Dr. med. Thilo Sprenger

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  • 2020 | Journal Article
    ​ ​The long-term influence of hospital and surgeon volume on local control and survival in the randomized German Rectal Cancer Trial CAO/ARO/AIO-94​
    Sprenger, T. ; Beißbarth, T. ; Sauer, R.; Tschmelitsch, J.; Fietkau, R.; Hohenberger, W. & Staib, L. et al.​ (2020) 
    Surgical Oncology, 35 pp. 200​-205​.​ DOI: https://doi.org/10.1016/j.suronc.2020.08.021 
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​Hiatal hernias in patients with GERD-like symptoms: evaluation of dynamic real-time MRI vs endoscopy​
    Hosseini, A. S. A. ; Uhlig, J.; Streit, U.; Uhlig, A.; Sprenger, T. ; Wedi, E.   & Ellenrieder, V.  et al.​ (2019) 
    European Radiology, 29(12) pp. 6653​-6661​.​ DOI: https://doi.org/10.1007/s00330-019-06284-8 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article
    ​ ​Hepatic arterial infusion of irinotecan and EmboCept® S results in high tumor concentration of SN-38 in a rat model of colorectal liver metastases​
    Kauffels, A. ; Kitzmüller, M.; Gruber, A.; Nowack, H.; Bohnenberger, H. ; Spitzner, M.   & Kuthning, A. et al.​ (2019) 
    Clinical & Experimental Metastasis, 36(1) pp. 57​-66​.​ DOI: https://doi.org/10.1007/s10585-019-09954-5 
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​Real-time MRI for the dynamic assessment of fundoplication failure in patients with gastroesophageal reflux disease​
    Hosseini, A. S. A. ; Uhlig, J.; Streit, U.; Voit, D.; Uhlig, A.; Ellenrieder, V.   & Ghadimi, M. B.  et al.​ (2019) 
    European Radiology, 29(9) pp. 4691​-4698​.​ DOI: https://doi.org/10.1007/s00330-019-06025-x 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article
    ​ ​The influence of hospital and surgeon volume on survival and local control in rectal cancer: Long-term results of the CAO/ARO/AIO-94 trial.​
    Sprenger, T. ; Beissbarth, T. ; Sauer, R.; Fokas, E.; Hohenberger, W.; Liersch, T.   & Rödel, C. et al.​ (2018) 
    Journal of Clinical Oncology, 36(4, Suppl.) pp. 738​-738​.​ DOI: https://doi.org/10.1200/JCO.2018.36.4_suppl.738 
    ​Details  DOI 
  • 2017 | Journal Article
    ​ ​The prognostic impact of surgical complications after combined modality treatment of rectal cancer: Long-term results of the CAO/ARO/AIO-94 trial​
    Sprenger, T. ; Fietkau, R.; Raab, H.-R.; Hohenberger, W.; Liersch, T. ; Rödel, C. & Ghadimi, M.  et al.​ (2017) 
    Journal of Clinical Oncology, 35(4, Suppl.) pp. 670​-670​.​ DOI: https://doi.org/10.1200/JCO.2017.35.4_suppl.670 
    ​Details  DOI 
  • 2017 | Journal Article | 
    ​ ​The Prognostic Value of Tyrosine Kinase SRC Expression in Locally Advanced Rectal Cancer​
    Rühlmann, F. ; Nietert, M. M. ; Sprenger, T. ; Wolff, H. A. ; Homayounfar, K. ; Middel, P. & Bohnenberger, H.  et al.​ (2017) 
    Journal of Cancer, 8(7) pp. 1229​-1237​.​ DOI: https://doi.org/10.7150/jca.16980 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Conference Abstract
    ​ ​The prognostic role of the host immune response in rectal cancer patients treated with neoadjuvant chemoradiation.​
    Sprenger, T. ; Wirtz, R. M; Pektas, S.; Bohnenberger, H. ; Kauffels, A. ; Conradi, L.-C.   & Homayounfar, K.  et al.​ (2016)
    34(4) pp. 575​-575. ​Gastrointestinal Cancers Symposium​, San Francisco, CA.
    Alexandria​: Amer Soc Clinical Oncology. DOI: https://doi.org/10.1200/jco.2016.34.4_suppl.575 
    ​Details  DOI  WoS 
  • 2016 | Journal Article
    ​ ​Stage-Dependent Frequency of Lymph Node Metastases in Patients With Rectal Carcinoma After Preoperative Chemoradiation: Results from the CAO/ARO/AIO-94 Trial and From a Comparative Prospective Evaluation With Extensive Pathological Workup​
    Sprenger, T. ; Rothe, H.; Conradi, L.-C. ; Beissbarth, T. ; Kauffels, A. ; Kitz, J.   & Homayounfar, K.  et al.​ (2016) 
    Diseases of the Colon & Rectum, 59(5) pp. 377​-385​.​ DOI: https://doi.org/10.1097/DCR.0000000000000570 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article
    ​ ​Lymph nodemetastases in ypT1/2 rectal cancer after neoadjuvant chemoradiotherapy. The Achilles heel of organ-preserving operative procedures?​
    Sprenger, T. ; Rothe, H.; Beißbarth, T. ; Conradi, L.-C. ; Kauffels, A. ; Homayounfar, K.   & Behnes, C.-L.  et al.​ (2016) 
    Der Chirurg, 87(7) pp. 593​-601​.​ DOI: https://doi.org/10.1007/s00104-016-0170-9 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Journal Article
    ​ ​HER-2 and HER-3 expression in liver metastases of patients with colorectal cancer​
    Styczen, H.; Nagelmeier, I.; Beißbarth, T. ; Nietert, M. M. ; Homayounfar, K. ; Sprenger, T.   & Boczek, U. et al.​ (2015) 
    Oncotarget, 6(17) pp. 15065​-15076​.​
    ​Details  PMID  PMC  WoS 
  • 2014 | Conference Abstract
    ​ ​SRC expression in locally advanced rectal cancer-before and after neoadjuvant chemoradiotherapy​
    Ruehlmann, F. ; Nietert, M. M. ; Sprenger, T. ; Wolff, H. A. ; Homayounfar, K. ; Ghadimi, M. B.   & Beißbarth, T.  et al.​ (2014)
    Oncology Research and Treatment, 37 
    Basel​: Karger.
    ​Details  WoS 
  • 2014 | Conference Abstract
    ​ ​Residual rectal cancer after preoperative radiochemotherapy (ypT1-2): An indication for local excision instead of radical surgery?​
    Sprenger, T. ; Rothe, H.; Conradi, L.-C. ; Homayounfar, K. ; Beißbarth, T. ; Ghadimi, M. B.   & Liersch, T. ​ (2014)
    Journal of Clinical Oncology, 32(3) ​Gastrointestinal Cancers Symposium​, San Francisco, CA.
    Alexandria​: Amer Soc Clinical Oncology.
    ​Details  WoS 
  • 2013 | Journal Article
    ​ ​Lymph Node Metastases in Rectal Cancer After Preoperative Radiochemotherapy Impact of Intramesorectal Distribution and Residual Micrometastatic Involvement​
    Sprenger, T. ; Rothe, H.; Becker, H.; Beißbarth, T. ; Homayounfar, K. ; Gauss, K. & Kitz, J.  et al.​ (2013) 
    American Journal of Surgical Pathology, 37(8) pp. 1283​-1289​.​
    ​Details  PMID  PMC  WoS 
  • 2013 | Conference Abstract
    ​ ​HER-2 and HER-3 expression in locally advanced rectal cancer and metachronous metastases: new targets for treatment approaches?​
    Conradi, L.-C. ; Styczen, H.; Sprenger, T. ; Wolff, H. A. ; Middel, P.; Nagelmeier, I. & Rüschoff, J. R.  et al.​ (2013)
    Onkologie, 36 
    Basel​: Karger.
    ​Details  WoS 
  • 2013 | Conference Abstract
    ​ ​5-FU dose monitoring under neoadjuvant radiochemotherapy and adjuvant chemotherapy for locally advanced rectal cancer​
    Conradi, L.-C. ; Quack, H.; Sprenger, T. ; Wolff, H. A. ; Binder, L.; Ghadimi, M. B.   & Homayounfar, K.  et al.​ (2013)
    Onkologie, 36 
    Basel​: Karger.
    ​Details  WoS 
  • 2013 | Conference Abstract
    ​ ​Association of CD133 expression levels with the k-ras mutation status in rectal cancers before and after preoperative radiochemotherapy​
    Sprenger, T. ; Gaedcke, J. ; Conradi, L.-C. ; Jo, P. ; Jung, K. ; Beißbarth, T.   & Homayounfar, K.  et al.​ (2013)
    Journal of Clinical Oncology, 31(4) ​Gastrointestinal Cancers Symposium of the American-Society-of-Clinical-Oncology (ASCO)​, San Francisco, CA.
    Alexandria​: Amer Soc Clinical Oncology.
    ​Details  WoS 
  • 2013 | Journal Article
    ​ ​Enrichment of CD133-expressing cells in rectal cancers treated with preoperative radiochemotherapy is an independent marker for metastasis and survival​
    Sprenger, T. ; Conradi, L.-C. ; Beißbarth, T. ; Ermert, H.; Homayounfar, K. ; Middel, P. & Rüschoff, J. R.  et al.​ (2013) 
    Cancer, 119(1) pp. 26​-35​.​ DOI: https://doi.org/10.1002/cncr.27703 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article
    ​ ​Frequency of HER-2 Positivity in Rectal Cancer and Prognosis​
    Conradi, L.-C. ; Styczen, H.; Sprenger, T. ; Wolff, H. A. ; Roedel, C.; Nietert, M. M.   & Homayounfar, K.  et al.​ (2013) 
    American Journal of Surgical Pathology, 37(4) pp. 522​-531​.​ DOI: https://doi.org/10.1097/PAS.0b013e318272ff4d 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article
    ​ ​Preoperative Chemoradiation Therapy With Capecitabine/Oxaliplatin and Cetuximab in Rectal Cancer: Long-Term Results of a Prospective Phase 1/2 Study​
    Fokas, E.; Conradi, L.-C. ; Weiss, C.; Sprenger, T. ; Middel, P.; Rau, T. & Dellas, K. et al.​ (2013) 
    International Journal of Radiation Oncology*Biology*Physics, 87(5) pp. 992​-999​.​ DOI: https://doi.org/10.1016/j.ijrobp.2013.09.011 
    ​Details  DOI  PMID  PMC  WoS 
  • 2012 | Conference Abstract
    ​ ​Clinical significance and prognostic impact of CD133 expression in rectal cancer treated with preoperative radiochemotherapy​
    Sprenger, T. ; Conradi, L.-C. ; Beißbarth, T. ; Homayounfar, K. ; Rüschoff, J. R. ; Roedel, C. & Ghadimi, M. B.  et al.​ (2012)
    Journal of Clinical Oncology, 30(15) ​48th Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO)​, Chicago, IL.
    Alexandria​: Amer Soc Clinical Oncology.
    ​Details  WoS 
  • 2012 | Conference Abstract
    ​ ​Cetuximab, capecitabine, oxaliplatin, and radiotherapy as preoperative triple treatment for rectal cancer (CET-CAPOX-RT-Phase-I/II Study): Influence on long-term survival and relevance of biomarkers​
    Liersch, T. ; Conradi, L.-C. ; Sprenger, T. ; Middel, P.; Suelberg, H.; Roedel, F. & Rüschoff, J. R.  et al.​ (2012)
    Journal of Clinical Oncology, 30(15) ​48th Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO)​, Chicago, IL.
    Alexandria​: Amer Soc Clinical Oncology.
    ​Details  WoS 
  • 2012 | Conference Abstract
    ​ ​HER-2 in locally advanced rectal cancer (cUICC II/III): positivity rate and prognostic value​
    Conradi, L.-C. ; Styczen, H.; Sprenger, T. ; Wolff, H. A. ; Homayounfar, K. ; Becker, H. & Ghadimi, M. B.  et al.​ (2012)
    British Journal of Surgery, 99 ​99th Annual Congress of the Swiss-Society-of-Surgery​, Davos, SWITZERLAND.
    Malden​: Wiley-blackwell.
    ​Details  WoS 
  • 2012 | Conference Abstract
    ​ ​HER2 status in locally advanced rectal cancer and metachronous metastases: Opportunity for a new therapeutic approach?​
    Conradi, L.-C. ; Styczen, H.; Sprenger, T. ; Homayounfar, K. ; Wolff, H. A. ; Bleckmann, A.   & Rüschoff, J. R.  et al.​ (2012)
    Journal of Clinical Oncology, 30(15) , Chicago, IL.
    Alexandria​: Amer Soc Clinical Oncology.
    ​Details  WoS 
  • 2011 | Conference Abstract
    ​ ​Thymidylate Synthase as Biomarker in Rectal Cancer Patients After 5-FU-based Radiochemotherapy - Evaluation of the Prognostic Capacity in Pre-treatment Biopsies and Resected Adenocarcinoma​
    Conradi, L.-C. ; Bleckmann, A. ; Sprenger, T. ; Schirmer, M. A. ; Homayounfar, K. ; Wolff, H. A.   & Becker, H. et al.​ (2011)
    European Journal of Cancer, 47 ​European Multidisciplinary Cancer Congress on Integrating Basic and Translational Science, Surgery, Radiotherapy, Medical oncology, Advocacy and Care​, Stockholm, SWEDEN.
    Oxford​: Elsevier Sci Ltd.
    ​Details  WoS 
  • 2011 | Conference Abstract
    ​ ​Biomarker study in rectal cancer patients after 5FU-based radiochemotherapy: Evaluation of the prognostic capacity of thymidylate synthase in pretreatment biopsies and resected adenocarcinoma.​
    Conradi, L.-C. ; Bleckmann, A. ; Schirmer, M. A. ; Sprenger, T. ; Homayounfar, K. ; Wolff, H. A.   & Becker, H. et al.​ (2011)
    Journal of Clinical Oncology, 29(4) 
    Alexandria​: Amer Soc Clinical Oncology.
    ​Details  PMID  PMC  WoS 
  • 2011 | Conference Abstract
    ​ ​Association of survivin expression following neoadjuvant radiochemotherapy in rectal cancer with distant metastases and survival.​
    Sprenger, T. ; Roedel, F.; Beißbarth, T. ; Conradi, L.-C. ; Homayounfar, K. ; Ghadimi, M. B.   & Yildrim, M. et al.​ (2011)
    Journal of Clinical Oncology, 29(4) 
    Alexandria​: Amer Soc Clinical Oncology.
    ​Details  PMID  PMC  WoS 
  • 2011 | Conference Abstract
    ​ ​Survivin Expression in Rectal Cancer During Preoperative Radiochemotherapy and Its Impact on Metastasis and Patients' Survival​
    Sprenger, T. ; Roedel, F.; Beißbarth, T. ; Conradi, L.-C. ; Yildirim, M.; Ghadimi, M. B.   & Becker, H. et al.​ (2011)
    European Journal of Cancer, 47 ​European Multidisciplinary Cancer Congress on Integrating Basic and Translational Science, Surgery, Radiotherapy, Medical oncology, Advocacy and Care​, Stockholm, SWEDEN.
    Oxford​: Elsevier Sci Ltd.
    ​Details  WoS 
  • 2011 | Conference Abstract
    ​ ​A lack of down-regulation of survivin after neoadjuvant Chemoradiotherapy for Rectal cancer with distant metastasis and Reduced survival rate linked​
    Roedel, F.; Sprenger, T. ; Beißbarth, T. ; Conradi, L.-C. ; Rothe, H.; Homayonfaur, K. & Wolff, H. A.  et al.​ (2011)
    Strahlentherapie und Onkologie, 187 ​17th Annual Meeting of the German-Society-for-Radiation-Oncology​, Wiesbaden, GERMANY.
    Munich​: Urban & Vogel.
    ​Details  WoS 
  • 2011 | Journal Article | 
    ​ ​Failure of Downregulation of Survivin Following Neoadjuvant Radiochemotherapy in Rectal Cancer Is Associated with Distant Metastases and Shortened Survival​
    Sprenger, T. ; Roedel, F.; Beißbarth, T. ; Conradi, L.-C. ; Rothe, H.; Homayounfar, K.   & Wolff, H. A.  et al.​ (2011) 
    Clinical Cancer Research, 17(6) pp. 1623​-1631​.​ DOI: https://doi.org/10.1158/1078-0432.CCR-10-2592 
    ​Details  DOI  PMID  PMC  WoS 
  • 2011 | Journal Article | 
    ​ ​Thymidylate Synthase as a Prognostic Biomarker for Locally Advanced Rectal Cancer after multimodal Treatment​
    Conradi, L.-C. ; Bleckmann, A. ; Schirmer, M. A. ; Sprenger, T. ; Jo, P. ; Homayounfar, K.   & Wolff, H. A.  et al.​ (2011) 
    Annals of Surgical Oncology, 18(9) pp. 2442​-2452​.​ DOI: https://doi.org/10.1245/s10434-011-1608-4 
    ​Details  DOI  PMID  PMC  WoS 
  • 2011 | Journal Article
    ​ ​Gender-Specific Acute Organ Toxicity during Intensified Preoperative Radiochemotherapy for Rectal Cancer​
    Wolff, H. A. ; Conradi, L.-C. ; Schirmer, M. A. ; Beißbarth, T. ; Sprenger, T. ; Rave-Fränk, M.   & Hennies, S. et al.​ (2011) 
    The Oncologist, 16(5) pp. 621​-631​.​ DOI: https://doi.org/10.1634/theoncologist.2010-0414 
    ​Details  DOI  PMID  PMC  WoS 
  • 2010 | Journal Article | 
    ​ ​Preoperative Chemoradiotherapy Does Not Necessarily Reduce Lymph Node Retrieval in Rectal Cancer Specimens-Results from a Prospective Evaluation with Extensive Pathological Work-up​
    Sprenger, T. ; Rothe, H.; Homayounfar, K. ; Beißbarth, T. ; Ghadimi, M. B. ; Becker, H. & Liersch, T. ​ (2010) 
    Journal of Gastrointestinal Surgery, 14(1) pp. 96​-103​.​ DOI: https://doi.org/10.1007/s11605-009-1057-6 
    ​Details  DOI  PMID  PMC  WoS 
  • 2009 | Journal Article | Letter Note
    ​ ​Comment on "Lymph Nodes After Preoperative Chemoradiotherapy for Rectal Carcinoma: Number, Status, and Impact on Survival"​
    Sprenger, T. ; Rothe, H.; Langer, C.; Becker, H. & Liersch, T.​ (2009) 
    American Journal of Surgical Pathology, 33(7).​
    ​Details  PMID  PMC  WoS 

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