.​
    San diego​: Elsevier Academic Press Inc. DOI: https://doi.org/10.1016/B978-0-12-391856-7.00033-0 
    ​Details  DOI  PMID  PMC  WoS 
  • 2011 | Journal Article | 
    ​ ​α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells.​
    Hansen, C.; Angot, E.; Bergström, A.-L.; Steiner, J. A.; Pieri, L.; Paul, G. & Outeiro, T. F.  et al.​ (2011) 
    The Journal of clinical investigation, 121(2) pp. 715​-25​.​ DOI: https://doi.org/10.1172/JCI43366 
    ​Details  DOI  PMID  PMC 
  • 2011 | Journal Article
    ​ ​Impaired Proteostasis Contributes to Renal Tubular Dysgenesis​
    de Oliveira, R. M.; Marijanovic, Z.; Carvalho, F.; Miltényi, G. M.; Matos, J. E.; Tenreiro, S. & Oliveira, S. et al.​ (2011) 
    PLoS ONE, 6(6) pp. e20854​.​ DOI: https://doi.org/10.1371/journal.pone.0020854 
    ​Details  DOI 
  • 2011 | Journal Article
    ​ ​Tau Enhances α-Synuclein Aggregation and Toxicity in Cellular Models of Synucleinopathy​
    Badiola, N.; de Oliveira, R. M.; Herrera, F.; Guardia-Laguarta, C.; Gonçalves, S. A.; Pera, M. & Suárez-Calvet, M. et al.​ (2011) 
    PLoS ONE, 6(10) pp. e26609​.​ DOI: https://doi.org/10.1371/journal.pone.0026609 
    ​Details  DOI 
  • 2011 | Journal Article
    ​ ​Synthesis and in vitro evaluation of fluorinated styryl benzazoles as amyloid-probes​
    Morais, G. R.; Vicente Miranda, H.; Santos, I. C.; Outeiro, T. F.   & Paulo, A.​ (2011) 
    Bioorganic & Medicinal Chemistry, 19(24) pp. 7698​-7710​.​ DOI: https://doi.org/10.1016/j.bmc.2011.09.065 
    ​Details  DOI  WoS 
  • 2011 | Journal Article
    ​ ​Amyloidogenesis FlAsH illuminates A beta aggregation​
    Outeiro, T. F. ​ (2011) 
    Nature Chemical Biology, 7(9) pp. 581​-582​.​
    ​Details  PMID  PMC  WoS 
  • 2011 | Journal Article
    ​ ​Epigenetics in neurodegeneration: A new layer of complexity​
    Marques, S. C.; Oliveira, C. R.; Pereira, C. M. & Outeiro, T. F. ​ (2011) 
    Progress in Neuro-Psychopharmacology and Biological Psychiatry, 35(2) pp. 348​-355​.​ DOI: https://doi.org/10.1016/j.pnpbp.2010.08.008 
    ​Details  DOI 
  • 2011 | Conference Abstract
    ​ ​SIRT2 is downregulated in insulin-resistant HepG2 cells: a possible role of oxidative stress.​
    Lemos, V.; de Oliveira, R.; Outeiro, T. F.   & Gomes, P.​ (2011)
    Molecular Biology of the Cell, 22 , Denver, CO.
    Bethesda​: Amer Soc Cell Biology.
    ​Details  WoS 
  • 2011 | Journal Article
    ​ ​Assessment of the Efficacy of Solutes from Extremophiles on Protein Aggregation in Cell Models of Huntington’s and Parkinson’s Diseases​
    Jorge, C. D.; Ventura, R.; Maycock, C.; Outeiro, T. F. ; Santos, H. & Costa, J.​ (2011) 
    Neurochemical Research, 36(6) pp. 1005​-1011​.​ DOI: https://doi.org/10.1007/s11064-011-0440-3 
    ​Details  DOI 
  • 2011 | Journal Article | 
    ​ ​FlAsH illuminates Aβ aggregation​
    Outeiro, T. F. ​ (2011) 
    Nature Chemical Biology, 7(9) pp. 581​-582​.​ DOI: https://doi.org/10.1038/nchembio.636 
    ​Details  DOI 
  • 2011 | Journal Article | 
    ​ ​Antibodies against Alpha-Synuclein Reduce Oligomerization in Living Cells​
    Nasstrom, T.; Goncalves, S. A.; Sahlin, C.; Nordstrom, E.; Sundquist, V. S.; Lannfelt, L. & Bergstrom, J. et al.​ (2011) 
    PLoS ONE, 6(10) art. e27230​.​ DOI: https://doi.org/10.1371/journal.pone.0027230 
    ​Details  DOI  PMID  PMC  WoS 
  • 2011 | Journal Article
    ​ ​Aggresome formation and segregation of inclusions influence toxicity of alpha-synuclein and synphilin-1 in yeast​
    Swinnen, E.; Buettner, S.; Outeiro, T. F. ; Galas, M.-C.; Madeo, F.; Winderickx, J. & Franssens, V.​ (2011) 
    Biochemical Society Transactions, 39 pp. 1476​-1481​.​ DOI: https://doi.org/10.1042/BST0391476 
    ​Details  DOI  PMID  PMC  WoS 
  • 2011 | Journal Article | 
    ​ ​Idebenone and Resveratrol Extend Lifespan and Improve Motor Function of HtrA2 Knockout Mice​
    Gerhardt, E.; Graeber, S.; Szego, E. M.; Moisoi, N.; Martins, L. M.; Outeiro, T. F.   & Kermer, P.​ (2011) 
    PLoS ONE, 6(12) art. e28855​.​ DOI: https://doi.org/10.1371/journal.pone.0028855 
    ​Details  DOI  PMID  PMC  WoS 
  • 2011 | Review
    ​ ​Modulating Alzheimer's Disease Through Caffeine: A Putative Link to Epigenetics​
    Marques, S.; Batalha, V. L.; Lopes, L. V.& Outeiro, T. F. ​ (2011)
    Journal of Alzheimer s Disease, 24​ pp. 161​-171​.​
    Ios Press. DOI: https://doi.org/10.3233/JAD-2011-110032 
    ​Details  DOI  PMID  PMC  WoS 
  • 2011 | Conference Paper
    ​ ​Dopamine-depletion and increased alpha-synuclein load induce degeneration of cortical cholinergic fibers in mice​
    Szego, E. M.; Gerhardt, E.; Outeiro, T. F.   & Kermer, P.​ (2011)
    Journal of the Neurological Sciences, 310(1-2) pp. 90​-95. , Barcelona, SPAIN.
    Amsterdam​: Elsevier Science Bv. DOI: https://doi.org/10.1016/j.jns.2011.06.048 
    ​Details  DOI  PMID  PMC  WoS 
  • 2011 | Journal Article | 
    ​ ​Convergence of miRNA Expression Profiling, alpha-Synuclein Interacton and GWAS in Parkinson's Disease​
    Martins, M.; Rosa, A.; Guedes, L. C.; Fonseca, B. V.; Gotovac, K.; Violante, S. & Mestre, T. et al.​ (2011) 
    PLoS ONE, 6(10) art. e25443​.​ DOI: https://doi.org/10.1371/journal.pone.0025443 
    ​Details  DOI  PMID  PMC  WoS 
  • 2010 | Journal Article | 
    ​ ​Zooming into protein oligomerization in neurodegeneration using BiFC.​
    Gonçalves, S. A.; Matos, J. E. & Outeiro, T. F. ​ (2010) 
    Trends in biochemical sciences, 35(11) pp. 643​-51​.​ DOI: https://doi.org/10.1016/j.tibs.2010.05.007 
    ​Details  DOI  PMID  PMC 
  • 2010 | Journal Article | 
    ​ ​Sirtuins: common targets in aging and in neurodegeneration.​
    de Oliveira, R. M.; Pais, T. F. & Outeiro, T. F. ​ (2010) 
    Current drug targets, 11(10) pp. 1270​-80​.​
    ​Details  PMID  PMC 
  • 2010 | Journal Article
    ​ ​Alzheimer's Disease: The Quest to Understand Complexity​
    Marques, S. C. F.; Oliveira, C. R.; Outeiro, T. F.   & Pereira, C. M. F.​ (2010) 
    Journal of Alzheimer's Disease, 21(2) pp. 373​-383​.​ DOI: https://doi.org/10.3233/JAD-2010-100303 
    ​Details  DOI 
  • 2010 | Journal Article
    ​ ​Increased serum HSP70 levels are associated with the duration of diabetes​
    Nakhjavani, M.; Morteza, A.; Khajeali, L.; Esteghamati, A.; Khalilzadeh, O.; Asgarani, F. & Outeiro, T. F. ​ (2010) 
    Cell Stress and Chaperones, 15(6) pp. 959​-964​.​ DOI: https://doi.org/10.1007/s12192-010-0204-z 
    ​Details  DOI 
  • 2010 | Journal Article
    ​ ​A non-invasive method based on saliva to characterize transthyretin in familial amyloidotic polyneuropathy patients using FT-ICR high-resolution MS​
    da Costa, G.; Guerreiro, A.; Correia, C. F.; Gomes, R. J.; Freire, A.; Monteiro, E. & Barroso, E. et al.​ (2010) 
    PROTEOMICS - Clinical Applications, 4(6-7) pp. 674​-678​.​ DOI: https://doi.org/10.1002/prca.200900118 
    ​Details  DOI 
  • 2010 | Journal Article
    ​ ​Simple is good: yeast models of neurodegeneration​
    Tenreiro, S. & Outeiro, T. F. ​ (2010) 
    FEMS Yeast Research, 10(8) pp. 970​-979​.​ DOI: https://doi.org/10.1111/j.1567-1364.2010.00649.x 
    ​Details  DOI 
  • 2010 | Journal Article
    ​ ​Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson’s disease models​
    Su, L. J.; Auluck, P. K.; Outeiro, T. F. ; Yeger-Lotem, E.; Kritzer, J. A.; Tardiff, D. F. & Strathearn, K. E. et al.​ (2010) 
    Disease Models & Mechanisms, 3(3-4) pp. 194​-208​.​ DOI: https://doi.org/10.1242/dmm.004267 
    ​Details  DOI 
  • 2010 | Journal Article | 
    ​ ​Functional Gene Expression Profiling in Yeast Implicates Translational Dysfunction in Mutant Huntingtin Toxicity​
    Tauber, E.; Miller-Fleming, L.; Mason, R. P.; Kwan, W.; Clapp, J.; Butler, N. J. & Outeiro, T. F.  et al.​ (2010) 
    Journal of Biological Chemistry, 286(1) pp. 410​-419​.​ DOI: https://doi.org/10.1074/jbc.M110.101527 
    ​Details  DOI  PMID  PMC 
  • 2010 | Journal Article | 
    ​ ​Synphilin-1 enhances α-synuclein aggregation in yeast and contributes to cellular stress and cell death in a Sir2-dependent manner.​
    Büttner, S.; Delay, C.; Franssens, V.; Bammens, T.; Ruli, D.; Zaunschirm, S. & de Oliveira, R. M. et al.​ (2010) 
    PLoS One, 5(10) art. e13700​.​ DOI: https://doi.org/10.1371/journal.pone.0013700 
    ​Details  DOI  PMID  PMC 
  • 2009 | Journal Article
    ​ ​Dopamine-Induced Conformational Changes in Alpha-Synuclein​
    Outeiro, T. F. ; Klucken, J.; Bercury, K.; Tetzlaff, J.; Putcha, P.; Oliveira, L. M. A. & Quintas, A. et al.​ (2009) 
    PLoS ONE, 4(9) pp. e6906​.​ DOI: https://doi.org/10.1371/journal.pone.0006906 
    ​Details  DOI 
  • 2009 | Journal Article
    ​ ​Current and Future Therapeutic Strategies for Parkinsons Disease​
    Outeiro, T. F.   & Ferreira, J.​ (2009) 
    Current Pharmaceutical Design, 15(34) pp. 3968​-3976​.​ DOI: https://doi.org/10.2174/138161209789649321 
    ​Details  DOI 
  • 2009 | Journal Article
    ​ ​The sour side of neurodegenerative disorders: the effects of protein glycation​
    Miranda, H. V. & Outeiro, T. F. ​ (2009) 
    The Journal of Pathology, 221(1) pp. 13​-25​.​ DOI: https://doi.org/10.1002/path.2682 
    ​Details  DOI 
  • 2008 | Book Chapter
    ​ ​Detection of Compounds That Rescue Rab1‐Synuclein Toxicity​
    Fleming, J.; Outeiro, T. F. ; Slack, M.; Lindquist, S. L.& Bulawa, C. E.​ (2008)
    In: Small GTPases in Disease, Part B pp. 339​-351. ​Elsevier. DOI: https://doi.org/10.1016/S0076-6879(07)00425-9 
    ​Details  DOI 
  • 2008 | Journal Article
    ​ ​Therapeutic role of sirtuins in neurodegenerative disease​
    Outeiro, T. F. ; Marques, O. & Kazantsev, A.​ (2008) 
    Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1782(6) pp. 363​-369​.​ DOI: https://doi.org/10.1016/j.bbadis.2008.02.010 
    ​Details  DOI 
  • 2008 | Journal Article
    ​ ​CHIP Targets Toxic α-Synuclein Oligomers for Degradation​
    Tetzlaff, J. E.; Putcha, P.; Outeiro, T. F. ; Ivanov, A.; Berezovska, O.; Hyman, B. T. & McLean, P. J.​ (2008) 
    Journal of Biological Chemistry, 283(26) pp. 17962​-17968​.​ DOI: https://doi.org/10.1074/jbc.M802283200 
    ​Details  DOI 
  • 2008 | Journal Article
    ​ ​Direct quantification of CSF alpha-synuclein by ELISA and first cross-sectional study in patients with neurodegeneration​
    Mollenhauer, B.; Cullen, V.; Kahn, I.; Krastins, B.; Outeiro, T. F. ; Pepivani, I. & Ng, J. et al.​ (2008) 
    Experimental Neurology, 213(2) pp. 315​-325​.​ DOI: https://doi.org/10.1016/j.expneurol.2008.06.004 
    ​Details  DOI  PMID  PMC  WoS 
  • 2008 | Journal Article | 
    ​ ​Formation of Toxic Oligomeric α-Synuclein Species in Living Cells​
    Outeiro, T. F. ; Putcha, P.; Tetzlaff, J. E.; Spoelgen, R.; Koker, M.; Carvalho, F. & Hyman, B. T. et al.​ (2008) 
    PLoS ONE, 3(4) art. e1867​.​ DOI: https://doi.org/10.1371/journal.pone.0001867 
    ​Details  DOI  PMID  PMC 
  • 2007 | Journal Article
    ​ ​Sirtuin 2 Inhibitors Rescue α-Synuclein-Mediated Toxicity in Models of Parkinson's Disease​
    Outeiro, T. F. ; Kontopoulos, E.; Altmann, S. M.; Kufareva, I.; Strathearn, K. E.; Amore, A. M. & Volk, C. B. et al.​ (2007) 
    Science, 317(5837) pp. 516​-519​.​ DOI: https://doi.org/10.1126/science.1143780 
    ​Details  DOI 
  • 2007 | Journal Article
    ​ ​Angiotensin II protects against α-synuclein toxicity and reduces protein aggregation in vitro​
    Grammatopoulos, T. N.; Outeiro, T. F. ; Hyman, B. T. & Standaert, D. G.​ (2007) 
    Biochemical and Biophysical Research Communications, 363(3) pp. 846​-851​.​ DOI: https://doi.org/10.1016/j.bbrc.2007.09.043 
    ​Details  DOI 
  • 2007 | Journal Article
    ​ ​Pharmacological inhibition of PARP-1 reduces α-synuclein- and MPP+-induced cytotoxicity in Parkinson’s disease in vitro models​
    Outeiro, T. F. ; Grammatopoulos, T. N.; Altmann, S.; Amore, A.; Standaert, D. G.; Hyman, B. T. & Kazantsev, A. G.​ (2007) 
    Biochemical and Biophysical Research Communications, 357(3) pp. 596​-602​.​ DOI: https://doi.org/10.1016/j.bbrc.2007.03.163 
    ​Details  DOI 
  • 2007 | Journal Article
    ​ ​Dopaminergic neuron loss and up-regulation of chaperone protein mRNA induced by targeted over-expression of alpha-synuclein in mouse substantia nigra​
    St Martin, J. L.; Klucken, J.; Outeiro, T. F. ; Nguyen, P.; Keller-McGandy, C.; Cantuti-Castelvetri, I. & Grammatopoulos, T. N. et al.​ (2007) 
    Journal of Neurochemistry, 0(0) pp. 070214184024010​-???​.​ DOI: https://doi.org/10.1111/j.1471-4159.2006.04310.x 
    ​Details  DOI 
  • 2006 | Journal Article
    ​ ​Small heat shock proteins protect against α-synuclein-induced toxicity and aggregation​
    Outeiro, T. F. ; Klucken, J.; Strathearn, K. E.; Liu, F.; Nguyen, P.; Rochet, J.-C. & Hyman, B. T. et al.​ (2006) 
    Biochemical and Biophysical Research Communications, 351(3) pp. 631​-638​.​ DOI: https://doi.org/10.1016/j.bbrc.2006.10.085 
    ​Details  DOI 
  • 2006 | Journal Article
    ​ ​Detection of novel intracellular O‐synuclein oligomeric species by fluorescence lifetime imaging​
    Klucken, J.; Outeiro, T. F. ; Nguyen, P.; McLean, P. J. & Hyman, B. T.​ (2006) 
    The FASEB Journal, 20(12) pp. 2050​-2057​.​ DOI: https://doi.org/10.1096/fj.05-5422com 
    ​Details  DOI 

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